TB-Profiler result

Run: ERR4831557

Summary

Run ID: ERR4831557

Sample name:

Date: 2024-04-14T02:36:02.749039

Number of reads: 1794862

Percentage reads mapped: 98.81

Median coverage: 55.0

Strain: lineage4.1.1.3;lineage4.3.2.1

Spoligotype:

Drug-resistance: Pre-XDR-TB


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.45
lineage4.3.2 Euro-American (LAM) None 0.45
lineage4.1 Euro-American None 0.55
lineage4.1.1.3 Euro-American (X-type) RD193 0.58
lineage4.3.2.1 Euro-American (LAM) RD761 0.43
lineage4 Euro-American None 1.0
lineage4.1.1 Euro-American (X-type) None 0.59
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ahpC c.-48G>A Uncertain significance Mutation from literature
ethambutol embB p.Met306Val Assoc w R
pyrazinamide pncA p.Val139Met Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Asp94Gly Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Gly Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide ethA c.597delC Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7582 p.Asp94Gly missense_variant 0.55 moxifloxacin Assoc w R High-level resistance
levofloxacin Assoc w R
rpoB 761155 p.Ser450Leu missense_variant 0.63 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.68 streptomycin Assoc w R
katG 2155167 p.Ser315Thr missense_variant 0.47 isoniazid Assoc w R High-level resistance
pncA 2288827 p.Val139Met missense_variant 0.54 pyrazinamide Assoc w R
ahpC 2726145 c.-48G>A upstream_gene_variant 0.51 isoniazid Uncertain significance Mutation from literature
embB 4247429 p.Met306Val missense_variant 0.52 ethambutol Assoc w R
ethA 4326876 c.597delC frameshift_variant 0.48 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5520 p.Pro94Leu missense_variant 0.47 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6608 p.Val457Leu missense_variant 0.54 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 7222 c.1983C>T synonymous_variant 0.43 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 0.68 ethionamide Uncertain significance
rpoC 764995 c.1626C>G synonymous_variant 0.43 rifampicin Not assoc w R
rpoC 765150 p.Gly594Glu missense_variant 0.5 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800219 c.-590T>C upstream_gene_variant 0.62 linezolid
rplC 801354 c.546G>A synonymous_variant 0.51 linezolid Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.47 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 0.98 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
thyA 3073868 p.Thr202Ala missense_variant 0.48 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3449616 p.Met371Ile missense_variant 0.51 ethionamide Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
fbiA 3640256 c.-287T>G upstream_gene_variant 0.46 clofazimine
pretomanid
delamanid
rpoA 3877949 p.Thr187Ala missense_variant 0.52 rifampicin Uncertain significance
clpC1 4038287 c.2418C>T synonymous_variant 0.45 pyrazinamide Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.51 ethambutol Not assoc w R
embB 4249408 c.2895G>A synonymous_variant 0.57 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 0.37 streptomycin Not assoc w R