TB-Profiler result

Run: SRR1011486
Summary

Run ID: SRR1011486

Sample name:

Date: 2024-10-05T06:12:24.688157

Number of reads: 7603620

Percentage reads mapped: 99.36

Median coverage: 178.0

Strain: lineage1.1.2;lineage4.3.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.1.2 Indo-Oceanic RD239 0.33
lineage4.3 Euro-American (LAM) None 0.69
lineage4.3.2 Euro-American (LAM) None 0.69
lineage1.1 Indo-Oceanic RD239 0.34
lineage4.3.2.1 Euro-American (LAM) RD761 0.65
lineage4 Euro-American None 0.71
lineage1 Indo-Oceanic RD239 0.35
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5520 p.Pro94Leu missense_variant 0.72 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 5764 c.525C>T synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 6112 p.Met291Ile missense_variant 0.34 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6124 c.885C>T synonymous_variant 0.35 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 7222 c.1983C>T synonymous_variant 0.7 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8452 p.Ala384Val missense_variant 0.33 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9143 c.1842T>C synonymous_variant 0.31 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 0.37 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 0.18 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 0.28 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.39 ethionamide
nusG 734116 c.-138T>C upstream_gene_variant 0.38 rifampicin Not assoc w R
rpoB 763031 c.3225T>C synonymous_variant 0.33 rifampicin Not assoc w R
rpoC 763884 p.Ala172Val missense_variant 0.33 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.33 rifampicin Not assoc w R
rpoC 764995 c.1626C>G synonymous_variant 0.67 rifampicin Not assoc w R
rpoC 765171 p.Pro601Leu missense_variant 0.36 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 0.32 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800357 c.-452C>A upstream_gene_variant 0.35 linezolid Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.36 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
embR 1417019 p.Cys110Tyr missense_variant 0.33 ethambutol Not assoc w R
embR 1417481 c.-134G>A upstream_gene_variant 0.25 ethambutol
embR 1417554 c.-207C>G upstream_gene_variant 0.26 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 0.25 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.64 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R - Interim
amikacin Not assoc w R
rpsA 1834885 c.1344G>A synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
tsnR 1853974 c.369C>T synonymous_variant 0.29 linezolid Not assoc w R
tsnR 1854045 p.Tyr147Cys missense_variant 0.32 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 0.31 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 0.29 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.32 pyrazinamide Not assoc w R
PPE35 2167983 p.Gly877Asp missense_variant 0.36 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 0.26 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.99 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518132 c.18C>T synonymous_variant 0.35 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 0.4 isoniazid
Rv2681 2996912 c.174C>T synonymous_variant 0.38 capreomycin Not assoc w R
Rv2752c 3064632 c.1560C>T synonymous_variant 0.27 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
thyA 3073868 p.Thr202Ala missense_variant 0.64 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 0.99 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 0.28 ethionamide Uncertain significance
lpqB 3624486 p.Asp142Gly missense_variant 0.31 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
alr 3841369 p.Arg18Trp missense_variant 0.34 cycloserine
clpC1 4038287 c.2418C>T synonymous_variant 0.62 pyrazinamide Not assoc w R
clpC1 4040517 p.Val63Ala missense_variant 0.33 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 0.4 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 0.3 ethambutol Not assoc w R
embC 4241042 p.Asn394Asp missense_variant 0.37 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243848 p.Val206Met missense_variant 0.28 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 0.34 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 0.17 ethambutol Not assoc w R
embB 4249673 p.Ser1054Pro missense_variant 0.3 ethambutol Not assoc w R - Interim
ubiA 4269387 p.Glu149Asp missense_variant 0.38 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 0.35 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 0.29 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338647 c.-126C>G upstream_gene_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 0.32 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 0.24 streptomycin Not assoc w R
gid 4407935 p.Leu90Val missense_variant 0.32 streptomycin Uncertain significance
gid 4407944 p.Gln87Glu missense_variant 0.29 streptomycin Uncertain significance
gid 4408156 p.Leu16Arg missense_variant 0.65 streptomycin Not assoc w R