TB-Profiler result

Run: SRR14802191
Summary

Run ID: SRR14802191

Sample name:

Date: 03-04-2023 12:19:47

Number of reads: 2788924

Percentage reads mapped: 83.29

Strain: lineage2.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.42
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 766645 p.Glu1092Asp missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304671 p.Val581Leu missense_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472545 n.700A>G non_coding_transcript_exon_variant 0.12
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.12
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.14
rrs 1472607 n.762G>C non_coding_transcript_exon_variant 0.14
rrs 1472608 n.763T>A non_coding_transcript_exon_variant 0.14
rrs 1472612 n.767G>A non_coding_transcript_exon_variant 0.15
rrs 1472615 n.770C>T non_coding_transcript_exon_variant 0.15
rrs 1472620 n.775A>G non_coding_transcript_exon_variant 0.14
rrs 1472634 n.789T>C non_coding_transcript_exon_variant 0.15
rrs 1472639 n.794G>A non_coding_transcript_exon_variant 0.14
rrs 1472643 n.798A>T non_coding_transcript_exon_variant 0.14
rrs 1472644 n.799C>G non_coding_transcript_exon_variant 0.14
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.15
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.12
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.13
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.5
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.51
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.51
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.49
rrs 1472970 n.1125C>A non_coding_transcript_exon_variant 0.49
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.17
rrs 1472975 n.1130T>A non_coding_transcript_exon_variant 0.32
rrs 1472977 n.1132G>T non_coding_transcript_exon_variant 0.48
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.48
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.47
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.47
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.46
rrs 1473001 n.1156G>C non_coding_transcript_exon_variant 0.47
rrs 1473002 n.1157G>A non_coding_transcript_exon_variant 0.47
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.47
rrs 1473008 n.1163C>T non_coding_transcript_exon_variant 0.47
rrs 1473009 n.1164T>G non_coding_transcript_exon_variant 0.47
rrs 1473020 n.1175T>C non_coding_transcript_exon_variant 0.47
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.32
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.27
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.17
rrs 1473070 n.1225G>A non_coding_transcript_exon_variant 0.12
rrs 1473248 n.1403G>A non_coding_transcript_exon_variant 0.12
rrs 1473249 n.1404T>C non_coding_transcript_exon_variant 0.13
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.12
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.12
rrs 1473262 n.1417T>A non_coding_transcript_exon_variant 0.12
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.11
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.3
rrl 1476229 n.2572C>G non_coding_transcript_exon_variant 0.33
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.46
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.47
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.48
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.54
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.52
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.53
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.53
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.53
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.53
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.61
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.61
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.61
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.68
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.68
rrl 1476353 n.2696G>A non_coding_transcript_exon_variant 0.68
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.64
rrl 1476359 n.2702C>T non_coding_transcript_exon_variant 0.65
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.65
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.65
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.61
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.61
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.55
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.55
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.49
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.47
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.46
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.41
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.31
rrl 1476513 n.2856G>A non_coding_transcript_exon_variant 0.18
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.16
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.14
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.13
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.13
rrl 1476544 n.2887T>C non_coding_transcript_exon_variant 0.12
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.14
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
panD 4043867 p.Gly139* stop_gained 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embB 4246584 p.Arg24Pro missense_variant 0.19
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0