Run ID: SRR28393388
Sample name:
Date: 2024-05-22T16:46:37.319537
Number of reads: 3403202
Percentage reads mapped: 99.5
Median coverage: 98.0
Strain: lineage4.3.4.1
Spoligotype:
Drug-resistance: MDR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.3 | Euro-American (LAM) | None | 1.0 |
lineage4.3.4.1 | Euro-American (LAM) | RD174 | 1.0 |
lineage4 | Euro-American | None | 1.0 |
lineage4.3.4 | Euro-American (LAM) | RD174 | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | rpoB | p.Asp435Val | Assoc w R | |
isoniazid | ahpC | c.-54C>T | Uncertain significance | Mutation from literature |
ethambutol | embA | c.-12C>T | Uncertain significance | Mutation from literature |
embB | p.Met306Leu | Assoc w R | ||
p.Gly406Asp | Assoc w R | |||
pyrazinamide | pncA | p.Val163Ala | Assoc w R - Interim | |
streptomycin | gid | c.111dupA | Assoc w R | |
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | tlyA | c.743delA | Assoc w R | |
kanamycin | ||||
cycloserine | ||||
ethionamide | ethA | p.Tyr147* | Assoc w R | |
c.67delC | Assoc w R | |||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rpoB | 761110 | p.Asp435Val | missense_variant | 1.0 | rifampicin | Assoc w R | |
tlyA | 1918681 | c.743delA | frameshift_variant | 0.54 | capreomycin | Assoc w R | |
pncA | 2288754 | p.Val163Ala | missense_variant | 1.0 | pyrazinamide | Assoc w R - Interim | |
ahpC | 2726139 | c.-54C>T | upstream_gene_variant | 1.0 | isoniazid | Uncertain significance | Mutation from literature |
embA | 4243221 | c.-12C>T | upstream_gene_variant | 0.49 | ethambutol | Uncertain significance | Mutation from literature |
embB | 4247429 | p.Met306Leu | missense_variant | 1.0 | ethambutol | Assoc w R | |
embB | 4247730 | p.Gly406Asp | missense_variant | 0.17 | ethambutol | Assoc w R | |
ethA | 4327033 | p.Tyr147* | stop_gained | 0.55 | ethionamide | Assoc w R | |
ethA | 4327406 | c.67delC | frameshift_variant | 0.52 | ethionamide | Assoc w R | |
gid | 4408091 | c.111dupA | frameshift_variant | 1.0 | streptomycin | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 0.99 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
rpoC | 764995 | c.1626C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781466 | c.-94A>T | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
Rv1129c | 1254264 | p.Val91Phe | missense_variant | 0.46 | moxifloxacin | |
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
sigE | 1364434 | p.Arg8Trp | missense_variant | 0.97 | pyrazinamide | Not assoc w R |
sigE | 1365000 | c.588G>A | synonymous_variant | 0.47 | pyrazinamide | Not assoc w R - Interim |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472923 | n.1078G>A | non_coding_transcript_exon_variant | 0.52 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
katG | 2154235 | p.Val626Glu | missense_variant | 1.0 | isoniazid | Uncertain significance |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 0.99 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
Rv2752c | 3064811 | p.Thr461Pro | missense_variant | 0.57 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
thyA | 3073868 | p.Thr202Ala | missense_variant | 1.0 | para-aminosalicylic_acid | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
Rv3236c | 3612009 | p.Ala370Thr | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
fbiA | 3640316 | c.-227A>C | upstream_gene_variant | 0.51 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
clpC1 | 4038287 | c.2418C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242736 | p.Ile958Met | missense_variant | 0.66 | ethambutol | |
whiB6 | 4338473 | c.49A>C | synonymous_variant | 0.5 | capreomycin | Not assoc w R - Interim |
amikacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
gid | 4408156 | p.Leu16Arg | missense_variant | 1.0 | streptomycin | Not assoc w R |