Run ID: ERR1034679
Sample name:
Date: 31-03-2023 09:33:06
Number of reads: 6783460
Percentage reads mapped: 99.66
Strain: lineage4.3.3
Drug-resistance: MDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.3 | Euro-American (LAM) | mainly-LAM | None | 1.0 |
lineage4.3.3 | Euro-American (LAM) | LAM;T | RD115 | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin |
katG | 2155168 | p.Ser315Asn | missense_variant | 1.0 | isoniazid |
pncA | 2289125 | c.116dupC | frameshift_variant | 1.0 | pyrazinamide, pyrazinamide |
embB | 4247429 | p.Met306Val | missense_variant | 0.14 | ethambutol |
gid | 4407906 | c.296dupA | frameshift_variant | 1.0 | streptomycin |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 8040 | p.Gly247Ser | missense_variant | 0.99 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
rpoB | 761880 | p.Ala692Thr | missense_variant | 1.0 |
rpoC | 764916 | p.Leu516Pro | missense_variant | 1.0 |
rpoC | 764995 | c.1626C>G | synonymous_variant | 1.0 |
rpoC | 767314 | p.Tyr1315* | stop_gained | 0.19 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rpsA | 1834836 | p.Met432Thr | missense_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
katG | 2154459 | c.1653C>T | synonymous_variant | 1.0 |
PPE35 | 2169320 | p.Leu431Phe | missense_variant | 0.18 |
PPE35 | 2169759 | p.Gly285Asp | missense_variant | 1.0 |
PPE35 | 2169803 | c.810A>G | synonymous_variant | 1.0 |
PPE35 | 2169808 | p.Leu269Ile | missense_variant | 1.0 |
PPE35 | 2169866 | c.747G>C | synonymous_variant | 0.28 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
kasA | 2518919 | p.Gly269Ser | missense_variant | 1.0 |
pepQ | 2859381 | c.1038C>G | synonymous_variant | 0.2 |
Rv2752c | 3064552 | p.Arg547Pro | missense_variant | 0.2 |
thyA | 3073868 | p.Thr202Ala | missense_variant | 1.0 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
clpC1 | 4038287 | c.2418C>T | synonymous_variant | 1.0 |
clpC1 | 4039932 | p.Gly258Val | missense_variant | 0.17 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embC | 4242822 | p.Val987Gly | missense_variant | 0.35 |
ubiA | 4269529 | p.Ala102Gly | missense_variant | 0.26 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
whiB6 | 4338600 | c.-79T>C | upstream_gene_variant | 1.0 |
gid | 4407720 | c.483C>G | synonymous_variant | 1.0 |
gid | 4408156 | p.Leu16Arg | missense_variant | 1.0 |