TB-Profiler result

Run: SRR7653080

Summary

Run ID: SRR7653080

Sample name:

Date: 04-04-2023 20:08:04

Number of reads: 6416950

Percentage reads mapped: 99.79

Strain: lineage4.3.3;lineage2.2.1

Drug-resistance: Pre-XDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.2
lineage4 Euro-American LAM;T;S;X;H None 0.81
lineage4.3 Euro-American (LAM) mainly-LAM None 0.81
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.17
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.18
lineage4.3.3 Euro-American (LAM) LAM;T RD115 0.82
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7582 p.Asp94Gly missense_variant 0.17 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 0.22 streptomycin
rrs 1473246 n.1401A>G non_coding_transcript_exon_variant 0.81 kanamycin, capreomycin, aminoglycosides, amikacin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289105 p.Ala46Val missense_variant 0.83 pyrazinamide
pncA 2289218 p.Asp8Glu missense_variant 0.18 pyrazinamide
eis 2715346 c.-14C>T upstream_gene_variant 0.26 kanamycin, amikacin
embB 4247429 p.Met306Val missense_variant 0.88 ethambutol
embB 4247574 p.Asp354Ala missense_variant 0.13 ethambutol
ethA 4327480 c.-7T>C upstream_gene_variant 0.26 ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 0.99
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8040 p.Gly247Ser missense_variant 0.81
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 0.24
mshA 575907 p.Ala187Val missense_variant 0.18
ccsA 620625 p.Ile245Met missense_variant 0.14
rpoC 763031 c.-339T>C upstream_gene_variant 0.2
rpoC 764995 c.1626C>G synonymous_variant 0.8
rpoC 765846 p.Asn826Thr missense_variant 0.22
rpoC 766645 p.Glu1092Asp missense_variant 0.2
rpoC 767007 p.Ala1213Glu missense_variant 0.82
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.2
mmpL5 776182 p.Asp767Asn missense_variant 0.22
mmpS5 779615 c.-710C>G upstream_gene_variant 0.19
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.2
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 0.2
rpsA 1834836 p.Met432Thr missense_variant 0.77
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.17
katG 2156196 c.-85C>T upstream_gene_variant 0.83
PPE35 2167926 p.Leu896Ser missense_variant 0.2
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518919 p.Gly269Ser missense_variant 0.83
folC 2746340 p.Ala420Val missense_variant 0.81
ribD 2986827 c.-12G>A upstream_gene_variant 0.83
thyA 3073868 p.Thr202Ala missense_variant 0.82
thyA 3074402 p.Thr24Pro missense_variant 0.16
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 0.2
clpC1 4038287 c.2418C>T synonymous_variant 0.84
clpC1 4038968 c.1737G>A synonymous_variant 0.76
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243217 c.-16C>A upstream_gene_variant 0.22
embA 4243460 c.228C>T synonymous_variant 0.23
embB 4246608 p.Ile32Thr missense_variant 0.84
aftB 4267647 p.Asp397Gly missense_variant 0.16
whiB6 4338563 c.-42G>T upstream_gene_variant 0.17
whiB6 4338594 c.-73T>G upstream_gene_variant 0.83
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.17
gid 4407927 p.Glu92Asp missense_variant 0.21
gid 4407985 p.Gly73Val missense_variant 0.83
gid 4408021 p.Arg61Pro missense_variant 0.84
gid 4408156 p.Leu16Arg missense_variant 0.81