TB-Profiler result

Run: SRR25827750

Summary

Run ID: SRR25827750

Sample name:

Date: 02-02-2024 18:08:43

Number of reads: 7460393

Percentage reads mapped: 98.1

Strain: lineage1.1.3

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage1 Indo-Oceanic EAI RD239 0.97
lineage1.1 Indo-Oceanic EAI3;EAI4;EAI5;EAI6 RD239 0.94
lineage1.1.3 Indo-Oceanic EAI6 RD239 0.95
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6112 p.Met291Ile missense_variant 0.96
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8063 c.762C>T synonymous_variant 0.98
gyrA 8452 p.Ala384Val missense_variant 0.95
gyrA 9143 c.1842T>C synonymous_variant 0.96
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491448 c.666C>T synonymous_variant 0.97
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 576453 p.Val369Gly missense_variant 0.25
mshA 576675 p.Arg443His missense_variant 0.96
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763884 p.Ala172Val missense_variant 0.97
rpoC 763886 c.517C>A synonymous_variant 0.95
rpoC 765171 p.Pro601Leu missense_variant 0.97
rpoC 765230 p.Ala621Thr missense_variant 0.97
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 778099 p.Asp128Asn missense_variant 0.97
mmpS5 778581 p.Gly109Ser missense_variant 0.97
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417019 p.Cys110Tyr missense_variant 0.96
rrs 1471659 n.-187C>T upstream_gene_variant 0.95
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155578 c.534C>T synonymous_variant 0.94
katG 2155800 c.312G>C synonymous_variant 0.94
PPE35 2167709 c.2904C>T synonymous_variant 0.96
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2167983 p.Gly877Asp missense_variant 0.96
Rv1979c 2222308 p.Asp286Gly missense_variant 0.95
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 0.99
ahpC 2726051 c.-142G>A upstream_gene_variant 0.97
Rv2752c 3064632 c.1560C>T synonymous_variant 0.97
thyX 3068043 c.-98A>G upstream_gene_variant 0.95
ald 3086767 c.-53A>T upstream_gene_variant 0.96
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448714 p.Asp71His missense_variant 0.99
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 0.96
fprA 3475159 p.Asn385Asp missense_variant 0.97
clpC1 4040517 p.Val63Ala missense_variant 0.98
embC 4240671 p.Thr270Ile missense_variant 0.97
embC 4241042 p.Asn394Asp missense_variant 0.96
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243848 p.Val206Met missense_variant 0.95
embA 4245314 c.2082G>C synonymous_variant 0.95
embA 4245835 p.Leu868Arg missense_variant 0.16
embA 4245969 p.Pro913Ser missense_variant 0.95
embB 4247646 p.Glu378Ala missense_variant 0.94
aftB 4267812 p.Pro342Leu missense_variant 0.97
ubiA 4269387 p.Glu149Asp missense_variant 0.97
aftB 4269606 c.-770T>C upstream_gene_variant 0.97
whiB6 4338308 c.213dupT frameshift_variant 0.97
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 0.95
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407780 c.423G>A synonymous_variant 0.96
gid 4407873 c.330G>T synonymous_variant 0.98