TB-Profiler result

Run: SRR13861528
Summary

Run ID: SRR13861528

Sample name:

Date: 03-04-2023 09:34:07

Number of reads: 645150

Percentage reads mapped: 64.58

Strain: lineage4.9

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.16 streptomycin
katG 2154411 c.1700delT frameshift_variant 1.0 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6223 c.984G>C synonymous_variant 0.18
gyrB 6242 p.Arg335Lys missense_variant 0.15
gyrB 6250 c.1011A>G synonymous_variant 0.16
gyrB 6253 c.1014G>C synonymous_variant 0.17
gyrB 6280 c.1041T>C synonymous_variant 0.17
gyrB 6286 c.1047T>C synonymous_variant 0.17
gyrB 6292 c.1053G>C synonymous_variant 0.17
gyrA 7694 c.393A>G synonymous_variant 0.16
gyrA 7697 c.396C>G synonymous_variant 0.16
gyrA 7710 c.409T>C synonymous_variant 0.16
gyrA 7715 c.414G>C synonymous_variant 0.17
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.15
gyrA 7760 c.459C>T synonymous_variant 0.14
gyrA 7949 c.648G>T synonymous_variant 0.93
gyrA 8096 c.795T>C synonymous_variant 0.15
gyrA 8123 p.Leu274Phe missense_variant 0.88
gyrA 8177 c.876A>C synonymous_variant 0.17
gyrA 8264 c.963T>C synonymous_variant 0.14
gyrA 8324 c.1023T>C synonymous_variant 0.15
gyrA 8366 c.1065G>C synonymous_variant 0.17
gyrA 8375 c.1074G>C synonymous_variant 0.14
gyrA 8672 c.1371A>G synonymous_variant 0.2
gyrA 8693 c.1392T>C synonymous_variant 0.2
gyrA 8699 c.1398A>G synonymous_variant 0.19
gyrA 8711 c.1410A>C synonymous_variant 0.19
gyrA 8714 c.1413A>G synonymous_variant 0.2
gyrA 8717 c.1416C>G synonymous_variant 0.2
gyrA 8720 c.1419G>A synonymous_variant 0.2
gyrA 8729 c.1428T>C synonymous_variant 0.21
gyrA 8732 c.1431G>C synonymous_variant 0.22
gyrA 8747 c.1446A>G synonymous_variant 0.21
gyrA 8756 c.1455A>G synonymous_variant 0.17
gyrA 8762 c.1461G>C synonymous_variant 0.18
gyrA 8765 p.Asp488Glu missense_variant 0.17
gyrA 8767 p.Arg489Lys missense_variant 0.17
gyrA 8786 c.1485T>C synonymous_variant 0.14
gyrA 8796 p.Ile499Val missense_variant 0.2
gyrA 8801 c.1500G>C synonymous_variant 0.18
gyrA 8810 c.1509A>C synonymous_variant 0.14
gyrA 8816 c.1515C>T synonymous_variant 0.14
gyrA 8903 c.1602T>C synonymous_variant 0.14
gyrA 9275 c.1974G>A synonymous_variant 0.14
gyrA 9278 c.1977G>C synonymous_variant 0.14
gyrA 9291 c.1990C>T synonymous_variant 0.15
gyrA 9296 c.1995T>C synonymous_variant 0.17
gyrA 9304 p.Gly668Asp missense_variant 0.14
gyrA 9311 c.2010C>T synonymous_variant 0.14
gyrA 9323 c.2022C>G synonymous_variant 0.13
gyrA 9335 c.2034G>C synonymous_variant 0.17
gyrA 9345 c.2044A>C synonymous_variant 0.16
gyrA 9768 p.Gly823Cys missense_variant 1.0
fgd1 491181 c.399T>C synonymous_variant 0.15
fgd1 491191 p.Gly137Arg missense_variant 0.15
fgd1 491194 c.412_414delCTAinsTTG synonymous_variant 0.15
fgd1 491202 c.420G>C synonymous_variant 0.14
fgd1 491212 p.Ser144Arg missense_variant 0.18
fgd1 491217 c.435T>C synonymous_variant 0.18
fgd1 491232 c.450T>C synonymous_variant 0.19
fgd1 491241 p.Asp153Glu missense_variant 0.2
fgd1 491244 c.462T>C synonymous_variant 0.17
fgd1 491259 c.477T>C synonymous_variant 0.21
fgd1 491286 c.504G>C synonymous_variant 0.21
fgd1 491292 c.510G>C synonymous_variant 0.22
fgd1 491295 c.513C>G synonymous_variant 0.21
fgd1 491296 p.Val172Ile missense_variant 0.21
fgd1 491301 c.519C>T synonymous_variant 0.21
fgd1 491319 c.537G>C synonymous_variant 0.17
mshA 575587 c.240C>A synonymous_variant 0.19
mshA 575623 c.276C>G synonymous_variant 0.22
mshA 575629 c.282A>C synonymous_variant 0.24
mshA 575635 c.288A>C synonymous_variant 0.19
mshA 575638 c.291T>C synonymous_variant 0.18
mshA 575641 c.294A>G synonymous_variant 0.17
mshA 575648 p.Val101Gln missense_variant 0.16
mshA 575659 c.312A>G synonymous_variant 0.17
mshA 575695 c.348C>G synonymous_variant 0.18
mshA 575704 c.357T>C synonymous_variant 0.18
mshA 575705 c.358T>C synonymous_variant 0.18
mshA 575713 c.366G>A synonymous_variant 0.18
mshA 575719 c.372C>T synonymous_variant 0.16
mshA 575734 c.387T>G synonymous_variant 0.18
mshA 575737 c.390T>C synonymous_variant 0.22
mshA 575746 c.399C>G synonymous_variant 0.2
mshA 575752 c.405G>A synonymous_variant 0.21
mshA 575767 c.420G>A synonymous_variant 0.14
mshA 575772 p.Val142Ala missense_variant 0.14
ccsA 620703 c.813G>C synonymous_variant 0.17
ccsA 620710 p.Val274Ile missense_variant 0.15
ccsA 620730 c.840C>T synonymous_variant 0.16
rpoB 760724 c.918T>C synonymous_variant 0.14
rpoB 761612 c.1806G>C synonymous_variant 0.15
rpoB 761675 c.1869G>C synonymous_variant 0.17
rpoB 761687 c.1881C>T synonymous_variant 0.16
rpoB 761690 c.1884G>C synonymous_variant 0.16
rpoB 762176 c.2370T>C synonymous_variant 0.16
rpoB 762185 c.2379G>C synonymous_variant 0.17
rpoB 762218 c.2412T>G synonymous_variant 0.19
rpoB 762254 c.2448T>C synonymous_variant 0.15
rpoB 762284 c.2478G>C synonymous_variant 0.14
rpoC 762443 c.-927G>C upstream_gene_variant 0.15
rpoC 762929 c.-441G>C upstream_gene_variant 0.21
rpoC 762989 c.-381G>C upstream_gene_variant 0.28
rpoC 762995 c.-375G>T upstream_gene_variant 0.28
rpoC 763028 c.-342T>C upstream_gene_variant 0.33
rpoC 763031 c.-339T>G upstream_gene_variant 0.29
rpoC 763034 c.-336C>G upstream_gene_variant 0.29
rpoC 763040 c.-330C>G upstream_gene_variant 0.2
rpoC 763070 c.-300T>C upstream_gene_variant 0.33
rpoC 763076 c.-294C>G upstream_gene_variant 0.31
rpoC 763085 c.-285C>G upstream_gene_variant 0.31
rpoC 763115 c.-255T>C upstream_gene_variant 0.28
rpoC 763136 c.-234C>T upstream_gene_variant 0.24
rpoC 763148 c.-222G>C upstream_gene_variant 0.25
rpoC 763158 c.-212C>T upstream_gene_variant 0.17
rpoC 763166 c.-204A>G upstream_gene_variant 0.18
rpoC 763169 c.-201A>G upstream_gene_variant 0.18
rpoC 763411 c.42T>G synonymous_variant 0.15
rpoC 763414 c.45T>C synonymous_variant 0.15
rpoC 763441 c.72C>G synonymous_variant 0.3
rpoC 763444 c.75T>C synonymous_variant 0.3
rpoC 763456 c.87A>G synonymous_variant 0.35
rpoC 763468 c.99G>C synonymous_variant 0.32
rpoC 763486 c.117T>C synonymous_variant 0.38
rpoC 763528 c.159G>A synonymous_variant 0.39
rpoC 763546 c.177A>G synonymous_variant 0.41
rpoC 763570 c.201G>C synonymous_variant 0.35
rpoC 763594 c.225C>T synonymous_variant 0.25
rpoC 763633 c.264T>C synonymous_variant 0.3
rpoC 763636 c.267T>C synonymous_variant 0.29
rpoC 763642 c.273G>C synonymous_variant 0.35
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.32
rpoC 763675 c.306C>G synonymous_variant 0.25
rpoC 763734 p.Pro122Leu missense_variant 0.89
rpoC 763967 p.Gly200Ser missense_variant 0.14
rpoC 763978 c.609C>G synonymous_variant 0.14
rpoC 763996 c.627T>C synonymous_variant 0.17
rpoC 764005 c.636G>C synonymous_variant 0.17
rpoC 764011 c.642T>C synonymous_variant 0.18
rpoC 764024 c.655T>C synonymous_variant 0.19
rpoC 764040 p.Ser224Asn missense_variant 0.19
rpoC 764044 c.675T>C synonymous_variant 0.21
rpoC 764059 c.690G>C synonymous_variant 0.18
rpoC 764083 c.714A>G synonymous_variant 0.24
rpoC 764098 c.729A>G synonymous_variant 0.27
rpoC 764101 c.732C>G synonymous_variant 0.27
rpoC 764131 c.762T>C synonymous_variant 0.24
rpoC 764161 c.792G>C synonymous_variant 0.28
rpoC 764188 c.819A>G synonymous_variant 0.3
rpoC 764195 p.Ser276Gln missense_variant 0.31
rpoC 764203 c.834G>T synonymous_variant 0.33
rpoC 764206 c.837T>C synonymous_variant 0.33
rpoC 764257 c.888G>C synonymous_variant 0.18
rpoC 764266 c.897T>C synonymous_variant 0.17
rpoC 764269 c.900G>C synonymous_variant 0.17
rpoC 764278 c.909A>G synonymous_variant 0.17
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.17
rpoC 764320 c.951C>G synonymous_variant 0.22
rpoC 764365 c.996C>T synonymous_variant 0.2
rpoC 764380 c.1011G>C synonymous_variant 0.17
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.17
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.2
rpoC 764405 c.1036A>C synonymous_variant 0.21
rpoC 764431 c.1062G>C synonymous_variant 0.17
rpoC 764434 c.1065A>G synonymous_variant 0.22
rpoC 764446 c.1077T>C synonymous_variant 0.15
rpoC 764714 c.1345C>T synonymous_variant 0.14
rpoC 764720 c.1351C>T synonymous_variant 0.14
rpoC 764752 c.1383G>C synonymous_variant 0.19
rpoC 764764 c.1395T>C synonymous_variant 0.18
rpoC 764791 c.1422C>G synonymous_variant 0.2
rpoC 764809 c.1440C>T synonymous_variant 0.18
rpoC 764812 c.1443C>G synonymous_variant 0.17
rpoC 764815 c.1446A>G synonymous_variant 0.18
rpoC 764824 c.1455T>C synonymous_variant 0.21
rpoC 764830 c.1461C>G synonymous_variant 0.22
rpoC 764858 c.1489T>C synonymous_variant 0.3
rpoC 764872 c.1503A>G synonymous_variant 0.3
rpoC 764893 c.1524T>C synonymous_variant 0.29
rpoC 764911 c.1542A>G synonymous_variant 0.28
rpoC 764923 c.1554A>G synonymous_variant 0.3
rpoC 764932 c.1563C>A synonymous_variant 0.29
rpoC 764968 c.1599T>C synonymous_variant 0.32
rpoC 764995 c.1626C>G synonymous_variant 0.21
rpoC 765007 c.1638T>G synonymous_variant 0.24
rpoC 765019 c.1650A>G synonymous_variant 0.27
rpoC 765022 c.1653G>C synonymous_variant 0.29
rpoC 765034 c.1665T>C synonymous_variant 0.25
rpoC 765040 c.1671T>C synonymous_variant 0.24
rpoC 765041 c.1672T>C synonymous_variant 0.24
rpoC 765047 c.1678T>C synonymous_variant 0.25
rpoC 765073 c.1704G>C synonymous_variant 0.21
rpoC 765076 c.1707A>G synonymous_variant 0.21
rpoC 765079 c.1710T>G synonymous_variant 0.21
rpoC 765082 c.1713G>C synonymous_variant 0.23
rpoC 765085 c.1716T>G synonymous_variant 0.2
rpoC 765089 c.1720T>C synonymous_variant 0.2
rpoC 765103 c.1734G>A synonymous_variant 0.23
rpoC 765300 p.Val644Ala missense_variant 0.19
rpoC 765319 c.1950A>G synonymous_variant 0.16
rpoC 765326 p.His653Ala missense_variant 0.16
rpoC 765330 p.Ser654Asn missense_variant 0.16
rpoC 765383 p.Met672Leu missense_variant 0.16
rpoC 765404 p.Leu679Val missense_variant 0.19
rpoC 765409 c.2040T>C synonymous_variant 0.15
rpoC 765412 c.2043T>C synonymous_variant 0.15
rpoC 765421 c.2052C>G synonymous_variant 0.15
rpoC 765451 c.2082C>G synonymous_variant 0.17
rpoC 765452 p.Ala695Ser missense_variant 0.17
rpoC 765499 c.2130C>G synonymous_variant 0.18
rpoC 765508 c.2139C>G synonymous_variant 0.21
rpoC 765541 c.2172C>G synonymous_variant 0.14
rpoC 765613 p.His748Gln missense_variant 0.14
rpoC 766009 c.2640G>C synonymous_variant 0.14
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.14
rpoC 766021 c.2652G>C synonymous_variant 0.15
rpoC 766043 p.Gln892Glu missense_variant 0.17
rpoC 766082 p.Ala905Gln missense_variant 0.14
rpoC 766096 c.2727G>C synonymous_variant 0.17
rpoC 766105 c.2736C>T synonymous_variant 0.17
rpoC 766135 c.2766G>A synonymous_variant 0.14
rpoC 766141 c.2772C>T synonymous_variant 0.13
rpoC 766142 c.2773C>T synonymous_variant 0.13
rpoC 766381 c.3012C>T synonymous_variant 0.15
rpoC 766384 c.3015A>G synonymous_variant 0.15
rpoC 766390 c.3021C>T synonymous_variant 0.19
rpoC 766408 c.3039C>T synonymous_variant 0.16
rpoC 766426 c.3057C>T synonymous_variant 0.25
rpoC 766447 c.3078T>C synonymous_variant 0.2
rpoC 766483 c.3114G>C synonymous_variant 0.22
rpoC 766484 p.Val1039Ile missense_variant 0.22
rpoC 766492 c.3123T>C synonymous_variant 0.25
rpoC 766495 c.3126C>T synonymous_variant 0.25
rpoC 766522 c.3153C>G synonymous_variant 0.2
rpoC 766528 c.3159T>C synonymous_variant 0.24
rpoC 766531 c.3162G>T synonymous_variant 0.24
rpoC 766543 c.3174C>T synonymous_variant 0.23
rpoC 766549 c.3180G>C synonymous_variant 0.2
rpoC 766583 p.Gly1072Ser missense_variant 0.12
rpoC 766588 c.3219G>A synonymous_variant 0.13
rpoC 766591 c.3222A>G synonymous_variant 0.14
rpoC 766594 c.3225G>C synonymous_variant 0.2
rpoC 766630 c.3261G>C synonymous_variant 0.15
mmpL5 775975 c.2506T>C synonymous_variant 0.19
mmpL5 775981 p.Leu834Met missense_variant 0.18
mmpL5 776009 c.2472A>G synonymous_variant 0.17
rpsL 781682 c.123T>C synonymous_variant 0.15
rpsL 781715 c.156T>C synonymous_variant 0.17
rpsL 781728 c.169T>C synonymous_variant 0.16
rpsL 781736 c.177T>C synonymous_variant 0.17
rpsL 781751 c.192G>C synonymous_variant 0.17
rpsL 781754 c.195G>C synonymous_variant 0.2
rpsL 781760 c.201T>C synonymous_variant 0.24
rpsL 781793 c.234G>C synonymous_variant 0.25
rpsL 781832 c.273T>C synonymous_variant 0.17
rpsL 781841 c.282C>G synonymous_variant 0.17
rpsL 781859 c.300T>C synonymous_variant 0.17
rpsL 781868 c.309T>C synonymous_variant 0.17
rpsL 781871 c.312G>C synonymous_variant 0.21
rpsL 781892 c.333A>G synonymous_variant 0.21
rpsL 781898 c.339A>T synonymous_variant 0.17
rpsL 781929 p.Gly124Ser missense_variant 0.17
rplC 800648 c.-161A>C upstream_gene_variant 0.15
rplC 800654 c.-155T>C upstream_gene_variant 0.14
rplC 800738 c.-71T>C upstream_gene_variant 0.18
rplC 800771 c.-38C>T upstream_gene_variant 0.16
rplC 800814 c.6A>G synonymous_variant 0.21
rplC 800817 c.9A>T synonymous_variant 0.22
rplC 800844 c.36T>C synonymous_variant 0.24
rplC 800865 c.57A>G synonymous_variant 0.2
rplC 800867 p.Ser20Asn missense_variant 0.18
rplC 800877 c.69A>C synonymous_variant 0.18
rplC 800880 c.72A>G synonymous_variant 0.18
rplC 800889 c.81C>G synonymous_variant 0.15
rplC 801301 c.493C>A synonymous_variant 0.12
rplC 801312 c.504G>C synonymous_variant 0.17
rplC 801324 c.516T>C synonymous_variant 0.17
rplC 801341 p.Leu178His missense_variant 0.18
fbiC 1304517 c.1587C>T synonymous_variant 0.13
fbiC 1304523 c.1593G>T synonymous_variant 0.13
fbiC 1304559 p.Glu543Asp missense_variant 0.15
fbiC 1304565 c.1635C>G synonymous_variant 0.15
fbiC 1304568 c.1638T>C synonymous_variant 0.17
fbiC 1304574 c.1644C>G synonymous_variant 0.2
fbiC 1304580 c.1650T>C synonymous_variant 0.22
fbiC 1304628 c.1698G>C synonymous_variant 0.15
fbiC 1304658 c.1728C>G synonymous_variant 0.17
fbiC 1304670 c.1740G>T synonymous_variant 0.17
fbiC 1304671 p.Val581Thr missense_variant 0.17
fbiC 1304675 p.Gly582Glu missense_variant 0.18
fbiC 1304691 c.1761G>C synonymous_variant 0.2
fbiC 1304694 c.1764A>C synonymous_variant 0.19
fbiC 1304703 c.1773C>G synonymous_variant 0.17
fbiC 1304715 c.1785G>C synonymous_variant 0.17
fbiC 1304724 c.1794A>G synonymous_variant 0.17
fbiC 1304727 c.1797A>G synonymous_variant 0.17
fbiC 1304742 c.1812T>C synonymous_variant 0.17
fbiC 1304748 c.1818T>C synonymous_variant 0.17
fbiC 1304754 c.1824G>A synonymous_variant 0.17
fbiC 1304757 c.1827A>G synonymous_variant 0.17
fbiC 1304784 c.1854T>C synonymous_variant 0.19
fbiC 1304787 c.1857T>C synonymous_variant 0.19
fbiC 1304790 c.1860C>G synonymous_variant 0.18
fbiC 1304808 c.1878C>G synonymous_variant 0.23
fbiC 1304811 c.1881C>G synonymous_variant 0.24
fbiC 1304817 c.1887T>C synonymous_variant 0.25
fbiC 1304829 c.1899T>C synonymous_variant 0.16
fbiC 1304832 c.1902C>G synonymous_variant 0.17
fbiC 1304853 c.1923C>G synonymous_variant 0.16
fbiC 1304856 c.1926C>G synonymous_variant 0.16
fbiC 1304878 p.Arg650Ser missense_variant 0.12
fbiC 1304893 p.Gly655Ser missense_variant 0.16
fbiC 1305276 c.2346G>C synonymous_variant 0.13
fbiC 1305331 p.Glu801Asn missense_variant 0.17
fbiC 1305336 c.2406T>C synonymous_variant 0.17
atpE 1461233 c.189A>G synonymous_variant 0.14
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.22
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.18
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.17
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.14
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.12
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.19
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.22
rrl 1475015 n.1358C>T non_coding_transcript_exon_variant 0.22
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.21
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.24
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.17
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.18
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.18
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.29
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.25
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.27
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.27
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.27
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.27
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.25
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.38
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.32
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.32
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.33
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.3
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.27
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.24
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.19
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.19
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.21
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.16
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.16
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.15
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.15
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.15
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.19
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.19
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.19
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.18
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.23
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.22
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.22
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.23
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.23
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.22
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.22
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.22
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.22
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.22
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.22
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.22
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.23
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.22
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.22
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.14
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.14
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.13
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.15
rrl 1476640 n.2983C>A non_coding_transcript_exon_variant 0.88
inhA 1674537 c.336C>G synonymous_variant 0.14
inhA 1674542 p.Ala114Glu missense_variant 0.14
inhA 1674561 c.360C>T synonymous_variant 0.24
inhA 1674564 c.363C>T synonymous_variant 0.25
inhA 1674582 c.381T>C synonymous_variant 0.25
inhA 1674585 c.384T>C synonymous_variant 0.25
inhA 1674589 p.Met130Leu missense_variant 0.26
inhA 1674624 c.423A>C synonymous_variant 0.26
inhA 1674627 c.426T>G synonymous_variant 0.26
inhA 1674630 c.429C>G synonymous_variant 0.26
inhA 1674636 c.435C>G synonymous_variant 0.26
inhA 1674654 c.453G>C synonymous_variant 0.27
inhA 1674693 c.492C>G synonymous_variant 0.22
inhA 1674703 c.502T>C synonymous_variant 0.23
inhA 1674741 c.540C>G synonymous_variant 0.14
rpsA 1833790 c.249T>A synonymous_variant 0.14
rpsA 1833799 c.258C>G synonymous_variant 0.16
rpsA 1833811 c.270G>C synonymous_variant 0.18
rpsA 1833838 c.297G>C synonymous_variant 0.19
rpsA 1833841 c.300C>G synonymous_variant 0.19
rpsA 1833847 c.306C>G synonymous_variant 0.19
rpsA 1833856 c.315A>G synonymous_variant 0.18
rpsA 1833862 c.321G>T synonymous_variant 0.18
rpsA 1833874 c.333T>C synonymous_variant 0.19
rpsA 1833928 c.387G>C synonymous_variant 0.24
rpsA 1833940 c.399C>G synonymous_variant 0.26
rpsA 1833970 c.429G>C synonymous_variant 0.25
rpsA 1833979 c.438T>C synonymous_variant 0.19
rpsA 1834000 c.459G>C synonymous_variant 0.19
rpsA 1834015 c.474G>C synonymous_variant 0.2
rpsA 1834021 c.480C>T synonymous_variant 0.2
rpsA 1834303 c.762T>G synonymous_variant 0.2
rpsA 1834306 c.765T>C synonymous_variant 0.19
rpsA 1834348 c.807T>C synonymous_variant 0.18
rpsA 1834366 c.825A>G synonymous_variant 0.17
rpsA 1834396 c.855G>C synonymous_variant 0.25
rpsA 1834411 c.870T>C synonymous_variant 0.16
rpsA 1834417 c.876G>C synonymous_variant 0.15
rpsA 1834423 c.882G>C synonymous_variant 0.15
rpsA 1834435 c.894G>C synonymous_variant 0.2
rpsA 1834451 c.910T>C synonymous_variant 0.16
rpsA 1834465 c.924T>C synonymous_variant 0.19
rpsA 1834468 c.927A>G synonymous_variant 0.19
rpsA 1834474 c.933C>G synonymous_variant 0.21
rpsA 1834489 c.948T>C synonymous_variant 0.2
rpsA 1834498 c.957C>T synonymous_variant 0.2
rpsA 1834528 c.987T>C synonymous_variant 0.23
rpsA 1834546 c.1005T>C synonymous_variant 0.14
rpsA 1834606 c.1065C>G synonymous_variant 0.14
tlyA 1918034 p.Val32Ala missense_variant 1.0
ndh 2102131 p.Gln304Lys missense_variant 0.14
ndh 2102184 c.859A>C synonymous_variant 0.17
ndh 2102203 c.840T>A synonymous_variant 0.14
ndh 2102206 c.837G>C synonymous_variant 0.14
ndh 2102212 c.831G>C synonymous_variant 0.15
ndh 2102218 c.825C>G synonymous_variant 0.15
ndh 2102233 c.810G>A synonymous_variant 0.14
ndh 2102242 c.801G>A synonymous_variant 0.12
katG 2155918 p.Ala65Val missense_variant 1.0
PPE35 2168767 p.Ser616Gly missense_variant 1.0
Rv1979c 2222377 p.Val263Gly missense_variant 1.0
pncA 2289958 c.-717T>C upstream_gene_variant 0.19
pncA 2289991 c.-750G>C upstream_gene_variant 0.14
pncA 2289994 c.-753A>G upstream_gene_variant 0.14
kasA 2517947 c.-168C>T upstream_gene_variant 0.17
kasA 2517989 c.-126T>C upstream_gene_variant 0.14
kasA 2517992 c.-123C>G upstream_gene_variant 0.15
kasA 2518025 c.-90G>C upstream_gene_variant 0.14
kasA 2518031 c.-84G>T upstream_gene_variant 0.14
kasA 2518035 c.-80C>G upstream_gene_variant 0.14
kasA 2518621 c.507G>A synonymous_variant 0.13
kasA 2518687 c.573C>T synonymous_variant 0.15
kasA 2518696 c.582C>G synonymous_variant 0.15
kasA 2518702 c.588C>T synonymous_variant 0.15
kasA 2518711 c.597A>G synonymous_variant 0.16
kasA 2518714 c.600A>C synonymous_variant 0.19
kasA 2518717 c.603C>T synonymous_variant 0.19
kasA 2518723 p.Glu203Asp missense_variant 0.22
kasA 2518732 c.618C>G synonymous_variant 0.24
kasA 2518741 c.627G>C synonymous_variant 0.19
kasA 2518747 c.633C>G synonymous_variant 0.18
kasA 2518768 c.654C>G synonymous_variant 0.23
kasA 2518783 c.669T>C synonymous_variant 0.21
kasA 2518792 c.678C>G synonymous_variant 0.2
kasA 2518795 c.681C>G synonymous_variant 0.22
kasA 2518822 c.708C>G synonymous_variant 0.17
kasA 2518825 c.711T>C synonymous_variant 0.18
kasA 2518855 c.741C>G synonymous_variant 0.15
folC 2747355 p.Val82Ile missense_variant 0.14
folC 2747359 c.240C>G synonymous_variant 0.19
folC 2747362 c.237G>C synonymous_variant 0.14
ribD 2986993 p.Gly52Val missense_variant 1.0
Rv2752c 3064928 c.1264T>C synonymous_variant 0.14
Rv2752c 3064932 c.1260T>C synonymous_variant 0.14
Rv2752c 3064935 c.1257A>G synonymous_variant 0.14
Rv2752c 3064941 p.Gln417Glu missense_variant 0.16
Rv2752c 3064956 p.Ser412Arg missense_variant 0.16
Rv2752c 3064962 c.1230C>A synonymous_variant 0.17
Rv2752c 3064973 p.Ala407Ser missense_variant 0.15
Rv2752c 3064974 c.1218T>C synonymous_variant 0.15
Rv2752c 3064980 c.1212C>G synonymous_variant 0.14
Rv2752c 3065787 c.405G>C synonymous_variant 1.0
thyX 3067244 c.702C>G synonymous_variant 0.18
thyX 3067252 p.Val232Met missense_variant 0.12
thyX 3067277 c.669C>G synonymous_variant 0.16
thyX 3067284 p.Ala221Asp missense_variant 0.14
thyX 3067640 c.306G>C synonymous_variant 0.14
thyX 3067643 c.303C>T synonymous_variant 0.13
thyX 3067682 c.264G>C synonymous_variant 0.15
thyX 3067685 c.261A>G synonymous_variant 0.15
thyX 3067688 c.258G>C synonymous_variant 0.15
thyX 3067694 c.252G>C synonymous_variant 0.15
thyX 3067718 c.228C>G synonymous_variant 0.15
thyX 3067721 c.225T>C synonymous_variant 0.17
thyX 3067724 c.222G>A synonymous_variant 0.14
thyX 3067727 c.219A>C synonymous_variant 0.14
thyA 3073929 c.543T>C synonymous_variant 0.14
thyA 3073953 c.519T>C synonymous_variant 0.14
thyA 3073977 c.495A>G synonymous_variant 0.16
thyA 3074339 p.Leu45Ile missense_variant 0.13
thyA 3074361 c.111T>C synonymous_variant 0.14
thyA 3074409 c.63C>A synonymous_variant 0.13
Rv3083 3448649 p.Arg49Pro missense_variant 1.0
Rv3236c 3613067 p.Val17Gly missense_variant 1.0
Rv3236c 3613315 c.-199T>G upstream_gene_variant 1.0
fbiA 3640435 c.-108A>C upstream_gene_variant 1.0
fbiB 3642581 c.1047A>C synonymous_variant 0.15
fbiB 3642593 c.1059G>C synonymous_variant 0.14
fbiB 3642602 c.1068A>C synonymous_variant 0.19
fbiB 3642605 c.1071A>G synonymous_variant 0.19
fbiB 3642614 c.1080C>T synonymous_variant 0.17
fbiB 3642620 c.1086T>C synonymous_variant 0.16
fbiB 3642656 c.1122G>C synonymous_variant 0.16
fbiB 3642659 c.1125C>G synonymous_variant 0.16
fbiB 3642668 c.1134A>C synonymous_variant 0.16
fbiB 3642677 c.1143A>G synonymous_variant 0.15
rpoA 3877613 p.Ile299Val missense_variant 0.16
rpoA 3878169 c.339G>C synonymous_variant 0.14
rpoA 3878184 c.324C>T synonymous_variant 0.17
rpoA 3878193 c.315T>C synonymous_variant 0.16
rpoA 3878199 c.309T>C synonymous_variant 0.15
rpoA 3878202 c.306G>C synonymous_variant 0.14
rpoA 3878217 c.291A>G synonymous_variant 0.15
rpoA 3878271 c.237T>C synonymous_variant 0.23
rpoA 3878284 p.Glu75Ala missense_variant 0.18
rpoA 3878292 c.216T>C synonymous_variant 0.18
rpoA 3878298 c.210A>G synonymous_variant 0.17
rpoA 3878304 c.204G>C synonymous_variant 0.17
rpoA 3878313 c.195G>C synonymous_variant 0.16
rpoA 3878346 c.162T>C synonymous_variant 0.18
rpoA 3878364 c.144A>G synonymous_variant 0.2
rpoA 3878367 c.141C>G synonymous_variant 0.18
rpoA 3878370 c.138T>C synonymous_variant 0.18
rpoA 3878376 c.132G>C synonymous_variant 0.19
rpoA 3878385 c.123C>G synonymous_variant 0.19
rpoA 3878391 c.117T>C synonymous_variant 0.19
rpoA 3878396 c.112C>T synonymous_variant 0.19
rpoA 3878472 p.Asp12Glu missense_variant 0.15
rpoA 3878478 c.30C>G synonymous_variant 0.15
clpC1 4039073 c.1632C>G synonymous_variant 0.17
clpC1 4039085 c.1620A>G synonymous_variant 0.18
clpC1 4039090 c.1615C>T synonymous_variant 0.19
clpC1 4039097 c.1608G>C synonymous_variant 0.21
clpC1 4039103 c.1602T>C synonymous_variant 0.18
clpC1 4039106 c.1599G>C synonymous_variant 0.17
clpC1 4039112 c.1593C>G synonymous_variant 0.2
clpC1 4039121 c.1584T>C synonymous_variant 0.2
clpC1 4039124 c.1581C>G synonymous_variant 0.2
clpC1 4039142 c.1563A>G synonymous_variant 0.22
clpC1 4039145 c.1560G>C synonymous_variant 0.21
clpC1 4039169 p.Glu512Asp missense_variant 0.23
clpC1 4039172 c.1533A>G synonymous_variant 0.23
clpC1 4039178 c.1527G>C synonymous_variant 0.25
clpC1 4039183 c.1522T>C synonymous_variant 0.25
clpC1 4039187 c.1518G>C synonymous_variant 0.28
clpC1 4039190 c.1515C>G synonymous_variant 0.25
clpC1 4039208 c.1497C>G synonymous_variant 0.23
clpC1 4039226 c.1479T>C synonymous_variant 0.21
clpC1 4039268 c.1437C>G synonymous_variant 0.17
clpC1 4039274 c.1431G>C synonymous_variant 0.23
clpC1 4039286 c.1419T>C synonymous_variant 0.23
clpC1 4039289 c.1416T>C synonymous_variant 0.23
clpC1 4039295 c.1410A>C synonymous_variant 0.24
clpC1 4039298 c.1407T>C synonymous_variant 0.24
clpC1 4039319 c.1386T>C synonymous_variant 0.19
clpC1 4039322 c.1383T>C synonymous_variant 0.19
clpC1 4039328 c.1377A>G synonymous_variant 0.15
clpC1 4039842 c.862_863insT frameshift_variant 1.0
clpC1 4039865 c.840T>C synonymous_variant 0.14
clpC1 4039898 c.807C>G synonymous_variant 0.16
clpC1 4039904 c.801A>G synonymous_variant 0.15
clpC1 4039930 p.Ser259Cys missense_variant 0.14
clpC1 4039979 c.726C>G synonymous_variant 0.14
clpC1 4039996 p.Glu237Gln missense_variant 0.14
clpC1 4040354 c.351A>G synonymous_variant 0.16
clpC1 4040363 c.342A>C synonymous_variant 0.16
clpC1 4040369 c.336C>G synonymous_variant 0.16
clpC1 4040380 c.325T>C synonymous_variant 0.17
clpC1 4040381 c.324T>C synonymous_variant 0.17
clpC1 4040387 c.318A>G synonymous_variant 0.17
clpC1 4040393 c.312G>C synonymous_variant 0.2
clpC1 4040411 c.294T>C synonymous_variant 0.2
clpC1 4040426 c.279T>C synonymous_variant 0.16
clpC1 4040431 c.274T>C synonymous_variant 0.16
clpC1 4040444 c.261C>G synonymous_variant 0.14
panD 4044103 p.Ile60Ser missense_variant 0.91
embC 4240671 p.Thr270Ile missense_variant 0.15
embC 4240678 c.816T>G synonymous_variant 0.15
embC 4240685 p.Thr275Ala missense_variant 0.16
embC 4240706 p.Val282Thr missense_variant 0.16
embC 4240726 c.864G>C synonymous_variant 0.2
embC 4240780 c.918T>C synonymous_variant 0.19
embC 4240783 c.921G>C synonymous_variant 0.19
embC 4240789 c.927T>C synonymous_variant 0.2
embC 4240819 c.957A>G synonymous_variant 0.15
embA 4245031 p.Arg600Gln missense_variant 1.0
embB 4247842 c.1329T>C synonymous_variant 0.14
embB 4247876 c.1363C>T synonymous_variant 0.21
embB 4247881 c.1368G>C synonymous_variant 0.16
embB 4247887 c.1374C>T synonymous_variant 0.16
embB 4247890 c.1377C>T synonymous_variant 0.17
embB 4247899 p.Met462Ile missense_variant 0.17
embB 4247977 c.1464C>G synonymous_variant 0.14
embB 4247986 c.1473C>G synonymous_variant 0.15
embB 4248007 c.1494C>G synonymous_variant 0.17
embB 4248011 p.Ser500Ala missense_variant 0.14
embB 4248118 c.1605T>C synonymous_variant 0.15
embB 4248127 c.1614G>C synonymous_variant 0.14
embB 4248142 c.1629T>C synonymous_variant 0.15
embB 4248157 c.1644A>G synonymous_variant 0.15
embB 4248241 c.1728C>T synonymous_variant 0.14
embB 4249381 c.2868A>G synonymous_variant 0.19
embB 4249417 c.2904A>G synonymous_variant 0.16
embB 4249420 c.2907G>C synonymous_variant 0.15
embB 4249423 p.Asp970Glu missense_variant 0.15
embB 4249424 p.Leu971Met missense_variant 0.15
embB 4249432 c.2919A>G synonymous_variant 0.17
embB 4249441 c.2928A>G synonymous_variant 0.15
embB 4249444 c.2931T>C synonymous_variant 0.15
embB 4249447 c.2934G>C synonymous_variant 0.15
embB 4249456 c.2943G>C synonymous_variant 0.16
embB 4249469 p.Leu986Met missense_variant 0.15
embB 4249483 c.2970C>G synonymous_variant 0.16
embB 4249486 c.2973T>G synonymous_variant 0.16
aftB 4267556 c.1281G>C synonymous_variant 0.21
aftB 4267571 c.1266T>C synonymous_variant 0.18
aftB 4267580 c.1257G>C synonymous_variant 0.18
aftB 4267607 c.1230G>A synonymous_variant 0.16
aftB 4268386 c.451T>C synonymous_variant 0.23
aftB 4268389 c.448C>T synonymous_variant 0.23
aftB 4268396 c.441T>C synonymous_variant 0.23
aftB 4268404 c.433T>C synonymous_variant 0.23
aftB 4268405 p.Val144Ala missense_variant 0.23
aftB 4268410 c.427C>T synonymous_variant 0.21
aftB 4268411 c.426G>T synonymous_variant 0.21
aftB 4268417 c.420G>A synonymous_variant 0.23
aftB 4268441 c.396C>G synonymous_variant 0.25
aftB 4268444 p.Ala131Ser missense_variant 0.25
aftB 4268450 c.387A>G synonymous_variant 0.25
aftB 4268455 p.Val128Leu missense_variant 0.25
aftB 4268462 c.375T>C synonymous_variant 0.25
aftB 4268465 c.372A>C synonymous_variant 0.27
aftB 4268480 c.357G>C synonymous_variant 0.27
aftB 4268483 c.354T>G synonymous_variant 0.27
aftB 4268498 c.339T>C synonymous_variant 0.27
aftB 4268504 c.333G>C synonymous_variant 0.27
aftB 4268516 c.321A>G synonymous_variant 0.25
gid 4408218 c.-16G>T upstream_gene_variant 1.0