TB-Profiler result

Run: SRR29093099
Summary

Run ID: SRR29093099

Sample name:

Date: 2025-02-11T10:39:37.349552

Number of reads: 2723487

Percentage reads mapped: 92.35

Median coverage: 87.0

Strain: La3;lineage2.2.2

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.2 East-Asian (Beijing) RD105;RD207 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
La3 M.orygis None 0.08
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Ile Assoc w R
p.His312Arg Mutation from literature
pyrazinamide
streptomycin rpsL p.Lys43Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid ddn c.59_102delTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN Assoc w R - Interim Confers DLM-PMD cross-resistance
c.62_104delTGTCACGGATTAATACCTGGATGTACCGCCGCAACGACGGGGA Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.91 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.74 streptomycin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
ddn 3986901 c.59_102delTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN frameshift_variant 1.0 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
ddn 3986901 c.62_104delTGTCACGGATTAATACCTGGATGTACCGCCGCAACGACGGGGA frameshift_variant 1.0 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247431 p.Met306Ile missense_variant 0.76 ethambutol Assoc w R
embB 4247448 p.His312Arg missense_variant 0.22 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6196 c.957C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6250 c.1011A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8090 c.789C>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8096 c.795T>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8375 c.1074G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8588 c.1287G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCTA synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8780 p.Asp493Glu missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8873 c.1572A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9017 c.1716C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9089 c.1788G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.17 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9224 c.1923C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.97 ethionamide Uncertain significance
rpoB 760130 p.Asp108Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.21 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.22 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.18 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.2 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.22 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.22 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.25 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.21 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.18 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.19 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.16 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.18 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.21 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.21 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.19 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.18 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.18 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.17 rifampicin
rpoB 760776 p.Ser324Thr missense_variant 0.16 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.21 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.22 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.21 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.25 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.17 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761885 c.2079T>C synonymous_variant 0.16 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.16 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.16 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.19 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.17 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.21 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.22 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.21 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.2 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763158 c.-212C>T upstream_gene_variant 0.18 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.17 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.16 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.17 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.16 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.2 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.19 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.18 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.18 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.16 rifampicin
rpoC 764489 c.1120C>T synonymous_variant 0.18 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.23 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.22 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.23 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.24 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.26 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.2 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765613 p.His748Gln missense_variant 0.16 rifampicin
rpoC 765814 c.2445A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766447 c.3078T>C synonymous_variant 0.18 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.17 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.17 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.16 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.17 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.2 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.19 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.19 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.17 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.18 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.17 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.16 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.18 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.18 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.21 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.24 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.25 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.22 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.22 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.32 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.32 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.3 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.28 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.2 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.19 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.2 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.19 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.18 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.16 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpS5 778743 p.Val55Met missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpS5 779560 c.-655C>A upstream_gene_variant 1.0 bedaquiline
clofazimine
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 0.99 streptomycin Not assoc w R
rpsL 781406 c.-154_-153insC upstream_gene_variant 1.0 streptomycin Uncertain significance
rpsL 781628 c.69T>C synonymous_variant 0.17 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.18 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.25 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.24 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.26 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.25 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.24 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.24 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.24 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.21 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.22 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.22 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.22 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.23 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.24 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.25 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.26 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.25 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.24 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.25 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.24 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.23 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.23 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.22 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.21 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.22 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.22 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.2 streptomycin Uncertain significance
rplC 800612 c.-197A>G upstream_gene_variant 0.18 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.19 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.18 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.21 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.19 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.19 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.16 linezolid
Rv1129c 1254131 p.Glu135Ala missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303632 c.702T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303641 c.711C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303650 c.720G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303654 c.724C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303659 c.729T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303661 p.Val244Ala missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303663 c.733C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303671 c.741C>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1303674 c.744C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303681 c.751T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.16 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303944 c.1014G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303953 p.Asp341Glu missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303956 c.1026A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303971 c.1041T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303980 c.1050G>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304004 c.1074A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304022 c.1092T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304031 c.1101C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304034 c.1104A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304040 c.1110C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304046 c.1116C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304049 c.1119T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304050 c.1120T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304058 c.1128G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304059 c.1129C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304064 c.1134G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304067 c.1137G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304085 c.1155C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304091 p.Asp387Glu missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304097 c.1167G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304661 c.1731C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304676 c.1746A>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.24 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.29 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305030 c.2100G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1305090 c.2160C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305092 p.Ala721Gly missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305099 c.2169T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
rrs 1471659 n.-187C>T upstream_gene_variant 0.99 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833667 c.126C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833909 p.Asp123Ala missense_variant 0.82 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
folC 2747289 p.Pro104Ala missense_variant 0.16 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.2 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.2 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.19 para-aminosalicylic_acid
Rv2477c 2783751 p.Ile98Val missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.18 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
thyA 3074122 p.Asp117Gly missense_variant 0.98 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 0.99 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625592 p.Ser341Thr missense_variant 0.94 rifampicin
bedaquiline
mtrB 3626049 p.Arg189Trp missense_variant 1.0 rifampicin
bedaquiline
rpoA 3877553 p.Glu319Gln missense_variant 0.17 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.19 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.25 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.32 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.31 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.38 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.32 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.26 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.25 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.27 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.25 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.28 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.29 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.28 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.28 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.28 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.29 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.29 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.27 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.27 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.24 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.23 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.22 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.22 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.22 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.22 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.2 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878094 c.414C>G synonymous_variant 0.22 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.21 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.2 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.24 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.24 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.23 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.24 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.26 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.27 rifampicin
rpoA 3878181 c.327C>T synonymous_variant 0.28 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.27 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.28 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.29 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.29 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.27 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.28 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.29 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.26 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.27 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.27 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.28 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.3 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.29 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.3 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.3 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.27 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.24 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.19 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.17 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.2 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.21 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.18 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.18 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.19 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.18 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.23 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.2 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.21 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.21 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.26 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.19 rifampicin
clpC1 4038356 c.2349T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.15 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.18 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.17 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.18 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038749 c.1956C>A synonymous_variant 0.18 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038893 c.1812C>T synonymous_variant 0.26 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.23 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.18 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.2 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039576 p.Ala377Pro missense_variant 0.17 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.15 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040092 p.Ser205Thr missense_variant 0.15 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.16 pyrazinamide
clpC1 4040228 c.477G>T synonymous_variant 0.15 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.15 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.17 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.18 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.19 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.19 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.18 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.19 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.18 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.17 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.17 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.18 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 0.18 pyrazinamide
panD 4045094 c.-813T>C upstream_gene_variant 0.17 pyrazinamide
panD 4045097 c.-816T>C upstream_gene_variant 0.17 pyrazinamide
panD 4045105 c.-824T>C upstream_gene_variant 0.17 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4246105 p.Pro958Leu missense_variant 0.9 ethambutol Uncertain significance
embB 4247389 c.876C>G synonymous_variant 0.19 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.24 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.24 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.23 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.22 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.24 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.25 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.25 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.25 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.24 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.18 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.18 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.17 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.16 ethambutol
embB 4247590 c.1077A>C synonymous_variant 0.16 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.15 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.15 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.15 ethambutol
embB 4247866 c.1353G>C synonymous_variant 0.17 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.17 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.18 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.2 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.19 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.19 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.19 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.17 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.18 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.19 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.2 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.21 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.16 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.18 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.17 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.15 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.18 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.17 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.17 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.17 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.17 ethambutol Uncertain significance
embB 4248220 c.1707A>C synonymous_variant 0.17 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.18 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.16 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.16 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.16 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.16 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.16 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.17 ethambutol
embB 4248382 c.1869C>G synonymous_variant 0.16 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.16 ethambutol
embB 4248433 p.Trp640Cys missense_variant 0.15 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.18 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.15 ethambutol
aftB 4267262 c.1575T>C synonymous_variant 1.0 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.99 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.99 streptomycin Not assoc w R