TB-Profiler result

Run: ERR9993035
Summary

Run ID: ERR9993035

Sample name:

Date: 02-04-2023 14:00:49

Number of reads: 2438690

Percentage reads mapped: 62.51

Strain: lineage4.4.1.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 1.0
lineage4.4.1 Euro-American (S-type) S;T None 1.0
lineage4.4.1.1 Euro-American S;Orphans None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761277 p.Ile491Phe missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289091 p.His51Asp missense_variant 1.0 pyrazinamide
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9138 p.Gln613Glu missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.29
rpoC 766467 p.Glu1033Ala missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777416 c.1065G>T synonymous_variant 1.0
mmpR5 779426 p.Met146Thr missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472089 n.244C>T non_coding_transcript_exon_variant 0.15
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.2
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.32
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.32
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.33
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.34
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.33
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.33
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.3
rrs 1472210 n.365A>T non_coding_transcript_exon_variant 0.3
rrs 1472213 n.368G>C non_coding_transcript_exon_variant 0.3
rrs 1472222 n.377G>A non_coding_transcript_exon_variant 0.3
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.3
rrs 1472229 n.384C>T non_coding_transcript_exon_variant 0.3
rrs 1472236 n.391C>G non_coding_transcript_exon_variant 0.29
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.22
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.22
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.22
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.22
rrs 1472669 n.824_825insTGG non_coding_transcript_exon_variant 0.21
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.22
rrs 1472678 n.833T>A non_coding_transcript_exon_variant 0.2
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.19
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.18
rrs 1472708 n.863T>A non_coding_transcript_exon_variant 0.18
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.19
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.19
rrs 1472733 n.888G>C non_coding_transcript_exon_variant 0.21
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.21
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.21
rrs 1472742 n.897C>G non_coding_transcript_exon_variant 0.21
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.21
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.15
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.16
rrs 1472958 n.1113A>T non_coding_transcript_exon_variant 0.17
rrs 1472959 n.1114T>A non_coding_transcript_exon_variant 0.16
rrs 1472969 n.1125_1126delCG non_coding_transcript_exon_variant 0.15
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.15
rrs 1472974 n.1129A>C non_coding_transcript_exon_variant 0.14
rrs 1472975 n.1130T>A non_coding_transcript_exon_variant 0.16
rrs 1472977 n.1132G>T non_coding_transcript_exon_variant 0.16
rrs 1472982 n.1137G>C non_coding_transcript_exon_variant 0.17
rrs 1472987 n.1142G>T non_coding_transcript_exon_variant 0.17
rrs 1472988 n.1143T>A non_coding_transcript_exon_variant 0.17
rrs 1473001 n.1156G>T non_coding_transcript_exon_variant 0.19
rrs 1473002 n.1157G>C non_coding_transcript_exon_variant 0.19
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.19
rrs 1473008 n.1163C>G non_coding_transcript_exon_variant 0.19
rrs 1473009 n.1164T>A non_coding_transcript_exon_variant 0.19
rrs 1473020 n.1175T>C non_coding_transcript_exon_variant 0.16
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.2
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.12
rrl 1473416 n.-242G>C upstream_gene_variant 1.0
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.1
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102990 p.Val18Ala missense_variant 1.0
PPE35 2168479 p.Thr712Pro missense_variant 1.0
PPE35 2169840 p.Gly258Asp missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518496 c.382C>T synonymous_variant 1.0
Rv2752c 3065023 p.Pro390Leu missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448522 p.Val7Phe missense_variant 1.0
Rv3083 3448608 c.105G>A synonymous_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568779 c.-100T>C upstream_gene_variant 1.0
Rv3236c 3612665 p.Val151Ala missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0