TB-Profiler result

Run: 5c24bd21-243f-4813-811b-f8143727ee27
Summary

Run ID: 5c24bd21-243f-4813-811b-f8143727ee27

Sample name:

Date: 09-05-2024 01:09:24

Number of reads: 1649989

Percentage reads mapped: 95.18

Median coverage: 39

Strain: lineage5.1

Spoligotype:

Drug-resistance: HR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage5 West-Africa 1 RD711 0.99
lineage5.1 West-Africa 1 RD711 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Asp117Ala Uncertain significance
ethambutol embB p.Val377Gly Uncertain significance
p.Ala388Gly Uncertain significance
pyrazinamide
moxifloxacin
levofloxacin
bedaquiline
delamanid
pretomanid
linezolid
streptomycin
amikacin
kanamycin
capreomycin
clofazimine
ethionamide
para-aminosalicylic_acid
cycloserine
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155762 p.Asp117Ala missense_variant 0.11 isoniazid Uncertain significance
embB 4247643 p.Val377Gly missense_variant 0.13 ethambutol Uncertain significance
embB 4247676 p.Ala388Gly missense_variant 0.17 ethambutol Uncertain significance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6446 p.Ala403Ser missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrB 7166 p.Ala643Pro missense_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7504 p.Arg68Pro missense_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 8445 p.Arg382Gly missense_variant 0.14 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.97 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 9196 p.Val632Gly missense_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 9566 c.2265C>T synonymous_variant 1.0 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 9649 p.Val783Gly missense_variant 0.14 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
fgd1 490830 c.48A>C synonymous_variant 0.13 delamanid
fgd1 491014 p.Thr78Pro missense_variant 0.18 delamanid
fgd1 491742 c.960T>C synonymous_variant 0.96 delamanid
mshA 575284 c.-64C>G upstream_gene_variant 0.16 ethionamide
isoniazid
mshA 575420 p.Thr25Pro missense_variant 0.12 ethionamide
isoniazid
mshA 575902 p.Asn185Lys missense_variant 0.15 ethionamide
isoniazid
mshA 575922 p.Asp192Gly missense_variant 0.14 ethionamide
isoniazid
mshA 576163 c.816A>C synonymous_variant 0.11 ethionamide
isoniazid
mshA 576321 p.Val325Gly missense_variant 0.11 ethionamide
isoniazid
mshA 576448 c.1101A>G synonymous_variant 0.12 ethionamide
isoniazid
mshA 576711 p.Arg455Pro missense_variant 0.12 ethionamide
isoniazid
mshA 576723 p.Val459Gly missense_variant 0.12 ethionamide
isoniazid
ccsA 619831 c.-60T>G upstream_gene_variant 0.12 capreomycin
amikacin
ccsA 620087 p.Asp66Ala missense_variant 0.25 capreomycin
amikacin
ccsA 620096 p.His69Pro missense_variant 0.27 capreomycin
amikacin
ccsA 620115 c.225C>G synonymous_variant 0.12 capreomycin
amikacin
ccsA 620248 p.Ser120Ala missense_variant 0.12 capreomycin
amikacin
ccsA 620748 c.858T>G synonymous_variant 0.13 capreomycin
amikacin
rpoB 759620 c.-187A>C upstream_gene_variant 0.14 rifampicin
rpoB 760912 p.Asn369Thr missense_variant 0.14 rifampicin
rpoB 761885 c.2079T>G synonymous_variant 0.24 rifampicin
rpoB 762625 p.Val940Gly missense_variant 0.14 rifampicin
rpoC 762854 c.-516G>C upstream_gene_variant 0.12 rifampicin
rpoB 762913 p.His1036Pro missense_variant 0.18 rifampicin
rpoB 762945 p.Thr1047Pro missense_variant 0.16 rifampicin
rpoC 763031 c.-339T>C upstream_gene_variant 1.0 rifampicin
rpoC 763854 p.Val162Gly missense_variant 0.19 rifampicin
rpoC 764372 p.Phe335Val missense_variant 0.17 rifampicin
rpoC 764378 p.Thr337Pro missense_variant 0.14 rifampicin
rpoC 764502 p.Val378Gly missense_variant 0.14 rifampicin
rpoC 764725 p.Phe452Leu missense_variant 0.13 rifampicin
rpoC 764876 p.Thr503Pro missense_variant 0.19 rifampicin
rpoC 765165 p.Tyr599Ser missense_variant 0.17 rifampicin
rpoC 765281 p.Thr638Pro missense_variant 0.15 rifampicin
rpoC 765353 p.Trp662Gly missense_variant 0.11 rifampicin
rpoC 765365 p.Thr666Pro missense_variant 0.15 rifampicin
rpoC 765582 p.Val738Gly missense_variant 0.11 rifampicin
rpoC 766632 p.Val1088Gly missense_variant 0.14 rifampicin
rpoC 766662 p.Val1098Gly missense_variant 0.14 rifampicin
rpoC 766938 p.Asn1190Thr missense_variant 0.16 rifampicin
rpoC 767052 p.Glu1228Gly missense_variant 0.12 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776100 p.Thr794Ile missense_variant 0.93 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 777336 p.Val382Gly missense_variant 0.14 clofazimine
bedaquiline
mmpL5 777354 p.Val376Gly missense_variant 0.12 clofazimine
bedaquiline
mmpL5 777366 p.Arg372Pro missense_variant 0.12 clofazimine
bedaquiline
mmpL5 777565 p.Thr306Pro missense_variant 0.11 clofazimine
bedaquiline
mmpR5 779348 p.Val120Gly missense_variant 0.12 clofazimine
bedaquiline
mmpR5 779356 p.Arg123Gly missense_variant 0.12 clofazimine
bedaquiline
mmpR5 779369 p.Asp127Ala missense_variant 0.23 clofazimine
bedaquiline
rpsL 781363 c.-197T>G upstream_gene_variant 0.13 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Uncertain significance
rplC 800758 c.-51A>C upstream_gene_variant 0.11 linezolid
rplC 800997 p.Asn63Lys missense_variant 0.11 linezolid
rplC 801210 c.402T>G synonymous_variant 0.15 linezolid
rplC 801222 p.Ser138Arg missense_variant 0.11 linezolid
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 delamanid Uncertain significance
fbiC 1303038 c.108T>G synonymous_variant 0.12 delamanid
fbiC 1303150 p.Gly74Arg missense_variant 0.12 delamanid
fbiC 1303157 p.His76Pro missense_variant 0.12 delamanid
fbiC 1303640 p.Asp237Ala missense_variant 0.14 delamanid
fbiC 1303649 p.Val240Gly missense_variant 0.15 delamanid
fbiC 1304066 p.Ala379Glu missense_variant 0.12 delamanid
fbiC 1304127 c.1197A>C synonymous_variant 0.12 delamanid
fbiC 1304270 p.Val447Gly missense_variant 0.19 delamanid
fbiC 1304422 p.Ala498Pro missense_variant 0.14 delamanid
Rv1258c 1406252 c.1089T>G synonymous_variant 0.13 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406363 c.978A>C synonymous_variant 0.18 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406379 p.Val321Gly missense_variant 0.11 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406452 p.Thr297Pro missense_variant 0.12 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406662 p.Thr227Pro missense_variant 0.12 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406750 c.591C>A synonymous_variant 0.15 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406842 p.Thr167Ala missense_variant 0.12 streptomycin
pyrazinamide Uncertain significance
isoniazid Uncertain significance
Rv1258c 1407120 p.Val74Gly missense_variant 0.17 streptomycin
pyrazinamide
isoniazid
Rv1258c 1407196 p.Ser49Gly missense_variant 0.33 streptomycin
pyrazinamide
isoniazid
Rv1258c 1407213 p.Gln43Arg missense_variant 0.14 streptomycin
pyrazinamide
isoniazid
Rv1258c 1407218 c.123T>G synonymous_variant 0.19 streptomycin
pyrazinamide
isoniazid
Rv1258c 1407228 p.Glu38Gly missense_variant 0.12 streptomycin
pyrazinamide
isoniazid
Rv1258c 1407240 p.Val34Gly missense_variant 0.19 streptomycin
pyrazinamide
isoniazid
Rv1258c 1407506 c.-166T>G upstream_gene_variant 0.14 streptomycin
pyrazinamide
isoniazid
Rv1258c 1407513 c.-173T>G upstream_gene_variant 0.16 streptomycin
pyrazinamide
isoniazid
Rv1258c 1407520 c.-180A>C upstream_gene_variant 0.11 streptomycin
pyrazinamide
isoniazid
embR 1416482 p.Val289Gly missense_variant 0.19 ethambutol Uncertain significance
embR 1416947 p.Ala134Gly missense_variant 0.11 ethambutol
embR 1416961 p.Gly129Arg missense_variant 0.12 ethambutol
embR 1416986 p.Ala121Gly missense_variant 0.11 ethambutol
embR 1417170 p.Trp60Gly missense_variant 0.12 ethambutol
embR 1417179 p.Thr57Pro missense_variant 0.16 ethambutol
embR 1417513 c.-166A>C upstream_gene_variant 0.17 ethambutol
atpE 1461125 c.81T>G synonymous_variant 0.12 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1471676 n.-170A>G upstream_gene_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473084 n.1239T>G non_coding_transcript_exon_variant 0.2 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473360 n.1515T>G non_coding_transcript_exon_variant 0.15 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrl 1476219 n.2562T>G non_coding_transcript_exon_variant 0.12 linezolid
inhA 1673338 c.-864G>A upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
fabG1 1673398 c.-42A>C upstream_gene_variant 0.11 ethionamide
isoniazid
fabG1 1673441 p.Val1Gly missense_variant 0.17 ethionamide
isoniazid
fabG1 1673564 p.Val42Gly missense_variant 0.24 ethionamide
isoniazid
fabG1 1673663 p.Val75Gly missense_variant 0.12 ethionamide
isoniazid
inhA 1674352 p.Thr51Pro missense_variant 0.11 ethionamide
isoniazid
rpsA 1833405 c.-137A>G upstream_gene_variant 0.14 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin
tlyA 1918103 p.Val55Gly missense_variant 0.14 capreomycin
tlyA 1918225 p.Phe96Val missense_variant 0.15 capreomycin
tlyA 1918328 p.Val130Gly missense_variant 0.12 capreomycin
ndh 2101705 c.1338C>G synonymous_variant 0.12 ethionamide
isoniazid
ndh 2101921 c.1122G>A synonymous_variant 1.0 ethionamide
isoniazid
ndh 2102897 p.His49Pro missense_variant 0.13 ethionamide
isoniazid
ndh 2103112 c.-70G>T upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Uncertain significance
katG 2155025 p.Thr363Pro missense_variant 0.13 isoniazid
katG 2155759 p.Gly118Ala missense_variant 0.11 isoniazid
PPE35 2167859 c.2754T>G synonymous_variant 0.18 pyrazinamide
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168091 p.Ile841Thr missense_variant 0.12 pyrazinamide
PPE35 2169854 c.759T>G synonymous_variant 0.18 pyrazinamide
PPE35 2170468 p.Thr49Pro missense_variant 0.15 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
pncA 2289162 p.Leu27Arg missense_variant 0.11 pyrazinamide
pncA 2289900 c.-659A>C upstream_gene_variant 0.11 pyrazinamide
pncA 2289970 c.-729C>T upstream_gene_variant 0.11 pyrazinamide
pncA 2289978 c.-737T>G upstream_gene_variant 0.15 pyrazinamide
pncA 2289994 c.-753A>C upstream_gene_variant 0.13 pyrazinamide
pncA 2290062 c.-821G>A upstream_gene_variant 1.0 pyrazinamide
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518302 p.His63Pro missense_variant 0.12 isoniazid
kasA 2518320 p.Asp69Ala missense_variant 0.13 isoniazid
kasA 2519025 p.Asp304Gly missense_variant 0.12 isoniazid
kasA 2519046 p.His311Pro missense_variant 0.12 isoniazid
kasA 2519079 p.Glu322Gly missense_variant 0.14 isoniazid
eis 2714312 p.Thr341Pro missense_variant 0.14 kanamycin
amikacin
eis 2714384 p.Phe317Val missense_variant 0.12 kanamycin
amikacin
eis 2714874 c.459A>C synonymous_variant 0.12 kanamycin
amikacin
eis 2715098 p.Thr79Pro missense_variant 0.13 kanamycin
amikacin
eis 2715114 c.219T>G synonymous_variant 0.12 kanamycin
amikacin
ahpC 2725940 c.-253A>C upstream_gene_variant 0.12 isoniazid
ahpC 2726015 c.-178A>C upstream_gene_variant 0.14 isoniazid
ahpC 2726338 p.Val49Gly missense_variant 0.14 isoniazid
ahpC 2726341 p.Val50Gly missense_variant 0.14 isoniazid
folC 2746886 p.Val238Gly missense_variant 0.12 para-aminosalicylic_acid
folC 2747170 c.429T>G synonymous_variant 0.18 para-aminosalicylic_acid
folC 2747510 p.Val30Gly missense_variant 0.12 para-aminosalicylic_acid
folC 2747618 c.-20A>C upstream_gene_variant 0.12 para-aminosalicylic_acid
pepQ 2859429 p.Leu330Phe missense_variant 0.14 clofazimine
bedaquiline
pepQ 2859438 c.981T>G synonymous_variant 0.14 clofazimine
bedaquiline
pepQ 2859448 p.Val324Gly missense_variant 0.14 clofazimine
bedaquiline
pepQ 2859904 p.Val172Gly missense_variant 0.15 clofazimine
bedaquiline
pepQ 2859912 p.Glu169Asp missense_variant 0.18 clofazimine
bedaquiline
pepQ 2859972 c.447A>C synonymous_variant 0.12 clofazimine
bedaquiline
pepQ 2859978 p.Cys147Trp missense_variant 0.11 clofazimine
bedaquiline
ribD 2987271 p.Thr145Pro missense_variant 0.13 para-aminosalicylic_acid
ribD 2987281 p.Val148Gly missense_variant 0.2 para-aminosalicylic_acid
ribD 2987396 c.558T>G synonymous_variant 0.12 para-aminosalicylic_acid
ribD 2987453 c.615T>G synonymous_variant 0.16 para-aminosalicylic_acid
ribD 2987571 p.Thr245Pro missense_variant 0.11 para-aminosalicylic_acid
Rv2752c 3064669 p.Val508Gly missense_variant 0.12 rifampicin
isoniazid
Rv2752c 3064704 c.1488T>G synonymous_variant 0.13 rifampicin
isoniazid
Rv2752c 3064745 p.Thr483Pro missense_variant 0.14 rifampicin
isoniazid
Rv2752c 3064811 p.Thr461Pro missense_variant 0.14 rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3064997 p.Thr399Pro missense_variant 0.13 rifampicin
isoniazid
Rv2752c 3065296 p.Gln299Pro missense_variant 0.12 rifampicin
isoniazid
thyX 3067472 c.474C>A synonymous_variant 0.11 para-aminosalicylic_acid
thyX 3067786 p.Thr54Pro missense_variant 0.14 para-aminosalicylic_acid
thyX 3067953 c.-8T>G upstream_gene_variant 0.12 para-aminosalicylic_acid
thyX 3067995 c.-50A>C upstream_gene_variant 0.19 para-aminosalicylic_acid
thyX 3067997 c.-52T>G upstream_gene_variant 0.12 para-aminosalicylic_acid
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
ald 3087184 c.368_373delCCGACG disruptive_inframe_deletion 1.0 cycloserine
fbiD 3339153 p.Leu12Phe missense_variant 0.16 delamanid
fbiD 3339224 p.Glu36Gly missense_variant 0.13 delamanid
fbiD 3339251 p.Asp45Ala missense_variant 0.15 delamanid
fbiD 3339273 c.156T>G synonymous_variant 0.13 delamanid
fbiD 3339350 p.Asp78Gly missense_variant 0.12 delamanid
fbiD 3339368 p.Thr84Asn missense_variant 0.14 delamanid
fbiD 3339386 p.Asp90Ala missense_variant 0.17 delamanid
fbiD 3339390 c.273A>C synonymous_variant 0.17 delamanid
Rv3083 3448973 p.His157Pro missense_variant 0.13 ethionamide
Rv3083 3449072 p.Val190Gly missense_variant 0.12 ethionamide
fprA 3473850 c.-157A>G upstream_gene_variant 0.12 capreomycin
amikacin Uncertain significance
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0 capreomycin
amikacin
fprA 3474400 p.Tyr132Asp missense_variant 0.18 capreomycin
amikacin
fprA 3475081 p.Trp359Gly missense_variant 0.27 capreomycin
amikacin
fprA 3475106 p.Val367Gly missense_variant 0.12 capreomycin
amikacin
fprA 3475159 p.Asn385Asp missense_variant 1.0 capreomycin Uncertain significance
amikacin Uncertain significance
fprA 3475280 p.Val425Gly missense_variant 0.14 capreomycin
amikacin
fprA 3475283 p.Ile426Ser missense_variant 0.14 capreomycin
amikacin
fprA 3475286 p.Asp427Ala missense_variant 0.15 capreomycin
amikacin
fprA 3475297 p.Arg431Gly missense_variant 0.11 capreomycin
amikacin
Rv3236c 3612835 c.282T>G synonymous_variant 0.12 pyrazinamide
fbiA 3640512 c.-31T>G upstream_gene_variant 0.12 delamanid
fbiA 3641270 p.Tyr243Ser missense_variant 0.13 delamanid
fbiB 3641663 c.129T>G synonymous_variant 0.12 delamanid
fbiB 3641955 p.Gly141Arg missense_variant 0.12 delamanid
fbiB 3641965 p.Val144Ala missense_variant 0.12 delamanid
fbiB 3642049 p.Val172Gly missense_variant 0.12 delamanid
fbiB 3642208 p.Asp225Ala missense_variant 0.11 delamanid
fbiB 3642677 c.1143A>C synonymous_variant 0.11 delamanid
fbiB 3642696 p.Leu388Val missense_variant 0.12 delamanid
fbiB 3642703 p.Val390Gly missense_variant 0.2 delamanid
fbiB 3642712 p.Leu393Arg missense_variant 0.18 delamanid
fbiB 3642720 p.Cys396Gly missense_variant 0.18 delamanid
alr 3840268 p.Thr385Pro missense_variant 0.17 cycloserine
alr 3840460 p.Ser321Ala missense_variant 0.12 cycloserine
alr 3840515 c.906A>C synonymous_variant 0.14 cycloserine
alr 3840932 c.489C>T synonymous_variant 0.98 cycloserine
alr 3841230 p.Val64Gly missense_variant 0.13 cycloserine
alr 3841463 c.-43A>C upstream_gene_variant 0.14 cycloserine
alr 3841509 c.-89A>C upstream_gene_variant 0.14 cycloserine
rpoA 3878152 p.His119Pro missense_variant 0.17 rifampicin
rpoA 3878301 c.207C>A synonymous_variant 0.16 rifampicin
rpoA 3878618 c.-111A>C upstream_gene_variant 0.12 rifampicin
rpoA 3878653 c.-146A>C upstream_gene_variant 0.14 rifampicin
ddn 3986761 c.-83T>G upstream_gene_variant 0.11 delamanid
ddn 3986919 p.Thr26Pro missense_variant 0.12 delamanid
ddn 3986987 c.144G>T synonymous_variant 0.96 delamanid
ddn 3987025 p.Val61Gly missense_variant 0.15 delamanid
ddn 3987180 p.Asp113Asn missense_variant 0.98 delamanid
clpC1 4038190 p.Ser839Gly missense_variant 0.14 pyrazinamide
clpC1 4038192 p.His838Pro missense_variant 0.11 pyrazinamide
clpC1 4038857 c.1848C>A synonymous_variant 0.14 pyrazinamide
clpC1 4038874 p.Thr611Pro missense_variant 0.16 pyrazinamide
clpC1 4038891 p.Glu605Gly missense_variant 0.15 pyrazinamide
clpC1 4039599 p.His369Pro missense_variant 0.14 pyrazinamide
clpC1 4040727 c.-23T>G upstream_gene_variant 0.11 pyrazinamide
clpC1 4040824 c.-120C>T upstream_gene_variant 0.96 pyrazinamide
embC 4239843 c.-20A>C upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4239869 p.Thr3His missense_variant 0.14 ethambutol
embC 4239873 p.Glu4Gly missense_variant 0.13 ethambutol
embC 4239883 c.21A>C synonymous_variant 0.11 ethambutol
embC 4239911 p.Thr17Pro missense_variant 0.2 ethambutol
embC 4240115 p.Thr85Pro missense_variant 0.12 ethambutol
embC 4240368 p.Val169Gly missense_variant 0.17 ethambutol
embC 4240377 p.Val172Gly missense_variant 0.2 ethambutol
embC 4240422 p.Glu187Gly missense_variant 0.13 ethambutol
embC 4240461 p.Val200Gly missense_variant 0.13 ethambutol
embC 4240470 p.Asp203Gly missense_variant 0.12 ethambutol
embC 4240475 p.Ala205Pro missense_variant 0.12 ethambutol
embC 4240583 p.Thr241Pro missense_variant 0.12 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Uncertain significance
embC 4240841 p.Tyr327Asp missense_variant 0.17 ethambutol
embC 4241029 p.Trp389Cys missense_variant 0.14 ethambutol
embC 4241100 p.Val413Gly missense_variant 0.12 ethambutol
embC 4241158 c.1296T>G synonymous_variant 0.13 ethambutol
embC 4241783 p.Trp641Gly missense_variant 0.12 ethambutol
embC 4242288 p.Leu809His missense_variant 0.14 ethambutol
embC 4242363 p.Gly834Ala missense_variant 0.12 ethambutol
embC 4242369 p.Arg836Pro missense_variant 0.18 ethambutol
embC 4242371 p.Ala837Pro missense_variant 0.12 ethambutol
embC 4242380 p.Pro840Ala missense_variant 0.12 ethambutol
embC 4242387 p.Asn842Thr missense_variant 0.19 ethambutol
embC 4242393 p.Asp844Ala missense_variant 0.15 ethambutol
embA 4242406 c.-827A>C upstream_gene_variant 0.2 ethambutol
embA 4242598 c.-635T>G upstream_gene_variant 0.12 ethambutol
embC 4242605 p.Met915Val missense_variant 0.12 ethambutol
embA 4242643 c.-590C>T upstream_gene_variant 1.0 ethambutol
embC 4242853 p.Phe997Leu missense_variant 0.13 ethambutol
embC 4242908 p.Phe1016Val missense_variant 0.12 ethambutol
embA 4243198 c.-35A>C upstream_gene_variant 0.11 ethambutol
embA 4243645 p.Ala138Gly missense_variant 0.14 ethambutol
embA 4243944 p.Thr238Pro missense_variant 0.16 ethambutol
embA 4243993 p.Asp254Ala missense_variant 0.16 ethambutol
embA 4244040 p.Thr270Pro missense_variant 0.15 ethambutol
embA 4244059 p.Tyr276Ser missense_variant 0.18 ethambutol
embA 4244220 c.988C>T synonymous_variant 0.82 ethambutol
embA 4244224 p.Ala331Gly missense_variant 0.12 ethambutol
embA 4244271 p.Leu347Val missense_variant 0.17 ethambutol
embA 4244275 p.Gly348Ala missense_variant 0.13 ethambutol Uncertain significance
embA 4244284 p.Pro351Arg missense_variant 0.25 ethambutol
embA 4244302 p.Asn357Thr missense_variant 0.13 ethambutol
embA 4244319 p.Thr363Pro missense_variant 0.12 ethambutol
embA 4244340 p.Ser370Pro missense_variant 0.13 ethambutol
embA 4244432 p.Ile400Met missense_variant 0.17 ethambutol
embA 4244437 p.Leu402Arg missense_variant 0.15 ethambutol
embA 4244441 c.1209A>C synonymous_variant 0.15 ethambutol
embA 4244469 p.Ile413Leu missense_variant 0.13 ethambutol
embA 4244572 p.Arg447Pro missense_variant 0.15 ethambutol
embA 4244635 p.Val468Ala missense_variant 1.0 ethambutol Uncertain significance
embA 4244638 p.Val469Gly missense_variant 0.17 ethambutol
embA 4245147 p.Pro639Ser missense_variant 1.0 ethambutol Uncertain significance
embA 4245748 p.Val839Gly missense_variant 0.14 ethambutol
embB 4245833 c.-681G>T upstream_gene_variant 0.12 ethambutol
embA 4246423 p.Val1064Gly missense_variant 0.14 ethambutol
embB 4246553 p.Arg14Trp missense_variant 0.15 ethambutol
embB 4246665 p.Gln51Pro missense_variant 0.17 ethambutol Uncertain significance
embB 4247028 p.Leu172Pro missense_variant 0.13 ethambutol
embB 4247046 p.Asp178Ala missense_variant 0.11 ethambutol
embB 4247076 p.Val188Gly missense_variant 0.13 ethambutol
embB 4247081 p.Thr190Pro missense_variant 0.12 ethambutol
embB 4247646 p.Glu378Ala missense_variant 0.94 ethambutol Uncertain significance
embB 4247666 p.Trp385Arg missense_variant 0.15 ethambutol
embB 4247673 p.Ala387Gly missense_variant 0.19 ethambutol
embB 4247682 p.Val390Gly missense_variant 0.15 ethambutol
embB 4247754 p.Val414Gly missense_variant 0.15 ethambutol Uncertain significance
embB 4247844 p.Val444Gly missense_variant 0.11 ethambutol
embB 4247906 p.Ile465Val missense_variant 0.17 ethambutol
embB 4248029 p.Thr506Pro missense_variant 0.12 ethambutol
embB 4248281 p.Thr590Pro missense_variant 0.12 ethambutol
embB 4248297 p.His595Pro missense_variant 0.11 ethambutol
embB 4248663 p.Val717Gly missense_variant 0.16 ethambutol
embB 4249359 p.Val949Gly missense_variant 0.12 ethambutol
embB 4249482 p.Val990Gly missense_variant 0.12 ethambutol
aftB 4267782 p.Val352Gly missense_variant 0.11 capreomycin
amikacin Uncertain significance
aftB 4267935 p.Val301Gly missense_variant 0.14 capreomycin
amikacin
aftB 4267940 c.897T>G synonymous_variant 0.13 capreomycin
amikacin
aftB 4267947 p.Asp297Ala missense_variant 0.15 capreomycin
amikacin
aftB 4268360 c.477A>C synonymous_variant 0.15 capreomycin
amikacin
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Uncertain significance
ubiA 4269575 p.Lys87Gln missense_variant 0.14 ethambutol
aftB 4269606 c.-770T>C upstream_gene_variant 1.0 capreomycin
amikacin
ubiA 4269899 c.-66A>C upstream_gene_variant 0.13 ethambutol
ubiA 4269915 c.-82T>G upstream_gene_variant 0.13 ethambutol
ubiA 4269976 c.-143C>G upstream_gene_variant 0.12 ethambutol
ubiA 4269979 c.-146T>G upstream_gene_variant 0.27 ethambutol
ubiA 4269985 c.-152T>G upstream_gene_variant 0.14 ethambutol
ethR 4326928 c.-621G>A upstream_gene_variant 1.0 ethionamide
ethA 4327103 p.Gly124Asp missense_variant 1.0 ethionamide Uncertain significance
ethR 4327768 p.Thr74Pro missense_variant 0.15 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 streptomycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin
gid 4407983 p.Leu74Val missense_variant 0.11 streptomycin
gid 4408271 c.-69A>C upstream_gene_variant 0.12 streptomycin