TB-Profiler result

Run: SRR13861341
Summary

Run ID: SRR13861341

Sample name:

Date: 2024-10-05T07:38:07.372377

Number of reads: 202196

Percentage reads mapped: 5.06

Median coverage: 6.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Gly442Glu Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Leu443Ile Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Leu449Val Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761131 p.Gly442Glu missense_variant 0.64 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761133 p.Leu443Ile missense_variant 0.64 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761151 p.Leu449Val missense_variant 0.7 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6662 p.Phe475Val missense_variant 1.0 levofloxacin
moxifloxacin Uncertain significance
rpoB 761126 c.1320G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761129 c.1323G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761156 c.1350G>C synonymous_variant 0.7 rifampicin
rpoB 761162 c.1356G>C synonymous_variant 0.64 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.64 rifampicin
rpoB 761178 p.Ser458Thr missense_variant 0.64 rifampicin Uncertain significance
rpoB 761192 c.1386C>G synonymous_variant 0.64 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 761196 p.Leu464Phe missense_variant 0.64 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.64 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.64 rifampicin
rpoB 761213 c.1407G>A synonymous_variant 0.64 rifampicin
rpoB 761220 p.Ser472Thr missense_variant 0.58 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 761235 p.Met477Val missense_variant 0.58 rifampicin
rpoC 766854 p.Leu1162Gln missense_variant 1.0 rifampicin
rrs 1472936 n.1091C>T non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472958 n.1113A>T non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472959 n.1114T>A non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472963 n.1118G>A non_coding_transcript_exon_variant 0.69 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472971 n.1126G>C non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472973 n.1128_1130delAATinsCG non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472982 n.1137G>C non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>T non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>A non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.75 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473002 n.1157G>T non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473008 n.1163C>A non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473009 n.1164T>C non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473044 n.1199C>G non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473051 n.1206T>C non_coding_transcript_exon_variant 0.73 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473053 n.1208T>G non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
ald 3087172 p.Glu118Ala missense_variant 1.0 cycloserine
lpqB 3624600 p.Val104Gly missense_variant 1.0 rifampicin
bedaquiline