TB-Profiler result

Run: ERR10762342
Summary

Run ID: ERR10762342

Sample name:

Date: 31-03-2023 11:04:13

Number of reads: 1259367

Percentage reads mapped: 99.55

Strain: lineage4.2.1;lineage2.2.1

Drug-resistance: Pre-XDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.3
lineage4 Euro-American LAM;T;S;X;H None 0.71
lineage4.2 Euro-American H;T;LAM None 0.66
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.31
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.27
lineage4.2.1 Euro-American (TUR) H3;H4 None 0.68
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7563 p.Gly88Cys missense_variant 0.17 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781822 p.Lys88Arg missense_variant 0.64 streptomycin
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 0.38 streptomycin
fabG1 1673425 c.-15C>T upstream_gene_variant 0.68 isoniazid, ethionamide
inhA 1674048 c.-154G>A upstream_gene_variant 0.34 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289081 p.Pro54Leu missense_variant 0.32 pyrazinamide
eis 2715344 c.-12C>T upstream_gene_variant 0.61 kanamycin
eis 2715346 c.-14C>T upstream_gene_variant 0.39 kanamycin, amikacin
folC 2747151 p.Ser150Gly missense_variant 0.17 para-aminosalicylic_acid
embB 4247402 p.Ser297Ala missense_variant 0.63 ethambutol
embB 4247429 p.Met306Val missense_variant 0.37 ethambutol
ethA 4326705 c.768delG frameshift_variant 0.26 ethionamide, ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491247 c.465C>T synonymous_variant 0.79
fgd1 491742 c.960T>C synonymous_variant 0.28
mshA 575907 p.Ala187Val missense_variant 0.23
ccsA 619969 p.Val27Ile missense_variant 0.62
ccsA 620625 p.Ile245Met missense_variant 0.14
rpoC 763031 c.-339T>C upstream_gene_variant 0.36
rpoC 764660 p.Val431Met missense_variant 0.43
rpoC 764817 p.Val483Gly missense_variant 0.73
rpoC 766645 p.Glu1092Asp missense_variant 0.2
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.31
mmpL5 776182 p.Asp767Asn missense_variant 0.29
mmpS5 779615 c.-710C>G upstream_gene_variant 0.17
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.17
rrs 1471659 n.-187C>T upstream_gene_variant 0.99
rpsA 1834177 c.636A>C synonymous_variant 0.31
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.22
PPE35 2167926 p.Leu896Ser missense_variant 0.41
PPE35 2169879 p.Phe245Cys missense_variant 0.66
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714885 c.447delT frameshift_variant 0.44
ald 3086742 c.-78A>C upstream_gene_variant 0.78
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 0.21
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.38
embB 4249594 c.3081G>A synonymous_variant 0.7
aftB 4267647 p.Asp397Gly missense_variant 0.28
aftB 4268616 p.Gly74Asp missense_variant 0.14
ethA 4326632 p.His281Pro missense_variant 0.73
ethA 4326869 p.Val202Ala missense_variant 0.24
ethA 4328376 c.-903G>C upstream_gene_variant 0.69
whiB6 4338563 c.-42G>T upstream_gene_variant 0.32
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.29
gid 4407927 p.Glu92Asp missense_variant 0.36