TB-Profiler result

Run: ERR4816969

Summary

Run ID: ERR4816969

Sample name:

Date: 01-04-2023 14:44:00

Number of reads: 1291246

Percentage reads mapped: 86.86

Strain: lineage4.8

Drug-resistance: Other


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.11 streptomycin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.88 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.17 kanamycin, capreomycin, aminoglycosides, amikacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5195 c.-45C>T upstream_gene_variant 0.12
gyrB 5706 p.Leu156Arg missense_variant 0.92
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7882 p.Leu194Gln missense_variant 0.11
rpoC 763699 c.330G>T synonymous_variant 0.19
rpoC 763708 c.339G>C synonymous_variant 0.17
rpoC 763717 c.348T>C synonymous_variant 0.15
rpoC 763726 c.357C>T synonymous_variant 0.1
rpoC 765947 c.2578T>C synonymous_variant 0.1
rpoC 765962 c.2593T>C synonymous_variant 0.1
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776522 c.1959G>T synonymous_variant 0.12
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
atpE 1460920 c.-124delC upstream_gene_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.2
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.45
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.73
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.56
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.5
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.17
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.12
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.12
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.12
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.12
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.12
rrs 1472130 n.285G>A non_coding_transcript_exon_variant 0.11
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.11
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.89
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.17
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.15
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.61
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.71
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 1.0
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 1.0
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 1.0
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 1.0
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 1.0
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 1.0
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 1.0
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.92
rrs 1472543 n.699_700delCA non_coding_transcript_exon_variant 0.78
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.92
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.96
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.88
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.93
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.33
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 1.0
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.95
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.95
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.41
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.91
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.82
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.18
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.91
rrs 1472670 n.825G>T non_coding_transcript_exon_variant 0.8
rrs 1472673 n.828T>A non_coding_transcript_exon_variant 1.0
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 1.0
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.88
rrs 1472681 n.837_838delTT non_coding_transcript_exon_variant 1.0
rrs 1472687 n.843dupT non_coding_transcript_exon_variant 1.0
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.82
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.32
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.82
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.21
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.81
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.86
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.86
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.12
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.86
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.16
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.83
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.86
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 1.0
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.27
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.5
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 1.0
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.6
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.57
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.8
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 1.0
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 1.0
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 1.0
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.75
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.8
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 1.0
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.88
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.88
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.88
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.88
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.88
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.88
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.88
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.75
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.8
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.3
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.67
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.61
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.12
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.16
rrs 1473199 n.1356delA non_coding_transcript_exon_variant 0.16
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.16
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.19
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.55
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.64
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.5
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.42
rrs 1473291 n.1446G>C non_coding_transcript_exon_variant 0.27
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 0.33
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.36
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.44
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.5
rrl 1474201 n.544T>A non_coding_transcript_exon_variant 0.67
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.33
rrl 1474228 n.571T>C non_coding_transcript_exon_variant 0.33
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.67
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.33
rrl 1474275 n.618T>C non_coding_transcript_exon_variant 0.67
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 1.0
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 1.0
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 1.0
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 1.0
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 1.0
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 1.0
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 1.0
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 1.0
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 1.0
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 1.0
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.67
rrl 1476211 n.2554G>A non_coding_transcript_exon_variant 0.5
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.5
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.5
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.25
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.5
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.25
rrl 1476229 n.2572C>G non_coding_transcript_exon_variant 0.33
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.29
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.57
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.29
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.71
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.67
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.29
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.79
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.86
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.96
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.79
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.75
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.62
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.64
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.57
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.5
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.5
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.5
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.5
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.5
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.5
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.5
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.5
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.5
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.33
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.5
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.5
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.4
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.5
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.4
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.5
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.4
inhA 1674504 c.303C>G synonymous_variant 0.12
inhA 1674672 c.471C>A synonymous_variant 0.17
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2222298 c.867G>T synonymous_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv3083 3448322 c.-182G>A upstream_gene_variant 1.0
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
rpoA 3878566 c.-59C>T upstream_gene_variant 0.5
clpC1 4039094 c.1611C>A synonymous_variant 0.14
clpC1 4039117 p.Lys530Gln missense_variant 0.22
clpC1 4039121 c.1584T>C synonymous_variant 0.22
clpC1 4039124 c.1581C>G synonymous_variant 0.22
embA 4242643 c.-590C>T upstream_gene_variant 1.0
ethA 4326753 p.Lys241Glu missense_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0