TB-Profiler result

Run: SRR29096784
Summary

Run ID: SRR29096784

Sample name:

Date: 2025-02-11T16:31:50.421650

Number of reads: 18846

Percentage reads mapped: 53.98

Median coverage: 0.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
fgd1 491563 c.781_782delAGinsTC synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fgd1 491595 c.813C>G synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 1.0 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 1.0 pretomanid
delamanid
clofazimine
nusG 734541 c.288A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
nusG 734544 c.291C>T synonymous_variant 0.9 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.9 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.9 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.9 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.9 rifampicin
nusG 734614 p.Ala121Ser missense_variant 0.9 rifampicin
rpoB 760283 c.477G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 1.0 rifampicin
rpoB 760313 c.507G>C synonymous_variant 1.0 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 1.0 rifampicin
rpoB 760331 c.525G>C synonymous_variant 1.0 rifampicin
rpoB 760337 c.531C>G synonymous_variant 1.0 rifampicin
rpoB 760340 c.534G>C synonymous_variant 1.0 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>C synonymous_variant 0.86 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764207 p.Val280Thr missense_variant 0.83 rifampicin Uncertain significance
rpoC 764213 p.Arg282Lys missense_variant 0.83 rifampicin Uncertain significance
rpoC 764242 c.873C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 1.0 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 1.0 rifampicin
rpoC 764908 c.1539G>A synonymous_variant 1.0 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 1.0 rifampicin
rpoC 764912 p.Met515Gln missense_variant 1.0 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764971 c.1602C>T synonymous_variant 1.0 rifampicin
rpoC 764983 c.1614T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R