TB-Profiler result

Run: ERR4819305
Summary

Run ID: ERR4819305

Sample name:

Date: 2024-10-05T00:34:25.910388

Number of reads: 19367

Percentage reads mapped: 3.28

Median coverage: 0.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
rpoB 761084 c.1278C>A synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.9 rifampicin
rpoB 761096 c.1290G>C synonymous_variant 1.0 rifampicin
rpoB 761099 c.1293C>T synonymous_variant 0.9 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 1.0 rifampicin
rpoB 762212 c.2406G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762227 c.2421G>A synonymous_variant 1.0 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762234 p.Pro810Ser missense_variant 1.0 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763038 p.Thr1078Ala missense_variant 1.0 rifampicin
rpoC 763043 c.-327G>C upstream_gene_variant 1.0 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763077 p.Val1091Thr missense_variant 1.0 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 1.0 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763119 p.Asn1105Asp missense_variant 1.0 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 1.0 rifampicin
rpoC 764543 p.Thr392Ala missense_variant 1.0 rifampicin
rpoC 764548 c.1179G>A synonymous_variant 1.0 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 1.0 rifampicin
rpsL 781796 p.Met79Ile missense_variant 1.0 streptomycin
rpsL 781802 c.243G>C synonymous_variant 1.0 streptomycin
rpsL 781811 c.252C>T synonymous_variant 1.0 streptomycin
rpsL 781814 c.255C>T synonymous_variant 1.0 streptomycin
rpsL 781817 c.258G>T synonymous_variant 1.0 streptomycin