TB-Profiler result

Run: ERR221663
Summary

Run ID: ERR221663

Sample name:

Date: 31-03-2023 16:20:59

Number of reads: 8147019

Percentage reads mapped: 99.41

Strain: lineage3.1.1;lineage1.1.3.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 0.34
lineage1 Indo-Oceanic EAI RD239 0.64
lineage1.1 Indo-Oceanic EAI3;EAI4;EAI5;EAI6 RD239 0.63
lineage3.1 East-African-Indian Non-CAS1-Delhi RD750 0.34
lineage1.1.3 Indo-Oceanic EAI6 RD239 0.66
lineage3.1.1 East-African-Indian CAS1-Kili RD750 0.35
lineage1.1.3.2 Indo-Oceanic NA RD239 0.65
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6112 p.Met291Ile missense_variant 0.66
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8188 p.Leu296Pro missense_variant 0.64
gyrA 8452 p.Ala384Val missense_variant 0.59
gyrA 9143 c.1842T>C synonymous_variant 0.67
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 0.99
ccsA 619695 c.-196G>A upstream_gene_variant 0.65
rpoB 759746 c.-61C>T upstream_gene_variant 0.35
rpoC 762434 c.-936T>G upstream_gene_variant 0.42
rpoC 763031 c.-339T>C upstream_gene_variant 0.99
rpoC 763884 p.Ala172Val missense_variant 0.64
rpoC 763886 c.517C>A synonymous_variant 0.64
rpoC 765171 p.Pro601Leu missense_variant 0.69
rpoC 765230 p.Ala621Thr missense_variant 0.67
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.99
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 801166 p.Gly120Ser missense_variant 0.66
embR 1417019 p.Cys110Tyr missense_variant 0.67
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474411 n.754C>A non_coding_transcript_exon_variant 0.63
inhA 1674883 p.Ile228Val missense_variant 0.63
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 0.99
PPE35 2167983 p.Gly877Asp missense_variant 0.65
PPE35 2170461 p.Gly51Glu missense_variant 0.33
Rv1979c 2222308 p.Asp286Gly missense_variant 0.68
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 0.39
pncA 2289365 c.-125delC upstream_gene_variant 0.36
kasA 2518132 c.18C>T synonymous_variant 0.67
ahpC 2726051 c.-142G>A upstream_gene_variant 0.68
ahpC 2726105 c.-88G>A upstream_gene_variant 0.34
Rv2752c 3064632 c.1560C>T synonymous_variant 0.65
ald 3086788 c.-32T>C upstream_gene_variant 0.99
Rv3083 3448714 p.Asp71His missense_variant 0.67
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 0.66
fprA 3475159 p.Asn385Asp missense_variant 0.58
fbiB 3642173 c.639G>A synonymous_variant 0.63
rpoA 3878687 c.-180A>C upstream_gene_variant 0.65
clpC1 4038857 c.1848C>A synonymous_variant 0.24
clpC1 4040517 p.Val63Ala missense_variant 0.65
embC 4239842 c.-21C>A upstream_gene_variant 0.26
embC 4240671 p.Thr270Ile missense_variant 0.66
embC 4241042 p.Asn394Asp missense_variant 0.6
embC 4241562 p.Arg567His missense_variant 0.35
embC 4242075 p.Arg738Gln missense_variant 0.31
embC 4242425 p.Arg855Gly missense_variant 0.25
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243848 p.Val206Met missense_variant 0.71
embA 4245969 p.Pro913Ser missense_variant 0.68
embB 4247646 p.Glu378Ala missense_variant 0.71
ubiA 4269387 p.Glu149Asp missense_variant 0.66
aftB 4269606 c.-770T>C upstream_gene_variant 0.64
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 0.59
gid 4407588 c.615A>G synonymous_variant 0.99
gid 4407780 c.423G>A synonymous_variant 0.58
gid 4407873 c.330G>T synonymous_variant 0.66