TB-Profiler result

Run: ERR9786531
Summary

Run ID: ERR9786531

Sample name:

Date: 02-04-2023 12:30:26

Number of reads: 3828059

Percentage reads mapped: 97.61

Strain: lineage6.3.1;lineage4.1.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 0.8
lineage6 West-Africa 2 AFRI_1 RD702 0.2
lineage4.1 Euro-American T;X;H None 0.81
lineage6.3 West-Africa 2 AFRI_1 RD702 0.19
lineage4.1.2 Euro-American T;H None 0.79
lineage6.3.1 West-Africa 2 AFRI_1 RD702 0.17
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 0.79
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6446 p.Ala403Ser missense_variant 0.27
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 0.21
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 0.78
fgd1 491668 p.Lys296Glu missense_variant 0.26
fgd1 491742 c.960T>C synonymous_variant 0.25
mshA 575679 p.Asn111Ser missense_variant 0.79
rpoB 760115 c.309C>T synonymous_variant 0.84
rpoB 760969 p.Ser388Leu missense_variant 0.18
rpoB 761723 p.Glu639Asp missense_variant 0.16
rpoC 763031 c.-339T>C upstream_gene_variant 0.23
rpoC 763963 c.594C>T synonymous_variant 0.82
rpoC 765150 p.Gly594Glu missense_variant 0.78
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.19
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302899 c.-32A>G upstream_gene_variant 0.18
Rv1258c 1406363 c.978A>G synonymous_variant 0.12
atpE 1461251 c.207G>T synonymous_variant 0.24
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.1
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.12
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.12
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.12
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.11
inhA 1674434 p.Val78Ala missense_variant 0.16
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102022 p.Lys341Glu missense_variant 0.2
ndh 2102694 p.Val117Ile missense_variant 0.2
katG 2154724 p.Arg463Leu missense_variant 0.18
katG 2155503 c.609C>T synonymous_variant 0.16
PPE35 2167926 p.Leu896Ser missense_variant 0.29
Rv1979c 2222308 p.Asp286Gly missense_variant 0.25
Rv1979c 2222852 p.Ala105Thr missense_variant 0.26
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 0.81
kasA 2518132 c.18C>T synonymous_variant 0.16
ald 3086728 c.-92C>T upstream_gene_variant 0.21
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086958 p.Asp47Tyr missense_variant 0.21
ald 3087084 c.266delA frameshift_variant 0.21
Rv3083 3449781 c.1278G>A synonymous_variant 0.16
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474911 p.Val302Gly missense_variant 0.23
fprA 3475159 p.Asn385Asp missense_variant 0.15
rpoA 3877696 p.Thr271Ile missense_variant 0.17
clpC1 4040489 c.216G>A synonymous_variant 0.23
embC 4240671 p.Thr270Ile missense_variant 0.18
embC 4241843 p.Leu661Ile missense_variant 0.23
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 0.83
embA 4244220 c.988C>T synonymous_variant 0.26
embA 4244379 p.Pro383Ser missense_variant 0.2
embB 4246864 c.351C>T synonymous_variant 0.19
embB 4247646 p.Glu378Ala missense_variant 0.15
aftB 4268477 c.360C>T synonymous_variant 0.11
aftB 4269351 c.-515C>T upstream_gene_variant 0.17
ubiA 4269387 p.Glu149Asp missense_variant 0.18
aftB 4269522 c.-686C>T upstream_gene_variant 0.22
aftB 4269606 c.-770T>C upstream_gene_variant 0.23
ethA 4326465 p.Ile337Val missense_variant 0.18
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.23
gid 4407990 c.213A>G synonymous_variant 0.78