TB-Profiler result

Run: SRR6207282
Summary

Run ID: SRR6207282

Sample name:

Date: 02-08-2023 15:09:28

Number of reads: NA

Percentage reads mapped: NA

Strain: lineage4.1.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 0.99
lineage4.1.2 Euro-American T;H None 1.0
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Tyr missense_variant 1.0 rifampicin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289031 p.His71Tyr missense_variant 1.0 pyrazinamide
ald 3086951 c.133delA frameshift_variant 1.0 cycloserine
embA 4243217 c.-16C>G upstream_gene_variant 1.0 ethambutol
embB 4247728 p.Glu405Asp missense_variant 1.0 ethambutol
gid 4407802 p.Ala134Glu missense_variant 1.0 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 575447 p.Ser34Pro missense_variant 0.17
mshA 575679 p.Asn111Ser missense_variant 1.0
mshA 576089 c.750_769delTGATCGGCGCGCGGCCCGGG frameshift_variant 0.13
ccsA 619876 c.-15C>G upstream_gene_variant 0.11
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoB 761477 c.1671C>A synonymous_variant 0.13
rpoB 761721 p.Glu639Lys missense_variant 0.1
rpoB 762577 c.2774_2780dupTTTTGGA frameshift_variant 0.25
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406813 c.528T>C synonymous_variant 1.0
Rv1258c 1406898 p.Ala148Glu missense_variant 0.1
embR 1417267 c.80delC frameshift_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1673380 c.-60C>G upstream_gene_variant 0.21
inhA 1674490 p.Phe97Leu missense_variant 0.22
rpsA 1834273 c.732C>T synonymous_variant 0.11
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918617 p.Lys226Asn missense_variant 0.12
PPE35 2170048 p.Leu189Val missense_variant 0.44
PPE35 2170053 p.Thr187Ser missense_variant 0.29
PPE35 2170298 c.315A>G synonymous_variant 0.17
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
pepQ 2860008 c.411C>T synonymous_variant 0.15
ald 3086646 c.-174G>T upstream_gene_variant 0.11
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087088 p.Ile90Asn missense_variant 0.11
ald 3087102 c.283T>C synonymous_variant 0.11
fbiD 3339175 p.Ala20Ser missense_variant 0.14
Rv3083 3448808 p.Leu102Pro missense_variant 0.17
Rv3083 3449458 p.Asp319Asn missense_variant 0.14
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568513 p.Ala56Val missense_variant 0.1
fbiB 3642018 c.485_489delATGCC frameshift_variant 0.33
fbiB 3642027 c.494delT frameshift_variant 0.33
fbiB 3642031 p.Gly166Ala missense_variant 0.33
alr 3840259 p.Tyr388Asp missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4247068 c.555T>C synonymous_variant 0.18
embB 4247738 p.Ala409Pro missense_variant 1.0
embB 4249488 p.Leu992Ser missense_variant 0.15
ethA 4326842 p.Tyr211Ser missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0