TB-Profiler result

Run: ERR12328189
Summary

Run ID: ERR12328189

Sample name:

Date: 12-03-2024 16:25:00

Number of reads: 2310762

Percentage reads mapped: 98.57

Strain: lineage2.2.1

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764896 c.1527C>T synonymous_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 801357 c.549T>C synonymous_variant 0.11
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471996 n.151C>T non_coding_transcript_exon_variant 0.17
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.14
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.12
rrs 1472032 n.187G>C non_coding_transcript_exon_variant 0.12
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.24
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.13
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.12
rpsA 1834177 c.636A>C synonymous_variant 1.0
rpsA 1834845 c.1313_1315delCCG disruptive_inframe_deletion 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2169023 c.1590G>A synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2517989 c.-126T>C upstream_gene_variant 0.13
kasA 2518248 p.Ala45Val missense_variant 0.12
kasA 2518255 c.141A>G synonymous_variant 0.12
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.99
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
rpoA 3877737 c.771G>C synonymous_variant 0.14
rpoA 3877770 c.738A>G synonymous_variant 0.14
rpoA 3877776 c.732T>C synonymous_variant 0.14
rpoA 3877782 c.726T>C synonymous_variant 0.16
rpoA 3877788 c.720G>A synonymous_variant 0.15
rpoA 3878205 c.303T>C synonymous_variant 0.12
rpoA 3878226 c.282C>G synonymous_variant 0.12
rpoA 3878229 c.279C>G synonymous_variant 0.16
rpoA 3878241 c.267G>A synonymous_variant 0.15
rpoA 3878271 c.237T>C synonymous_variant 0.16
rpoA 3878276 c.232C>T synonymous_variant 0.14
rpoA 3878283 p.Glu75Asp missense_variant 0.14
rpoA 3878304 c.204G>C synonymous_variant 0.12
rpoA 3878313 c.195G>C synonymous_variant 0.12
rpoA 3878322 c.186A>G synonymous_variant 0.12
clpC1 4038790 c.1915C>T synonymous_variant 0.13
clpC1 4038812 c.1893T>C synonymous_variant 0.16
clpC1 4038845 c.1860G>C synonymous_variant 0.16
clpC1 4038848 c.1857C>T synonymous_variant 0.16
clpC1 4038863 c.1842G>C synonymous_variant 0.17
clpC1 4038878 c.1827A>G synonymous_variant 0.16
clpC1 4038881 c.1824C>T synonymous_variant 0.15
clpC1 4038923 c.1782A>G synonymous_variant 0.11
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.99
aftB 4267647 p.Asp397Gly missense_variant 1.0
ethA 4326676 p.Ser266Arg missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407595 p.Val203Gly missense_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0