Run ID: SRR7592380
Sample name:
Date: 04-04-2023 19:50:37
Number of reads: 1429184
Percentage reads mapped: 99.63
Strain: lineage4.8
Drug-resistance: Pre-XDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.8 | Euro-American (mainly T) | T1;T2;T3;T5 | RD219 | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
gyrB | 6579 | p.Ser447Phe | missense_variant | 0.83 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin |
rpoC | 764363 | p.Gly332Arg | missense_variant | 1.0 | rifampicin |
rpsL | 781821 | p.Lys88Gln | missense_variant | 0.69 | streptomycin |
rrs | 1472359 | n.514A>C | non_coding_transcript_exon_variant | 0.29 | streptomycin |
rrs | 1473246 | n.1401A>G | non_coding_transcript_exon_variant | 1.0 | kanamycin, capreomycin, aminoglycosides, amikacin |
fabG1 | 1673425 | c.-15C>T | upstream_gene_variant | 1.0 | isoniazid, ethionamide |
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
pncA | 2288805 | p.Ala146Val | missense_variant | 1.0 | pyrazinamide |
embB | 4247431 | p.Met306Ile | missense_variant | 1.0 | ethambutol |
ethA | 4326082 | c.1391dupA | frameshift_variant | 1.0 | ethionamide, ethionamide |
gid | 4407830 | p.Gln125* | stop_gained | 1.0 | streptomycin |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
rpoC | 765008 | p.Leu547Val | missense_variant | 1.0 |
rpoC | 766085 | p.Pro906Ala | missense_variant | 1.0 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
atpE | 1460992 | c.-53A>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
pepQ | 2860159 | p.Ala87Gly | missense_variant | 0.15 |
ald | 3087228 | p.Ala137Thr | missense_variant | 0.63 |
fbiD | 3339734 | p.Ala206Gly | missense_variant | 1.0 |
fbiD | 3339749 | p.Val211Gly | missense_variant | 0.25 |
whiB7 | 3568406 | p.Ala92Thr | missense_variant | 0.34 |
alr | 3840764 | c.657G>C | synonymous_variant | 1.0 |
alr | 3841362 | p.Thr20Met | missense_variant | 0.24 |
rpoA | 3878641 | c.-134C>G | upstream_gene_variant | 0.2 |
embC | 4240409 | p.Pro183Ala | missense_variant | 0.19 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
Rv3083 | 3448507 | c.5_*1408del | frameshift_variant&stop_lost&splice_region_variant | 1.0 |