TB-Profiler result

Run: ERR4797122
Summary

Run ID: ERR4797122

Sample name:

Date: 2024-10-03T23:53:47.236547

Number of reads: 117190119

Percentage reads mapped: 99.4

Median coverage: 2011.5

Strain: lineage1.2.2.2

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.2 Indo-Oceanic RD239 0.97
lineage1.2.2.2 Indo-Oceanic RD239 0.97
lineage1 Indo-Oceanic RD239 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5075 c.-165C>T upstream_gene_variant 0.97 levofloxacin
moxifloxacin
gyrB 6112 p.Met291Ile missense_variant 0.97 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8452 p.Ala384Val missense_variant 0.97 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9143 c.1842T>C synonymous_variant 0.97 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 0.97 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 0.86 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 0.9 isoniazid Not assoc w R
Rv0010c 13699 c.-141A>G upstream_gene_variant 0.97 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 0.97 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 576108 p.Ala254Gly missense_variant 0.22 isoniazid
ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.97 ethionamide
nusG 734116 c.-138T>C upstream_gene_variant 0.97 rifampicin Not assoc w R
nusG 734754 c.501G>C synonymous_variant 0.96 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 0.97 rifampicin Not assoc w R
rpoC 763884 p.Ala172Val missense_variant 0.97 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.97 rifampicin Not assoc w R
rpoC 767011 c.3642G>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 0.96 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 777598 c.883C>A synonymous_variant 0.98 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800357 c.-452C>A upstream_gene_variant 0.98 linezolid Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.97 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
embR 1417019 p.Cys110Tyr missense_variant 0.97 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 0.96 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 0.97 ethambutol
rrs 1471506 n.-340G>A upstream_gene_variant 0.97 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrl 1474687 n.1030C>T non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
tsnR 1853974 c.369C>T synonymous_variant 0.98 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 0.97 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
bacA 2064486 c.243A>G synonymous_variant 0.96 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 0.98 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.98 pyrazinamide Not assoc w R
PPE35 2168742 p.Gly624Asp missense_variant 0.97 pyrazinamide Uncertain significance
PPE35 2170065 p.Ala183Gly missense_variant 0.23 pyrazinamide
Rv1979c 2221725 c.1440T>G synonymous_variant 0.97 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
Rv1979c 2222308 p.Asp286Gly missense_variant 0.96 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223553 c.-389C>A upstream_gene_variant 0.97 bedaquiline Uncertain significance
clofazimine Not assoc w R
kasA 2518132 c.18C>T synonymous_variant 0.97 isoniazid
eis 2714152 p.Val394Ala missense_variant 0.98 kanamycin
amikacin
ahpC 2726051 c.-142G>A upstream_gene_variant 0.97 isoniazid
Rv2477c 2783932 c.111C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3064889 p.Lys435Glu missense_variant 0.97 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Uncertain significance
thyA 3074422 p.Pro17Leu missense_variant 0.97 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 0.97 ethionamide Uncertain significance
lpqB 3624486 p.Asp142Gly missense_variant 0.97 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626467 c.147G>A synonymous_variant 0.97 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
mtrA 3627602 c.-253C>T upstream_gene_variant 0.97 rifampicin Uncertain significance
bedaquiline Uncertain significance
alr 3841546 c.-126C>A upstream_gene_variant 0.88 cycloserine
alr 3841568 c.-148G>A upstream_gene_variant 0.77 cycloserine
alr 3841570 c.-151delA upstream_gene_variant 0.76 cycloserine
alr 3841574 c.-154T>G upstream_gene_variant 0.76 cycloserine
alr 3841578 c.-158G>T upstream_gene_variant 0.75 cycloserine
alr 3841582 c.-162A>G upstream_gene_variant 0.74 cycloserine
alr 3841584 c.-164C>A upstream_gene_variant 0.74 cycloserine
alr 3841589 c.-170delG upstream_gene_variant 0.73 cycloserine
alr 3841612 c.-193_-192insC upstream_gene_variant 0.56 cycloserine
rpoA 3878637 c.-130G>C upstream_gene_variant 0.24 rifampicin
clpC1 4040517 p.Val63Ala missense_variant 0.97 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 0.96 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 0.98 ethambutol Not assoc w R
embC 4241042 p.Asn394Asp missense_variant 0.97 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 0.97 ethambutol Not assoc w R
embB 4246548 p.Pro12Gln missense_variant 0.15 ethambutol Uncertain significance
embB 4246555 c.42G>C synonymous_variant 0.16 ethambutol
embB 4246556 p.Ala15Pro missense_variant 0.15 ethambutol Uncertain significance
embB 4246563 p.Leu17Trp missense_variant 0.13 ethambutol Uncertain significance
embB 4246567 c.54G>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 0.97 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 0.97 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 0.98 ethambutol Not assoc w R
ethA 4326439 p.Asn345Lys missense_variant 0.96 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 0.97 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338635 c.-114A>C upstream_gene_variant 0.97 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 0.98 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 0.97 streptomycin Not assoc w R