TB-Profiler result

Run: SRR28351584
Summary

Run ID: SRR28351584

Sample name:

Date: 2024-05-22T15:38:33.924157

Number of reads: 1636259

Percentage reads mapped: 94.8

Median coverage: 41.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embA c.-11C>A Uncertain significance Mutation from literature
embB p.Met306Val Assoc w R
pyrazinamide pncA p.Leu27Pro Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
ethA c.448_481delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNT Assoc w R
c.449_481delGATTCGCCGGCTCGGAGGATTTCGTCGGGCCGA Mutation from literature
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.820_822delTTAinsAT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGT Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1120_1122delTTGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1825_1827delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin Assoc w R
fbiC 1303750 c.820_822delTTAinsAT frameshift_variant&missense_variant 0.8 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGT frameshift_variant&missense_variant 0.86 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.53 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304050 c.1120_1122delTTGinsCC frameshift_variant&missense_variant 0.6 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304755 c.1825_1827delCTAinsTG frameshift_variant&stop_gained 0.79 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2289162 p.Leu27Pro missense_variant 1.0 pyrazinamide Assoc w R
embA 4243222 c.-11C>A upstream_gene_variant 1.0 ethambutol Uncertain significance Mutation from literature
embB 4247429 p.Met306Val missense_variant 0.83 ethambutol Assoc w R
ethA 4326992 c.448_481delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNT frameshift_variant 1.0 ethionamide Assoc w R
ethA 4326992 c.449_481delGATTCGCCGGCTCGGAGGATTTCGTCGGGCCGA disruptive_inframe_deletion 1.0 ethionamide Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 876 c.876C>G synonymous_variant 0.36 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.37 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.39 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.41 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.39 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.39 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.42 isoniazid
dnaA 936 c.936C>G synonymous_variant 0.47 isoniazid
dnaA 939 c.939C>T synonymous_variant 0.48 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.48 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.47 isoniazid
dnaA 952 c.952C>T synonymous_variant 0.47 isoniazid
dnaA 955 c.955_957delAGAinsCC frameshift_variant&missense_variant 0.45 isoniazid Uncertain significance
dnaA 966 c.966T>C synonymous_variant 0.44 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.48 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>T synonymous_variant 0.41 isoniazid
dnaA 993 c.993A>G synonymous_variant 0.41 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.41 isoniazid
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8324 c.1023T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.66 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8354 c.1053G>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8357 c.1056G>C synonymous_variant 0.68 levofloxacin
moxifloxacin
gyrA 8363 c.1062C>G synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 8372 c.1071G>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.7 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.7 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.71 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8402 c.1101C>T synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.66 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8429 c.1128C>G synonymous_variant 0.61 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 620583 c.693G>C synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620589 c.699G>C synonymous_variant 0.38 capreomycin
amikacin
kanamycin
ccsA 620598 c.708C>G synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620607 c.717T>G synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620613 c.723C>G synonymous_variant 0.42 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.5 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 0.5 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
ccsA 620649 c.759A>G synonymous_variant 0.65 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.67 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620712 c.822G>C synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.69 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
rpoB 760235 c.429T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.31 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.33 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.36 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760355 c.549G>A synonymous_variant 0.35 rifampicin
rpoB 760356 p.Thr184Ser missense_variant 0.37 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760649 c.843G>C synonymous_variant 0.81 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760658 c.852G>A synonymous_variant 0.81 rifampicin
rpoB 760661 c.855A>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.86 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.81 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.77 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.71 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.67 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.66 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.63 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.62 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.54 rifampicin
rpoB 760808 c.1002C>G synonymous_variant 0.51 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.55 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.48 rifampicin
rpoB 761357 c.1551G>C synonymous_variant 0.55 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.6 rifampicin
rpoB 761369 p.Glu521Asp missense_variant 0.6 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.58 rifampicin
rpoB 761648 c.1842T>C synonymous_variant 0.7 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.85 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.84 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.87 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.88 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.87 rifampicin
rpoB 761760 p.Ile652Val missense_variant 0.87 rifampicin
rpoB 761765 c.1959T>G synonymous_variant 0.86 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.86 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.86 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.85 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.76 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.62 rifampicin
rpoB 762820 p.Phe1005Tyr missense_variant 0.62 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 762851 c.-519C>T upstream_gene_variant 0.68 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.72 rifampicin Uncertain significance
rpoB 762923 c.3117C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 766488 p.Pro1040Arg missense_variant 1.0 rifampicin Uncertain significance
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775892 c.2589C>T synonymous_variant 0.79 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.83 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.81 clofazimine
bedaquiline
mmpL5 775916 c.2565T>A synonymous_variant 0.83 clofazimine
bedaquiline
mmpL5 775922 c.2559G>T synonymous_variant 0.83 clofazimine
bedaquiline
mmpL5 775925 c.2556G>C synonymous_variant 0.84 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.87 clofazimine
bedaquiline
mmpL5 775961 c.2520C>G synonymous_variant 0.87 clofazimine
bedaquiline
mmpL5 775975 c.2506T>C synonymous_variant 0.84 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.84 clofazimine
bedaquiline
mmpL5 776000 c.2481G>C synonymous_variant 0.76 clofazimine
bedaquiline
mmpL5 776009 c.2472A>G synonymous_variant 0.73 clofazimine
bedaquiline
mmpL5 776017 p.Ile822Phe missense_variant 0.72 clofazimine
bedaquiline
mmpL5 776030 c.2451G>T synonymous_variant 0.67 clofazimine
bedaquiline
mmpL5 776039 c.2442C>G synonymous_variant 0.67 clofazimine
bedaquiline
mmpL5 776048 c.2433G>C synonymous_variant 0.65 clofazimine
bedaquiline
mmpL5 776053 c.2428T>C synonymous_variant 0.64 clofazimine
bedaquiline
mmpL5 776057 c.2424G>C synonymous_variant 0.61 clofazimine
bedaquiline
mmpL5 776060 c.2421C>G synonymous_variant 0.6 clofazimine
bedaquiline
mmpL5 776072 c.2409C>G synonymous_variant 0.5 clofazimine
bedaquiline
mmpL5 776075 c.2406C>G synonymous_variant 0.47 clofazimine
bedaquiline
mmpL5 776081 c.2400G>C synonymous_variant 0.43 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781814 c.255C>T synonymous_variant 0.33 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.41 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.3 streptomycin
rpsL 781862 c.303G>C synonymous_variant 0.3 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.31 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.31 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.31 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.3 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.24 streptomycin
rplC 801109 c.301T>C synonymous_variant 0.23 linezolid Not assoc w R - Interim
rplC 801117 c.309G>C synonymous_variant 0.49 linezolid
rplC 801132 c.324T>C synonymous_variant 0.57 linezolid
rplC 801147 c.339T>C synonymous_variant 0.57 linezolid
rplC 801150 c.342G>C synonymous_variant 0.58 linezolid
rplC 801153 c.345G>C synonymous_variant 0.58 linezolid
rplC 801156 c.348T>C synonymous_variant 0.61 linezolid
rplC 801160 c.352_353delTCinsAG synonymous_variant 0.6 linezolid
rplC 801171 c.363A>G synonymous_variant 0.63 linezolid
rplC 801174 c.366T>C synonymous_variant 0.61 linezolid
rplC 801210 c.402T>C synonymous_variant 0.61 linezolid
rplC 801220 c.412_414delAGTinsTCC synonymous_variant 0.58 linezolid
rplC 801228 c.420T>C synonymous_variant 0.57 linezolid
rplC 801231 c.423C>G synonymous_variant 0.55 linezolid
rplC 801237 c.429G>C synonymous_variant 0.55 linezolid
rplC 801249 c.441T>G synonymous_variant 0.52 linezolid
rplC 801258 c.450C>G synonymous_variant 0.48 linezolid
rplC 801264 c.456C>T synonymous_variant 0.33 linezolid
rplC 801267 c.459A>C synonymous_variant 0.24 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303681 c.751T>C synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>G synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303740 c.810C>G synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1303746 p.Asp272Glu missense_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303755 c.825T>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1303764 c.834C>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1303765 p.Lys279Arg missense_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304001 c.1071C>G synonymous_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.57 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304013 c.1083G>C synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304016 c.1086C>T synonymous_variant 0.58 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.61 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.63 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>G synonymous_variant 0.6 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.59 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.56 clofazimine
pretomanid
delamanid
fbiC 1304475 c.1545G>C synonymous_variant 0.53 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304481 c.1551T>G synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiC 1304499 c.1569T>G synonymous_variant 0.67 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304508 p.Glu526Asp missense_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1304511 c.1581C>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304514 c.1584T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304520 c.1590A>G synonymous_variant 0.69 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiC 1304529 c.1599T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304530 p.Ser534Ala missense_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304541 c.1611C>G synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304546 p.Val539Ala missense_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304562 c.1632G>C synonymous_variant 0.71 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1304637 c.1707G>A synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1304665 c.1735C>T synonymous_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Ala missense_variant 0.85 clofazimine
pretomanid
delamanid
fbiC 1304682 c.1752C>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fbiC 1304706 c.1776C>T synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fbiC 1304727 c.1797A>G synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304751 c.1821C>G synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1304763 c.1833C>G synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>T synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304772 c.1842C>T synonymous_variant 0.81 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304784 c.1854T>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304830 c.1900_1901delTCinsAG synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1304835 c.1905G>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1304868 c.1938G>C synonymous_variant 0.64 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.41 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305150 c.2220C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305154 c.2224T>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1305159 c.2229G>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305172 p.Asn748Ser missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305177 c.2247A>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305181 c.2251T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305186 c.2256C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305195 c.2265T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305197 p.Ala756Gly missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305204 c.2274C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305210 c.2280G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1305213 c.2283C>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305215 p.Ser762Thr missense_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1305219 c.2289T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1305231 c.2301C>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305237 c.2307A>G synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305240 c.2310T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305243 c.2313T>G synonymous_variant 0.41 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305244 c.2314T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1305259 c.2329T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
sigE 1364919 c.507T>C synonymous_variant 0.6 pyrazinamide
sigE 1364950 c.538_540delGCAinsTC frameshift_variant&missense_variant 0.36 pyrazinamide Uncertain significance
sigE 1364956 c.544C>T synonymous_variant 0.34 pyrazinamide
sigE 1364960 p.Gly183Ala missense_variant 0.33 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
sigE 1364967 c.555C>T synonymous_variant 0.34 pyrazinamide
sigE 1364970 c.558G>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
sigE 1364976 c.564T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
sigE 1364980 c.568T>C synonymous_variant 0.33 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.33 pyrazinamide
sigE 1364988 c.576G>A synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
sigE 1364992 c.580_582delCCGinsGC frameshift_variant&missense_variant 0.39 pyrazinamide Uncertain significance
sigE 1364997 c.585G>C synonymous_variant 0.4 pyrazinamide
sigE 1365003 c.591T>C synonymous_variant 0.41 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.41 pyrazinamide
sigE 1365012 c.600G>A synonymous_variant 0.41 pyrazinamide
sigE 1365019 c.607C>T synonymous_variant 0.41 pyrazinamide
sigE 1365024 c.612T>C synonymous_variant 0.43 pyrazinamide
sigE 1365036 c.624T>C synonymous_variant 0.44 pyrazinamide
sigE 1365042 c.630G>C synonymous_variant 0.44 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1475381 n.1724G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475647 n.1990G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
inhA 1673607 c.-595T>C upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.45 ethionamide
isoniazid
inhA 1673634 c.-568C>T upstream_gene_variant 0.42 ethionamide
isoniazid
fabG1 1673636 p.Asp66Ala missense_variant 0.41 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.42 ethionamide
isoniazid
inhA 1673658 c.-544G>C upstream_gene_variant 0.45 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.46 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.48 ethionamide
isoniazid
inhA 1673667 c.-535A>G upstream_gene_variant 0.48 ethionamide
isoniazid
inhA 1673670 c.-532G>A upstream_gene_variant 0.48 ethionamide
isoniazid
inhA 1673679 c.-523T>G upstream_gene_variant 0.5 ethionamide
isoniazid
inhA 1673682 c.-520G>C upstream_gene_variant 0.5 ethionamide Uncertain significance
isoniazid Uncertain significance
fabG1 1673710 c.271_273delCTAinsAC frameshift_variant&missense_variant 0.44 ethionamide
isoniazid
inhA 1674462 c.261G>A synonymous_variant 0.66 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.8 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.83 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.84 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.83 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674534 c.333G>C synonymous_variant 0.94 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674542 p.Ala114Glu missense_variant 0.95 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.96 ethionamide
isoniazid
inhA 1674573 c.372G>C synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674579 c.378G>C synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.96 ethionamide
isoniazid
inhA 1674585 c.384T>G synonymous_variant 0.95 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674589 p.Met130Leu missense_variant 0.96 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.95 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.94 ethionamide
isoniazid
inhA 1674651 c.450C>T synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.94 ethionamide
isoniazid
inhA 1674687 c.486G>C synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674699 c.498C>T synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCC frameshift_variant&missense_variant 0.87 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.87 ethionamide
isoniazid
inhA 1674729 c.528G>A synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674732 c.531C>G synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674745 p.Tyr182Val missense_variant 0.89 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.89 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.89 ethionamide
isoniazid
inhA 1674765 c.564C>G synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674777 c.576C>A synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.89 ethionamide
isoniazid
inhA 1674789 c.588G>C synonymous_variant 0.89 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674813 c.612C>G synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 0.92 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674837 c.636C>T synonymous_variant 0.9 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674840 c.639C>G synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.91 ethionamide
isoniazid
inhA 1674883 c.682_684delATCinsTG frameshift_variant&missense_variant 0.89 ethionamide
isoniazid
inhA 1674888 c.687C>A synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.87 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.88 ethionamide
isoniazid
inhA 1674909 c.708G>C synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.81 ethionamide
isoniazid
inhA 1674957 c.756G>C synonymous_variant 0.72 ethionamide
isoniazid
inhA 1674963 c.762G>C synonymous_variant 0.63 ethionamide
isoniazid
inhA 1674966 c.765T>C synonymous_variant 0.61 ethionamide
isoniazid
inhA 1674967 p.Asp256Thr missense_variant 0.58 ethionamide
isoniazid
inhA 1674970 p.Ile257Val missense_variant 0.56 ethionamide
isoniazid
rpsA 1833892 c.351G>A synonymous_variant 0.78 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.8 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.89 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.96 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.97 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.97 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.97 pyrazinamide
rpsA 1833995 c.454C>T synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim
rpsA 1834000 c.459G>C synonymous_variant 0.98 pyrazinamide
rpsA 1834009 c.468C>G synonymous_variant 0.98 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.98 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.98 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.98 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.97 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.97 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.94 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.93 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.95 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102098 c.945G>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102103 p.Tyr314His missense_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102104 c.939G>T synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102113 c.930C>G synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102124 p.Pro307Ser missense_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102131 c.910_912delCAAinsAG frameshift_variant&synonymous_variant 0.25 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102146 c.897G>C synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102152 c.891C>G synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102155 c.888G>A synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102158 c.885T>C synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102161 c.880_882delCGGinsGA frameshift_variant&synonymous_variant 0.28 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102164 c.879A>C synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2102167 c.876A>G synonymous_variant 0.3 ethionamide
delamanid
isoniazid
ndh 2102176 c.867T>C synonymous_variant 0.31 ethionamide
delamanid
isoniazid
ndh 2102182 c.859_861delAGGinsCC frameshift_variant&missense_variant 0.3 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102188 c.853_855delTTGinsCC frameshift_variant&missense_variant 0.32 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102192 p.Arg284Pro missense_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102194 c.849T>C synonymous_variant 0.32 ethionamide
delamanid
isoniazid
ndh 2102203 c.840T>G synonymous_variant 0.33 ethionamide
delamanid
isoniazid
ndh 2102230 c.811_813delTCGinsGC frameshift_variant&missense_variant 0.33 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517941 c.-174C>G upstream_gene_variant 0.55 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.42 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.42 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.42 isoniazid
kasA 2518636 c.522C>G synonymous_variant 0.43 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.42 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.4 isoniazid
kasA 2518657 c.543G>A synonymous_variant 0.4 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.36 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.29 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.49 isoniazid
kasA 2518708 c.594C>G synonymous_variant 0.53 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.52 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.54 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.52 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.67 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.69 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.68 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.68 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.67 isoniazid
kasA 2518785 p.Glu224Ala missense_variant 0.67 isoniazid
kasA 2518787 p.Arg225Gly missense_variant 0.66 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.67 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.69 isoniazid
kasA 2518798 c.684G>C synonymous_variant 0.71 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.68 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.63 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.6 isoniazid
kasA 2518845 p.Ala244Val missense_variant 0.6 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.6 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.59 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.62 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.56 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.54 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.41 isoniazid
kasA 2519203 c.1089C>T synonymous_variant 0.72 isoniazid
kasA 2519224 c.1110C>G synonymous_variant 0.7 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.52 isoniazid
kasA 2519242 c.1128C>G synonymous_variant 0.48 isoniazid
kasA 2519245 c.1131T>C synonymous_variant 0.46 isoniazid
kasA 2519257 c.1143C>T synonymous_variant 0.43 isoniazid
kasA 2519260 c.1146T>C synonymous_variant 0.47 isoniazid
kasA 2519263 c.1149C>T synonymous_variant 0.43 isoniazid
kasA 2519269 c.1155C>T synonymous_variant 0.43 isoniazid
kasA 2519272 c.1158C>G synonymous_variant 0.41 isoniazid
kasA 2519278 c.1164A>G synonymous_variant 0.39 isoniazid
kasA 2519281 c.1167G>A synonymous_variant 0.37 isoniazid
kasA 2519284 c.1170C>G synonymous_variant 0.35 isoniazid
kasA 2519293 c.1179T>C synonymous_variant 0.34 isoniazid
kasA 2519298 p.Arg395Gln missense_variant 0.34 isoniazid
kasA 2519305 c.1191A>C synonymous_variant 0.33 isoniazid
kasA 2519306 p.Val398Ile missense_variant 0.33 isoniazid
kasA 2519332 c.1218C>T synonymous_variant 0.29 isoniazid
thyA 3073839 c.633T>C synonymous_variant 0.52 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.66 para-aminosalicylic_acid
thyA 3073863 c.609T>A synonymous_variant 0.66 para-aminosalicylic_acid
thyA 3073881 c.591C>G synonymous_variant 0.66 para-aminosalicylic_acid
thyA 3073884 c.588C>G synonymous_variant 0.69 para-aminosalicylic_acid
thyA 3073887 c.583_585delTCGinsAC frameshift_variant&missense_variant 0.7 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.7 para-aminosalicylic_acid
thyA 3073893 c.579C>T synonymous_variant 0.72 para-aminosalicylic_acid
thyA 3073902 c.570C>A synonymous_variant 0.82 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.78 para-aminosalicylic_acid
thyA 3073950 c.522G>A synonymous_variant 0.78 para-aminosalicylic_acid
thyA 3073953 c.519T>G synonymous_variant 0.78 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.77 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.76 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.75 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 0.71 para-aminosalicylic_acid
thyA 3073992 c.478_480delAGCinsTCG synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3073997 c.475C>T synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3074000 c.472C>A synonymous_variant 0.5 para-aminosalicylic_acid
thyA 3074004 p.Asp156Gly missense_variant 0.5 para-aminosalicylic_acid
thyA 3074007 c.465C>G synonymous_variant 0.51 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3074046 c.426G>C synonymous_variant 0.29 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
whiB7 3568555 p.Leu42Pro missense_variant 0.92 streptomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB7 3568854 c.-176delG upstream_gene_variant 1.0 streptomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB7 3569220 c.-541C>T upstream_gene_variant 0.89 streptomycin
amikacin
kanamycin
Rv3236c 3612813 p.Thr102Ala missense_variant 0.94 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3626846 c.504G>A synonymous_variant 0.94 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.94 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrA 3626870 c.480C>T synonymous_variant 0.93 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.93 bedaquiline
rifampicin
mtrB 3626903 c.-290T>G upstream_gene_variant 0.94 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.95 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626915 c.-302C>G upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.96 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.95 bedaquiline
rifampicin
mtrB 3626942 c.-329A>C upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.96 bedaquiline
rifampicin
mtrA 3626978 p.Asp124Glu missense_variant 0.96 bedaquiline
rifampicin Uncertain significance
mtrB 3626996 c.-383G>C upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3627005 c.-392G>A upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.96 bedaquiline
rifampicin
mtrB 3627016 c.-403C>T upstream_gene_variant 0.96 bedaquiline
rifampicin
mtrA 3627020 c.330G>A synonymous_variant 0.96 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrA 3627041 c.307_309delATCinsGG frameshift_variant&missense_variant 0.97 bedaquiline
rifampicin
mtrB 3627068 c.-455T>A upstream_gene_variant 0.96 bedaquiline
rifampicin
mtrB 3627071 c.-458G>C upstream_gene_variant 0.96 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.95 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.95 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.96 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.95 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627139 c.-526T>C upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.95 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627149 c.-536G>C upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.94 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.92 bedaquiline
rifampicin
mtrA 3627187 c.163T>C synonymous_variant 0.91 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.91 bedaquiline
rifampicin
mtrB 3627203 c.-590C>G upstream_gene_variant 0.9 bedaquiline
rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.94 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.95 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877689 c.819C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.98 rifampicin
rpoA 3877749 c.759C>T synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoA 3877758 c.750G>C synonymous_variant 0.98 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877788 c.720G>A synonymous_variant 0.98 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3877872 c.636C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.8 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.76 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.74 rifampicin
rpoA 3877950 c.558C>G synonymous_variant 0.71 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.66 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.63 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.53 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877992 c.516C>G synonymous_variant 0.5 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.22 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.79 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoA 3878229 c.279C>G synonymous_variant 0.82 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.83 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.83 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.83 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.83 rifampicin
rpoA 3878262 c.244_246delAGCinsGT frameshift_variant&synonymous_variant 0.82 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoA 3878274 c.234G>C synonymous_variant 0.87 rifampicin
rpoA 3878283 p.Glu75Asp missense_variant 0.89 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.9 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.92 rifampicin
rpoA 3878358 c.150C>G synonymous_variant 0.91 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.91 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.93 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.92 rifampicin
rpoA 3878421 c.87A>T synonymous_variant 0.9 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.9 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.85 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.79 rifampicin
rpoA 3878457 c.49_51delAACinsGT frameshift_variant&missense_variant 0.74 rifampicin
rpoA 3878460 p.Asp16Glu missense_variant 0.74 rifampicin
rpoA 3878465 p.Thr15Ala missense_variant 0.73 rifampicin
rpoA 3878468 p.Leu14Ile missense_variant 0.73 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.74 rifampicin
rpoA 3878475 c.33G>A synonymous_variant 0.74 rifampicin
rpoA 3878479 c.28_29delTCinsAG synonymous_variant 0.74 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.75 rifampicin
rpoA 3878499 c.9C>T synonymous_variant 0.76 rifampicin
rpoA 3878683 c.-176G>C upstream_gene_variant 0.6 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.57 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.57 rifampicin
rpoA 3878704 c.-197C>T upstream_gene_variant 0.57 rifampicin
rpoA 3878725 c.-220_-218delCTAinsTG upstream_gene_variant 0.57 rifampicin
rpoA 3878731 c.-224C>T upstream_gene_variant 0.54 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.58 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.58 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.55 rifampicin
rpoA 3878755 c.-248G>C upstream_gene_variant 0.52 rifampicin
rpoA 3878758 c.-251G>C upstream_gene_variant 0.54 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.54 rifampicin
rpoA 3878769 c.-262C>A upstream_gene_variant 0.53 rifampicin
rpoA 3878773 c.-268_-266delAGCinsTCG upstream_gene_variant 0.52 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.54 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.58 rifampicin Uncertain significance
rpoA 3878794 c.-287G>C upstream_gene_variant 0.53 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.52 rifampicin
rpoA 3878803 c.-296G>C upstream_gene_variant 0.52 rifampicin Uncertain significance
rpoA 3878809 c.-302T>C upstream_gene_variant 0.52 rifampicin
rpoA 3878823 c.-316G>C upstream_gene_variant 0.46 rifampicin
rpoA 3878830 c.-325_-323delCTGinsAC upstream_gene_variant 0.21 rifampicin
rpoA 3878844 c.-337C>A upstream_gene_variant 0.19 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.53 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.54 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.54 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.53 rifampicin
rpoA 3879121 c.-616_-614delCTTinsACC upstream_gene_variant 0.53 rifampicin
rpoA 3879124 c.-618_-617delTGinsGC upstream_gene_variant 0.53 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.53 rifampicin
rpoA 3879130 c.-623A>G upstream_gene_variant 0.53 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.52 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.51 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.53 rifampicin
rpoA 3879190 c.-685_-683delGCCinsTG upstream_gene_variant 0.47 rifampicin
rpoA 3879196 c.-689C>T upstream_gene_variant 0.46 rifampicin
rpoA 3879199 c.-692C>T upstream_gene_variant 0.46 rifampicin
clpC1 4038623 c.2082A>G synonymous_variant 0.32 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.39 pyrazinamide
clpC1 4038647 c.2058T>A synonymous_variant 0.35 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.34 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038671 c.2034T>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038679 p.Pro676Ala missense_variant 0.41 pyrazinamide
clpC1 4038683 c.2020_2022delTCTinsAGC synonymous_variant 0.43 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.43 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.67 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.71 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.71 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.75 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.76 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.78 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.76 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.76 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.74 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
clpC1 4038997 c.1708T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039082 c.1623C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.35 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.48 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039574 p.Ala377Ser missense_variant 0.41 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.47 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039628 c.1077C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039682 c.1023C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.91 pyrazinamide
clpC1 4039856 c.849C>T synonymous_variant 0.94 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.96 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.97 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.96 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.95 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.94 pyrazinamide
clpC1 4040001 p.His235Ala missense_variant 0.86 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.86 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.84 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.81 pyrazinamide
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
ethA 4326676 p.Ser266Arg missense_variant 0.91 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.89 streptomycin Not assoc w R
gid 4408417 c.-215G>T upstream_gene_variant 1.0 streptomycin