TB-Profiler result

Run: SRR13861629
Summary

Run ID: SRR13861629

Sample name:

Date: 03-04-2023 09:36:46

Number of reads: 709083

Percentage reads mapped: 14.2

Strain: lineage4.9

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761131 p.Gly442Glu missense_variant 0.17 rifampicin
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.39 streptomycin
embB 4247448 p.His312Arg missense_variant 0.17 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5149 c.-91G>C upstream_gene_variant 1.0
gyrB 7090 p.Asp617Glu missense_variant 0.86
gyrA 7799 c.498A>G synonymous_variant 0.14
gyrA 8324 c.1023T>C synonymous_variant 0.15
gyrA 8339 c.1038A>G synonymous_variant 0.16
gyrA 8342 c.1041G>C synonymous_variant 0.16
gyrA 8366 c.1065G>C synonymous_variant 0.15
gyrA 8391 p.Tyr364His missense_variant 0.18
gyrA 8399 c.1098T>C synonymous_variant 0.15
gyrA 8436 p.Tyr379Asn missense_variant 0.96
gyrA 8729 c.1428T>C synonymous_variant 0.14
gyrA 8786 c.1485T>C synonymous_variant 0.19
gyrA 8796 p.Ile499Val missense_variant 0.2
gyrA 8801 c.1500G>C synonymous_variant 0.19
gyrA 8810 c.1509A>C synonymous_variant 0.19
gyrA 8816 c.1515C>T synonymous_variant 0.19
gyrA 8837 c.1536C>T synonymous_variant 0.14
gyrA 8897 c.1596T>C synonymous_variant 0.15
gyrA 8903 c.1602T>C synonymous_variant 0.15
gyrA 8915 c.1614A>G synonymous_variant 0.19
gyrA 8939 c.1638T>C synonymous_variant 0.15
gyrA 8945 c.1644G>C synonymous_variant 0.14
gyrA 8951 p.Lys550Asn missense_variant 0.17
gyrA 8966 c.1665C>G synonymous_variant 0.18
gyrA 8967 p.Ala556Arg missense_variant 0.18
gyrA 8987 c.1686C>G synonymous_variant 0.21
gyrA 8990 c.1689C>G synonymous_variant 0.2
gyrA 8996 c.1695T>C synonymous_variant 0.2
gyrA 8998 p.Leu566Trp missense_variant 0.2
gyrA 9023 c.1722A>C synonymous_variant 0.19
gyrA 9032 c.1731T>C synonymous_variant 0.14
gyrA 9035 c.1734G>C synonymous_variant 0.14
gyrA 9099 c.1798T>C synonymous_variant 0.17
gyrA 9275 c.1974G>A synonymous_variant 0.15
gyrA 9278 c.1977G>C synonymous_variant 0.15
gyrA 9281 c.1980C>G synonymous_variant 0.15
gyrA 9284 c.1983T>C synonymous_variant 0.15
gyrA 9291 c.1990C>T synonymous_variant 0.17
gyrA 9296 c.1995T>C synonymous_variant 0.16
gyrA 9304 p.Gly668Glu missense_variant 0.17
gyrA 9311 c.2010C>T synonymous_variant 0.16
gyrA 9323 c.2022C>G synonymous_variant 0.15
gyrA 9335 c.2034G>C synonymous_variant 0.2
gyrA 9345 c.2044A>C synonymous_variant 0.15
gyrA 9374 c.2073G>C synonymous_variant 0.14
gyrA 9386 c.2085T>C synonymous_variant 0.15
gyrA 9395 c.2094G>C synonymous_variant 0.19
fgd1 491701 p.His307Asn missense_variant 1.0
mshA 575659 c.312A>G synonymous_variant 0.15
mshA 575771 p.Val142Ser missense_variant 0.13
ccsA 619765 c.-126G>A upstream_gene_variant 1.0
rpoB 760181 c.375T>C synonymous_variant 0.15
rpoB 760184 c.378A>G synonymous_variant 0.15
rpoB 760223 c.417T>C synonymous_variant 0.15
rpoB 760235 c.429T>C synonymous_variant 0.18
rpoB 760307 c.501T>C synonymous_variant 0.15
rpoB 760328 c.522G>C synonymous_variant 0.16
rpoB 760337 c.531C>G synonymous_variant 0.18
rpoB 760340 c.534G>C synonymous_variant 0.16
rpoB 760563 p.Arg253Met missense_variant 0.14
rpoB 760591 p.Val262Ala missense_variant 0.18
rpoB 760611 c.805T>C synonymous_variant 0.15
rpoB 760934 c.1128C>T synonymous_variant 0.13
rpoB 761021 c.1215G>C synonymous_variant 0.14
rpoB 761027 c.1221A>G synonymous_variant 0.15
rpoB 761126 c.1320G>T synonymous_variant 0.17
rpoB 761129 c.1323G>C synonymous_variant 0.17
rpoB 761133 p.Leu443Ile missense_variant 0.19
rpoB 761150 c.1344A>C synonymous_variant 0.28
rpoB 761151 p.Leu449Val missense_variant 0.16
rpoB 761156 c.1350G>C synonymous_variant 0.15
rpoB 761162 c.1356G>C synonymous_variant 0.16
rpoB 761165 c.1359G>C synonymous_variant 0.28
rpoB 761168 c.1362C>G synonymous_variant 0.25
rpoB 761178 p.Ser458Thr missense_variant 0.16
rpoB 761192 c.1386C>G synonymous_variant 0.18
rpoB 761195 c.1389G>C synonymous_variant 0.17
rpoB 761196 p.Leu464Phe missense_variant 0.17
rpoB 761204 c.1398C>T synonymous_variant 0.16
rpoB 761207 c.1401C>T synonymous_variant 0.16
rpoB 761213 c.1407G>A synonymous_variant 0.15
rpoB 761220 p.Ser472Thr missense_variant 0.15
rpoB 761234 c.1428G>C synonymous_variant 0.16
rpoB 761261 c.1455G>T synonymous_variant 0.13
rpoB 762053 c.2247T>C synonymous_variant 0.15
rpoB 762062 c.2256T>C synonymous_variant 0.16
rpoB 762065 c.2259T>C synonymous_variant 0.16
rpoB 762149 c.2343G>C synonymous_variant 0.13
rpoB 762167 c.2361T>C synonymous_variant 0.21
rpoB 762176 c.2370T>C synonymous_variant 0.17
rpoB 762185 c.2379G>C synonymous_variant 0.18
rpoB 762218 c.2412T>G synonymous_variant 0.24
rpoB 762254 c.2448T>C synonymous_variant 0.21
rpoB 762266 c.2460T>C synonymous_variant 0.19
rpoB 762284 c.2478G>C synonymous_variant 0.19
rpoB 762293 c.2487T>C synonymous_variant 0.19
rpoB 762317 c.2511A>G synonymous_variant 0.17
rpoB 762329 c.2523G>C synonymous_variant 0.17
rpoB 762338 c.2532T>C synonymous_variant 0.17
rpoB 762347 c.2541T>C synonymous_variant 0.17
rpoB 762362 p.Glu852Asp missense_variant 0.17
rpoB 762369 c.2563T>C synonymous_variant 0.17
rpoC 762380 c.-990T>G upstream_gene_variant 0.16
rpoC 762410 c.-960T>C upstream_gene_variant 0.17
rpoC 762416 c.-954A>G upstream_gene_variant 0.17
rpoC 762443 c.-927G>C upstream_gene_variant 0.17
rpoB 762490 p.Val895Asp missense_variant 0.13
rpoC 762929 c.-441G>C upstream_gene_variant 0.17
rpoC 762989 c.-381G>C upstream_gene_variant 0.23
rpoC 762995 c.-375G>T upstream_gene_variant 0.21
rpoC 763028 c.-342T>C upstream_gene_variant 0.17
rpoC 763031 c.-339T>G upstream_gene_variant 0.17
rpoC 763034 c.-336C>G upstream_gene_variant 0.16
rpoC 763040 c.-330C>G upstream_gene_variant 0.17
rpoC 763528 c.159G>A synonymous_variant 0.14
rpoC 763546 c.177A>G synonymous_variant 0.15
rpoC 763633 c.264T>C synonymous_variant 0.16
rpoC 763636 c.267T>C synonymous_variant 0.16
rpoC 763642 c.273G>C synonymous_variant 0.16
rpoC 763660 c.291T>G synonymous_variant 0.15
rpoC 763675 c.306C>G synonymous_variant 0.15
rpoC 763696 c.327T>C synonymous_variant 0.15
rpoC 763702 c.333C>G synonymous_variant 0.16
rpoC 763708 c.339G>A synonymous_variant 0.16
rpoC 763709 c.340C>T synonymous_variant 0.16
rpoC 763714 c.345G>C synonymous_variant 0.15
rpoC 763717 c.348T>C synonymous_variant 0.15
rpoC 763723 c.354G>C synonymous_variant 0.16
rpoC 763744 c.375G>C synonymous_variant 0.15
rpoC 763768 c.399C>G synonymous_variant 0.15
rpoC 763780 c.411C>G synonymous_variant 0.16
rpoC 763783 c.414G>C synonymous_variant 0.16
rpoC 763801 c.432C>G synonymous_variant 0.15
rpoC 763807 c.438T>C synonymous_variant 0.22
rpoC 763819 c.450G>C synonymous_variant 0.22
rpoC 763835 p.Ala156Met missense_variant 0.15
rpoC 763858 c.489A>G synonymous_variant 0.23
rpoC 763872 p.Gly168Ala missense_variant 0.23
rpoC 763876 p.Glu169Asp missense_variant 0.23
rpoC 763879 c.510A>G synonymous_variant 0.22
rpoC 763888 c.519G>C synonymous_variant 0.23
rpoC 763891 c.522G>C synonymous_variant 0.23
rpoC 763894 c.525A>G synonymous_variant 0.19
rpoC 763919 c.550C>T synonymous_variant 0.21
rpoC 763933 c.564C>T synonymous_variant 0.18
rpoC 763945 c.576T>C synonymous_variant 0.2
rpoC 763960 c.591T>C synonymous_variant 0.18
rpoC 763967 p.Gly200Ser missense_variant 0.17
rpoC 763978 c.609C>G synonymous_variant 0.17
rpoC 763996 c.627T>C synonymous_variant 0.19
rpoC 764005 c.636G>C synonymous_variant 0.18
rpoC 764011 c.642T>C synonymous_variant 0.17
rpoC 764024 c.655T>C synonymous_variant 0.17
rpoC 764040 p.Ser224Asn missense_variant 0.16
rpoC 764044 c.675T>C synonymous_variant 0.2
rpoC 764387 c.1018T>C synonymous_variant 0.22
rpoC 764401 c.1032C>T synonymous_variant 0.15
rpoC 764404 c.1035C>T synonymous_variant 0.15
rpoC 764405 c.1036A>C synonymous_variant 0.19
rpoC 764419 c.1050C>T synonymous_variant 0.16
rpoC 764428 c.1059G>T synonymous_variant 0.17
rpoC 764434 c.1065A>G synonymous_variant 0.21
rpoC 764435 c.1066_1068delAGGinsCGC synonymous_variant 0.17
rpoC 764441 p.Ile358Leu missense_variant 0.16
rpoC 764446 c.1077T>C synonymous_variant 0.21
rpoC 764451 p.Gly361Ala missense_variant 0.17
rpoC 764455 c.1086G>T synonymous_variant 0.17
rpoC 764461 p.Glu364Asp missense_variant 0.17
rpoC 764470 c.1101C>G synonymous_variant 0.15
rpoC 764471 p.Asn368Arg missense_variant 0.15
rpoC 764479 c.1110G>A synonymous_variant 0.15
rpoC 764485 c.1116G>C synonymous_variant 0.16
rpoC 764498 p.Ser377Ala missense_variant 0.18
rpoC 764503 c.1134G>C synonymous_variant 0.18
rpoC 764509 c.1140G>C synonymous_variant 0.17
rpoC 764513 p.Phe382Leu missense_variant 0.17
rpoC 764521 c.1152T>C synonymous_variant 0.23
rpoC 764809 c.1440C>T synonymous_variant 0.14
rpoC 764812 c.1443C>G synonymous_variant 0.15
rpoC 764815 c.1446A>G synonymous_variant 0.15
rpoC 765508 c.2139C>G synonymous_variant 0.15
rpoC 765541 c.2172C>G synonymous_variant 0.14
rpoC 765556 c.2187G>C synonymous_variant 0.15
rpoC 765559 c.2190G>C synonymous_variant 0.19
rpoC 765578 c.2209C>T synonymous_variant 0.16
rpoC 765583 c.2214G>T synonymous_variant 0.15
rpoC 765658 c.2289C>T synonymous_variant 0.12
rpoC 765700 c.2331T>C synonymous_variant 0.15
rpoC 765753 p.Asp795Ala missense_variant 0.14
rpoC 765772 c.2403C>G synonymous_variant 0.15
rpoC 766345 c.2976T>C synonymous_variant 0.12
rpoC 766381 c.3012C>T synonymous_variant 0.14
rpoC 766384 c.3015A>G synonymous_variant 0.14
rpoC 766408 c.3039C>T synonymous_variant 0.15
rpoC 766426 c.3057C>T synonymous_variant 0.18
rpoC 766447 c.3078T>C synonymous_variant 0.17
rpoC 766651 c.3282T>C synonymous_variant 0.16
rpoC 766657 c.3288A>G synonymous_variant 0.17
rpoC 766672 c.3303T>C synonymous_variant 0.17
rpoC 766738 c.3369G>T synonymous_variant 0.15
rpoC 766765 c.3396A>C synonymous_variant 0.24
rpoC 766774 c.3405T>C synonymous_variant 0.25
rpoC 767062 c.3693C>A synonymous_variant 0.13
mmpL5 775867 p.Arg872Gly missense_variant 0.94
mmpL5 775981 p.Leu834Met missense_variant 0.13
mmpL5 775991 c.2490G>A synonymous_variant 0.12
mmpL5 776710 p.Cys591Ser missense_variant 1.0
mmpL5 777625 p.Gln286Lys missense_variant 1.0
mmpS5 778811 p.Phe32Ser missense_variant 1.0
rpsL 781892 c.333A>G synonymous_variant 0.13
rplC 800771 c.-38C>T upstream_gene_variant 0.24
rplC 800814 c.6A>G synonymous_variant 0.17
rplC 800817 c.9A>T synonymous_variant 0.17
rplC 800844 c.36T>C synonymous_variant 0.2
rplC 800865 c.57A>G synonymous_variant 0.22
rplC 800867 p.Ser20Asn missense_variant 0.24
rplC 800874 c.66A>G synonymous_variant 0.24
rplC 800877 c.69A>C synonymous_variant 0.29
rplC 800880 c.72A>G synonymous_variant 0.27
rplC 800889 c.81C>G synonymous_variant 0.28
rplC 800907 c.99C>G synonymous_variant 0.32
rplC 800916 c.108A>G synonymous_variant 0.21
rplC 800937 c.129A>G synonymous_variant 0.15
rplC 800939 p.Arg44His missense_variant 0.14
rplC 800946 c.138T>C synonymous_variant 0.14
rplC 800955 c.147C>G synonymous_variant 0.14
rplC 800970 c.162T>C synonymous_variant 0.14
fbiC 1303509 c.579G>C synonymous_variant 0.14
fbiC 1303512 c.582T>C synonymous_variant 0.14
fbiC 1304517 c.1587C>T synonymous_variant 0.14
embR 1416901 c.447G>C synonymous_variant 1.0
atpE 1461194 c.150C>T synonymous_variant 0.13
atpE 1461233 c.189A>G synonymous_variant 0.13
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.12
rrs 1472936 n.1091C>T non_coding_transcript_exon_variant 0.27
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.29
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.29
rrs 1472958 n.1113A>T non_coding_transcript_exon_variant 0.29
rrs 1472959 n.1114T>A non_coding_transcript_exon_variant 0.26
rrs 1472963 n.1118G>A non_coding_transcript_exon_variant 0.28
rrs 1472971 n.1126G>C non_coding_transcript_exon_variant 0.29
rrs 1472982 n.1137G>C non_coding_transcript_exon_variant 0.31
rrs 1472987 n.1142G>T non_coding_transcript_exon_variant 0.3
rrs 1472988 n.1143T>A non_coding_transcript_exon_variant 0.3
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.31
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.32
rrs 1473002 n.1157G>T non_coding_transcript_exon_variant 0.31
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.32
rrs 1473008 n.1163C>A non_coding_transcript_exon_variant 0.3
rrs 1473009 n.1164T>C non_coding_transcript_exon_variant 0.3
rrs 1473044 n.1199C>G non_coding_transcript_exon_variant 0.29
rrs 1473051 n.1206T>C non_coding_transcript_exon_variant 0.26
rrs 1473053 n.1208T>G non_coding_transcript_exon_variant 0.25
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.15
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.15
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.17
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.21
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.19
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.19
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.17
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.19
rrl 1474466 n.810delA non_coding_transcript_exon_variant 0.96
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.15
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.15
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.15
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.17
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.18
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.17
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.17
rrl 1475224 n.1567T>C non_coding_transcript_exon_variant 0.81
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.16
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.19
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.16
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.16
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.16
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.17
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.16
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.17
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.21
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.21
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.22
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.22
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.16
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.16
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.71
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.8
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.79
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.79
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.78
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.81
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.8
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.8
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.8
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.79
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.81
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.81
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.8
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.81
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.8
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.8
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.77
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.77
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.76
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.76
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.45
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.25
rrl 1476589 n.2932G>A non_coding_transcript_exon_variant 0.87
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.14
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.12
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.16
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.16
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.16
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.16
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.13
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.13
inhA 1674231 c.30T>C synonymous_variant 0.17
inhA 1674237 c.36T>C synonymous_variant 0.17
inhA 1674239 p.Ser13Thr missense_variant 0.17
inhA 1674243 c.42A>G synonymous_variant 0.17
inhA 1674279 c.78A>C synonymous_variant 0.15
inhA 1674280 p.Arg27Lys missense_variant 0.15
inhA 1674285 c.84A>G synonymous_variant 0.15
inhA 1674301 c.102_103delCC frameshift_variant 0.18
inhA 1674307 c.106C>T synonymous_variant 0.18
inhA 1674315 c.114C>G synonymous_variant 0.17
inhA 1674321 c.120G>C synonymous_variant 0.17
inhA 1674624 c.423A>C synonymous_variant 0.17
inhA 1674627 c.426T>G synonymous_variant 0.17
inhA 1674630 c.429C>G synonymous_variant 0.17
inhA 1674636 c.435C>G synonymous_variant 0.17
inhA 1674654 c.453G>C synonymous_variant 0.2
inhA 1674693 c.492C>G synonymous_variant 0.17
inhA 1674703 c.502T>C synonymous_variant 0.16
ndh 2102009 p.Ser345Asn missense_variant 0.17
ndh 2102020 c.1023A>G synonymous_variant 0.14
ndh 2102023 c.1020G>C synonymous_variant 0.14
ndh 2102026 c.1017G>C synonymous_variant 0.14
ndh 2102131 p.Gln304Lys missense_variant 0.17
ndh 2102140 c.903C>G synonymous_variant 0.17
ndh 2102149 c.894C>T synonymous_variant 0.17
ndh 2102158 c.885T>C synonymous_variant 0.15
ndh 2102242 c.801G>A synonymous_variant 0.13
katG 2155632 c.480A>C synonymous_variant 0.2
katG 2155637 p.Leu159Ile missense_variant 0.2
katG 2155641 p.Lys157Asn missense_variant 0.22
katG 2155677 c.435C>G synonymous_variant 0.17
katG 2155680 c.432G>C synonymous_variant 0.17
katG 2155691 c.421T>C synonymous_variant 0.16
katG 2155695 p.Ala139Val missense_variant 0.15
katG 2155701 c.411C>T synonymous_variant 0.15
katG 2155704 c.408C>G synonymous_variant 0.15
PPE35 2170487 c.126T>A synonymous_variant 0.95
Rv1979c 2221853 p.Phe438Ile missense_variant 1.0
kasA 2518468 c.354A>T synonymous_variant 0.19
kasA 2518475 c.361A>C synonymous_variant 0.16
kasA 2518483 c.369C>G synonymous_variant 0.17
kasA 2518504 c.390T>C synonymous_variant 0.17
kasA 2518506 p.Ala131Glu missense_variant 0.17
kasA 2518513 c.399C>G synonymous_variant 0.17
kasA 2518519 c.405G>C synonymous_variant 0.16
kasA 2518528 c.414C>G synonymous_variant 0.15
kasA 2518540 c.426T>G synonymous_variant 0.19
kasA 2518561 c.447T>C synonymous_variant 0.19
kasA 2518567 c.453G>C synonymous_variant 0.19
kasA 2518570 c.456G>C synonymous_variant 0.2
kasA 2518574 p.Ile154Val missense_variant 0.2
kasA 2518588 c.474T>C synonymous_variant 0.2
kasA 2518591 c.477G>C synonymous_variant 0.2
kasA 2518609 p.Met165Ile missense_variant 0.17
kasA 2518642 c.528A>G synonymous_variant 0.15
kasA 2518663 c.549T>C synonymous_variant 0.16
kasA 2518672 c.558G>C synonymous_variant 0.17
kasA 2518687 c.573C>T synonymous_variant 0.18
kasA 2518702 c.588C>T synonymous_variant 0.14
ribD 2987369 c.531G>A synonymous_variant 1.0
thyX 3067376 c.570G>C synonymous_variant 0.15
thyX 3067391 c.555G>C synonymous_variant 0.17
thyX 3067394 c.552G>C synonymous_variant 0.17
thyX 3067412 c.534C>G synonymous_variant 0.2
thyX 3067439 c.507A>G synonymous_variant 0.17
thyX 3067445 c.501C>G synonymous_variant 0.17
thyX 3067451 c.495G>A synonymous_variant 0.17
thyX 3067457 c.489C>G synonymous_variant 0.17
thyX 3067463 c.483C>A synonymous_variant 0.14
thyX 3067493 c.453A>G synonymous_variant 0.14
thyX 3067643 c.303C>T synonymous_variant 0.15
thyX 3067652 c.294T>C synonymous_variant 0.14
thyX 3067718 c.228C>G synonymous_variant 0.14
thyX 3067721 c.225T>C synonymous_variant 0.13
thyX 3067724 c.222G>A synonymous_variant 0.13
thyX 3067739 c.207T>C synonymous_variant 0.13
thyX 3067761 p.Arg62Lys missense_variant 0.14
thyX 3067765 p.Leu61Ile missense_variant 0.13
thyX 3067781 c.165C>G synonymous_variant 0.13
thyX 3067787 c.159G>A synonymous_variant 0.13
thyX 3067799 c.147G>A synonymous_variant 0.14
thyX 3067814 c.132T>C synonymous_variant 0.13
thyA 3073975 p.Arg166Pro missense_variant 0.93
Rv3236c 3612013 c.1104A>T synonymous_variant 1.0
Rv3236c 3612032 p.Met362Arg missense_variant 1.0
fbiB 3642614 c.1080C>T synonymous_variant 0.12
fbiB 3642710 c.1176G>C synonymous_variant 0.16
fbiB 3642719 c.1185T>C synonymous_variant 0.14
rpoA 3877743 c.765T>C synonymous_variant 0.14
rpoA 3877839 c.669G>C synonymous_variant 0.13
rpoA 3877857 c.651G>A synonymous_variant 0.14
rpoA 3877899 p.Ser203Thr missense_variant 0.15
rpoA 3877905 c.603A>G synonymous_variant 0.15
rpoA 3877908 p.Asn200Ser missense_variant 0.15
rpoA 3877953 c.555G>A synonymous_variant 0.22
rpoA 3877962 c.546G>T synonymous_variant 0.21
rpoA 3877986 c.522G>C synonymous_variant 0.16
rpoA 3877989 c.519A>G synonymous_variant 0.16
rpoA 3878001 c.507A>G synonymous_variant 0.15
rpoA 3878040 c.468T>C synonymous_variant 0.17
rpoA 3878046 c.462T>C synonymous_variant 0.17
rpoA 3878049 c.459G>C synonymous_variant 0.21
rpoA 3878055 c.453A>G synonymous_variant 0.21
rpoA 3878061 c.447G>C synonymous_variant 0.22
rpoA 3878067 c.441C>G synonymous_variant 0.23
rpoA 3878070 c.438T>C synonymous_variant 0.19
rpoA 3878082 c.426T>C synonymous_variant 0.19
rpoA 3878094 c.414C>G synonymous_variant 0.22
rpoA 3878100 c.408C>G synonymous_variant 0.19
rpoA 3878103 c.405A>G synonymous_variant 0.2
rpoA 3878106 c.402G>C synonymous_variant 0.21
rpoA 3878118 c.390T>C synonymous_variant 0.25
rpoA 3878141 p.Met123Leu missense_variant 0.29
rpoA 3878142 p.Gly122Glu missense_variant 0.29
rpoA 3878169 c.339G>C synonymous_variant 0.31
rpoA 3878184 c.324C>T synonymous_variant 0.28
rpoA 3878187 c.321C>G synonymous_variant 0.28
rpoA 3878193 c.315T>C synonymous_variant 0.28
rpoA 3878199 c.309T>C synonymous_variant 0.25
rpoA 3878202 c.306G>C synonymous_variant 0.25
rpoA 3878217 c.291A>G synonymous_variant 0.25
rpoA 3878220 c.288C>T synonymous_variant 0.25
rpoA 3878271 c.237T>C synonymous_variant 0.21
clpC1 4038271 p.Pro812Ala missense_variant 0.21
clpC1 4038272 p.Gly811Ser missense_variant 0.21
clpC1 4038278 c.2427T>C synonymous_variant 0.2
clpC1 4038293 c.2412G>C synonymous_variant 0.21
clpC1 4038302 c.2403C>G synonymous_variant 0.17
clpC1 4038308 p.Val799Ile missense_variant 0.2
clpC1 4038317 c.2388G>C synonymous_variant 0.2
clpC1 4038347 c.2358G>C synonymous_variant 0.18
clpC1 4038356 c.2349T>C synonymous_variant 0.17
clpC1 4038359 c.2346A>G synonymous_variant 0.18
clpC1 4038388 c.2317T>C synonymous_variant 0.13
clpC1 4038398 c.2307G>T synonymous_variant 0.19
clpC1 4038403 c.2302T>C synonymous_variant 0.17
clpC1 4038419 c.2286T>C synonymous_variant 0.19
clpC1 4038434 c.2271G>C synonymous_variant 0.23
clpC1 4038444 p.Ala754Lys missense_variant 0.22
clpC1 4038446 c.2259T>C synonymous_variant 0.21
clpC1 4038452 c.2253G>C synonymous_variant 0.23
clpC1 4038461 p.Ala748Asp missense_variant 0.22
clpC1 4038498 p.Ser736Thr missense_variant 0.2
clpC1 4038530 p.Glu725Asp missense_variant 0.17
clpC1 4038536 c.2169C>T synonymous_variant 0.19
clpC1 4038596 c.2109A>G synonymous_variant 0.17
clpC1 4038611 c.2094C>T synonymous_variant 0.15
clpC1 4038640 p.Asp689Asn missense_variant 0.15
clpC1 4038653 c.2052C>T synonymous_variant 0.17
clpC1 4038658 p.Lys683Gln missense_variant 0.17
clpC1 4038661 p.Ser682Thr missense_variant 0.17
clpC1 4038662 c.2043T>C synonymous_variant 0.17
clpC1 4038671 c.2034T>C synonymous_variant 0.17
clpC1 4039226 c.1479T>C synonymous_variant 0.2
clpC1 4039268 c.1437C>G synonymous_variant 0.19
clpC1 4039274 c.1431G>C synonymous_variant 0.22
clpC1 4039286 c.1419T>C synonymous_variant 0.2
clpC1 4039289 c.1416T>C synonymous_variant 0.17
clpC1 4039295 c.1410A>C synonymous_variant 0.17
clpC1 4039298 c.1407T>C synonymous_variant 0.18
clpC1 4039319 c.1386T>C synonymous_variant 0.16
clpC1 4039322 c.1383T>C synonymous_variant 0.16
clpC1 4039328 c.1377A>G synonymous_variant 0.16
clpC1 4039334 c.1371G>C synonymous_variant 0.17
clpC1 4039337 p.Thr456Gln missense_variant 0.17
clpC1 4039388 c.1317C>A synonymous_variant 0.17
clpC1 4039391 c.1314T>G synonymous_variant 0.17
clpC1 4039409 c.1296T>C synonymous_variant 0.17
clpC1 4039412 c.1293T>G synonymous_variant 0.2
clpC1 4039430 c.1275T>C synonymous_variant 0.19
clpC1 4039442 c.1263A>G synonymous_variant 0.17
clpC1 4039448 c.1257A>G synonymous_variant 0.17
clpC1 4039454 c.1251A>G synonymous_variant 0.17
clpC1 4039463 c.1242C>G synonymous_variant 0.16
clpC1 4039466 c.1239T>C synonymous_variant 0.16
clpC1 4039469 c.1236T>C synonymous_variant 0.17
clpC1 4039481 c.1224T>G synonymous_variant 0.17
clpC1 4039484 c.1221T>G synonymous_variant 0.17
clpC1 4039517 c.1188C>G synonymous_variant 0.15
clpC1 4039524 p.Phe394Tyr missense_variant 0.15
clpC1 4039526 c.1179G>C synonymous_variant 0.15
clpC1 4039586 c.1119G>C synonymous_variant 0.14
clpC1 4039610 c.1095G>C synonymous_variant 0.21
clpC1 4039616 c.1089G>C synonymous_variant 0.23
clpC1 4039622 c.1083C>G synonymous_variant 0.23
clpC1 4039682 c.1023C>G synonymous_variant 0.19
clpC1 4039685 c.1020C>T synonymous_variant 0.19
clpC1 4039694 c.1011G>C synonymous_variant 0.17
clpC1 4039724 c.981A>G synonymous_variant 0.14
clpC1 4039748 c.957G>C synonymous_variant 0.15
clpC1 4040033 c.672G>C synonymous_variant 0.13
clpC1 4040092 p.Ser205Thr missense_variant 0.14
clpC1 4040093 c.612C>G synonymous_variant 0.14
clpC1 4040225 c.480A>C synonymous_variant 0.13
clpC1 4040228 c.477G>C synonymous_variant 0.13
clpC1 4040237 c.468C>T synonymous_variant 0.13
clpC1 4040249 c.456A>G synonymous_variant 0.15
clpC1 4040273 c.432T>C synonymous_variant 0.16
clpC1 4040570 c.135C>G synonymous_variant 0.16
clpC1 4040573 c.132T>G synonymous_variant 0.17
clpC1 4040582 c.123G>C synonymous_variant 0.2
clpC1 4040597 c.108C>T synonymous_variant 0.14
clpC1 4040600 c.103_105delTTAinsCTG synonymous_variant 0.14
clpC1 4040603 c.102T>G synonymous_variant 0.15
clpC1 4040606 c.99T>C synonymous_variant 0.19
embC 4240425 p.Arg188Pro missense_variant 1.0
embC 4240477 c.615C>A synonymous_variant 1.0
embC 4240645 c.783G>C synonymous_variant 0.14
embC 4240654 c.792C>T synonymous_variant 0.12
embC 4240671 p.Thr270Ile missense_variant 0.16
embC 4240678 c.816T>G synonymous_variant 0.18
embC 4240685 p.Thr275Ala missense_variant 0.2
embC 4240693 c.831T>C synonymous_variant 0.19
embC 4240706 p.Val282Thr missense_variant 0.16
embC 4240726 c.864G>C synonymous_variant 0.16
embC 4240780 c.918T>C synonymous_variant 0.15
embC 4240783 c.921G>C synonymous_variant 0.15
embC 4241140 c.1278A>G synonymous_variant 0.18
embA 4244214 p.Ala328Ser missense_variant 1.0
embA 4244849 c.1617C>G synonymous_variant 1.0
embB 4247198 p.Thr229Pro missense_variant 1.0
embB 4247381 p.Trp290Arg missense_variant 1.0
embB 4247437 c.924A>G synonymous_variant 0.17
embB 4247440 c.927C>G synonymous_variant 0.17
embB 4247470 c.957T>C synonymous_variant 0.16
embB 4247491 c.978G>C synonymous_variant 0.2
embB 4247497 c.984T>C synonymous_variant 0.2
embB 4247500 c.987C>G synonymous_variant 0.2
embB 4247512 c.999T>C synonymous_variant 0.2
embB 4247536 c.1023C>G synonymous_variant 0.21
embB 4248097 c.1584C>G synonymous_variant 0.16
embB 4248118 c.1605T>C synonymous_variant 0.17
embB 4248127 c.1614G>C synonymous_variant 0.18
embB 4248133 c.1620C>G synonymous_variant 0.18
embB 4248142 c.1629T>C synonymous_variant 0.18
embB 4248143 c.1630T>C synonymous_variant 0.19
embB 4248157 c.1644A>G synonymous_variant 0.2
embB 4248206 p.Ser565Gly missense_variant 0.24
embB 4248220 c.1707A>G synonymous_variant 0.24
embB 4248241 c.1728C>T synonymous_variant 0.2
embB 4248265 c.1752C>T synonymous_variant 0.21
embB 4248266 c.1753C>T synonymous_variant 0.2
embB 4248277 c.1764G>C synonymous_variant 0.19
embB 4248304 c.1791G>T synonymous_variant 0.19
embB 4248316 c.1803C>G synonymous_variant 0.24
embB 4248319 c.1806A>G synonymous_variant 0.24
embB 4248322 c.1809G>C synonymous_variant 0.23
embB 4248343 c.1830G>C synonymous_variant 0.18
embB 4248346 c.1833G>C synonymous_variant 0.18
embB 4248350 c.1837T>C synonymous_variant 0.18
embB 4248355 c.1842A>G synonymous_variant 0.18
embB 4248358 c.1845C>G synonymous_variant 0.18
embB 4248361 c.1848A>G synonymous_variant 0.18
embB 4248362 p.Ser617Ala missense_variant 0.18
aftB 4268115 p.Leu241Arg missense_variant 1.0
aftB 4268696 c.141G>A synonymous_variant 1.0
ethA 4326298 c.1176G>A synonymous_variant 0.94
whiB6 4338567 c.-46C>A upstream_gene_variant 1.0