TB-Profiler result

Run: SRR1180243
Summary

Run ID: SRR1180243

Sample name:

Date: 03-04-2023 03:56:14

Number of reads: 3094272

Percentage reads mapped: 93.55

Strain: lineage4.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.2 Euro-American H;T;LAM None 1.0
lineage4.2.1 Euro-American (TUR) H3;H4 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761110 p.Asp435Val missense_variant 1.0 rifampicin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.31 streptomycin
rrs 1473246 n.1401A>G non_coding_transcript_exon_variant 0.96 kanamycin, capreomycin, aminoglycosides, amikacin
inhA 1674048 c.-154G>A upstream_gene_variant 1.0 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289213 p.Gln10Pro missense_variant 1.0 pyrazinamide
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
embB 4249583 p.Asp1024Asn missense_variant 1.0 ethambutol
gid 4408100 c.102delG frameshift_variant 0.98 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7581 p.Asp94Arg missense_variant 0.21
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620191 c.303delC frameshift_variant 0.13
rpoB 761707 c.1910_1912dupTCG disruptive_inframe_insertion 0.13
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.14
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.2
rrs 1472122 n.277G>A non_coding_transcript_exon_variant 0.19
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.2
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.23
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.28
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.33
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.31
rrs 1472164 n.319G>A non_coding_transcript_exon_variant 0.36
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.37
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.38
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.33
rrs 1472210 n.365A>C non_coding_transcript_exon_variant 0.27
rrs 1472213 n.368G>C non_coding_transcript_exon_variant 0.27
rrs 1472215 n.370A>G non_coding_transcript_exon_variant 0.27
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.26
rrs 1472234 n.389T>C non_coding_transcript_exon_variant 0.21
rrs 1472236 n.391C>G non_coding_transcript_exon_variant 0.21
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.21
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.17
rrs 1472253 n.408G>T non_coding_transcript_exon_variant 0.14
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.18
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.23
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.23
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.22
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.2
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.21
rrs 1472596 n.751G>T non_coding_transcript_exon_variant 0.19
rrs 1472598 n.753A>T non_coding_transcript_exon_variant 0.19
rrs 1472614 n.769G>T non_coding_transcript_exon_variant 0.17
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.18
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.2
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.22
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.3
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.3
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.33
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.33
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.31
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.26
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.17
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.17
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.22
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.22
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.28
rrl 1475866 n.2209T>A non_coding_transcript_exon_variant 0.17
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.26
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.4
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.45
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.49
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.48
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.53
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.52
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.64
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.64
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.64
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.64
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.58
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.44
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.21
tlyA 1917919 c.-21C>A upstream_gene_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169879 p.Phe245Cys missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518698 p.Cys195Tyr missense_variant 0.15
ald 3086742 c.-78A>C upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3642210 p.Gly226Ser missense_variant 0.4
clpC1 4038857 c.1848C>A synonymous_variant 0.14
embC 4241124 c.1268_1270dupTGC disruptive_inframe_insertion 0.21
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4249594 c.3081G>A synonymous_variant 1.0
ethA 4326113 p.Pro454Leu missense_variant 1.0
ethA 4328376 c.-903G>C upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0