TB-Profiler result

Run: ERR11081224
Summary

Run ID: ERR11081224

Sample name:

Date: 08-04-2023 12:02:08

Number of reads: 3149895

Percentage reads mapped: 99.54

Strain: lineage4.2.1;lineage2.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.56
lineage4 Euro-American LAM;T;S;X;H None 0.45
lineage4.2 Euro-American H;T;LAM None 0.46
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.56
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.54
lineage4.2.1 Euro-American (TUR) H3;H4 None 0.42
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.4 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.36 streptomycin
rpsL 781822 p.Lys88Arg missense_variant 0.41 streptomycin
fabG1 1673425 c.-15C>T upstream_gene_variant 0.54 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 0.86 isoniazid
pncA 2288782 p.Arg154Gly missense_variant 0.37 pyrazinamide
embB 4247729 p.Gly406Cys missense_variant 0.44 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491247 c.465C>T synonymous_variant 0.39
fgd1 491742 c.960T>C synonymous_variant 0.53
mshA 575907 p.Ala187Val missense_variant 0.67
mshA 576108 p.Ala254Gly missense_variant 0.16
ccsA 619969 p.Val27Ile missense_variant 0.4
ccsA 620625 p.Ile245Met missense_variant 0.55
rpoC 763031 c.-339T>C upstream_gene_variant 0.47
rpoC 764817 p.Val483Gly missense_variant 0.43
rpoC 766645 p.Glu1092Asp missense_variant 0.4
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.5
mmpL5 776182 p.Asp767Asn missense_variant 0.55
mmpL5 777076 c.1400_1404delAGATC frameshift_variant 0.15
mmpS5 779615 c.-710C>G upstream_gene_variant 0.52
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.57
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 0.56
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.55
PPE35 2167926 p.Leu896Ser missense_variant 0.58
PPE35 2169879 p.Phe245Cys missense_variant 0.47
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ribD 2986827 c.-12G>A upstream_gene_variant 0.56
ald 3086742 c.-78A>C upstream_gene_variant 0.5
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 0.53
embC 4241078 p.Ile406Val missense_variant 0.17
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243217 c.-16C>A upstream_gene_variant 0.38
embA 4243460 c.228C>T synonymous_variant 0.62
embB 4249594 c.3081G>A synonymous_variant 0.48
aftB 4267647 p.Asp397Gly missense_variant 0.61
ethA 4328376 c.-903G>C upstream_gene_variant 0.38
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.48
gid 4407927 p.Glu92Asp missense_variant 0.46