TB-Profiler result

Run: ERR234626
Summary

Run ID: ERR234626

Sample name:

Date: 31-03-2023 18:08:15

Number of reads: 7327687

Percentage reads mapped: 99.5

Strain: lineage4.2.1.1;lineage2.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.36
lineage4 Euro-American LAM;T;S;X;H None 0.66
lineage4.2 Euro-American H;T;LAM None 0.64
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.36
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.35
lineage4.2.1 Euro-American (TUR) H3;H4 None 0.65
lineage4.2.1.1 Euro-American (TUR) H3;H4 None 0.64
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.33 rifampicin
rpoB 762089 p.Glu761Asp missense_variant 0.33 rifampicin
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 0.31 streptomycin
katG 2155168 p.Ser315Thr missense_variant 0.98 isoniazid
eis 2715369 c.-37G>T upstream_gene_variant 0.33 kanamycin
embB 4247574 p.Asp354Ala missense_variant 0.28 ethambutol
ethA 4327480 c.-7T>C upstream_gene_variant 0.27 ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 0.32
mshA 575907 p.Ala187Val missense_variant 0.38
ccsA 620625 p.Ile245Met missense_variant 0.27
rpoC 763031 c.-339T>C upstream_gene_variant 0.4
rpoC 766645 p.Glu1092Asp missense_variant 0.37
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.36
mmpL5 776182 p.Asp767Asn missense_variant 0.39
mmpL5 776536 p.Lys649Gln missense_variant 0.67
mmpL5 777451 p.Val344Leu missense_variant 0.61
mmpS5 779615 c.-710C>G upstream_gene_variant 0.43
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304159 p.Val410Gly missense_variant 0.24
Rv1258c 1406760 c.580_581insC frameshift_variant 0.34
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 0.43
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.38
PPE35 2167926 p.Leu896Ser missense_variant 0.34
PPE35 2169879 p.Phe245Cys missense_variant 0.6
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289226 p.Ile6Leu missense_variant 0.4
ald 3086742 c.-78A>C upstream_gene_variant 0.59
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 0.39
rpoA 3877978 p.Lys177Met missense_variant 0.36
ddn 3987092 p.Glu83Asp missense_variant 0.62
clpC1 4038857 c.1848C>A synonymous_variant 0.25
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.35
aftB 4267647 p.Asp397Gly missense_variant 0.29
ethA 4327505 c.-32C>T upstream_gene_variant 0.74
whiB6 4338563 c.-42G>T upstream_gene_variant 0.3
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.39
gid 4407793 p.Arg137Pro missense_variant 0.64
gid 4407927 p.Glu92Asp missense_variant 0.36
gid 4408213 c.-11C>T upstream_gene_variant 0.62