Run ID: 40e76dc6-19bb-4cc1-8ae1-efe0c3eef9ae
Sample name:
Date: 08-05-2024 17:07:39
Number of reads: 1649989
Percentage reads mapped: 95.18
Median coverage: 39
Strain: lineage5.1
Spoligotype:
Drug-resistance: HR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage5 | West-Africa 1 | RD711 | 0.99 |
lineage5.1 | West-Africa 1 | RD711 | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | katG | p.Asp117Ala | Uncertain significance | |
ethambutol | embB | p.Val377Gly | Uncertain significance | |
p.Ala388Gly | Uncertain significance | |||
pyrazinamide | ||||
moxifloxacin | ||||
levofloxacin | ||||
bedaquiline | ||||
delamanid | ||||
pretomanid | ||||
linezolid | ||||
streptomycin | ||||
amikacin | ||||
kanamycin | ||||
capreomycin | ||||
clofazimine | ||||
ethionamide | ||||
para-aminosalicylic_acid | ||||
cycloserine |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
katG | 2155762 | p.Asp117Ala | missense_variant | 0.11 | isoniazid | Uncertain significance | |
embB | 4247643 | p.Val377Gly | missense_variant | 0.13 | ethambutol | Uncertain significance | |
embB | 4247676 | p.Ala388Gly | missense_variant | 0.17 | ethambutol | Uncertain significance |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 6446 | p.Ala403Ser | missense_variant | 1.0 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrB | 7166 | p.Ala643Pro | missense_variant | 0.12 | fluoroquinolones | |
moxifloxacin | ||||||
levofloxacin | ||||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 7504 | p.Arg68Pro | missense_variant | 0.12 | fluoroquinolones | |
moxifloxacin | ||||||
levofloxacin | ||||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 8445 | p.Arg382Gly | missense_variant | 0.14 | fluoroquinolones | |
moxifloxacin | ||||||
levofloxacin | ||||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 9143 | c.1842T>C | synonymous_variant | 0.97 | fluoroquinolones | |
moxifloxacin | ||||||
levofloxacin | ||||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 9196 | p.Val632Gly | missense_variant | 0.11 | fluoroquinolones | |
moxifloxacin | ||||||
levofloxacin | ||||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | fluoroquinolones | |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 9566 | c.2265C>T | synonymous_variant | 1.0 | fluoroquinolones | |
moxifloxacin | ||||||
levofloxacin | ||||||
ciprofloxacin | ||||||
ofloxacin | ||||||
gyrA | 9649 | p.Val783Gly | missense_variant | 0.14 | fluoroquinolones | |
moxifloxacin | ||||||
levofloxacin | ||||||
ciprofloxacin | ||||||
ofloxacin | ||||||
fgd1 | 490830 | c.48A>C | synonymous_variant | 0.13 | delamanid | |
fgd1 | 491014 | p.Thr78Pro | missense_variant | 0.18 | delamanid | |
fgd1 | 491742 | c.960T>C | synonymous_variant | 0.96 | delamanid | |
mshA | 575284 | c.-64C>G | upstream_gene_variant | 0.16 | ethionamide | |
isoniazid | ||||||
mshA | 575420 | p.Thr25Pro | missense_variant | 0.12 | ethionamide | |
isoniazid | ||||||
mshA | 575902 | p.Asn185Lys | missense_variant | 0.15 | ethionamide | |
isoniazid | ||||||
mshA | 575922 | p.Asp192Gly | missense_variant | 0.14 | ethionamide | |
isoniazid | ||||||
mshA | 576163 | c.816A>C | synonymous_variant | 0.11 | ethionamide | |
isoniazid | ||||||
mshA | 576321 | p.Val325Gly | missense_variant | 0.11 | ethionamide | |
isoniazid | ||||||
mshA | 576448 | c.1101A>G | synonymous_variant | 0.12 | ethionamide | |
isoniazid | ||||||
mshA | 576711 | p.Arg455Pro | missense_variant | 0.12 | ethionamide | |
isoniazid | ||||||
mshA | 576723 | p.Val459Gly | missense_variant | 0.12 | ethionamide | |
isoniazid | ||||||
ccsA | 619831 | c.-60T>G | upstream_gene_variant | 0.12 | capreomycin | |
amikacin | ||||||
ccsA | 620087 | p.Asp66Ala | missense_variant | 0.25 | capreomycin | |
amikacin | ||||||
ccsA | 620096 | p.His69Pro | missense_variant | 0.27 | capreomycin | |
amikacin | ||||||
ccsA | 620115 | c.225C>G | synonymous_variant | 0.12 | capreomycin | |
amikacin | ||||||
ccsA | 620248 | p.Ser120Ala | missense_variant | 0.12 | capreomycin | |
amikacin | ||||||
ccsA | 620748 | c.858T>G | synonymous_variant | 0.13 | capreomycin | |
amikacin | ||||||
rpoB | 759620 | c.-187A>C | upstream_gene_variant | 0.14 | rifampicin | |
rpoB | 760912 | p.Asn369Thr | missense_variant | 0.14 | rifampicin | |
rpoB | 761885 | c.2079T>G | synonymous_variant | 0.24 | rifampicin | |
rpoB | 762625 | p.Val940Gly | missense_variant | 0.14 | rifampicin | |
rpoC | 762854 | c.-516G>C | upstream_gene_variant | 0.12 | rifampicin | |
rpoB | 762913 | p.His1036Pro | missense_variant | 0.18 | rifampicin | |
rpoB | 762945 | p.Thr1047Pro | missense_variant | 0.16 | rifampicin | |
rpoC | 763031 | c.-339T>C | upstream_gene_variant | 1.0 | rifampicin | |
rpoC | 763854 | p.Val162Gly | missense_variant | 0.19 | rifampicin | |
rpoC | 764372 | p.Phe335Val | missense_variant | 0.17 | rifampicin | |
rpoC | 764378 | p.Thr337Pro | missense_variant | 0.14 | rifampicin | |
rpoC | 764502 | p.Val378Gly | missense_variant | 0.14 | rifampicin | |
rpoC | 764725 | p.Phe452Leu | missense_variant | 0.13 | rifampicin | |
rpoC | 764876 | p.Thr503Pro | missense_variant | 0.19 | rifampicin | |
rpoC | 765165 | p.Tyr599Ser | missense_variant | 0.17 | rifampicin | |
rpoC | 765281 | p.Thr638Pro | missense_variant | 0.15 | rifampicin | |
rpoC | 765353 | p.Trp662Gly | missense_variant | 0.11 | rifampicin | |
rpoC | 765365 | p.Thr666Pro | missense_variant | 0.15 | rifampicin | |
rpoC | 765582 | p.Val738Gly | missense_variant | 0.11 | rifampicin | |
rpoC | 766632 | p.Val1088Gly | missense_variant | 0.14 | rifampicin | |
rpoC | 766662 | p.Val1098Gly | missense_variant | 0.14 | rifampicin | |
rpoC | 766938 | p.Asn1190Thr | missense_variant | 0.16 | rifampicin | |
rpoC | 767052 | p.Glu1228Gly | missense_variant | 0.12 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 0.93 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
mmpL5 | 777336 | p.Val382Gly | missense_variant | 0.14 | clofazimine | |
bedaquiline | ||||||
mmpL5 | 777354 | p.Val376Gly | missense_variant | 0.12 | clofazimine | |
bedaquiline | ||||||
mmpL5 | 777366 | p.Arg372Pro | missense_variant | 0.12 | clofazimine | |
bedaquiline | ||||||
mmpL5 | 777565 | p.Thr306Pro | missense_variant | 0.11 | clofazimine | |
bedaquiline | ||||||
mmpR5 | 779348 | p.Val120Gly | missense_variant | 0.12 | clofazimine | |
bedaquiline | ||||||
mmpR5 | 779356 | p.Arg123Gly | missense_variant | 0.12 | clofazimine | |
bedaquiline | ||||||
mmpR5 | 779369 | p.Asp127Ala | missense_variant | 0.23 | clofazimine | |
bedaquiline | ||||||
rpsL | 781363 | c.-197T>G | upstream_gene_variant | 0.13 | streptomycin | |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
rplC | 800758 | c.-51A>C | upstream_gene_variant | 0.11 | linezolid | |
rplC | 800997 | p.Asn63Lys | missense_variant | 0.11 | linezolid | |
rplC | 801210 | c.402T>G | synonymous_variant | 0.15 | linezolid | |
rplC | 801222 | p.Ser138Arg | missense_variant | 0.11 | linezolid | |
fbiC | 1302899 | c.-32A>G | upstream_gene_variant | 1.0 | delamanid | Uncertain significance |
fbiC | 1303038 | c.108T>G | synonymous_variant | 0.12 | delamanid | |
fbiC | 1303150 | p.Gly74Arg | missense_variant | 0.12 | delamanid | |
fbiC | 1303157 | p.His76Pro | missense_variant | 0.12 | delamanid | |
fbiC | 1303640 | p.Asp237Ala | missense_variant | 0.14 | delamanid | |
fbiC | 1303649 | p.Val240Gly | missense_variant | 0.15 | delamanid | |
fbiC | 1304066 | p.Ala379Glu | missense_variant | 0.12 | delamanid | |
fbiC | 1304127 | c.1197A>C | synonymous_variant | 0.12 | delamanid | |
fbiC | 1304270 | p.Val447Gly | missense_variant | 0.19 | delamanid | |
fbiC | 1304422 | p.Ala498Pro | missense_variant | 0.14 | delamanid | |
Rv1258c | 1406252 | c.1089T>G | synonymous_variant | 0.13 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1406363 | c.978A>C | synonymous_variant | 0.18 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1406379 | p.Val321Gly | missense_variant | 0.11 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1406452 | p.Thr297Pro | missense_variant | 0.12 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1406662 | p.Thr227Pro | missense_variant | 0.12 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1406750 | c.591C>A | synonymous_variant | 0.15 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1406842 | p.Thr167Ala | missense_variant | 0.12 | streptomycin | |
pyrazinamide | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
Rv1258c | 1407120 | p.Val74Gly | missense_variant | 0.17 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1407196 | p.Ser49Gly | missense_variant | 0.33 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1407213 | p.Gln43Arg | missense_variant | 0.14 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1407218 | c.123T>G | synonymous_variant | 0.19 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1407228 | p.Glu38Gly | missense_variant | 0.12 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1407240 | p.Val34Gly | missense_variant | 0.19 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1407506 | c.-166T>G | upstream_gene_variant | 0.14 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1407513 | c.-173T>G | upstream_gene_variant | 0.16 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
Rv1258c | 1407520 | c.-180A>C | upstream_gene_variant | 0.11 | streptomycin | |
pyrazinamide | ||||||
isoniazid | ||||||
embR | 1416482 | p.Val289Gly | missense_variant | 0.19 | ethambutol | Uncertain significance |
embR | 1416947 | p.Ala134Gly | missense_variant | 0.11 | ethambutol | |
embR | 1416961 | p.Gly129Arg | missense_variant | 0.12 | ethambutol | |
embR | 1416986 | p.Ala121Gly | missense_variant | 0.11 | ethambutol | |
embR | 1417170 | p.Trp60Gly | missense_variant | 0.12 | ethambutol | |
embR | 1417179 | p.Thr57Pro | missense_variant | 0.16 | ethambutol | |
embR | 1417513 | c.-166A>C | upstream_gene_variant | 0.17 | ethambutol | |
atpE | 1461125 | c.81T>G | synonymous_variant | 0.12 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | linezolid | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
aminoglycosides | ||||||
streptomycin | ||||||
rrs | 1471676 | n.-170A>G | upstream_gene_variant | 0.12 | linezolid | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
aminoglycosides | ||||||
streptomycin | ||||||
rrs | 1473084 | n.1239T>G | non_coding_transcript_exon_variant | 0.2 | linezolid | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
aminoglycosides | ||||||
streptomycin | ||||||
rrs | 1473360 | n.1515T>G | non_coding_transcript_exon_variant | 0.15 | linezolid | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
aminoglycosides | ||||||
streptomycin | ||||||
rrl | 1476219 | n.2562T>G | non_coding_transcript_exon_variant | 0.12 | linezolid | |
inhA | 1673338 | c.-864G>A | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
isoniazid | Uncertain significance | |||||
fabG1 | 1673398 | c.-42A>C | upstream_gene_variant | 0.11 | ethionamide | |
isoniazid | ||||||
fabG1 | 1673441 | p.Val1Gly | missense_variant | 0.17 | ethionamide | |
isoniazid | ||||||
fabG1 | 1673564 | p.Val42Gly | missense_variant | 0.24 | ethionamide | |
isoniazid | ||||||
fabG1 | 1673663 | p.Val75Gly | missense_variant | 0.12 | ethionamide | |
isoniazid | ||||||
inhA | 1674352 | p.Thr51Pro | missense_variant | 0.11 | ethionamide | |
isoniazid | ||||||
rpsA | 1833405 | c.-137A>G | upstream_gene_variant | 0.14 | pyrazinamide | |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | |
tlyA | 1918103 | p.Val55Gly | missense_variant | 0.14 | capreomycin | |
tlyA | 1918225 | p.Phe96Val | missense_variant | 0.15 | capreomycin | |
tlyA | 1918328 | p.Val130Gly | missense_variant | 0.12 | capreomycin | |
ndh | 2101705 | c.1338C>G | synonymous_variant | 0.12 | ethionamide | |
isoniazid | ||||||
ndh | 2101921 | c.1122G>A | synonymous_variant | 1.0 | ethionamide | |
isoniazid | ||||||
ndh | 2102897 | p.His49Pro | missense_variant | 0.13 | ethionamide | |
isoniazid | ||||||
ndh | 2103112 | c.-70G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
isoniazid | Uncertain significance | |||||
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Uncertain significance |
katG | 2155025 | p.Thr363Pro | missense_variant | 0.13 | isoniazid | |
katG | 2155759 | p.Gly118Ala | missense_variant | 0.11 | isoniazid | |
PPE35 | 2167859 | c.2754T>G | synonymous_variant | 0.18 | pyrazinamide | |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
PPE35 | 2168091 | p.Ile841Thr | missense_variant | 0.12 | pyrazinamide | |
PPE35 | 2169854 | c.759T>G | synonymous_variant | 0.18 | pyrazinamide | |
PPE35 | 2170468 | p.Thr49Pro | missense_variant | 0.15 | pyrazinamide | |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
pncA | 2289162 | p.Leu27Arg | missense_variant | 0.11 | pyrazinamide | |
pncA | 2289900 | c.-659A>C | upstream_gene_variant | 0.11 | pyrazinamide | |
pncA | 2289970 | c.-729C>T | upstream_gene_variant | 0.11 | pyrazinamide | |
pncA | 2289978 | c.-737T>G | upstream_gene_variant | 0.15 | pyrazinamide | |
pncA | 2289994 | c.-753A>C | upstream_gene_variant | 0.13 | pyrazinamide | |
pncA | 2290062 | c.-821G>A | upstream_gene_variant | 1.0 | pyrazinamide | |
kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
kasA | 2518302 | p.His63Pro | missense_variant | 0.12 | isoniazid | |
kasA | 2518320 | p.Asp69Ala | missense_variant | 0.13 | isoniazid | |
kasA | 2519025 | p.Asp304Gly | missense_variant | 0.12 | isoniazid | |
kasA | 2519046 | p.His311Pro | missense_variant | 0.12 | isoniazid | |
kasA | 2519079 | p.Glu322Gly | missense_variant | 0.14 | isoniazid | |
eis | 2714312 | p.Thr341Pro | missense_variant | 0.14 | kanamycin | |
amikacin | ||||||
eis | 2714384 | p.Phe317Val | missense_variant | 0.12 | kanamycin | |
amikacin | ||||||
eis | 2714874 | c.459A>C | synonymous_variant | 0.12 | kanamycin | |
amikacin | ||||||
eis | 2715098 | p.Thr79Pro | missense_variant | 0.13 | kanamycin | |
amikacin | ||||||
eis | 2715114 | c.219T>G | synonymous_variant | 0.12 | kanamycin | |
amikacin | ||||||
ahpC | 2725940 | c.-253A>C | upstream_gene_variant | 0.12 | isoniazid | |
ahpC | 2726015 | c.-178A>C | upstream_gene_variant | 0.14 | isoniazid | |
ahpC | 2726338 | p.Val49Gly | missense_variant | 0.14 | isoniazid | |
ahpC | 2726341 | p.Val50Gly | missense_variant | 0.14 | isoniazid | |
folC | 2746886 | p.Val238Gly | missense_variant | 0.12 | para-aminosalicylic_acid | |
folC | 2747170 | c.429T>G | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
folC | 2747510 | p.Val30Gly | missense_variant | 0.12 | para-aminosalicylic_acid | |
folC | 2747618 | c.-20A>C | upstream_gene_variant | 0.12 | para-aminosalicylic_acid | |
pepQ | 2859429 | p.Leu330Phe | missense_variant | 0.14 | clofazimine | |
bedaquiline | ||||||
pepQ | 2859438 | c.981T>G | synonymous_variant | 0.14 | clofazimine | |
bedaquiline | ||||||
pepQ | 2859448 | p.Val324Gly | missense_variant | 0.14 | clofazimine | |
bedaquiline | ||||||
pepQ | 2859904 | p.Val172Gly | missense_variant | 0.15 | clofazimine | |
bedaquiline | ||||||
pepQ | 2859912 | p.Glu169Asp | missense_variant | 0.18 | clofazimine | |
bedaquiline | ||||||
pepQ | 2859972 | c.447A>C | synonymous_variant | 0.12 | clofazimine | |
bedaquiline | ||||||
pepQ | 2859978 | p.Cys147Trp | missense_variant | 0.11 | clofazimine | |
bedaquiline | ||||||
ribD | 2987271 | p.Thr145Pro | missense_variant | 0.13 | para-aminosalicylic_acid | |
ribD | 2987281 | p.Val148Gly | missense_variant | 0.2 | para-aminosalicylic_acid | |
ribD | 2987396 | c.558T>G | synonymous_variant | 0.12 | para-aminosalicylic_acid | |
ribD | 2987453 | c.615T>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
ribD | 2987571 | p.Thr245Pro | missense_variant | 0.11 | para-aminosalicylic_acid | |
Rv2752c | 3064669 | p.Val508Gly | missense_variant | 0.12 | rifampicin | |
isoniazid | ||||||
Rv2752c | 3064704 | c.1488T>G | synonymous_variant | 0.13 | rifampicin | |
isoniazid | ||||||
Rv2752c | 3064745 | p.Thr483Pro | missense_variant | 0.14 | rifampicin | |
isoniazid | ||||||
Rv2752c | 3064811 | p.Thr461Pro | missense_variant | 0.14 | rifampicin | Uncertain significance |
isoniazid | Uncertain significance | |||||
Rv2752c | 3064997 | p.Thr399Pro | missense_variant | 0.13 | rifampicin | |
isoniazid | ||||||
Rv2752c | 3065296 | p.Gln299Pro | missense_variant | 0.12 | rifampicin | |
isoniazid | ||||||
thyX | 3067472 | c.474C>A | synonymous_variant | 0.11 | para-aminosalicylic_acid | |
thyX | 3067786 | p.Thr54Pro | missense_variant | 0.14 | para-aminosalicylic_acid | |
thyX | 3067953 | c.-8T>G | upstream_gene_variant | 0.12 | para-aminosalicylic_acid | |
thyX | 3067995 | c.-50A>C | upstream_gene_variant | 0.19 | para-aminosalicylic_acid | |
thyX | 3067997 | c.-52T>G | upstream_gene_variant | 0.12 | para-aminosalicylic_acid | |
ald | 3087084 | c.266delA | frameshift_variant | 1.0 | cycloserine | |
ald | 3087184 | c.368_373delCCGACG | disruptive_inframe_deletion | 1.0 | cycloserine | |
fbiD | 3339153 | p.Leu12Phe | missense_variant | 0.16 | delamanid | |
fbiD | 3339224 | p.Glu36Gly | missense_variant | 0.13 | delamanid | |
fbiD | 3339251 | p.Asp45Ala | missense_variant | 0.15 | delamanid | |
fbiD | 3339273 | c.156T>G | synonymous_variant | 0.13 | delamanid | |
fbiD | 3339350 | p.Asp78Gly | missense_variant | 0.12 | delamanid | |
fbiD | 3339368 | p.Thr84Asn | missense_variant | 0.14 | delamanid | |
fbiD | 3339386 | p.Asp90Ala | missense_variant | 0.17 | delamanid | |
fbiD | 3339390 | c.273A>C | synonymous_variant | 0.17 | delamanid | |
Rv3083 | 3448973 | p.His157Pro | missense_variant | 0.13 | ethionamide | |
Rv3083 | 3449072 | p.Val190Gly | missense_variant | 0.12 | ethionamide | |
fprA | 3473850 | c.-157A>G | upstream_gene_variant | 0.12 | capreomycin | |
amikacin | Uncertain significance | |||||
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
fprA | 3474400 | p.Tyr132Asp | missense_variant | 0.18 | capreomycin | |
amikacin | ||||||
fprA | 3475081 | p.Trp359Gly | missense_variant | 0.27 | capreomycin | |
amikacin | ||||||
fprA | 3475106 | p.Val367Gly | missense_variant | 0.12 | capreomycin | |
amikacin | ||||||
fprA | 3475159 | p.Asn385Asp | missense_variant | 1.0 | capreomycin | Uncertain significance |
amikacin | Uncertain significance | |||||
fprA | 3475280 | p.Val425Gly | missense_variant | 0.14 | capreomycin | |
amikacin | ||||||
fprA | 3475283 | p.Ile426Ser | missense_variant | 0.14 | capreomycin | |
amikacin | ||||||
fprA | 3475286 | p.Asp427Ala | missense_variant | 0.15 | capreomycin | |
amikacin | ||||||
fprA | 3475297 | p.Arg431Gly | missense_variant | 0.11 | capreomycin | |
amikacin | ||||||
Rv3236c | 3612835 | c.282T>G | synonymous_variant | 0.12 | pyrazinamide | |
fbiA | 3640512 | c.-31T>G | upstream_gene_variant | 0.12 | delamanid | |
fbiA | 3641270 | p.Tyr243Ser | missense_variant | 0.13 | delamanid | |
fbiB | 3641663 | c.129T>G | synonymous_variant | 0.12 | delamanid | |
fbiB | 3641955 | p.Gly141Arg | missense_variant | 0.12 | delamanid | |
fbiB | 3641965 | p.Val144Ala | missense_variant | 0.12 | delamanid | |
fbiB | 3642049 | p.Val172Gly | missense_variant | 0.12 | delamanid | |
fbiB | 3642208 | p.Asp225Ala | missense_variant | 0.11 | delamanid | |
fbiB | 3642677 | c.1143A>C | synonymous_variant | 0.11 | delamanid | |
fbiB | 3642696 | p.Leu388Val | missense_variant | 0.12 | delamanid | |
fbiB | 3642703 | p.Val390Gly | missense_variant | 0.2 | delamanid | |
fbiB | 3642712 | p.Leu393Arg | missense_variant | 0.18 | delamanid | |
fbiB | 3642720 | p.Cys396Gly | missense_variant | 0.18 | delamanid | |
alr | 3840268 | p.Thr385Pro | missense_variant | 0.17 | cycloserine | |
alr | 3840460 | p.Ser321Ala | missense_variant | 0.12 | cycloserine | |
alr | 3840515 | c.906A>C | synonymous_variant | 0.14 | cycloserine | |
alr | 3840932 | c.489C>T | synonymous_variant | 0.98 | cycloserine | |
alr | 3841230 | p.Val64Gly | missense_variant | 0.13 | cycloserine | |
alr | 3841463 | c.-43A>C | upstream_gene_variant | 0.14 | cycloserine | |
alr | 3841509 | c.-89A>C | upstream_gene_variant | 0.14 | cycloserine | |
rpoA | 3878152 | p.His119Pro | missense_variant | 0.17 | rifampicin | |
rpoA | 3878301 | c.207C>A | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878618 | c.-111A>C | upstream_gene_variant | 0.12 | rifampicin | |
rpoA | 3878653 | c.-146A>C | upstream_gene_variant | 0.14 | rifampicin | |
ddn | 3986761 | c.-83T>G | upstream_gene_variant | 0.11 | delamanid | |
ddn | 3986919 | p.Thr26Pro | missense_variant | 0.12 | delamanid | |
ddn | 3986987 | c.144G>T | synonymous_variant | 0.96 | delamanid | |
ddn | 3987025 | p.Val61Gly | missense_variant | 0.15 | delamanid | |
ddn | 3987180 | p.Asp113Asn | missense_variant | 0.98 | delamanid | |
clpC1 | 4038190 | p.Ser839Gly | missense_variant | 0.14 | pyrazinamide | |
clpC1 | 4038192 | p.His838Pro | missense_variant | 0.11 | pyrazinamide | |
clpC1 | 4038857 | c.1848C>A | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038874 | p.Thr611Pro | missense_variant | 0.16 | pyrazinamide | |
clpC1 | 4038891 | p.Glu605Gly | missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4039599 | p.His369Pro | missense_variant | 0.14 | pyrazinamide | |
clpC1 | 4040727 | c.-23T>G | upstream_gene_variant | 0.11 | pyrazinamide | |
clpC1 | 4040824 | c.-120C>T | upstream_gene_variant | 0.96 | pyrazinamide | |
embC | 4239843 | c.-20A>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
embC | 4239869 | p.Thr3His | missense_variant | 0.14 | ethambutol | |
embC | 4239873 | p.Glu4Gly | missense_variant | 0.13 | ethambutol | |
embC | 4239883 | c.21A>C | synonymous_variant | 0.11 | ethambutol | |
embC | 4239911 | p.Thr17Pro | missense_variant | 0.2 | ethambutol | |
embC | 4240115 | p.Thr85Pro | missense_variant | 0.12 | ethambutol | |
embC | 4240368 | p.Val169Gly | missense_variant | 0.17 | ethambutol | |
embC | 4240377 | p.Val172Gly | missense_variant | 0.2 | ethambutol | |
embC | 4240422 | p.Glu187Gly | missense_variant | 0.13 | ethambutol | |
embC | 4240461 | p.Val200Gly | missense_variant | 0.13 | ethambutol | |
embC | 4240470 | p.Asp203Gly | missense_variant | 0.12 | ethambutol | |
embC | 4240475 | p.Ala205Pro | missense_variant | 0.12 | ethambutol | |
embC | 4240583 | p.Thr241Pro | missense_variant | 0.12 | ethambutol | |
embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Uncertain significance |
embC | 4240841 | p.Tyr327Asp | missense_variant | 0.17 | ethambutol | |
embC | 4241029 | p.Trp389Cys | missense_variant | 0.14 | ethambutol | |
embC | 4241100 | p.Val413Gly | missense_variant | 0.12 | ethambutol | |
embC | 4241158 | c.1296T>G | synonymous_variant | 0.13 | ethambutol | |
embC | 4241783 | p.Trp641Gly | missense_variant | 0.12 | ethambutol | |
embC | 4242288 | p.Leu809His | missense_variant | 0.14 | ethambutol | |
embC | 4242363 | p.Gly834Ala | missense_variant | 0.12 | ethambutol | |
embC | 4242369 | p.Arg836Pro | missense_variant | 0.18 | ethambutol | |
embC | 4242371 | p.Ala837Pro | missense_variant | 0.12 | ethambutol | |
embC | 4242380 | p.Pro840Ala | missense_variant | 0.12 | ethambutol | |
embC | 4242387 | p.Asn842Thr | missense_variant | 0.19 | ethambutol | |
embC | 4242393 | p.Asp844Ala | missense_variant | 0.15 | ethambutol | |
embA | 4242406 | c.-827A>C | upstream_gene_variant | 0.2 | ethambutol | |
embA | 4242598 | c.-635T>G | upstream_gene_variant | 0.12 | ethambutol | |
embC | 4242605 | p.Met915Val | missense_variant | 0.12 | ethambutol | |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 | ethambutol | |
embC | 4242853 | p.Phe997Leu | missense_variant | 0.13 | ethambutol | |
embC | 4242908 | p.Phe1016Val | missense_variant | 0.12 | ethambutol | |
embA | 4243198 | c.-35A>C | upstream_gene_variant | 0.11 | ethambutol | |
embA | 4243645 | p.Ala138Gly | missense_variant | 0.14 | ethambutol | |
embA | 4243944 | p.Thr238Pro | missense_variant | 0.16 | ethambutol | |
embA | 4243993 | p.Asp254Ala | missense_variant | 0.16 | ethambutol | |
embA | 4244040 | p.Thr270Pro | missense_variant | 0.15 | ethambutol | |
embA | 4244059 | p.Tyr276Ser | missense_variant | 0.18 | ethambutol | |
embA | 4244220 | c.988C>T | synonymous_variant | 0.82 | ethambutol | |
embA | 4244224 | p.Ala331Gly | missense_variant | 0.12 | ethambutol | |
embA | 4244271 | p.Leu347Val | missense_variant | 0.17 | ethambutol | |
embA | 4244275 | p.Gly348Ala | missense_variant | 0.13 | ethambutol | Uncertain significance |
embA | 4244284 | p.Pro351Arg | missense_variant | 0.25 | ethambutol | |
embA | 4244302 | p.Asn357Thr | missense_variant | 0.13 | ethambutol | |
embA | 4244319 | p.Thr363Pro | missense_variant | 0.12 | ethambutol | |
embA | 4244340 | p.Ser370Pro | missense_variant | 0.13 | ethambutol | |
embA | 4244432 | p.Ile400Met | missense_variant | 0.17 | ethambutol | |
embA | 4244437 | p.Leu402Arg | missense_variant | 0.15 | ethambutol | |
embA | 4244441 | c.1209A>C | synonymous_variant | 0.15 | ethambutol | |
embA | 4244469 | p.Ile413Leu | missense_variant | 0.13 | ethambutol | |
embA | 4244572 | p.Arg447Pro | missense_variant | 0.15 | ethambutol | |
embA | 4244635 | p.Val468Ala | missense_variant | 1.0 | ethambutol | Uncertain significance |
embA | 4244638 | p.Val469Gly | missense_variant | 0.17 | ethambutol | |
embA | 4245147 | p.Pro639Ser | missense_variant | 1.0 | ethambutol | Uncertain significance |
embA | 4245748 | p.Val839Gly | missense_variant | 0.14 | ethambutol | |
embB | 4245833 | c.-681G>T | upstream_gene_variant | 0.12 | ethambutol | |
embA | 4246423 | p.Val1064Gly | missense_variant | 0.14 | ethambutol | |
embB | 4246553 | p.Arg14Trp | missense_variant | 0.15 | ethambutol | |
embB | 4246665 | p.Gln51Pro | missense_variant | 0.17 | ethambutol | Uncertain significance |
embB | 4247028 | p.Leu172Pro | missense_variant | 0.13 | ethambutol | |
embB | 4247046 | p.Asp178Ala | missense_variant | 0.11 | ethambutol | |
embB | 4247076 | p.Val188Gly | missense_variant | 0.13 | ethambutol | |
embB | 4247081 | p.Thr190Pro | missense_variant | 0.12 | ethambutol | |
embB | 4247646 | p.Glu378Ala | missense_variant | 0.94 | ethambutol | Uncertain significance |
embB | 4247666 | p.Trp385Arg | missense_variant | 0.15 | ethambutol | |
embB | 4247673 | p.Ala387Gly | missense_variant | 0.19 | ethambutol | |
embB | 4247682 | p.Val390Gly | missense_variant | 0.15 | ethambutol | |
embB | 4247754 | p.Val414Gly | missense_variant | 0.15 | ethambutol | Uncertain significance |
embB | 4247844 | p.Val444Gly | missense_variant | 0.11 | ethambutol | |
embB | 4247906 | p.Ile465Val | missense_variant | 0.17 | ethambutol | |
embB | 4248029 | p.Thr506Pro | missense_variant | 0.12 | ethambutol | |
embB | 4248281 | p.Thr590Pro | missense_variant | 0.12 | ethambutol | |
embB | 4248297 | p.His595Pro | missense_variant | 0.11 | ethambutol | |
embB | 4248663 | p.Val717Gly | missense_variant | 0.16 | ethambutol | |
embB | 4249359 | p.Val949Gly | missense_variant | 0.12 | ethambutol | |
embB | 4249482 | p.Val990Gly | missense_variant | 0.12 | ethambutol | |
aftB | 4267782 | p.Val352Gly | missense_variant | 0.11 | capreomycin | |
amikacin | Uncertain significance | |||||
aftB | 4267935 | p.Val301Gly | missense_variant | 0.14 | capreomycin | |
amikacin | ||||||
aftB | 4267940 | c.897T>G | synonymous_variant | 0.13 | capreomycin | |
amikacin | ||||||
aftB | 4267947 | p.Asp297Ala | missense_variant | 0.15 | capreomycin | |
amikacin | ||||||
aftB | 4268360 | c.477A>C | synonymous_variant | 0.15 | capreomycin | |
amikacin | ||||||
ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Uncertain significance |
ubiA | 4269575 | p.Lys87Gln | missense_variant | 0.14 | ethambutol | |
aftB | 4269606 | c.-770T>C | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
ubiA | 4269899 | c.-66A>C | upstream_gene_variant | 0.13 | ethambutol | |
ubiA | 4269915 | c.-82T>G | upstream_gene_variant | 0.13 | ethambutol | |
ubiA | 4269976 | c.-143C>G | upstream_gene_variant | 0.12 | ethambutol | |
ubiA | 4269979 | c.-146T>G | upstream_gene_variant | 0.27 | ethambutol | |
ubiA | 4269985 | c.-152T>G | upstream_gene_variant | 0.14 | ethambutol | |
ethR | 4326928 | c.-621G>A | upstream_gene_variant | 1.0 | ethionamide | |
ethA | 4327103 | p.Gly124Asp | missense_variant | 1.0 | ethionamide | Uncertain significance |
ethR | 4327768 | p.Thr74Pro | missense_variant | 0.15 | ethionamide | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | |
gid | 4407983 | p.Leu74Val | missense_variant | 0.11 | streptomycin | |
gid | 4408271 | c.-69A>C | upstream_gene_variant | 0.12 | streptomycin |