TB-Profiler result

Run: ERR036191
Summary

Run ID: ERR036191

Sample name:

Date: 31-03-2023 08:28:58

Number of reads: 7597878

Percentage reads mapped: 85.48

Strain: lineage4.9.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
lineage4.9.1 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8978 c.1677C>T synonymous_variant 1.0
rpoB 759831 p.Thr9Pro missense_variant 0.27
rpoC 762836 c.-534C>G upstream_gene_variant 0.32
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
atpE 1461019 c.-26C>A upstream_gene_variant 0.19
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.11
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.19
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.19
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.24
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.26
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.26
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.25
rrs 1472338 n.493A>C non_coding_transcript_exon_variant 0.13
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.13
rrs 1472379 n.534T>G non_coding_transcript_exon_variant 0.11
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.11
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.26
rrs 1472779 n.934G>A non_coding_transcript_exon_variant 0.21
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.25
rrs 1472786 n.941C>T non_coding_transcript_exon_variant 0.21
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.18
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.16
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.1
rrs 1472953 n.1108_1109insA non_coding_transcript_exon_variant 0.11
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.14
rrs 1473053 n.1208T>A non_coding_transcript_exon_variant 0.15
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.16
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.16
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.17
rrs 1473070 n.1225G>A non_coding_transcript_exon_variant 0.16
rrs 1473352 n.1507C>T non_coding_transcript_exon_variant 0.11
rrl 1474380 n.723G>T non_coding_transcript_exon_variant 0.31
rrl 1474804 n.1147C>T non_coding_transcript_exon_variant 0.11
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.13
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.14
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.15
rrl 1474844 n.1187G>T non_coding_transcript_exon_variant 0.2
rrl 1474866 n.1209C>A non_coding_transcript_exon_variant 0.19
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.14
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 0.13
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.12
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.19
rrl 1475672 n.2015C>G non_coding_transcript_exon_variant 0.1
rrl 1475673 n.2016T>C non_coding_transcript_exon_variant 0.11
rrl 1475687 n.2030C>T non_coding_transcript_exon_variant 0.17
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.17
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 0.17
rrl 1475707 n.2050T>A non_coding_transcript_exon_variant 0.17
rrl 1475716 n.2059A>G non_coding_transcript_exon_variant 0.17
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.12
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.15
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.26
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.26
rrl 1475843 n.2186G>A non_coding_transcript_exon_variant 0.24
rrl 1475849 n.2192G>A non_coding_transcript_exon_variant 0.23
rrl 1475853 n.2196C>T non_coding_transcript_exon_variant 0.23
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.23
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.17
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.23
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.34
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.38
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.4
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.43
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.43
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.59
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.5
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.5
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.29
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.18
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.1
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.12
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.15
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.16
rrl 1476608 n.2951C>A non_coding_transcript_exon_variant 0.15
rrl 1476614 n.2957A>G non_coding_transcript_exon_variant 0.13
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102891 p.Phe51Ser missense_variant 0.23
PPE35 2169320 p.Leu431Phe missense_variant 0.23
PPE35 2169866 c.747G>C synonymous_variant 0.31
Rv1979c 2223145 p.Arg7Lys missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289138 p.Leu35Arg missense_variant 0.99
pncA 2289448 c.-207G>A upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.29
eis 2715586 c.-254G>C upstream_gene_variant 0.56
Rv2752c 3064552 p.Arg547Pro missense_variant 0.2
Rv2752c 3067191 c.-1000G>A upstream_gene_variant 1.0
thyA 3073806 c.666C>G synonymous_variant 0.29
fbiD 3339385 p.Asp90Asn missense_variant 1.0
fbiD 3339550 p.Gly145Trp missense_variant 0.21
clpC1 4038857 c.1848C>A synonymous_variant 0.17
clpC1 4039932 p.Gly258Val missense_variant 0.24
embC 4239842 c.-21C>A upstream_gene_variant 0.23
embC 4242476 p.Pro872Ala missense_variant 0.25
embC 4242822 p.Val987Gly missense_variant 0.43
ubiA 4269529 p.Ala102Gly missense_variant 0.16
whiB6 4338595 c.-75delG upstream_gene_variant 1.0