TB-Profiler result

Run: ERR4797174
Summary

Run ID: ERR4797174

Sample name:

Date: 20-10-2023 02:13:27

Number of reads: 9633255

Percentage reads mapped: 99.41

Strain: lineage2.2.1;lineage1.2.2.2

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin R rpoB p.Ser450Leu (0.44)
Isoniazid R katG p.Ser315Thr (0.43)
Ethambutol R embB p.Met306Val (0.36)
Pyrazinamide
Streptomycin R rpsL p.Lys43Arg (0.39)
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.41
lineage1 Indo-Oceanic EAI RD239 0.61
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.39
lineage1.2.2 Indo-Oceanic EAI1 RD239 0.6
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.4
lineage1.2.2.2 Indo-Oceanic NA RD239 0.61
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.44 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.39 streptomycin
katG 2155168 p.Ser315Thr missense_variant 0.43 isoniazid
embB 4247429 p.Met306Val missense_variant 0.36 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5075 c.-165C>T upstream_gene_variant 0.59
gyrB 6112 p.Met291Ile missense_variant 0.54
gyrA 7268 c.-34C>T upstream_gene_variant 0.61
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8452 p.Ala384Val missense_variant 0.64
gyrA 9143 c.1842T>C synonymous_variant 0.63
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 0.41
ccsA 620553 c.663T>C synonymous_variant 0.32
ccsA 620625 p.Ile245Met missense_variant 0.35
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763884 p.Ala172Val missense_variant 0.6
rpoC 763886 c.517C>A synonymous_variant 0.62
rpoC 764817 p.Val483Ala missense_variant 0.45
rpoC 766953 p.Ala1195Val missense_variant 0.62
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 0.38
mmpL5 776540 c.1941C>T synonymous_variant 0.64
mmpS5 779615 c.-710C>G upstream_gene_variant 0.42
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.39
embR 1417019 p.Cys110Tyr missense_variant 0.67
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474523 n.866C>T non_coding_transcript_exon_variant 0.72
rpsA 1834177 c.636A>C synonymous_variant 0.41
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2156239 c.-128T>G upstream_gene_variant 0.56
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168742 p.Gly624Asp missense_variant 0.64
Rv1979c 2222308 p.Asp286Gly missense_variant 0.71
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 0.55
ahpC 2726051 c.-142G>A upstream_gene_variant 0.6
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339303 c.186C>T synonymous_variant 0.56
Rv3083 3448714 p.Asp71His missense_variant 0.58
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 0.61
fprA 3475159 p.Asn385Asp missense_variant 0.6
Rv3236c 3612813 p.Thr102Ala missense_variant 0.41
clpC1 4040517 p.Val63Ala missense_variant 0.52
embC 4240671 p.Thr270Ile missense_variant 0.67
embC 4241042 p.Asn394Asp missense_variant 0.55
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.37
embA 4245969 p.Pro913Ser missense_variant 0.61
embB 4247646 p.Glu378Ala missense_variant 0.55
embB 4248157 c.1644A>G synonymous_variant 0.56
embB 4249757 p.Thr1082Ala missense_variant 0.47
aftB 4267647 p.Asp397Gly missense_variant 0.42
ubiA 4269387 p.Glu149Asp missense_variant 0.66
aftB 4269606 c.-770T>C upstream_gene_variant 0.62
ethA 4326148 c.1326G>T synonymous_variant 0.6
ethA 4326439 p.Asn345Lys missense_variant 0.58
whiB6 4338203 p.Arg107Cys missense_variant 0.62
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 0.56
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407873 c.330G>T synonymous_variant 0.64
gid 4407927 p.Glu92Asp missense_variant 0.37
gid 4407946 p.Leu86Arg missense_variant 0.6