Run ID: SRR5153855
Sample name:
Date: 04-04-2023 09:27:12
Number of reads: 8438657
Percentage reads mapped: 99.44
Strain: lineage4.2.1;lineage2.2.1
Drug-resistance: Pre-XDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage2 | East-Asian | Beijing | RD105 | 0.56 |
lineage4 | Euro-American | LAM;T;S;X;H | None | 0.46 |
lineage4.2 | Euro-American | H;T;LAM | None | 0.47 |
lineage2.2 | East-Asian (Beijing) | Beijing-RD207 | RD105;RD207 | 0.57 |
lineage2.2.1 | East-Asian (Beijing) | Beijing-RD181 | RD105;RD207;RD181 | 0.52 |
lineage4.2.1 | Euro-American (TUR) | H3;H4 | None | 0.45 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
gyrA | 7582 | p.Asp94Gly | missense_variant | 0.52 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
rpoB | 761155 | p.Ser450Leu | missense_variant | 0.99 | rifampicin |
rpsL | 781687 | p.Lys43Arg | missense_variant | 0.57 | streptomycin |
rpsL | 781822 | p.Lys88Arg | missense_variant | 0.46 | streptomycin |
inhA | 1674048 | c.-154G>A | upstream_gene_variant | 0.37 | isoniazid, ethionamide |
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
pncA | 2289213 | p.Gln10Pro | missense_variant | 0.29 | pyrazinamide |
eis | 2715344 | c.-12C>T | upstream_gene_variant | 0.13 | kanamycin |
embA | 4243217 | c.-16C>T | upstream_gene_variant | 0.16 | ethambutol |
embB | 4247402 | p.Ser297Ala | missense_variant | 0.14 | ethambutol |
embB | 4247429 | p.Met306Val | missense_variant | 0.51 | ethambutol |
embB | 4247730 | p.Gly406Ala | missense_variant | 0.37 | ethambutol |
embB | 4249583 | p.Asp1024Asn | missense_variant | 0.39 | ethambutol |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
fgd1 | 491247 | c.465C>T | synonymous_variant | 0.46 |
fgd1 | 491742 | c.960T>C | synonymous_variant | 0.54 |
mshA | 575907 | p.Ala187Val | missense_variant | 0.62 |
ccsA | 619969 | p.Val27Ile | missense_variant | 0.49 |
ccsA | 620625 | p.Ile245Met | missense_variant | 0.51 |
rpoB | 761528 | p.Asp574Glu | missense_variant | 0.59 |
rpoC | 763031 | c.-339T>C | upstream_gene_variant | 0.59 |
rpoC | 764888 | p.Leu507Val | missense_variant | 0.3 |
rpoC | 766645 | p.Glu1092Asp | missense_variant | 0.53 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 0.5 |
mmpL5 | 776182 | p.Asp767Asn | missense_variant | 0.55 |
mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 0.59 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
fbiC | 1304253 | c.1323G>T | synonymous_variant | 0.34 |
Rv1258c | 1406760 | c.580_581insC | frameshift_variant | 0.58 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rpsA | 1834177 | c.636A>C | synonymous_variant | 0.47 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
katG | 2154724 | p.Arg463Leu | missense_variant | 0.56 |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 0.58 |
PPE35 | 2169879 | p.Phe245Cys | missense_variant | 0.43 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 0.99 |
ribD | 2986827 | c.-12G>A | upstream_gene_variant | 0.38 |
Rv2752c | 3064700 | p.Ser498Pro | missense_variant | 0.58 |
ald | 3086742 | c.-78A>C | upstream_gene_variant | 0.42 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 0.53 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 0.99 |
embA | 4243460 | c.228C>T | synonymous_variant | 0.57 |
embB | 4249594 | c.3081G>A | synonymous_variant | 0.5 |
aftB | 4267647 | p.Asp397Gly | missense_variant | 0.51 |
ethA | 4326632 | p.His281Pro | missense_variant | 0.14 |
ethA | 4328376 | c.-903G>C | upstream_gene_variant | 0.38 |
whiB6 | 4338298 | p.Leu75Gln | missense_variant | 0.61 |
whiB6 | 4338563 | c.-42G>T | upstream_gene_variant | 0.66 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
gid | 4407588 | c.615A>G | synonymous_variant | 0.53 |
gid | 4407927 | p.Glu92Asp | missense_variant | 0.53 |