TB-Profiler result

Run: ERR4819224
Summary

Run ID: ERR4819224

Sample name:

Date: 01-04-2023 15:59:35

Number of reads: 1587499

Percentage reads mapped: 87.6

Strain: lineage1.2.1.2.1

Drug-resistance: Other

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage1 Indo-Oceanic EAI RD239 1.0
lineage1.2.1 Indo-Oceanic EAI2 RD239 1.0
lineage1.2.1.2 Indo-Oceanic NA RD239 1.0
lineage1.2.1.2.1 Indo-Oceanic NA RD239 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.79 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6112 p.Met291Ile missense_variant 1.0
gyrA 6310 c.-992G>T upstream_gene_variant 0.13
gyrB 7008 p.Leu590Pro missense_variant 0.15
gyrA 7355 c.54T>C synonymous_variant 0.1
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8452 p.Ala384Val missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9260 c.1959G>C synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575368 c.21T>C synonymous_variant 1.0
rpoB 761862 p.Ala686Thr missense_variant 0.12
rpoB 761889 p.Val695Met missense_variant 0.11
rpoB 762057 p.Ile751Val missense_variant 0.11
rpoB 762062 c.2256T>C synonymous_variant 0.13
rpoB 762065 c.2259T>C synonymous_variant 0.13
rpoB 762071 p.Asp755Glu missense_variant 0.12
rpoB 762080 c.2274G>C synonymous_variant 0.11
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763053 c.-317T>C upstream_gene_variant 0.13
rpoC 763070 c.-300T>C upstream_gene_variant 0.14
rpoB 763077 p.Val1091Ile missense_variant 0.16
rpoC 763103 c.-267G>C upstream_gene_variant 0.19
rpoC 763115 c.-255T>C upstream_gene_variant 0.19
rpoB 763119 p.Asn1105Asp missense_variant 0.18
rpoC 763127 c.-243G>C upstream_gene_variant 0.21
rpoC 763133 c.-237G>C upstream_gene_variant 0.21
rpoC 763531 c.162G>C synonymous_variant 1.0
rpoC 763884 p.Ala172Val missense_variant 1.0
rpoC 763886 c.517C>A synonymous_variant 1.0
rpoC 764809 c.1440C>T synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302821 c.-110G>A upstream_gene_variant 1.0
Rv1258c 1406312 c.1029T>C synonymous_variant 1.0
embR 1417019 p.Cys110Tyr missense_variant 1.0
atpE 1460907 c.-138T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.21
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.23
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.23
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.27
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.24
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.29
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.29
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.29
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.57
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.24
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.28
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.31
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.24
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.4
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.1
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.33
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.43
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.43
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.56
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.67
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.72
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.72
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.89
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.89
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.81
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.77
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.5
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.88
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.85
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.85
rrs 1472611 n.766G>T non_coding_transcript_exon_variant 0.12
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.6
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.18
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.78
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.78
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.76
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.76
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.77
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.77
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.73
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.75
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.33
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.25
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.44
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.11
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.19
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.5
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.69
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.69
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.88
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.82
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.82
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 1.0
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.18
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.18
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.82
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.67
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.67
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.58
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.62
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.5
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.4
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.4
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.4
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.4
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.4
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.31
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.4
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.15
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.63
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.68
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.35
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.35
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.13
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.21
rrs 1473199 n.1356delA non_coding_transcript_exon_variant 0.22
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.2
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.41
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.4
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.33
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.67
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 1.0
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 1.0
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 1.0
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.67
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.67
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.67
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 1.0
rrl 1474635 n.979_982delACCG non_coding_transcript_exon_variant 1.0
rrl 1475697 n.2040C>T non_coding_transcript_exon_variant 0.33
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.33
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.22
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.18
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.2
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.18
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.55
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.55
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.55
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.62
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.77
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.46
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.73
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.73
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 1.0
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.92
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.91
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.87
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.75
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.75
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.53
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.54
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.3
inhA 1674162 c.-40C>T upstream_gene_variant 1.0
inhA 1674479 p.His93Leu missense_variant 0.12
rpsA 1833676 c.135A>G synonymous_variant 0.14
rpsA 1833679 c.138G>C synonymous_variant 0.16
rpsA 1833684 p.Arg48His missense_variant 0.16
rpsA 1833694 c.153G>C synonymous_variant 0.14
rpsA 1833700 c.159C>T synonymous_variant 0.12
rpsA 1833721 c.180A>G synonymous_variant 0.12
rpsA 1833724 c.183C>T synonymous_variant 0.12
rpsA 1833727 c.186G>C synonymous_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168103 p.Pro837Leu missense_variant 0.11
PPE35 2168506 p.Gly703Cys missense_variant 0.2
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2222750 c.415C>T synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
kasA 2519048 p.Gly312Ser missense_variant 1.0
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0
ribD 2986947 p.Asp37Asn missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339417 c.300A>G synonymous_variant 1.0
Rv3083 3448714 p.Asp71His missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
whiB7 3568488 c.191delG frameshift_variant 1.0
fbiB 3640557 c.-978T>C upstream_gene_variant 1.0
clpC1 4040517 p.Val63Ala missense_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 1.0
embC 4241042 p.Asn394Asp missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243580 c.348G>A synonymous_variant 1.0
embA 4244420 c.1188G>C synonymous_variant 1.0
embA 4245969 p.Pro913Ser missense_variant 1.0
embB 4247578 c.1065G>A synonymous_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
ubiA 4269864 c.-32delG upstream_gene_variant 1.0
whiB6 4338361 p.Arg54Gln missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0
whiB6 4338639 c.-118T>C upstream_gene_variant 0.1
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407873 c.330G>T synonymous_variant 1.0