TB-Profiler result

Run: ERR4816183
Summary

Run ID: ERR4816183

Sample name:

Date: 01-04-2023 14:17:10

Number of reads: 236071

Percentage reads mapped: 43.54

Strain:

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.81 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 761027 c.1221A>G synonymous_variant 0.29
rpoB 761030 c.1224G>C synonymous_variant 0.25
rpoB 761037 c.1231T>C synonymous_variant 0.25
rpoB 761051 c.1245G>C synonymous_variant 0.25
rpoB 761054 c.1248G>C synonymous_variant 0.25
rpoB 761057 c.1251G>C synonymous_variant 0.25
rpoB 761060 c.1254C>G synonymous_variant 0.25
rpoB 761084 c.1278C>A synonymous_variant 0.29
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.29
rpoB 761096 c.1290G>C synonymous_variant 0.29
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.29
rpoB 761102 c.1296A>G synonymous_variant 0.29
rpoB 762194 c.2388G>C synonymous_variant 0.2
rpoB 762200 c.2394C>T synonymous_variant 0.27
rpoB 762218 c.2412T>C synonymous_variant 0.18
rpoB 762233 c.2427G>C synonymous_variant 0.38
rpoB 762234 p.Pro810Ser missense_variant 0.25
rpoB 762245 c.2439G>C synonymous_variant 0.38
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763675 c.306C>G synonymous_variant 0.4
rpoC 763699 c.330G>T synonymous_variant 0.4
rpoC 763708 c.339G>C synonymous_variant 0.6
rpoC 763714 c.345G>C synonymous_variant 0.6
rpoC 763717 c.348T>C synonymous_variant 0.5
rpoC 763718 p.Leu117Val missense_variant 0.5
rpoC 763723 c.354G>C synonymous_variant 0.43
rpoC 763724 p.Asp119Asn missense_variant 0.29
rpoC 763729 c.360G>C synonymous_variant 0.43
rpoC 763732 c.363C>G synonymous_variant 0.33
rpoC 763735 c.366G>C synonymous_variant 0.29
rpoC 763744 c.375G>C synonymous_variant 0.29
rpoC 763751 p.Ile128Val missense_variant 0.43
rpoC 764512 c.1143G>C synonymous_variant 0.6
rpoC 764521 c.1152T>C synonymous_variant 0.5
rpoC 764536 c.1167G>C synonymous_variant 0.5
rpoC 764543 p.Thr392Ala missense_variant 0.44
rpoC 764548 c.1179G>T synonymous_variant 0.44
rpoC 764551 c.1182G>C synonymous_variant 0.44
rpoC 764573 p.Leu402Ile missense_variant 0.44
rpoC 764578 c.1209C>G synonymous_variant 0.38
rpoC 764581 c.1212T>C synonymous_variant 0.38
rpoC 764582 p.Leu405Met missense_variant 0.38
rpoC 764602 c.1233C>T synonymous_variant 0.43
rpoC 764605 c.1236G>T synonymous_variant 0.43
rpoC 764611 c.1242G>T synonymous_variant 0.33
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776967 p.Gly505Asp missense_variant 1.0
mmpL5 778348 p.Val45Ile missense_variant 0.25
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781745 c.186G>A synonymous_variant 0.22
rpsL 781751 c.192G>C synonymous_variant 0.2
rpsL 781760 c.201T>C synonymous_variant 0.3
rpsL 781766 c.207C>T synonymous_variant 0.33
rpsL 781796 p.Met79Ile missense_variant 0.33
rpsL 781802 c.243G>C synonymous_variant 0.33
rpsL 781811 c.252C>T synonymous_variant 0.38
rpsL 781814 c.255C>T synonymous_variant 0.38
rpsL 781817 c.258G>T synonymous_variant 0.33
rpsL 781832 c.273T>C synonymous_variant 0.3
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.2
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.75
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.24
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.56
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.59
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.61
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.16
rrs 1472128 n.283G>C non_coding_transcript_exon_variant 0.16
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.89
rrs 1472150 n.305T>G non_coding_transcript_exon_variant 0.71
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.33
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.67
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.63
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.27
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.56
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.86
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.41
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.55
rrs 1472462 n.617T>G non_coding_transcript_exon_variant 1.0
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 1.0
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 1.0
rrs 1472474 n.629C>G non_coding_transcript_exon_variant 1.0
rrs 1472476 n.631A>G non_coding_transcript_exon_variant 1.0
rrs 1472484 n.639A>T non_coding_transcript_exon_variant 1.0
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 1.0
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 1.0
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 1.0
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 1.0
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.8
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.19
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.77
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.74
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.8
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.83
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.13
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.86
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.87
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.81
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.63
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.62
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.99
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.12
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.85
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.85
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.62
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 1.0
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.75
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.21
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.83
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.16
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.82
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.8
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.8
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.8
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.23
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.73
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.74
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 1.0
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.33
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.5
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 1.0
rrs 1472875 n.1030T>C non_coding_transcript_exon_variant 1.0
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.92
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.19
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.5
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.19
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.75
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.71
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.14
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.8
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.8
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.15
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.29
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.14
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.29
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.95
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.54
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.57
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.94
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.92
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 1.0
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.93
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.81
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.75
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.85
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.8
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.9
rrs 1473101 n.1256C>T non_coding_transcript_exon_variant 0.6
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.2
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.9
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.91
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.91
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.73
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.83
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.75
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.9
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.91
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.61
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.69
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.16
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.16
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.56
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 1.0
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 1.0
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 1.0
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.67
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.29
rrs 1473291 n.1446G>C non_coding_transcript_exon_variant 0.6
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 0.43
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.43
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.5
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.71
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 1.0
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.75
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.75
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.75
rrl 1474200 n.545delT non_coding_transcript_exon_variant 1.0
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.67
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.67
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 1.0
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.67
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.75
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 1.0
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.67
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.67
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.67
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.67
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.75
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 1.0
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.67
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.67
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.67
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.67
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.67
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0
rrl 1476164 n.2507A>T non_coding_transcript_exon_variant 1.0
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 1.0
rrl 1476194 n.2537A>T non_coding_transcript_exon_variant 1.0
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 1.0
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.67
rrl 1476207 n.2550T>C non_coding_transcript_exon_variant 1.0
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 1.0
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.67
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 1.0
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 1.0
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 1.0
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 1.0
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 1.0
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.12
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.18
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.11
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.84
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.14
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.14
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.88
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.12
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.2
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.74
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.64
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.63
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.6
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.57
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.67
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 1.0
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 1.0
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.67
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.67
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.67
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.67
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.5
rpsA 1834249 c.708T>C synonymous_variant 0.29
rpsA 1834261 c.720A>G synonymous_variant 0.33
rpsA 1834264 c.723G>C synonymous_variant 0.33
rpsA 1834294 c.753G>C synonymous_variant 0.29
rpsA 1834298 p.Gln253Glu missense_variant 0.29
rpsA 1834306 c.765T>C synonymous_variant 0.29
rpsA 1834307 p.Asp256Gln missense_variant 0.29
rpsA 1834312 c.771G>A synonymous_variant 0.29
rpsA 1834327 c.786G>T synonymous_variant 0.38
rpsA 1834345 c.804C>T synonymous_variant 0.4
rpsA 1834348 c.807T>C synonymous_variant 0.4
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2156068 p.Ala15Val missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 0.25
embC 4241307 p.Val482Ala missense_variant 1.0
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0