Run ID: SRR11349141
Sample name:
Date: 02-04-2023 20:52:45
Number of reads: 6699837
Percentage reads mapped: 89.19
Strain: lineage4.1.1.3
Drug-resistance: MDR-TB
Drug | Resistance | Supporting mutations |
---|
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.1 | Euro-American | T;X;H | None | 1.0 |
lineage4.1.1 | Euro-American (X-type) | X1;X2;X3 | None | 1.0 |
lineage4.1.1.3 | Euro-American (X-type) | X1;X3 | RD193 | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
rpoB | 761155 | p.Ser450Leu | missense_variant | 1.0 | rifampicin |
rrs | 1472723 | n.878G>A | non_coding_transcript_exon_variant | 0.88 | streptomycin |
fabG1 | 1673425 | c.-15C>T | upstream_gene_variant | 1.0 | isoniazid, ethionamide |
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid |
pncA | 2288782 | p.Arg154Gly | missense_variant | 1.0 | pyrazinamide |
ald | 3087278 | c.464delG | frameshift_variant | 1.0 | cycloserine |
embA | 4243217 | c.-16C>G | upstream_gene_variant | 1.0 | ethambutol |
embB | 4247431 | p.Met306Ile | missense_variant | 1.0 | ethambutol |
ethA | 4326279 | c.1192_1194dupGTG | conservative_inframe_insertion | 0.98 | ethionamide |
ethA | 4326604 | c.869dupA | frameshift_variant | 1.0 | ethionamide, ethionamide |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
mshA | 576108 | p.Ala254Gly | missense_variant | 0.27 |
mshA | 576482 | p.Val379Leu | missense_variant | 0.12 |
rpoB | 762285 | p.Arg827Cys | missense_variant | 1.0 |
rpoC | 765150 | p.Gly594Glu | missense_variant | 1.0 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
rpsL | 781435 | c.-125G>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrs | 1472616 | n.771G>A | non_coding_transcript_exon_variant | 0.12 |
rrs | 1472655 | n.810G>A | non_coding_transcript_exon_variant | 0.11 |
rrs | 1472658 | n.813G>A | non_coding_transcript_exon_variant | 0.12 |
rrs | 1472661 | n.816A>G | non_coding_transcript_exon_variant | 0.12 |
rrs | 1472697 | n.852T>C | non_coding_transcript_exon_variant | 0.1 |
rrs | 1472713 | n.868T>C | non_coding_transcript_exon_variant | 0.14 |
rrs | 1472716 | n.871C>T | non_coding_transcript_exon_variant | 0.12 |
rrs | 1472936 | n.1091C>T | non_coding_transcript_exon_variant | 0.12 |
rrs | 1472956 | n.1111T>C | non_coding_transcript_exon_variant | 0.13 |
rrs | 1472957 | n.1112C>T | non_coding_transcript_exon_variant | 0.15 |
rrs | 1472958 | n.1113A>T | non_coding_transcript_exon_variant | 0.13 |
rrs | 1472959 | n.1114T>A | non_coding_transcript_exon_variant | 0.15 |
rrs | 1472963 | n.1118G>A | non_coding_transcript_exon_variant | 0.13 |
rrs | 1472973 | n.1128A>T | non_coding_transcript_exon_variant | 0.12 |
rrs | 1472975 | n.1130T>A | non_coding_transcript_exon_variant | 0.13 |
rrs | 1472982 | n.1137G>C | non_coding_transcript_exon_variant | 0.15 |
rrs | 1472987 | n.1142G>T | non_coding_transcript_exon_variant | 0.15 |
rrs | 1472988 | n.1143T>A | non_coding_transcript_exon_variant | 0.14 |
rrs | 1472989 | n.1144G>A | non_coding_transcript_exon_variant | 0.13 |
rrs | 1472990 | n.1145A>G | non_coding_transcript_exon_variant | 0.13 |
rrs | 1473002 | n.1157G>T | non_coding_transcript_exon_variant | 0.16 |
rrs | 1473004 | n.1159T>A | non_coding_transcript_exon_variant | 0.16 |
rrs | 1473008 | n.1163C>A | non_coding_transcript_exon_variant | 0.15 |
rrs | 1473009 | n.1164T>C | non_coding_transcript_exon_variant | 0.16 |
rrl | 1476358 | n.2701T>C | non_coding_transcript_exon_variant | 0.21 |
rrl | 1476369 | n.2712C>T | non_coding_transcript_exon_variant | 0.2 |
rrl | 1476372 | n.2715T>C | non_coding_transcript_exon_variant | 0.11 |
rrl | 1476382 | n.2725A>G | non_coding_transcript_exon_variant | 0.2 |
rrl | 1476383 | n.2726T>G | non_coding_transcript_exon_variant | 0.11 |
rrl | 1476408 | n.2751G>A | non_coding_transcript_exon_variant | 0.12 |
rrl | 1476411 | n.2754G>A | non_coding_transcript_exon_variant | 0.12 |
rrl | 1476429 | n.2772A>C | non_coding_transcript_exon_variant | 0.17 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
PPE35 | 2170065 | p.Ala183Gly | missense_variant | 0.16 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 |
fbiD | 3339734 | p.Ala206Gly | missense_variant | 0.33 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
rpoA | 3878641 | c.-134C>G | upstream_gene_variant | 0.17 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embC | 4242803 | p.Val981Leu | missense_variant | 1.0 |
embB | 4248324 | p.Ala604Gly | missense_variant | 0.22 |
embB | 4249408 | c.2895G>A | synonymous_variant | 1.0 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
gid | 4407798 | c.405G>T | synonymous_variant | 1.0 |