TB-Profiler result

Run: ERR4814355
Summary

Run ID: ERR4814355

Sample name:

Date: 20-10-2023 07:31:36

Number of reads: 4436927

Percentage reads mapped: 95.19

Strain: La1.6

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide R pncA p.His57Asp (1.00)
Streptomycin R rrs n.888G>A (0.76)
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
La1 M.bovis None None 1.0
La1.6 M.bovis None None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.76 streptomycin
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5724 p.Ala162Val missense_variant 1.0
gyrB 5752 c.513G>A synonymous_variant 1.0
gyrA 6406 c.-896C>T upstream_gene_variant 1.0
gyrB 6446 p.Ala403Ser missense_variant 1.0
gyrA 7042 c.-260C>T upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8285 c.984C>T synonymous_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9217 p.Asp639Ala missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 0.99
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0
embR 1416489 p.Gln287* stop_gained 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.64
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.69
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.69
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.69
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.79
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.81
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.76
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.73
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.72
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.73
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.73
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.59
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.71
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.57
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.26
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.68
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.26
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.63
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.63
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.56
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.68
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.68
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.72
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.72
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.79
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.17
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.77
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.74
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.47
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.35
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.42
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.47
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.61
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.6
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.57
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.48
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.48
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.58
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.6
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.47
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.47
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.69
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.73
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.72
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.7
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.59
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.65
rpsA 1834859 p.Ala440Thr missense_variant 0.99
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918536 c.597T>C synonymous_variant 1.0
ndh 2103173 c.-132delG upstream_gene_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155503 c.609C>T synonymous_variant 1.0
katG 2156025 c.87C>A synonymous_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168011 p.Ser868Arg missense_variant 1.0
PPE35 2168319 p.Thr765Ile missense_variant 1.0
PPE35 2168814 c.1798dupA frameshift_variant 1.0
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2223062 p.Thr35Ala missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
folC 2746245 p.Ala452Thr missense_variant 1.0
ribD 2987615 c.777A>G stop_lost&splice_region_variant 1.0
ald 3086728 c.-92C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087084 c.266delA frameshift_variant 1.0
Rv3083 3448783 p.Val94Ile missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474427 p.Val141Ile missense_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
clpC1 4038403 c.2302T>C synonymous_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4242970 c.-263C>T upstream_gene_variant 1.0
embA 4243763 c.531G>C synonymous_variant 1.0
embA 4244220 c.988C>T synonymous_variant 1.0
embB 4246551 p.Asn13Ser missense_variant 0.99
embB 4246663 c.150G>A synonymous_variant 1.0
embB 4246864 c.351C>T synonymous_variant 1.0
embB 4246974 p.His154Arg missense_variant 0.99
embB 4247646 p.Glu378Ala missense_variant 1.0
embB 4247791 c.1278C>T synonymous_variant 1.0
aftB 4267858 p.Ile327Val missense_variant 1.0
aftB 4269351 c.-515C>T upstream_gene_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0