TB-Profiler result

Run: ERR4896322
Summary

Run ID: ERR4896322

Sample name:

Date: 02-08-2023 08:27:02

Number of reads: NA

Percentage reads mapped: NA

Strain: lineage4.1.2.1;lineage2.2.1.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.34
lineage4 Euro-American LAM;T;S;X;H None 0.67
lineage4.1 Euro-American T;X;H None 0.63
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.41
lineage4.1.2 Euro-American T;H None 0.65
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.37
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 0.64
lineage2.2.1.1 East-Asian (Beijing) Beijing-RD150 RD105;RD207;RD181;RD150 0.36
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 0.56
fgd1 491742 c.960T>C synonymous_variant 0.28
mshA 575679 p.Asn111Ser missense_variant 0.63
mshA 575907 p.Ala187Val missense_variant 0.23
ccsA 620625 p.Ile245Met missense_variant 0.56
rpoB 760115 c.309C>T synonymous_variant 0.65
rpoB 760990 p.Arg395Gln missense_variant 0.14
rpoB 761017 p.Glu404Gly missense_variant 0.22
rpoC 763031 c.-339T>C upstream_gene_variant 0.39
rpoC 765150 p.Gly594Glu missense_variant 0.75
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.35
mmpL5 776182 p.Asp767Asn missense_variant 0.43
mmpS5 779615 c.-710C>G upstream_gene_variant 0.29
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302818 c.-113G>C upstream_gene_variant 0.36
Rv1258c 1406760 c.580_581insC frameshift_variant 0.21
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 0.3
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101933 c.1109_1110insCTT disruptive_inframe_insertion 0.2
katG 2154724 p.Arg463Leu missense_variant 0.42
PPE35 2167926 p.Leu896Ser missense_variant 0.38
PPE35 2170048 p.Leu189Val missense_variant 0.42
PPE35 2170053 p.Thr187Ser missense_variant 0.4
Rv1979c 2223014 p.Tyr51Asn missense_variant 0.36
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 0.58
eis 2714846 p.Val163Ile missense_variant 0.29
eis 2715436 c.-104G>A upstream_gene_variant 0.64
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474930 c.924C>T synonymous_variant 0.33
Rv3236c 3612813 p.Thr102Ala missense_variant 0.24
fbiB 3642167 c.633G>C synonymous_variant 0.19
rpoA 3878567 c.-60C>G upstream_gene_variant 0.16
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 0.69
embA 4243460 c.228C>T synonymous_variant 0.45
embB 4246544 p.Thr11Pro missense_variant 0.29
embB 4246548 p.Pro12Gln missense_variant 0.35
embB 4246555 c.42G>C synonymous_variant 0.31
embB 4246556 p.Ala15Pro missense_variant 0.33
embB 4246563 p.Leu17Trp missense_variant 0.23
embB 4248115 c.1602C>T synonymous_variant 0.38
aftB 4267647 p.Asp397Gly missense_variant 0.27
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.33
gid 4407927 p.Glu92Asp missense_variant 0.33