TB-Profiler result

Run: ERR4797011
Summary

Run ID: ERR4797011

Sample name:

Date: 01-04-2023 07:17:47

Number of reads: 3690271

Percentage reads mapped: 99.46

Strain: lineage3;lineage1.1.3.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3 East-African-Indian CAS RD750 0.33
lineage1 Indo-Oceanic EAI RD239 0.69
lineage1.1 Indo-Oceanic EAI3;EAI4;EAI5;EAI6 RD239 0.69
lineage1.1.3 Indo-Oceanic EAI6 RD239 0.7
lineage1.1.3.1 Indo-Oceanic NA RD239 0.67
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6112 p.Met291Ile missense_variant 0.67
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8452 p.Ala384Val missense_variant 0.65
gyrA 9143 c.1842T>C synonymous_variant 0.71
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.22
mshA 576113 p.Arg256Gly missense_variant 0.28
rpoB 759746 c.-61C>T upstream_gene_variant 0.29
rpoC 762434 c.-936T>G upstream_gene_variant 0.33
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763884 p.Ala172Val missense_variant 0.63
rpoC 763886 c.517C>A synonymous_variant 0.64
rpoC 765171 p.Pro601Leu missense_variant 0.65
rpoC 765230 p.Ala621Thr missense_variant 0.64
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 777572 c.909C>T synonymous_variant 0.64
mmpL5 777883 p.Gly200Arg missense_variant 0.16
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1305434 p.Ala835Val missense_variant 0.7
embR 1417019 p.Cys110Tyr missense_variant 0.73
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472480 n.635G>T non_coding_transcript_exon_variant 0.18
fabG1 1673553 p.Asp38Glu missense_variant 0.27
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2167983 p.Gly877Asp missense_variant 0.79
PPE35 2170065 p.Ala183Gly missense_variant 0.38
Rv1979c 2222308 p.Asp286Gly missense_variant 0.72
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 0.24
pncA 2289365 c.-125delC upstream_gene_variant 0.25
kasA 2518132 c.18C>T synonymous_variant 0.61
kasA 2519071 p.Asp319Glu missense_variant 0.18
eis 2714352 c.981C>G synonymous_variant 0.6
ahpC 2726051 c.-142G>A upstream_gene_variant 0.7
ahpC 2726105 c.-88G>A upstream_gene_variant 0.33
pepQ 2860159 p.Ala87Gly missense_variant 0.22
Rv2752c 3064632 c.1560C>T synonymous_variant 0.67
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.67
fbiD 3339744 c.627A>C synonymous_variant 0.29
fbiD 3339751 p.Ala212Pro missense_variant 0.19
Rv3083 3448714 p.Asp71His missense_variant 0.53
fprA 3473820 c.-187C>A upstream_gene_variant 0.24
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 0.58
fprA 3475159 p.Asn385Asp missense_variant 0.73
whiB7 3568431 c.249C>G synonymous_variant 0.33
alr 3841253 c.168C>T synonymous_variant 0.78
alr 3841277 c.144C>T synonymous_variant 0.79
rpoA 3878637 c.-130G>C upstream_gene_variant 0.33
rpoA 3878641 c.-134C>G upstream_gene_variant 0.33
clpC1 4040517 p.Val63Ala missense_variant 0.85
embC 4240009 c.147G>A synonymous_variant 0.36
embC 4240409 p.Pro183Ala missense_variant 0.23
embC 4240671 p.Thr270Ile missense_variant 0.7
embC 4241042 p.Asn394Asp missense_variant 0.65
embC 4242075 p.Arg738Gln missense_variant 0.26
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243848 p.Val206Met missense_variant 0.66
embA 4245969 p.Pro913Ser missense_variant 0.68
embB 4246548 p.Pro12Gln missense_variant 0.2
embB 4246555 c.42G>C synonymous_variant 0.21
embB 4246556 p.Ala15Pro missense_variant 0.19
embB 4246563 p.Leu17Trp missense_variant 0.12
embB 4246567 c.54G>T synonymous_variant 0.15
embB 4247646 p.Glu378Ala missense_variant 0.62
aftB 4268619 p.Val73Gly missense_variant 0.25
ubiA 4269387 p.Glu149Asp missense_variant 0.64
aftB 4269606 c.-770T>C upstream_gene_variant 0.63
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407780 c.423G>A synonymous_variant 0.67
gid 4407873 c.330G>T synonymous_variant 0.72