Run ID: SRR29096685
Sample name:
Date: 2025-02-11T13:32:43.559325
Number of reads: 25576
Percentage reads mapped: 28.01
Median coverage: 0.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage4 | Euro-American | None | 1.0 |
| lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| mshA | 575725 | c.378C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575734 | c.387T>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575744 | p.Ala133Thr | missense_variant | 1.0 | isoniazid | Uncertain significance |
| ethionamide | ||||||
| mshA | 575749 | c.402C>A | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575761 | c.414C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575764 | c.417C>G | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575771 | p.Val142Thr | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575776 | c.429C>T | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575782 | c.435G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575785 | c.438T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575795 | p.Ile150Val | missense_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575800 | c.453G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575803 | c.456C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| ethionamide | ||||||
| mshA | 575821 | c.474G>T | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575837 | c.490C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
| ethionamide | Not assoc w R - Interim | |||||
| mshA | 575842 | c.495G>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| mshA | 575864 | c.517T>C | synonymous_variant | 1.0 | isoniazid | |
| ethionamide | ||||||
| lpqB | 3624605 | p.Glu102Asp | missense_variant | 1.0 | rifampicin | Uncertain significance |
| bedaquiline | ||||||
| lpqB | 3624614 | c.297A>T | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624635 | p.His92Arg | missense_variant | 1.0 | rifampicin | Uncertain significance |
| bedaquiline | ||||||
| lpqB | 3624643 | p.Ile90Leu | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624646 | c.265T>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624649 | c.262T>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624650 | c.261G>A | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624656 | c.255C>T | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624673 | p.Ala80Ser | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624675 | p.Asn79Ser | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624680 | c.231T>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624701 | c.210T>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624704 | c.207G>C | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624719 | c.192C>T | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624725 | c.186G>T | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3624734 | c.177A>G | synonymous_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| embB | 4247470 | c.957T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247491 | c.978G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247497 | c.984T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247511 | p.Tyr333Phe | missense_variant | 1.0 | ethambutol | |
| embB | 4247527 | c.1014G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247536 | c.1023C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247554 | c.1041T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247555 | p.Leu348Ile | missense_variant | 1.0 | ethambutol | |
| embB | 4247566 | c.1053C>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247572 | c.1059A>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247578 | c.1065_1066insATCTGT | conservative_inframe_insertion | 1.0 | ethambutol | |
| embB | 4247581 | c.1069_1074delGCCGGG | conservative_inframe_deletion | 1.0 | ethambutol | |
| embB | 4247590 | c.1077A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
