Run ID: ERR11466062
Sample name:
Date: 2024-04-16T06:36:14.703549
Number of reads: 2790719
Percentage reads mapped: 98.57
Median coverage: 57.0
Strain: lineage4.9.1
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.9.1 | Euro-American (H37Rv-like) | None | 0.98 |
lineage4 | Euro-American | None | 1.0 |
lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 6286 | c.1047T>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6295 | c.1056A>G | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6299 | c.1060C>T | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6307 | c.1068T>G | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6310 | c.-992G>C | upstream_gene_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6319 | c.1080G>A | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7394 | c.93T>C | synonymous_variant | 0.12 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7397 | c.96G>C | synonymous_variant | 0.12 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7631 | c.330G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7652 | c.351C>T | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7745 | c.444G>A | synonymous_variant | 0.25 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7748 | c.447A>G | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7758 | p.Ile153Val | missense_variant | 0.32 | levofloxacin | Uncertain significance |
moxifloxacin | ||||||
gyrA | 7763 | c.462T>G | synonymous_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7814 | c.513C>G | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8366 | c.1065G>T | synonymous_variant | 0.13 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8378 | c.1077C>T | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8382 | p.Leu361Met | missense_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8903 | c.1602T>C | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8915 | c.1614A>G | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8924 | c.1623C>T | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8930 | c.1629C>T | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8933 | c.1632G>A | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8939 | c.1638T>C | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8942 | c.1641G>C | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8945 | c.1644G>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8946 | c.1645_1647delTTGinsCC | frameshift_variant&missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8978 | c.1677C>T | synonymous_variant | 0.89 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9365 | p.Glu688Asp | missense_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9377 | c.2076A>G | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9653 | c.2352C>T | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
ccsA | 620676 | c.786C>T | synonymous_variant | 0.17 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
nusG | 734472 | c.219T>C | synonymous_variant | 0.14 | rifampicin | |
nusG | 734475 | c.222T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
nusG | 734502 | c.249G>A | synonymous_variant | 0.21 | rifampicin | |
nusG | 734559 | c.306T>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
nusG | 734571 | c.318C>G | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760496 | c.690G>C | synonymous_variant | 0.12 | rifampicin | |
rpoB | 761222 | c.1416G>C | synonymous_variant | 0.25 | rifampicin | |
rpoB | 761240 | c.1434C>T | synonymous_variant | 0.33 | rifampicin | |
rpoB | 761249 | c.1443A>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 761255 | c.1449T>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 761258 | c.1452G>A | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 761261 | c.1455G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 761282 | c.1476C>A | synonymous_variant | 0.26 | rifampicin | |
rpoB | 761300 | c.1494G>A | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 761579 | c.1773G>T | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761675 | c.1869G>C | synonymous_variant | 0.13 | rifampicin | |
rpoB | 761969 | c.2163G>A | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761972 | c.2166C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 762212 | c.2406G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 762293 | c.2487T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 762338 | c.2532T>C | synonymous_variant | 0.12 | rifampicin | |
rpoB | 762347 | c.2541T>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 762362 | p.Glu852Asp | missense_variant | 0.18 | rifampicin | |
rpoB | 762369 | c.2563T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 762374 | c.-996G>C | upstream_gene_variant | 0.21 | rifampicin | |
rpoC | 762380 | c.-990T>G | upstream_gene_variant | 0.15 | rifampicin | |
rpoB | 762470 | c.2664G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762917 | c.3111C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 762920 | c.3114C>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 763136 | c.3330C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763142 | c.-228C>G | upstream_gene_variant | 0.14 | rifampicin | |
rpoC | 763148 | c.-222G>C | upstream_gene_variant | 0.16 | rifampicin | |
rpoC | 763169 | c.-201A>G | upstream_gene_variant | 0.16 | rifampicin | |
rpoC | 763486 | c.117T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 763492 | c.123G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763633 | c.264T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764611 | c.1242G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765370 | c.2001G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765383 | p.Met672Leu | missense_variant | 0.17 | rifampicin | Uncertain significance |
rpoC | 765562 | c.2193G>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 765611 | p.His748Ser | missense_variant | 0.15 | rifampicin | Uncertain significance |
rpoC | 765625 | c.2256C>T | synonymous_variant | 0.15 | rifampicin | |
rpoC | 765628 | c.2259G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 765635 | c.2266_2268delGTCinsCG | frameshift_variant&missense_variant | 0.12 | rifampicin | |
rpoC | 765640 | c.2271A>G | synonymous_variant | 0.13 | rifampicin | |
rpoC | 765835 | c.2466C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 765871 | c.2502T>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765875 | p.Val836Ile | missense_variant | 0.16 | rifampicin | Uncertain significance |
rpoC | 765908 | c.2539C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765937 | c.2568T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765946 | c.2577C>A | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 766009 | c.2640G>T | synonymous_variant | 0.31 | rifampicin | |
rpoC | 766012 | c.2643C>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 766061 | p.Val898Ile | missense_variant | 0.17 | rifampicin | |
rpoC | 766381 | c.3012C>T | synonymous_variant | 0.29 | rifampicin | |
rpoC | 766384 | c.3015A>G | synonymous_variant | 0.32 | rifampicin | |
rpoC | 766390 | c.3021C>T | synonymous_variant | 0.39 | rifampicin | |
rpoC | 766408 | c.3039C>T | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 766435 | p.Glu1022Asp | missense_variant | 0.21 | rifampicin | Uncertain significance |
rpoC | 766456 | c.3087C>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766459 | c.3090G>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766484 | c.3115_3117delGTAinsAT | frameshift_variant&missense_variant | 0.2 | rifampicin | |
rpoC | 766702 | c.3333G>C | synonymous_variant | 0.12 | rifampicin | |
rpoC | 766708 | c.3339A>G | synonymous_variant | 0.13 | rifampicin | |
rpoC | 766711 | c.3342C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 766726 | c.3357T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766738 | c.3369G>T | synonymous_variant | 0.26 | rifampicin | |
rpoC | 766750 | c.3381C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766753 | c.3384C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766804 | c.3435A>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 766843 | c.3474T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 766846 | c.3477C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 766996 | c.3627C>T | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 767002 | c.3633G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 767152 | c.3783T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 767158 | c.3789T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 767167 | c.3798C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 767182 | c.3813G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 767197 | c.3828G>A | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 767221 | c.3852C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 767230 | c.3861G>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 767233 | c.3864T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.15 | linezolid | |
rplC | 800715 | c.-94A>C | upstream_gene_variant | 0.15 | linezolid | |
fbiC | 1303512 | c.582T>G | synonymous_variant | 0.14 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303575 | c.645G>C | synonymous_variant | 0.25 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303581 | c.651G>C | synonymous_variant | 0.17 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304559 | p.Glu543Asp | missense_variant | 0.12 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304567 | p.Phe546Tyr | missense_variant | 0.2 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304580 | c.1650T>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1304608 | p.Thr560Ala | missense_variant | 0.12 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
atpE | 1461104 | c.60C>T | synonymous_variant | 0.14 | bedaquiline | |
atpE | 1461132 | p.Val30Ile | missense_variant | 0.14 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 0.99 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1471986 | n.141C>T | non_coding_transcript_exon_variant | 0.3 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472075 | n.230A>G | non_coding_transcript_exon_variant | 0.13 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472106 | n.261G>A | non_coding_transcript_exon_variant | 0.29 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.28 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472489 | n.644A>G | non_coding_transcript_exon_variant | 0.23 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.18 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 0.58 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474151 | n.494C>T | non_coding_transcript_exon_variant | 0.68 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474174 | n.517A>G | non_coding_transcript_exon_variant | 0.84 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474181 | n.524C>A | non_coding_transcript_exon_variant | 0.85 | capreomycin | |
linezolid | ||||||
rrl | 1474249 | n.592G>T | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474263 | n.606G>A | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474552 | n.895C>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | |
linezolid | ||||||
rrl | 1474708 | n.1052dupG | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474711 | n.1054_1055insA | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1474715 | n.1061delA | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474753 | n.1096A>G | non_coding_transcript_exon_variant | 0.57 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474760 | n.1103A>G | non_coding_transcript_exon_variant | 0.54 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>A | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.58 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474830 | n.1173A>T | non_coding_transcript_exon_variant | 0.62 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474831 | n.1174A>T | non_coding_transcript_exon_variant | 0.63 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475120 | n.1463G>T | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475202 | n.1545G>C | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475291 | n.1634A>C | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475315 | n.1658A>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475480 | n.1823A>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475544 | n.1887A>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475573 | n.1916G>A | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475916 | n.2259C>T | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
fabG1 | 1673941 | p.Ala168Ser | missense_variant | 0.13 | ethionamide | |
isoniazid | ||||||
inhA | 1673955 | c.-247G>C | upstream_gene_variant | 0.14 | ethionamide | |
isoniazid | ||||||
inhA | 1674507 | c.306G>C | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
inhA | 1674690 | c.489C>G | synonymous_variant | 0.23 | ethionamide | |
isoniazid | ||||||
inhA | 1674702 | c.501G>C | synonymous_variant | 0.12 | ethionamide | |
isoniazid | ||||||
inhA | 1674714 | c.513C>G | synonymous_variant | 0.14 | ethionamide | |
isoniazid | ||||||
inhA | 1674718 | c.517A>C | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
inhA | 1674745 | p.Tyr182Val | missense_variant | 0.18 | ethionamide | |
isoniazid | ||||||
inhA | 1674750 | c.549T>A | synonymous_variant | 0.22 | ethionamide | Not assoc w R - Interim |
isoniazid | Not assoc w R - Interim | |||||
inhA | 1674756 | c.555T>A | synonymous_variant | 0.21 | ethionamide | |
isoniazid | ||||||
inhA | 1674765 | c.564C>G | synonymous_variant | 0.23 | ethionamide | |
isoniazid | ||||||
inhA | 1674771 | c.570C>G | synonymous_variant | 0.22 | ethionamide | |
isoniazid | ||||||
inhA | 1674774 | c.573A>C | synonymous_variant | 0.16 | ethionamide | |
isoniazid | ||||||
inhA | 1674777 | c.576C>G | synonymous_variant | 0.14 | ethionamide | |
isoniazid | ||||||
inhA | 1674780 | c.579T>G | synonymous_variant | 0.18 | ethionamide | |
isoniazid | ||||||
rpsA | 1833589 | c.48A>C | synonymous_variant | 0.12 | pyrazinamide | |
rpsA | 1833661 | c.120A>G | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1833664 | c.123C>G | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1833949 | c.408T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1833970 | c.429G>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.13 | pyrazinamide | |
rpsA | 1834105 | c.564C>T | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834189 | c.648G>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834294 | c.753G>T | synonymous_variant | 0.13 | pyrazinamide | |
rpsA | 1834297 | c.756C>T | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834303 | c.762T>G | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834361 | c.820T>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834375 | c.834G>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834396 | c.855G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834423 | c.882G>T | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834432 | c.891G>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834498 | c.957C>T | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834573 | c.1032G>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834732 | c.1191T>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834738 | c.1197A>G | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834747 | c.1206A>G | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834751 | c.1210_1212delCTTinsAC | frameshift_variant&missense_variant | 0.14 | pyrazinamide | Uncertain significance |
rpsA | 1834756 | c.1215G>A | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834759 | c.1218A>T | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834765 | p.Glu408Asp | missense_variant | 0.14 | pyrazinamide | |
rpsA | 1834775 | p.Ala412Thr | missense_variant | 0.19 | pyrazinamide | |
rpsA | 1834780 | c.1239A>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834786 | c.1245A>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834789 | c.1248T>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834792 | c.1251G>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834810 | c.1269C>T | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834813 | c.1272G>T | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834852 | c.1311C>T | synonymous_variant | 0.14 | pyrazinamide | |
tsnR | 1853361 | c.-245T>C | upstream_gene_variant | 0.16 | linezolid | |
tsnR | 1853370 | c.-236_-234delGCAinsTC | upstream_gene_variant | 0.18 | linezolid | |
tsnR | 1853375 | c.-231G>C | upstream_gene_variant | 0.17 | linezolid | |
tsnR | 1853387 | c.-219T>G | upstream_gene_variant | 0.13 | linezolid | |
tsnR | 1853390 | c.-216G>C | upstream_gene_variant | 0.13 | linezolid | |
tsnR | 1853394 | c.-212_-211delCTinsGC | upstream_gene_variant | 0.14 | linezolid | |
tsnR | 1853420 | c.-186T>G | upstream_gene_variant | 0.25 | linezolid | |
tsnR | 1853429 | c.-177G>C | upstream_gene_variant | 0.19 | linezolid | |
tsnR | 1853432 | c.-174G>C | upstream_gene_variant | 0.2 | linezolid | |
tsnR | 1853444 | c.-162C>T | upstream_gene_variant | 0.31 | linezolid | |
tsnR | 1853459 | c.-147G>C | upstream_gene_variant | 0.32 | linezolid | |
tsnR | 1853462 | c.-144A>G | upstream_gene_variant | 0.31 | linezolid | |
tsnR | 1853468 | c.-138C>G | upstream_gene_variant | 0.26 | linezolid | |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
pncA | 2289138 | p.Leu35Arg | missense_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
kasA | 2517917 | c.-198G>T | upstream_gene_variant | 0.34 | isoniazid | |
kasA | 2517926 | c.-189G>A | upstream_gene_variant | 0.35 | isoniazid | |
kasA | 2517941 | c.-174C>G | upstream_gene_variant | 0.36 | isoniazid | |
kasA | 2517950 | c.-165C>G | upstream_gene_variant | 0.36 | isoniazid | |
kasA | 2517974 | c.-141T>C | upstream_gene_variant | 0.21 | isoniazid | |
kasA | 2517989 | c.-126T>G | upstream_gene_variant | 0.15 | isoniazid | |
kasA | 2518528 | c.414C>G | synonymous_variant | 0.14 | isoniazid | |
kasA | 2518606 | c.492G>C | synonymous_variant | 0.2 | isoniazid | |
kasA | 2518609 | p.Met165Ile | missense_variant | 0.22 | isoniazid | |
Rv2477c | 2782453 | c.1590C>T | synonymous_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782483 | c.1560G>C | synonymous_variant | 0.24 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782522 | c.1521G>C | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2782528 | c.1515G>C | synonymous_variant | 0.14 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
thyX | 3067457 | c.489C>G | synonymous_variant | 0.12 | para-aminosalicylic_acid | |
thyX | 3067910 | c.36C>T | synonymous_variant | 0.13 | para-aminosalicylic_acid | |
fbiD | 3339385 | p.Asp90Asn | missense_variant | 1.0 | clofazimine | Uncertain significance |
pretomanid | ||||||
delamanid | Uncertain significance | |||||
mtrB | 3625837 | c.777C>G | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625852 | c.-942A>T | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625861 | c.-951C>T | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625867 | c.747A>G | synonymous_variant | 0.17 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625882 | c.-972G>T | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625899 | p.Val239Leu | missense_variant | 0.13 | bedaquiline | |
rifampicin | ||||||
fbiA | 3640350 | c.-193C>T | upstream_gene_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiA | 3640355 | c.-188C>T | upstream_gene_variant | 0.17 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
rpoA | 3877596 | c.912G>C | synonymous_variant | 0.13 | rifampicin | |
rpoA | 3877728 | c.780C>G | synonymous_variant | 0.13 | rifampicin | |
rpoA | 3877803 | c.705G>C | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3877818 | c.690A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoA | 3877848 | c.660C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3877905 | c.603A>C | synonymous_variant | 0.12 | rifampicin | |
rpoA | 3877908 | c.600T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3878217 | c.291A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
clpC1 | 4038335 | c.2370C>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038356 | c.2349T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038388 | c.2317T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038395 | c.2310C>G | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4038726 | p.Thr660Cys | missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4038941 | c.1764G>A | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038956 | c.1749T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038971 | c.1734T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038974 | c.1731T>C | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039145 | c.1560G>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039169 | p.Glu512Asp | missense_variant | 0.16 | pyrazinamide | |
clpC1 | 4039183 | c.1522T>C | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4039187 | c.1518G>C | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4039274 | c.1431G>C | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039277 | c.1428C>T | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039280 | c.1425G>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039292 | c.1413C>A | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039295 | c.1410A>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039298 | c.1407T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039313 | c.1392C>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039349 | c.1356C>T | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039352 | c.1353C>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039382 | c.1323C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039391 | c.1314T>G | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4039394 | c.1311G>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039517 | c.1188C>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039541 | c.1164C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039931 | c.774T>C | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4040021 | c.684A>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040030 | c.675C>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4040033 | c.672G>T | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4040057 | c.648C>T | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4040090 | c.613_615delTCTinsAGC | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4040093 | c.612C>G | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040393 | c.312G>C | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040402 | c.303C>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040411 | c.294T>C | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040423 | c.282A>G | synonymous_variant | 0.26 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040431 | c.274T>C | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4040441 | c.264C>T | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4040444 | c.261C>G | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4040450 | c.255A>G | synonymous_variant | 0.26 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040456 | c.249C>T | synonymous_variant | 0.28 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040459 | c.246C>A | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4040465 | c.240T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4040471 | c.234T>C | synonymous_variant | 0.23 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040522 | c.183T>C | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
embC | 4241194 | c.1332C>G | synonymous_variant | 0.12 | ethambutol | |
embA | 4244885 | c.1653A>G | synonymous_variant | 0.19 | ethambutol | |
embA | 4246062 | c.2830_2832delTATinsAC | frameshift_variant&missense_variant | 0.17 | ethambutol | Uncertain significance |
embB | 4247462 | c.949_950delTCinsAG | synonymous_variant | 0.14 | ethambutol | |
embB | 4247470 | c.957T>C | synonymous_variant | 0.13 | ethambutol | |
embB | 4247491 | c.978G>C | synonymous_variant | 0.13 | ethambutol | |
embB | 4247494 | c.981G>A | synonymous_variant | 0.13 | ethambutol | |
embB | 4247497 | c.984T>C | synonymous_variant | 0.14 | ethambutol | |
embB | 4247500 | c.987C>G | synonymous_variant | 0.13 | ethambutol | |
aftB | 4268194 | p.Leu215Val | missense_variant | 0.13 | ethambutol | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R |