TB-Profiler result

Run: 513a1acf-db2a-4f51-b4e8-8a5bb16e6690
Summary

Run ID: 513a1acf-db2a-4f51-b4e8-8a5bb16e6690

Sample name:

Date: 18-06-2023 16:23:15

Number of reads: 452946

Percentage reads mapped: 13.63

Median coverage: 10

Strain: lineage3

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Gln436Pro Assoc w R - interim
isoniazid
ethambutol embB p.Asn318Ser Uncertain significance
pyrazinamide pncA p.Gly105Arg Uncertain significance
p.Phe58Leu Assoc w R
moxifloxacin
levofloxacin
bedaquiline
delamanid
pretomanid
linezolid
streptomycin
amikacin
kanamycin
capreomycin
clofazimine
ethionamide
para-aminosalicylic_acid
cycloserine
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761113 p.Gln436Pro missense_variant 0.2 rifampicin Assoc w R - interim
pncA 2288929 p.Gly105Arg missense_variant 0.18 pyrazinamide Uncertain significance
pncA 2289070 p.Phe58Leu missense_variant 0.12 pyrazinamide Assoc w R
embB 4247466 p.Asn318Ser missense_variant 0.13 ethambutol Uncertain significance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5283 p.Ala15Gly missense_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 5325 p.Arg29Pro missense_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 5385 p.Val49Ala missense_variant 0.18 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 5712 p.Leu158Pro missense_variant 0.18 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 5796 p.Asp186Gly missense_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 5814 p.Arg192Leu missense_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 5892 p.Val218Ala missense_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 6006 p.Gly256Val missense_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 6315 p.Ser359* stop_gained 0.17 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 6334 c.-968G>T upstream_gene_variant 0.2 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 6515 p.Leu426Met missense_variant 0.18 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 6522 p.Arg428Gln missense_variant 0.18 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 6734 p.Asn499His missense_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 6968 p.Asp577Tyr missense_variant 0.15 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 7017 p.Ala593Val missense_variant 0.17 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrB 7019 p.Gly594Trp missense_variant 0.17 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrB 7108 p.Glu623Asp missense_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7274 c.-28C>A upstream_gene_variant 0.11 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7475 c.174A>C synonymous_variant 0.22 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7857 p.Ala186Thr missense_variant 0.1 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7900 c.601delG frameshift_variant 0.12 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8019 p.Thr240Ala missense_variant 0.14 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8349 p.Asp350His missense_variant 0.17 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 8846 p.Asp515Glu missense_variant 0.2 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 9596 c.2295G>T synonymous_variant 1.0 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 9701 c.2400T>C synonymous_variant 0.18 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
fgd1 490693 c.-90G>T upstream_gene_variant 0.1 delamanid
fgd1 490923 p.Gln47His missense_variant 0.12 delamanid
fgd1 490946 p.Leu55Arg missense_variant 0.13 delamanid
fgd1 491515 p.Asn245Asp missense_variant 0.18 delamanid
fgd1 491656 p.Glu292Gln missense_variant 0.11 delamanid
mshA 575382 p.Leu12Ser missense_variant 0.11 ethionamide
isoniazid Uncertain significance
mshA 575423 p.Arg26Ser missense_variant 0.1 ethionamide
isoniazid
mshA 575478 p.Pro44Gln missense_variant 0.11 ethionamide
isoniazid
mshA 575594 p.Gly83Ser missense_variant 0.12 ethionamide
isoniazid
mshA 575768 p.Ala141Ser missense_variant 0.13 ethionamide
isoniazid
mshA 575787 p.Tyr147Cys missense_variant 0.11 ethionamide
isoniazid
mshA 575844 p.Arg166Leu missense_variant 0.11 ethionamide
isoniazid
mshA 575932 c.587delC frameshift_variant 0.2 ethionamide
isoniazid
mshA 576165 p.Arg273Pro missense_variant 0.17 ethionamide
isoniazid
mshA 576190 p.Asp281Glu missense_variant 0.14 ethionamide
isoniazid
mshA 576198 p.Leu284Pro missense_variant 0.14 ethionamide
isoniazid
mshA 576393 p.Pro349Gln missense_variant 0.15 ethionamide
isoniazid
mshA 576469 c.1122G>T synonymous_variant 0.13 ethionamide
isoniazid
ccsA 619786 c.-105G>T upstream_gene_variant 0.17 capreomycin
amikacin
ccsA 619846 c.-45C>A upstream_gene_variant 0.11 capreomycin
amikacin
ccsA 619882 c.-9G>C upstream_gene_variant 0.2 capreomycin
amikacin
ccsA 620227 p.Phe113Leu missense_variant 0.14 capreomycin
amikacin
ccsA 620825 p.Leu312Pro missense_variant 0.14 capreomycin
amikacin
rpoB 759867 p.Ser21Pro missense_variant 0.14 rifampicin
rpoB 760152 p.Cys116Arg missense_variant 0.2 rifampicin
rpoB 760462 p.Arg219Leu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760503 p.Lys233Gln missense_variant 0.14 rifampicin
rpoB 761037 c.1231T>C synonymous_variant 0.13 rifampicin
rpoB 761397 p.Asp531Tyr missense_variant 0.2 rifampicin Uncertain significance
rpoB 761744 p.Glu646Asp missense_variant 0.14 rifampicin
rpoB 761767 p.Val654Ala missense_variant 0.12 rifampicin
rpoB 761785 p.Thr660Ser missense_variant 0.2 rifampicin
rpoB 761862 p.Ala686Pro missense_variant 0.17 rifampicin
rpoB 761907 p.Cys701Gly missense_variant 0.13 rifampicin
rpoB 762131 c.2325C>A synonymous_variant 0.2 rifampicin
rpoB 762213 p.Lys803Gln missense_variant 0.11 rifampicin
rpoB 762265 c.2460delT frameshift_variant 0.2 rifampicin
rpoB 762295 p.Ser830Trp missense_variant 0.12 rifampicin
rpoB 762324 p.Lys840Gln missense_variant 0.12 rifampicin
rpoB 762351 p.Arg849Ser missense_variant 0.1 rifampicin
rpoC 762434 c.-936T>G upstream_gene_variant 1.0 rifampicin
rpoB 762549 p.Gly915Cys missense_variant 0.2 rifampicin
rpoB 762655 p.Ala950Asp missense_variant 0.18 rifampicin
rpoB 762846 p.Pro1014Thr missense_variant 0.11 rifampicin
rpoC 762959 c.-411G>T upstream_gene_variant 0.12 rifampicin
rpoB 762986 p.Gln1060His missense_variant 0.12 rifampicin
rpoC 763975 p.Glu202Asp missense_variant 0.17 rifampicin
rpoC 764181 p.Asp271Gly missense_variant 1.0 rifampicin Uncertain significance
rpoC 764239 c.870T>C synonymous_variant 0.14 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin
rpoC 764583 p.Leu405Arg missense_variant 0.12 rifampicin
rpoC 764649 p.Arg427Pro missense_variant 0.1 rifampicin
rpoC 764654 p.Val429Phe missense_variant 0.11 rifampicin
rpoC 765146 p.Pro593Thr missense_variant 0.15 rifampicin
rpoC 765269 p.Lys634Gln missense_variant 0.12 rifampicin
rpoC 765358 p.Met663Ile missense_variant 0.13 rifampicin Uncertain significance
rpoC 765367 c.1998C>G synonymous_variant 0.13 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.18 rifampicin
rpoC 765993 p.Arg875Pro missense_variant 0.11 rifampicin
rpoC 766067 p.Glu900* stop_gained 0.1 rifampicin
rpoC 767123 p.Val1252Leu missense_variant 0.15 rifampicin
rpoC 767297 p.Tyr1310His missense_variant 0.18 rifampicin
mmpL5 776173 p.Asp770Asn missense_variant 0.17 clofazimine
bedaquiline
mmpL5 776326 p.Ile719Leu missense_variant 0.17 clofazimine
bedaquiline
mmpL5 776874 p.Met536Lys missense_variant 0.2 clofazimine
bedaquiline
mmpL5 778015 p.Asn156Asp missense_variant 0.12 clofazimine
bedaquiline
mmpL5 778063 p.Gln140Lys missense_variant 0.15 clofazimine
bedaquiline
mmpL5 778376 p.Ile35Met missense_variant 0.2 clofazimine
bedaquiline
mmpR5 778460 c.-530A>G upstream_gene_variant 0.2 clofazimine
bedaquiline
mmpL5 778474 p.Val3Leu missense_variant 0.12 clofazimine
bedaquiline
mmpS5 778536 p.Asp124His missense_variant 0.17 clofazimine
bedaquiline
mmpS5 778656 p.Ala84Thr missense_variant 0.14 clofazimine
bedaquiline
mmpS5 778748 p.Pro53His missense_variant 0.17 clofazimine
bedaquiline
mmpS5 778790 p.Val39Ala missense_variant 0.17 clofazimine
bedaquiline
mmpS5 778847 p.Ile20Asn missense_variant 0.2 clofazimine
bedaquiline
mmpR5 779204 p.Arg72Pro missense_variant 0.2 clofazimine
bedaquiline
mmpR5 779222 p.Gly78Val missense_variant 0.18 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Uncertain significance
rpsL 781665 p.Arg36Ser missense_variant 0.2 streptomycin
rpsL 781874 p.Gln105His missense_variant 0.2 streptomycin
fbiC 1302917 c.-14G>C upstream_gene_variant 0.15 delamanid
fbiC 1303216 c.286C>A synonymous_variant 0.15 delamanid
fbiC 1303314 p.Ile128Met missense_variant 0.17 delamanid
fbiC 1303425 c.495G>T synonymous_variant 0.17 delamanid
fbiC 1304334 p.Ser468Arg missense_variant 0.13 delamanid
fbiC 1304366 p.Gln479Arg missense_variant 0.14 delamanid
Rv1258c 1406250 p.Leu364Pro missense_variant 0.12 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406259 p.Pro361Gln missense_variant 0.11 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406330 p.Gln337His missense_variant 0.11 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406722 p.Gly207Trp missense_variant 0.14 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406933 c.408C>A synonymous_variant 0.17 streptomycin
pyrazinamide
isoniazid
Rv1258c 1406954 c.387C>A synonymous_variant 0.17 streptomycin
pyrazinamide
isoniazid
embR 1416437 p.Gln304Pro missense_variant 0.11 ethambutol
embR 1416927 p.Ala141Thr missense_variant 0.18 ethambutol
embR 1416935 p.Leu138Arg missense_variant 0.14 ethambutol
embR 1417225 p.Met41Ile missense_variant 0.17 ethambutol
atpE 1461200 c.156G>A synonymous_variant 0.1 bedaquiline
atpE 1461253 p.Phe70Ser missense_variant 0.11 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1471874 n.29A>G non_coding_transcript_exon_variant 0.2 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1471891 n.46C>A non_coding_transcript_exon_variant 0.2 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472018 n.173G>T non_coding_transcript_exon_variant 0.17 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472251 n.406G>T non_coding_transcript_exon_variant 0.17 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472494 n.649A>C non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472501 n.656G>T non_coding_transcript_exon_variant 0.14 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472865 n.1020C>G non_coding_transcript_exon_variant 0.17 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472896 n.1051T>C non_coding_transcript_exon_variant 0.1 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrl 1475271 n.1614A>G non_coding_transcript_exon_variant 0.2 linezolid
rrl 1475413 n.1756A>G non_coding_transcript_exon_variant 0.2 linezolid
rrl 1475463 n.1806A>C non_coding_transcript_exon_variant 0.12 linezolid
rrl 1475677 n.2020A>G non_coding_transcript_exon_variant 0.2 linezolid
rrl 1475846 n.2189T>C non_coding_transcript_exon_variant 0.17 linezolid
rrl 1476564 n.2907G>C non_coding_transcript_exon_variant 0.18 linezolid
fabG1 1673217 c.-223A>C upstream_gene_variant 0.36 ethionamide
isoniazid
fabG1 1673620 p.Asp61His missense_variant 0.11 ethionamide
isoniazid
inhA 1674502 p.Thr101Ala missense_variant 0.14 ethionamide
isoniazid
inhA 1674520 p.Pro107Thr missense_variant 0.17 ethionamide
isoniazid
inhA 1674568 p.Ser123Pro missense_variant 0.2 ethionamide
isoniazid
inhA 1674646 p.Phe149Leu missense_variant 0.14 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.1 ethionamide
isoniazid
inhA 1674737 p.Ala179Val missense_variant 0.1 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.13 ethionamide
isoniazid
rpsA 1833461 c.-80_-78delCCA upstream_gene_variant 0.2 pyrazinamide
rpsA 1833643 p.Asn34Lys missense_variant 0.11 pyrazinamide
rpsA 1833686 p.Asp49His missense_variant 0.18 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834636 c.1095C>G synonymous_variant 0.13 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin
tlyA 1918118 p.Arg60Pro missense_variant 0.2 capreomycin
tlyA 1918489 p.Gln184Lys missense_variant 0.2 capreomycin
tlyA 1918525 p.Gly196Trp missense_variant 0.14 capreomycin
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Uncertain significance
katG 2155034 p.Gly360Cys missense_variant 0.15 isoniazid
katG 2155293 c.819T>C synonymous_variant 0.15 isoniazid
katG 2155427 p.Tyr229Asp missense_variant 0.2 isoniazid
katG 2155476 c.636T>C synonymous_variant 0.2 isoniazid
katG 2156396 c.-285C>A upstream_gene_variant 0.17 isoniazid
katG 2156406 c.-295C>A upstream_gene_variant 0.12 isoniazid
katG 2156521 c.-410C>G upstream_gene_variant 0.15 isoniazid
PPE35 2169777 p.Phe279Cys missense_variant 0.18 pyrazinamide
PPE35 2169894 p.Gly240Asp missense_variant 0.2 pyrazinamide
PPE35 2170354 p.Ala87Pro missense_variant 0.2 pyrazinamide
PPE35 2170509 p.Ala35Glu missense_variant 0.15 pyrazinamide
PPE35 2170542 p.Met24Arg missense_variant 0.14 pyrazinamide
PPE35 2170577 c.36G>C synonymous_variant 0.18 pyrazinamide
PPE35 2170769 c.-157C>T upstream_gene_variant 1.0 pyrazinamide
PPE35 2170784 c.-172A>G upstream_gene_variant 0.12 pyrazinamide
Rv1979c 2221747 p.Arg473Leu missense_variant 0.12 clofazimine
bedaquiline
Rv1979c 2221771 p.Leu465Gln missense_variant 0.13 clofazimine
bedaquiline
Rv1979c 2221876 p.Val430Gly missense_variant 0.1 clofazimine
bedaquiline
Rv1979c 2221972 p.Arg398Lys missense_variant 0.15 clofazimine
bedaquiline
Rv1979c 2222096 p.Ala357Ser missense_variant 0.17 clofazimine
bedaquiline
Rv1979c 2222102 p.Ile355Val missense_variant 0.17 clofazimine
bedaquiline
Rv1979c 2222115 p.Met350Ile missense_variant 0.17 clofazimine
bedaquiline
Rv1979c 2222318 p.Ala283Ser missense_variant 0.14 clofazimine
bedaquiline
Rv1979c 2222394 c.771G>T synonymous_variant 0.11 clofazimine
bedaquiline
Rv1979c 2222510 p.Ser219Pro missense_variant 0.11 clofazimine
bedaquiline
Rv1979c 2222617 p.Trp183Leu missense_variant 0.17 clofazimine
bedaquiline
Rv1979c 2222650 p.Phe172Ser missense_variant 0.17 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223319 c.-155C>A upstream_gene_variant 0.14 clofazimine
bedaquiline
Rv1979c 2223350 c.-186T>G upstream_gene_variant 0.17 clofazimine Uncertain significance
bedaquiline
pncA 2288810 p.Glu144Asp missense_variant 0.12 pyrazinamide
pncA 2288898 p.Pro115Gln missense_variant 0.17 pyrazinamide
pncA 2288964 p.Val93Gly missense_variant 0.17 pyrazinamide
pncA 2289003 p.Asp80Gly missense_variant 0.17 pyrazinamide
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide
pncA 2289157 p.Arg29Cys missense_variant 0.12 pyrazinamide
pncA 2289501 c.-260G>C upstream_gene_variant 0.17 pyrazinamide
pncA 2289823 c.-582T>G upstream_gene_variant 0.2 pyrazinamide
pncA 2290194 c.-953G>C upstream_gene_variant 0.18 pyrazinamide
kasA 2518003 c.-112A>C upstream_gene_variant 0.11 isoniazid
kasA 2518069 c.-46C>A upstream_gene_variant 0.2 isoniazid
kasA 2518781 p.Pro223Thr missense_variant 0.18 isoniazid
kasA 2518854 p.Leu247Arg missense_variant 0.2 isoniazid
kasA 2518883 p.Arg257Ser missense_variant 0.17 isoniazid
kasA 2519035 p.His307Gln missense_variant 0.13 isoniazid
eis 2714132 p.Glu401* stop_gained 0.18 kanamycin
amikacin
eis 2714743 p.Trp197Leu missense_variant 0.15 kanamycin
amikacin
eis 2715091 p.Gly81Val missense_variant 0.2 kanamycin
amikacin
ahpC 2725937 c.-256T>C upstream_gene_variant 0.14 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Uncertain significance
ahpC 2726182 c.-11T>G upstream_gene_variant 0.12 isoniazid
ahpC 2726223 p.Pro11Thr missense_variant 0.15 isoniazid
ahpC 2726671 p.Glu160Gly missense_variant 0.17 isoniazid
ahpC 2726717 c.525A>C synonymous_variant 0.2 isoniazid
folC 2746139 p.Gln487Arg missense_variant 0.12 para-aminosalicylic_acid
folC 2746147 c.1452T>G synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746370 p.Arg410Leu missense_variant 0.12 para-aminosalicylic_acid
folC 2746375 c.1224G>T synonymous_variant 0.11 para-aminosalicylic_acid
folC 2746997 p.His201Pro missense_variant 0.15 para-aminosalicylic_acid
folC 2747057 p.Trp181Leu missense_variant 0.12 para-aminosalicylic_acid
folC 2747091 p.Val170Leu missense_variant 0.17 para-aminosalicylic_acid
pepQ 2859682 p.Gln246Arg missense_variant 0.15 clofazimine
bedaquiline
pepQ 2859854 p.Ser189Ala missense_variant 0.18 clofazimine
bedaquiline
pepQ 2859962 p.Ala153Ser missense_variant 0.17 clofazimine
bedaquiline
pepQ 2860007 p.Gly138Arg missense_variant 0.2 clofazimine
bedaquiline
pepQ 2860010 p.Ala137Ser missense_variant 0.2 clofazimine Uncertain significance
bedaquiline Uncertain significance
pepQ 2860317 c.102A>C synonymous_variant 0.1 clofazimine
bedaquiline
pepQ 2860373 p.Ala16Ser missense_variant 0.11 clofazimine
bedaquiline
ribD 2986797 c.-42C>A upstream_gene_variant 0.18 para-aminosalicylic_acid
Rv2752c 3065140 p.Val351Gly missense_variant 0.12 rifampicin
isoniazid
Rv2752c 3065176 p.Ser339Leu missense_variant 0.1 rifampicin
isoniazid
Rv2752c 3065179 p.Ser338Leu missense_variant 0.11 rifampicin
isoniazid
Rv2752c 3065230 p.Gly321Val missense_variant 0.12 rifampicin
isoniazid
Rv2752c 3065317 p.Ala292Val missense_variant 0.18 rifampicin
isoniazid Uncertain significance
Rv2752c 3065413 p.Ser260Trp missense_variant 0.18 rifampicin
isoniazid
Rv2752c 3065491 p.Ile234Arg missense_variant 0.2 rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065566 p.Pro209His missense_variant 0.11 rifampicin
isoniazid
Rv2752c 3065574 c.618C>G synonymous_variant 0.11 rifampicin
isoniazid
Rv2752c 3066189 c.2delT frameshift_variant 0.17 rifampicin
isoniazid
Rv2752c 3066358 c.-167G>C upstream_gene_variant 0.18 rifampicin
isoniazid
Rv2752c 3067059 c.-868G>C upstream_gene_variant 0.2 rifampicin
isoniazid
thyX 3067466 c.480G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073688 p.Ala262Pro missense_variant 0.14 para-aminosalicylic_acid
thyA 3073750 p.Tyr241Cys missense_variant 0.13 para-aminosalicylic_acid
thyA 3073792 p.Tyr227Ser missense_variant 0.17 para-aminosalicylic_acid
thyA 3073973 p.Ser167Arg missense_variant 0.17 para-aminosalicylic_acid
thyA 3074015 p.Tyr153His missense_variant 0.17 para-aminosalicylic_acid
thyA 3074165 p.Ala103Ser missense_variant 0.11 para-aminosalicylic_acid
thyA 3074199 c.273G>T synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3074233 p.Trp80Leu missense_variant 0.15 para-aminosalicylic_acid
thyA 3074473 c.-2T>A upstream_gene_variant 0.15 para-aminosalicylic_acid
thyA 3074520 c.-49G>T upstream_gene_variant 0.15 para-aminosalicylic_acid
thyA 3074631 c.-160T>G upstream_gene_variant 0.2 para-aminosalicylic_acid
ald 3087034 p.Leu72Pro missense_variant 0.11 cycloserine
ald 3087100 p.Phe94Ser missense_variant 0.17 cycloserine
ald 3087175 p.Thr119Ile missense_variant 0.2 cycloserine
ald 3087204 p.Leu129Met missense_variant 0.18 cycloserine
ald 3087770 c.951G>C synonymous_variant 0.15 cycloserine
ald 3087809 c.990G>T synonymous_variant 0.14 cycloserine
fbiD 3338932 c.-186A>G upstream_gene_variant 0.15 delamanid
fbiD 3339066 c.-52C>A upstream_gene_variant 0.17 delamanid
fbiD 3339295 p.Thr60Ala missense_variant 0.17 delamanid
fbiD 3339397 p.Thr94Pro missense_variant 0.2 delamanid
fbiD 3339483 c.366A>C synonymous_variant 0.12 delamanid
fbiD 3339727 p.Gly204Trp missense_variant 0.11 delamanid
fbiD 3339732 c.615C>A synonymous_variant 0.12 delamanid
Rv3083 3448305 c.-199T>C upstream_gene_variant 0.15 ethionamide
Rv3083 3448944 c.441G>T synonymous_variant 0.15 ethionamide
Rv3083 3448958 p.Asp152Gly missense_variant 0.13 ethionamide
Rv3083 3448964 p.Pro154Leu missense_variant 0.12 ethionamide
Rv3083 3449488 p.Ile329Leu missense_variant 0.17 ethionamide
Rv3083 3449571 p.Met356Ile missense_variant 0.14 ethionamide
fprA 3473875 c.-132G>T upstream_gene_variant 0.2 capreomycin
amikacin
fprA 3473899 c.-108C>T upstream_gene_variant 0.17 capreomycin
amikacin
fprA 3475140 c.1134C>A synonymous_variant 0.12 capreomycin
amikacin
whiB7 3568650 c.30C>A synonymous_variant 0.2 streptomycin
kanamycin
amikacin
whiB7 3568660 p.Pro7His missense_variant 0.2 streptomycin
kanamycin
amikacin
Rv3236c 3612345 c.772C>A synonymous_variant 0.13 pyrazinamide
Rv3236c 3612615 p.Leu168Met missense_variant 0.2 pyrazinamide
Rv3236c 3613127 c.-11G>T upstream_gene_variant 0.17 pyrazinamide
Rv3236c 3613161 c.-45A>C upstream_gene_variant 0.15 pyrazinamide
Rv3236c 3613201 c.-86delG upstream_gene_variant 0.2 pyrazinamide
Rv3236c 3613212 c.-96C>A upstream_gene_variant 0.17 pyrazinamide
fbiA 3640564 p.Gly8Arg missense_variant 0.17 delamanid
fbiA 3641363 p.Arg274Pro missense_variant 0.11 delamanid
fbiA 3641465 p.Leu308Arg missense_variant 0.1 delamanid
fbiA 3641525 p.Gly328Val missense_variant 0.2 delamanid
fbiB 3642623 c.1089C>A synonymous_variant 0.18 delamanid
fbiB 3642749 c.1215T>G synonymous_variant 0.15 delamanid
fbiB 3642764 p.Asp410Glu missense_variant 0.15 delamanid
fbiB 3642777 p.Pro415Ser missense_variant 0.15 delamanid
alr 3840407 c.1014G>T synonymous_variant 0.12 cycloserine
alr 3840455 c.966G>T synonymous_variant 0.11 cycloserine
alr 3840497 c.924G>T synonymous_variant 0.12 cycloserine
alr 3840501 p.Leu307Pro missense_variant 0.12 cycloserine
alr 3840586 p.Cys279Gly missense_variant 0.12 cycloserine
alr 3840666 p.Arg252Gln missense_variant 0.18 cycloserine
alr 3840817 p.Lys202Glu missense_variant 0.17 cycloserine
alr 3841194 p.Arg76Pro missense_variant 0.15 cycloserine
alr 3841250 c.171C>A synonymous_variant 0.2 cycloserine
alr 3841335 p.Ser29Cys missense_variant 0.12 cycloserine
alr 3841338 p.Ile28Arg missense_variant 0.12 cycloserine
alr 3841448 c.-28A>C upstream_gene_variant 0.13 cycloserine
rpoA 3877933 p.Leu192Pro missense_variant 0.12 rifampicin
ddn 3986737 c.-107G>T upstream_gene_variant 0.18 delamanid
ddn 3986752 c.-92C>A upstream_gene_variant 0.18 delamanid
ddn 3986777 c.-67C>G upstream_gene_variant 0.18 delamanid
ddn 3987200 c.357C>G synonymous_variant 0.14 delamanid
ddn 3987229 p.Met129Arg missense_variant 0.12 delamanid
clpC1 4038185 c.2520G>T synonymous_variant 0.14 pyrazinamide
clpC1 4038207 c.2497delG frameshift_variant 0.17 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039987 p.Glu240* stop_gained 0.11 pyrazinamide
clpC1 4039990 p.Pro239Ser missense_variant 0.11 pyrazinamide
clpC1 4040011 p.Ala232Ser missense_variant 0.12 pyrazinamide
clpC1 4040741 c.-37G>C upstream_gene_variant 0.2 pyrazinamide
panD 4043887 p.Leu132Pro missense_variant 0.18 pyrazinamide Uncertain significance
panD 4044260 p.Ser8Pro missense_variant 0.2 pyrazinamide
panD 4044426 c.-145T>G upstream_gene_variant 0.18 pyrazinamide
embC 4240076 p.Ala72Thr missense_variant 0.2 ethambutol
embC 4240322 p.Arg154Gly missense_variant 0.2 ethambutol
embC 4240374 p.Leu171Gln missense_variant 0.18 ethambutol
embC 4240572 p.Gly237Val missense_variant 0.14 ethambutol
embC 4240586 p.Gly242Arg missense_variant 0.17 ethambutol
embC 4240709 p.Trp283Gly missense_variant 0.15 ethambutol
embC 4240755 p.Leu298Pro missense_variant 0.2 ethambutol
embC 4240862 p.Trp334Val missense_variant 0.2 ethambutol
embC 4240903 c.1041C>A synonymous_variant 0.22 ethambutol
embC 4241034 p.Pro391Gln missense_variant 0.17 ethambutol
embC 4241462 p.Arg534Gly missense_variant 0.13 ethambutol
embC 4241654 p.Gly598Arg missense_variant 0.18 ethambutol
embC 4241809 c.1947A>C synonymous_variant 0.18 ethambutol
embC 4241982 p.Pro707Gln missense_variant 0.11 ethambutol
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Uncertain significance
embC 4242151 c.2289A>C synonymous_variant 0.15 ethambutol
embC 4242189 p.Ala776Gly missense_variant 0.15 ethambutol
embA 4242445 c.-788C>G upstream_gene_variant 0.25 ethambutol
embC 4242747 p.Pro962Arg missense_variant 0.12 ethambutol
embC 4242837 p.Pro992His missense_variant 0.11 ethambutol
embC 4242843 p.Gln994Pro missense_variant 0.14 ethambutol
embA 4243832 c.600C>G synonymous_variant 0.2 ethambutol
embA 4243948 p.Arg239Pro missense_variant 0.17 ethambutol
embA 4244151 p.Tyr307Asp missense_variant 0.2 ethambutol
embA 4244396 c.1164T>G synonymous_variant 0.14 ethambutol
embA 4244428 p.Ser399* stop_gained 0.17 ethambutol
embA 4244689 p.Lys486Arg missense_variant 0.15 ethambutol
embA 4244761 p.Asn510Ser missense_variant 0.17 ethambutol
embA 4245255 p.Glu675Gln missense_variant 0.2 ethambutol
embA 4245291 p.Ser687Ala missense_variant 0.12 ethambutol
embB 4246178 c.-336G>T upstream_gene_variant 0.17 ethambutol
embB 4246741 c.228G>T synonymous_variant 0.14 ethambutol
embB 4247548 c.1035C>T synonymous_variant 0.2 ethambutol
embB 4247577 p.Leu355Pro missense_variant 0.18 ethambutol
embB 4247637 c.1126delG frameshift_variant 0.18 ethambutol
embB 4248013 c.1500A>C synonymous_variant 0.11 ethambutol
embB 4248016 c.1503G>T synonymous_variant 0.12 ethambutol
embB 4248884 p.Asn791Asp missense_variant 0.18 ethambutol
aftB 4267619 c.1218C>G synonymous_variant 0.2 capreomycin
amikacin
aftB 4268138 c.699A>C synonymous_variant 0.18 capreomycin
amikacin
aftB 4268207 c.630C>G synonymous_variant 0.15 capreomycin
amikacin
aftB 4268335 p.Ser168Gly missense_variant 0.14 capreomycin
amikacin
ubiA 4269130 p.Leu235Pro missense_variant 0.14 ethambutol
aftB 4269132 c.-296G>C upstream_gene_variant 0.12 capreomycin
amikacin
aftB 4269150 c.-314G>T upstream_gene_variant 0.1 capreomycin
amikacin
ethA 4326090 p.Leu462Ile missense_variant 0.12 ethionamide
ethA 4326608 p.Trp289Leu missense_variant 0.2 ethionamide
ethA 4326816 p.Gly220Cys missense_variant 0.12 ethionamide
ethA 4326971 p.Pro168Leu missense_variant 0.12 ethionamide
ethA 4327524 c.-51A>G upstream_gene_variant 0.18 ethionamide
ethA 4327538 c.-65T>G upstream_gene_variant 0.15 ethionamide
ethR 4327612 p.Gly22Arg missense_variant 0.2 ethionamide
ethA 4327656 c.-183A>C upstream_gene_variant 0.14 ethionamide
ethA 4328247 c.-774G>C upstream_gene_variant 0.18 ethionamide
whiB6 4338176 p.Ala116Pro missense_variant 0.17 streptomycin
capreomycin
amikacin
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 streptomycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin
gid 4407693 c.510A>G synonymous_variant 0.11 streptomycin
gid 4407755 p.Met150Leu missense_variant 0.11 streptomycin
gid 4407757 c.445delA frameshift_variant 0.11 streptomycin
gid 4407819 p.Leu128Phe missense_variant 0.1 streptomycin
gid 4407885 c.318A>C synonymous_variant 0.11 streptomycin
gid 4407892 p.Met104Thr missense_variant 0.11 streptomycin
gid 4408199 p.Ser2Pro missense_variant 0.12 streptomycin
gid 4408397 c.-195A>G upstream_gene_variant 0.12 streptomycin