TB-Profiler result

Run: SRR25827428

Summary

Run ID: SRR25827428

Sample name:

Date: 02-02-2024 03:06:55

Number of reads: 6526424

Percentage reads mapped: 99.15

Strain: lineage4;lineage3;lineage2.2.1

Drug-resistance: MDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin R rpoB p.Ser450Leu (0.34), rpoC p.Leu527Val (0.14)
Isoniazid R katG p.Ser315Thr (0.41)
Ethambutol R embB p.Met306Val (0.14)
Pyrazinamide
Streptomycin R rpsL p.Lys43Arg (0.28)
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 0.72
lineage2 East-Asian Beijing RD105 0.21
lineage4 Euro-American LAM;T;S;X;H None 0.07
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.2
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.2
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.34 rifampicin
rpoC 764948 p.Leu527Val missense_variant 0.14 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.28 streptomycin
katG 2155168 p.Ser315Thr missense_variant 0.41 isoniazid
embB 4247429 p.Met306Val missense_variant 0.14 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9629 c.2328C>T synonymous_variant 0.6
fgd1 491290 p.Val170Met missense_variant 0.16
fgd1 491742 c.960T>C synonymous_variant 0.93
mshA 575907 p.Ala187Val missense_variant 0.28
ccsA 620625 p.Ile245Met missense_variant 0.21
rpoB 759746 c.-61C>T upstream_gene_variant 0.67
rpoC 762434 c.-936T>G upstream_gene_variant 0.74
rpoC 762441 c.-929C>T upstream_gene_variant 0.69
rpoC 763031 c.-339T>C upstream_gene_variant 0.93
mmpL5 775639 p.Ile948Val missense_variant 0.99
mmpL5 776100 p.Thr794Ile missense_variant 0.92
mmpL5 776182 p.Asp767Asn missense_variant 0.21
mmpS5 779615 c.-710C>G upstream_gene_variant 0.19
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.23
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 0.29
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.95
PPE35 2167926 p.Leu896Ser missense_variant 0.93
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 0.74
pncA 2289365 c.-125delC upstream_gene_variant 0.74
ahpC 2726105 c.-88G>A upstream_gene_variant 0.67
ribD 2986827 c.-12G>A upstream_gene_variant 0.16
Rv2752c 3066143 p.Arg17Trp missense_variant 0.58
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.99
Rv3236c 3612813 p.Thr102Ala missense_variant 0.15
rpoA 3878544 c.-37C>G upstream_gene_variant 0.71
embC 4241022 p.Ala387Val missense_variant 0.14
embC 4242075 p.Arg738Gln missense_variant 0.65
embA 4242643 c.-590C>T upstream_gene_variant 0.99
embA 4243460 c.228C>T synonymous_variant 0.21
embB 4247028 p.Leu172Arg missense_variant 0.2
embB 4248216 p.Arg568Pro missense_variant 0.59
aftB 4267647 p.Asp397Gly missense_variant 0.24
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.94
gid 4407620 p.Tyr195His missense_variant 0.17
gid 4407927 p.Glu92Asp missense_variant 0.23