TB-Profiler result

Run: SRR19303774
Summary

Run ID: SRR19303774

Sample name:

Date: 03-04-2023 21:06:14

Number of reads: 2557626

Percentage reads mapped: 53.81

Strain: lineage4.1.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 575679 p.Asn111Ser missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.21
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 763963 c.594C>T synonymous_variant 1.0
rpoC 764537 p.Pro390Ala missense_variant 0.14
rpoC 764582 p.Leu405Met missense_variant 0.13
rpoC 764605 c.1236G>C synonymous_variant 0.23
rpoC 764611 c.1242G>C synonymous_variant 0.23
rpoC 764620 c.1251G>C synonymous_variant 0.21
rpoC 764621 c.1252_1254delCTCinsTTG synonymous_variant 0.19
rpoC 764632 c.1263T>C synonymous_variant 0.2
rpoC 764641 c.1272C>T synonymous_variant 0.17
rpoC 764650 c.1281G>T synonymous_variant 0.12
rpoC 764671 c.1302G>C synonymous_variant 0.1
rpoC 764672 p.Gln435Glu missense_variant 0.1
rpoC 764677 c.1308C>G synonymous_variant 0.1
rpoC 764695 c.1326T>C synonymous_variant 0.1
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.24
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.26
rrl 1476384 n.2727G>C non_coding_transcript_exon_variant 0.23
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.25
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.23
rrl 1476428 n.2771C>A non_coding_transcript_exon_variant 0.23
rrl 1476443 n.2786G>C non_coding_transcript_exon_variant 0.21
rrl 1476455 n.2798C>G non_coding_transcript_exon_variant 0.18
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.18
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.16
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.16
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.16
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.14
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.3
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 0.99
embB 4246584 p.Arg24Pro missense_variant 0.11
embB 4248324 p.Ala604Gly missense_variant 0.25
whiB6 4338595 c.-75delG upstream_gene_variant 1.0