TB-Profiler result

Run: SRR6280286
Summary

Run ID: SRR6280286

Sample name:

Date: 18-08-2022 08:43:40

Number of reads: 3705280

Percentage reads mapped: 78.53

Strain: lineage2.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.99
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472089 n.244C>T non_coding_transcript_exon_variant 0.21
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.27
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.39
rrs 1472108 n.263C>A non_coding_transcript_exon_variant 0.44
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.52
rrs 1472128 n.283G>C non_coding_transcript_exon_variant 0.52
rrs 1472129 n.284G>A non_coding_transcript_exon_variant 0.52
rrs 1472135 n.290C>T non_coding_transcript_exon_variant 0.52
rrs 1472138 n.293C>T non_coding_transcript_exon_variant 0.52
rrs 1472147 n.302G>A non_coding_transcript_exon_variant 0.52
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.52
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.52
rrs 1472153 n.308G>A non_coding_transcript_exon_variant 0.5
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.52
rrs 1472210 n.365A>T non_coding_transcript_exon_variant 0.52
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.52
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.48
rrs 1472235 n.390G>C non_coding_transcript_exon_variant 0.45
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.35
rrs 1472242 n.397C>T non_coding_transcript_exon_variant 0.29
rrs 1472251 n.406G>T non_coding_transcript_exon_variant 0.17
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.17
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.17
rrs 1472786 n.941C>T non_coding_transcript_exon_variant 0.2
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.2
rrs 1473051 n.1206T>C non_coding_transcript_exon_variant 0.17
rrs 1473053 n.1208T>G non_coding_transcript_exon_variant 0.17
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.17
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.2
rrs 1473070 n.1225G>A non_coding_transcript_exon_variant 0.2
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.27
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.27
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.25
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.23
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.14
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.14
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.14
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.15
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.15
rrs 1473123 n.1278A>G non_coding_transcript_exon_variant 0.15
rrs 1473131 n.1286G>A non_coding_transcript_exon_variant 0.12
rrs 1473134 n.1289T>C non_coding_transcript_exon_variant 0.12
rrs 1473139 n.1294T>C non_coding_transcript_exon_variant 0.12
rrs 1473142 n.1297G>C non_coding_transcript_exon_variant 0.11
rrl 1475230 n.1573C>T non_coding_transcript_exon_variant 0.2
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 0.17
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.68
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.73
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.58
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.58
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.67
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.58
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.68
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.59
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.68
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.65
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.59
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.59
rrl 1476411 n.2754G>T non_coding_transcript_exon_variant 0.62
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.55
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.55
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.55
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.59
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.5
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.47
rrl 1476463 n.2806C>A non_coding_transcript_exon_variant 0.47
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.45
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.43
rrl 1476483 n.2826G>A non_coding_transcript_exon_variant 0.35
rrl 1476501 n.2844C>T non_coding_transcript_exon_variant 0.18
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.18
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
pepQ 2860297 p.Gly41Asp missense_variant 0.98
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiB 3641776 p.Glu81Ala missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4246085 p.Glu951Asp missense_variant 0.98
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0