TB-Profiler result

Run: ERR2229760

Summary

Run ID: ERR2229760

Sample name:

Date: 20-10-2023 20:52:15

Number of reads: 1813935

Percentage reads mapped: 98.35

Strain: lineage4.8

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.67
rrl 1475752 n.2095C>T non_coding_transcript_exon_variant 0.5
rrl 1475758 n.2101delAinsGG non_coding_transcript_exon_variant 0.5
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.55
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.55
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.55
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.55
rrl 1475769 n.2112_2113insC non_coding_transcript_exon_variant 0.55
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.4
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.44
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.44
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.41
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.41
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.53
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.47
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.47
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.47
fabG1 1673380 c.-60C>G upstream_gene_variant 0.18
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2170048 p.Leu189Val missense_variant 0.35
PPE35 2170053 p.Thr187Ser missense_variant 0.34
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448497 c.-6_*1408del transcript_ablation 1.0