TB-Profiler result

Run: SRR8692825
Summary

Run ID: SRR8692825

Sample name:

Date: 13-08-2023 21:01:34

Number of reads: NA

Percentage reads mapped: NA

Strain: lineage4.9

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 0.97
lineage4.9 Euro-American (H37Rv-like) T1 None 0.96
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rplC 801268 p.Cys154Arg missense_variant 0.44 linezolid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5908 c.669C>A synonymous_variant 0.17
gyrB 6115 c.876A>G synonymous_variant 0.16
gyrB 6127 c.888G>C synonymous_variant 0.26
gyrB 6130 c.891T>C synonymous_variant 0.26
gyrB 6133 c.894G>C synonymous_variant 0.28
gyrB 6178 c.939C>T synonymous_variant 0.36
gyrB 6196 c.957C>G synonymous_variant 0.38
gyrB 6202 c.963C>G synonymous_variant 0.38
gyrB 6203 p.Ser322Ala missense_variant 0.36
gyrB 6214 c.975G>C synonymous_variant 0.36
gyrB 6215 p.Ser326Thr missense_variant 0.36
gyrB 6223 c.984G>C synonymous_variant 0.33
gyrB 6242 p.Arg335Lys missense_variant 0.27
gyrB 6250 c.1011A>G synonymous_variant 0.27
gyrB 6253 c.1014G>C synonymous_variant 0.25
gyrB 6265 c.1026C>T synonymous_variant 0.14
gyrB 6268 c.1029C>G synonymous_variant 0.14
gyrA 6580 c.-722C>T upstream_gene_variant 0.25
gyrA 6727 c.-575G>T upstream_gene_variant 0.22
gyrA 6904 c.-398C>A upstream_gene_variant 0.2
gyrB 6930 p.Ala564Glu missense_variant 0.15
gyrB 7005 p.Gly589Asp missense_variant 0.17
gyrA 7078 c.-224A>G upstream_gene_variant 0.14
gyrA 7081 c.-221T>C upstream_gene_variant 0.15
gyrA 7084 c.-218A>G upstream_gene_variant 0.15
gyrA 7093 c.-209T>C upstream_gene_variant 0.15
gyrA 7100 c.-202T>C upstream_gene_variant 0.12
gyrA 7275 c.-27C>A upstream_gene_variant 0.15
gyrA 7362 p.Glu21Gln missense_variant 0.44
gyrA 7965 p.Arg222Trp missense_variant 0.14
gyrA 8085 p.Asp262Tyr missense_variant 0.2
gyrA 8306 c.1005C>A synonymous_variant 0.29
gyrA 8624 c.1323G>T synonymous_variant 0.25
gyrA 9080 c.1779G>T synonymous_variant 0.25
gyrA 9086 c.1785C>T synonymous_variant 0.25
gyrA 9200 c.1899A>G synonymous_variant 0.14
gyrA 9304 p.Gly668Asp missense_variant 0.17
gyrA 9596 c.2295G>C synonymous_variant 0.15
fgd1 491437 p.Asp219Tyr missense_variant 0.18
fgd1 491488 p.Asp236Tyr missense_variant 0.17
fgd1 491494 p.Asp238Tyr missense_variant 0.15
mshA 575652 p.Arg102Leu missense_variant 0.2
mshA 575699 p.Glu118* stop_gained 0.33
mshA 575716 c.369C>T synonymous_variant 0.29
mshA 575821 c.474G>T synonymous_variant 0.15
mshA 576181 p.Lys278Asn missense_variant 0.22
mshA 576602 c.1255C>A synonymous_variant 0.18
ccsA 620012 p.Gly41Val missense_variant 0.13
ccsA 620128 p.Gly80Arg missense_variant 0.25
ccsA 620303 p.Trp138Leu missense_variant 0.67
ccsA 620427 c.537C>A synonymous_variant 0.29
ccsA 620550 c.660C>A synonymous_variant 0.18
ccsA 620625 p.Ile245Met missense_variant 0.21
ccsA 620705 p.Trp272Leu missense_variant 0.14
ccsA 620742 c.852G>T synonymous_variant 0.18
rpoB 759693 c.-114C>A upstream_gene_variant 0.29
rpoB 759887 c.81C>T synonymous_variant 0.25
rpoB 760262 c.456G>T synonymous_variant 0.25
rpoB 760673 c.867G>T synonymous_variant 0.13
rpoB 760706 p.Tyr300* stop_gained 0.14
rpoB 760764 p.Glu320* stop_gained 0.17
rpoB 760768 p.Pro321His missense_variant 0.17
rpoB 760791 p.Glu329* stop_gained 0.22
rpoB 760833 p.His343Asn missense_variant 0.18
rpoB 760842 p.Gln346Lys missense_variant 0.15
rpoB 761012 p.Asp402Glu missense_variant 0.13
rpoB 761419 p.Ala538Asp missense_variant 0.14
rpoB 761816 c.2010C>A synonymous_variant 0.2
rpoB 762065 c.2259T>C synonymous_variant 0.15
rpoB 762083 c.2277T>C synonymous_variant 0.12
rpoB 762086 c.2280G>C synonymous_variant 0.12
rpoB 762101 c.2295C>G synonymous_variant 0.12
rpoB 762114 p.Ile770Val missense_variant 0.13
rpoB 762122 c.2316C>T synonymous_variant 0.13
rpoB 762131 c.2325C>G synonymous_variant 0.15
rpoB 762137 c.2331C>T synonymous_variant 0.14
rpoB 762140 c.2334G>C synonymous_variant 0.13
rpoB 762143 c.2337T>C synonymous_variant 0.13
rpoB 762149 c.2343G>C synonymous_variant 0.15
rpoB 762156 p.Val784Ile missense_variant 0.14
rpoB 762167 c.2361T>C synonymous_variant 0.15
rpoB 762176 c.2370T>C synonymous_variant 0.17
rpoB 762185 c.2379G>C synonymous_variant 0.15
rpoC 762434 c.-936T>C upstream_gene_variant 0.13
rpoC 762857 c.-513C>G upstream_gene_variant 0.17
rpoC 762863 c.-507T>C upstream_gene_variant 0.17
rpoB 762879 p.Met1025Leu missense_variant 0.15
rpoC 762899 c.-471G>C upstream_gene_variant 0.17
rpoC 762917 c.-453C>G upstream_gene_variant 0.17
rpoC 762920 c.-450C>T upstream_gene_variant 0.17
rpoC 762923 c.-447C>G upstream_gene_variant 0.17
rpoC 762929 c.-441G>C upstream_gene_variant 0.17
rpoC 762959 c.-411G>C upstream_gene_variant 0.29
rpoC 762962 c.-408C>T upstream_gene_variant 0.29
rpoC 762983 c.-387C>T upstream_gene_variant 0.24
rpoC 762989 c.-381G>A upstream_gene_variant 0.25
rpoC 762995 c.-375G>T upstream_gene_variant 0.25
rpoC 763004 c.-366G>A upstream_gene_variant 0.14
rpoC 763007 c.-363C>T upstream_gene_variant 0.15
rpoC 763028 c.-342T>C upstream_gene_variant 0.17
rpoC 763031 c.-339T>C upstream_gene_variant 0.17
rpoC 763049 c.-321G>A upstream_gene_variant 0.18
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 0.17
rpoC 763070 c.-300T>C upstream_gene_variant 0.15
rpoC 763660 c.291T>G synonymous_variant 0.2
rpoC 763693 p.Lys108Asn missense_variant 0.15
rpoC 763696 c.327T>C synonymous_variant 0.15
rpoC 763699 c.330G>C synonymous_variant 0.15
rpoC 763702 c.333C>G synonymous_variant 0.15
rpoC 763708 c.339G>C synonymous_variant 0.15
rpoC 763709 c.340C>T synonymous_variant 0.15
rpoC 763714 c.345G>C synonymous_variant 0.17
rpoC 763717 c.348T>C synonymous_variant 0.17
rpoC 763726 c.357C>T synonymous_variant 0.17
rpoC 763940 p.Ala191Ser missense_variant 0.17
rpoC 763945 c.576T>C synonymous_variant 0.17
rpoC 763947 p.Ala193Val missense_variant 0.17
rpoC 763951 c.582G>C synonymous_variant 0.17
rpoC 763960 c.591T>G synonymous_variant 0.17
rpoC 763963 c.594C>T synonymous_variant 0.22
rpoC 763987 c.618C>T synonymous_variant 0.28
rpoC 763991 p.Ile208Leu missense_variant 0.29
rpoC 764005 c.636G>C synonymous_variant 0.29
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.31
rpoC 764029 p.Glu220Asp missense_variant 0.33
rpoC 764032 p.Asp221Glu missense_variant 0.36
rpoC 764040 p.Ser224Thr missense_variant 0.42
rpoC 764044 c.675T>C synonymous_variant 0.42
rpoC 764059 c.690G>T synonymous_variant 0.43
rpoC 764071 c.702G>C synonymous_variant 0.43
rpoC 764077 c.708C>G synonymous_variant 0.46
rpoC 764083 c.714A>G synonymous_variant 0.33
rpoC 764084 p.Asn239Val missense_variant 0.33
rpoC 764093 p.Arg242Ser missense_variant 0.15
rpoC 764098 c.729A>G synonymous_variant 0.31
rpoC 764126 p.Thr253Glu missense_variant 0.22
rpoC 764131 c.762T>C synonymous_variant 0.22
rpoC 764140 c.771C>T synonymous_variant 0.22
rpoC 764143 c.774G>C synonymous_variant 0.22
rpoC 764153 p.Gln262Lys missense_variant 0.22
rpoC 764452 c.1083T>C synonymous_variant 0.25
rpoC 764458 c.1089G>C synonymous_variant 0.22
rpoC 764461 c.1092A>G synonymous_variant 0.22
rpoC 764485 c.1116G>C synonymous_variant 0.13
rpoC 764491 c.1122G>T synonymous_variant 0.14
rpoC 764800 c.1431G>A synonymous_variant 0.15
rpoC 764803 c.1434C>T synonymous_variant 0.15
rpoC 764809 c.1440C>T synonymous_variant 0.15
rpoC 764815 c.1446A>G synonymous_variant 0.16
rpoC 764827 c.1458G>C synonymous_variant 0.16
rpoC 765397 c.2028G>T synonymous_variant 0.15
rpoC 765934 c.2565C>T synonymous_variant 0.25
rpoC 765937 c.2568T>C synonymous_variant 0.25
rpoC 765940 c.2571A>T synonymous_variant 0.25
rpoC 765946 c.2577C>T synonymous_variant 0.25
rpoC 765947 c.2578T>C synonymous_variant 0.25
rpoC 765952 c.2583G>C synonymous_variant 0.22
rpoC 765962 c.2593T>C synonymous_variant 0.25
rpoC 765967 c.2598C>T synonymous_variant 0.25
rpoC 766037 p.Asp890Tyr missense_variant 0.4
rpoC 766640 p.His1091Asn missense_variant 0.15
rpoC 766738 c.3369G>T synonymous_variant 0.13
rpoC 766750 c.3381C>G synonymous_variant 0.12
rpoC 766765 c.3396A>C synonymous_variant 0.13
rpoC 766771 c.3402G>C synonymous_variant 0.13
rpoC 766774 c.3405T>C synonymous_variant 0.13
rpoC 766777 c.3408C>G synonymous_variant 0.13
rpoC 766798 c.3429C>G synonymous_variant 0.13
rpoC 766804 c.3435A>G synonymous_variant 0.14
rpoC 766807 c.3438T>C synonymous_variant 0.14
rpoC 766837 c.3468G>C synonymous_variant 0.15
rpoC 767065 c.3696G>T synonymous_variant 0.14
rpoC 767098 c.3729T>C synonymous_variant 0.17
rpoC 767107 p.Asn1246Lys missense_variant 0.12
rpoC 767119 c.3750A>G synonymous_variant 0.12
rpoC 767155 c.3786C>G synonymous_variant 0.14
rpoC 767162 p.Asn1265Ala missense_variant 0.15
rpoC 767173 c.3804C>G synonymous_variant 0.14
rpoC 767174 p.Asn1269Asp missense_variant 0.14
rpoC 767180 p.Ala1271Pro missense_variant 0.14
rpoC 767185 c.3816G>C synonymous_variant 0.14
rpoC 767186 p.Gln1273Asn missense_variant 0.14
rpoC 767191 c.3822C>G synonymous_variant 0.14
rpoC 767197 c.3828G>A synonymous_variant 0.14
mmpL5 775834 p.Ala883Pro missense_variant 1.0
mmpL5 775970 c.2511G>C synonymous_variant 0.14
mmpL5 775981 p.Leu834Met missense_variant 0.14
mmpL5 775994 p.Ile829Leu missense_variant 0.12
mmpL5 775997 c.2484T>C synonymous_variant 0.12
mmpL5 776000 c.2481G>C synonymous_variant 0.12
mmpL5 776009 c.2472A>G synonymous_variant 0.24
mmpL5 776036 p.Ser815Ala missense_variant 0.31
mmpL5 776039 p.Ala814Ser missense_variant 0.31
mmpL5 776042 c.2439C>G synonymous_variant 0.28
mmpL5 776048 c.2433G>C synonymous_variant 0.29
mmpL5 776060 c.2421C>G synonymous_variant 0.33
mmpL5 776072 c.2409C>G synonymous_variant 0.29
mmpL5 776075 c.2406C>G synonymous_variant 0.31
mmpL5 776081 c.2400G>C synonymous_variant 0.31
mmpL5 776087 p.Val798Leu missense_variant 0.31
mmpL5 776100 p.Thr794Ile missense_variant 0.38
mmpL5 776107 p.Leu792Met missense_variant 0.13
mmpL5 776129 c.2352C>G synonymous_variant 0.19
mmpL5 776132 c.2349A>G synonymous_variant 0.19
mmpL5 776137 p.Ser782Ala missense_variant 0.21
mmpL5 776141 c.2340A>G synonymous_variant 0.2
mmpL5 776259 p.Ala741Asp missense_variant 0.15
mmpL5 776336 c.2145G>T synonymous_variant 0.15
mmpL5 776347 p.Asp712Tyr missense_variant 0.15
mmpL5 777014 c.1467C>A synonymous_variant 0.33
mmpL5 777509 c.972G>A synonymous_variant 0.15
mmpR5 778181 c.-809C>T upstream_gene_variant 0.15
mmpL5 778241 p.Lys80Asn missense_variant 0.17
mmpL5 778278 p.Ala68Glu missense_variant 0.15
mmpL5 778501 c.-21C>A upstream_gene_variant 0.17
mmpS5 778830 p.Gln26Lys missense_variant 0.18
mmpL5 779137 c.-657G>T upstream_gene_variant 0.17
mmpR5 779299 p.Glu104* stop_gained 0.18
mmpR5 779305 p.Glu106* stop_gained 0.15
mmpS5 779615 c.-710C>G upstream_gene_variant 0.25
rpsL 781751 c.192G>C synonymous_variant 0.14
rpsL 781754 c.195G>C synonymous_variant 0.14
rpsL 781760 c.201T>C synonymous_variant 0.2
rpsL 781769 c.210G>A synonymous_variant 0.23
rpsL 781805 c.246G>C synonymous_variant 0.2
rpsL 781811 c.252C>T synonymous_variant 0.2
rpsL 781814 c.255C>T synonymous_variant 0.2
rpsL 781817 c.258G>T synonymous_variant 0.25
rpsL 781829 c.270G>C synonymous_variant 0.33
rpsL 781832 c.273T>G synonymous_variant 0.33
rpsL 781859 c.300T>C synonymous_variant 0.5
rpsL 781868 c.309T>C synonymous_variant 0.6
rpsL 781871 c.312G>C synonymous_variant 0.6
rpsL 781892 c.333A>G synonymous_variant 0.57
rpsL 781901 c.342C>T synonymous_variant 0.57
rpsL 781916 c.357T>G synonymous_variant 0.5
rpsL 781929 p.Gly124Ser missense_variant 0.5
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.5
rplC 800671 c.-138G>T upstream_gene_variant 0.22
rplC 800726 c.-83G>A upstream_gene_variant 0.14
rplC 801162 c.354C>A synonymous_variant 0.18
fbiC 1302931 p.Val1Leu missense_variant 0.17
fbiC 1303486 p.Gly186Trp missense_variant 0.18
fbiC 1304165 p.Gly412Ala missense_variant 0.12
fbiC 1304613 c.1683T>C synonymous_variant 0.22
fbiC 1304634 c.1704C>G synonymous_variant 0.25
fbiC 1304640 c.1710A>C synonymous_variant 0.25
fbiC 1304646 c.1716T>C synonymous_variant 0.25
fbiC 1304658 c.1728C>G synonymous_variant 0.29
fbiC 1304671 p.Val581Thr missense_variant 0.29
fbiC 1304676 c.1746A>C synonymous_variant 0.29
fbiC 1304682 c.1752C>T synonymous_variant 0.25
fbiC 1304691 c.1761G>C synonymous_variant 0.2
fbiC 1304694 c.1764A>C synonymous_variant 0.18
fbiC 1304703 c.1773C>G synonymous_variant 0.2
fbiC 1304715 c.1785G>C synonymous_variant 0.17
fbiC 1304724 c.1794A>G synonymous_variant 0.15
fbiC 1304727 c.1797A>C synonymous_variant 0.15
fbiC 1305367 p.Glu813* stop_gained 0.22
Rv1258c 1406686 p.Val219Ile missense_variant 1.0
Rv1258c 1406775 p.Ala189Asp missense_variant 0.17
Rv1258c 1406789 c.552C>A synonymous_variant 0.18
Rv1258c 1407402 c.-62C>A upstream_gene_variant 0.2
embR 1416485 p.Ala288Glu missense_variant 0.29
embR 1417052 p.Pro99Gln missense_variant 0.2
embR 1417440 c.-93G>T upstream_gene_variant 0.2
embR 1417449 c.-102C>T upstream_gene_variant 0.18
atpE 1460855 c.-190T>C upstream_gene_variant 0.14
atpE 1461006 c.-39C>A upstream_gene_variant 0.18
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471663 n.-183C>A upstream_gene_variant 0.17
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.19
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.19
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.2
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.2
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.29
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.32
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.36
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.36
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.23
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.23
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.21
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.21
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.21
rrs 1472043 n.198T>G non_coding_transcript_exon_variant 0.21
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.27
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.23
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.2
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.22
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.33
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.33
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.33
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.25
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.47
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.37
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.37
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.37
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.37
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.39
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.39
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.39
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.39
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.31
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.33
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.27
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.27
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.27
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.27
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.27
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.5
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.5
rrs 1473023 n.1178G>T non_coding_transcript_exon_variant 0.2
rrs 1473090 n.1245G>T non_coding_transcript_exon_variant 0.15
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.25
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.29
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.29
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.25
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.29
rrl 1473572 n.-85delG upstream_gene_variant 0.17
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.29
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.2
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.2
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.3
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.25
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.25
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.31
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.36
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.33
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.25
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.25
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.25
rrl 1473828 n.171G>C non_coding_transcript_exon_variant 0.3
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.3
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.3
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.3
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.38
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.43
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.43
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.29
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.29
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.29
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.29
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.29
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.29
rrl 1474255 n.598C>A non_coding_transcript_exon_variant 0.18
rrl 1474285 n.628C>A non_coding_transcript_exon_variant 0.2
rrl 1474295 n.638C>A non_coding_transcript_exon_variant 0.25
rrl 1474534 n.877G>T non_coding_transcript_exon_variant 0.22
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.36
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.4
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.36
rrl 1474709 n.1053delT non_coding_transcript_exon_variant 0.4
rrl 1474714 n.1058delT non_coding_transcript_exon_variant 0.36
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.67
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.69
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.69
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.67
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.69
rrl 1475031 n.1374G>T non_coding_transcript_exon_variant 0.67
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.75
rrl 1475108 n.1451C>G non_coding_transcript_exon_variant 0.6
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.13
rrl 1475343 n.1686A>G non_coding_transcript_exon_variant 0.17
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.2
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.18
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.18
rrl 1475639 n.1982C>T non_coding_transcript_exon_variant 0.33
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.67
rrl 1475759 n.2102C>T non_coding_transcript_exon_variant 0.75
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.86
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.86
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.86
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.86
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.88
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.43
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.45
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.42
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.35
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.38
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.38
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.38
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.38
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.38
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.4
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.43
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.47
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.78
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.86
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.75
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.75
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.75
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.75
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.75
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.67
rrl 1476196 n.2539C>A non_coding_transcript_exon_variant 0.14
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.5
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.46
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.46
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.5
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.47
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.47
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.47
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.5
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.5
rrl 1476467 n.2810A>C non_coding_transcript_exon_variant 0.13
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.75
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.69
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.59
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.56
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.5
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.3
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.3
inhA 1674629 p.Ser143Tyr missense_variant 0.29
inhA 1674839 p.Ala213Val missense_variant 0.2
inhA 1674957 c.756G>T synonymous_variant 0.18
rpsA 1833473 c.-69C>G upstream_gene_variant 0.18
rpsA 1833676 c.135A>G synonymous_variant 0.17
rpsA 1833679 c.138G>C synonymous_variant 0.13
rpsA 1833697 c.156C>G synonymous_variant 0.12
rpsA 1833703 c.162C>T synonymous_variant 0.17
rpsA 1833709 c.168C>T synonymous_variant 0.14
rpsA 1833734 p.Ala65Ser missense_variant 0.17
rpsA 1833745 c.204G>C synonymous_variant 0.17
rpsA 1833760 c.219C>T synonymous_variant 0.18
rpsA 1833787 c.246C>G synonymous_variant 0.21
rpsA 1833790 c.249T>C synonymous_variant 0.21
rpsA 1833793 c.252C>T synonymous_variant 0.23
rpsA 1833802 c.261A>G synonymous_variant 0.29
rpsA 1833808 c.267G>C synonymous_variant 0.21
rpsA 1833811 c.270G>T synonymous_variant 0.14
rpsA 1833968 p.Gly143Cys missense_variant 0.17
rpsA 1833976 c.435C>T synonymous_variant 0.25
rpsA 1833979 c.438T>C synonymous_variant 0.25
rpsA 1833991 c.450C>A synonymous_variant 0.31
rpsA 1834000 c.459G>C synonymous_variant 0.28
rpsA 1834012 c.471G>C synonymous_variant 0.28
rpsA 1834015 c.474G>C synonymous_variant 0.29
rpsA 1834021 c.480C>T synonymous_variant 0.28
rpsA 1834030 c.489C>G synonymous_variant 0.29
rpsA 1834069 c.528G>C synonymous_variant 0.21
rpsA 1834096 c.555G>C synonymous_variant 0.18
rpsA 1834099 c.558C>G synonymous_variant 0.17
rpsA 1834102 c.561T>C synonymous_variant 0.17
rpsA 1834108 c.567C>G synonymous_variant 0.18
rpsA 1834526 p.Arg329Ser missense_variant 0.2
rpsA 1834579 c.1038C>A synonymous_variant 0.18
tlyA 1917902 c.-38G>C upstream_gene_variant 0.12
tlyA 1918458 c.519C>A synonymous_variant 0.22
ndh 2101779 p.Leu422Ile missense_variant 0.17
ndh 2102598 p.Gly149Cys missense_variant 0.17
ndh 2102616 p.Asp143Tyr missense_variant 0.17
ndh 2102722 c.321C>T synonymous_variant 0.18
katG 2154724 p.Arg463Leu missense_variant 0.29
katG 2154835 p.Tyr426Cys missense_variant 0.15
katG 2154852 p.Met420Ile missense_variant 0.17
katG 2155384 p.Ala243Asp missense_variant 0.2
katG 2156531 c.-420C>A upstream_gene_variant 0.25
PPE35 2167820 c.2793G>T synonymous_variant 0.15
PPE35 2167871 c.2742G>T synonymous_variant 0.22
PPE35 2167926 p.Leu896Ser missense_variant 0.25
PPE35 2168527 p.Gly696* stop_gained 0.14
PPE35 2168736 p.Ser626Ile missense_variant 0.15
PPE35 2168913 p.Pro567Gln missense_variant 0.17
PPE35 2169226 p.Pro463Thr missense_variant 0.17
PPE35 2169271 p.Gln448Lys missense_variant 0.15
Rv1979c 2221899 c.1266C>A synonymous_variant 0.18
Rv1979c 2222109 c.1056C>A synonymous_variant 0.17
Rv1979c 2222349 c.816G>T synonymous_variant 0.18
Rv1979c 2222900 p.Arg89Trp missense_variant 0.14
Rv1979c 2223271 c.-107G>T upstream_gene_variant 0.15
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.24
pncA 2288872 p.Gly124Cys missense_variant 0.22
pncA 2288909 p.Glu111Asp missense_variant 0.18
pncA 2290115 c.-874C>A upstream_gene_variant 0.14
kasA 2518481 p.Val123Phe missense_variant 0.13
kasA 2518616 p.Val168Met missense_variant 0.17
kasA 2519355 p.Gly414Val missense_variant 0.4
eis 2714207 p.Arg376Ser missense_variant 0.33
eis 2715066 c.267G>A synonymous_variant 0.25
folC 2746172 p.Gly476Val missense_variant 0.13
folC 2747013 p.Pro196Thr missense_variant 0.18
pepQ 2859342 c.1077G>T synonymous_variant 0.18
pepQ 2860352 p.Leu23Val missense_variant 0.29
ribD 2987594 p.Tyr252* stop_gained 0.15
Rv2752c 3064990 p.Arg401Leu missense_variant 0.25
Rv2752c 3065008 p.Pro395Gln missense_variant 0.22
thyX 3068022 c.-77C>A upstream_gene_variant 0.14
thyA 3073725 p.Lys249Asn missense_variant 0.14
thyA 3073742 p.Glu244* stop_gained 0.21
thyA 3073754 p.Glu240* stop_gained 0.17
thyA 3073947 c.525G>C synonymous_variant 0.15
thyA 3073953 c.519T>C synonymous_variant 0.14
thyA 3073956 c.516G>C synonymous_variant 0.14
thyA 3073959 c.513T>C synonymous_variant 0.14
thyA 3073968 c.504C>G synonymous_variant 0.15
thyA 3073977 c.495A>G synonymous_variant 0.14
thyA 3073983 c.489C>G synonymous_variant 0.15
thyA 3073989 c.483T>C synonymous_variant 0.16
thyA 3073993 c.478_479delAGinsTC synonymous_variant 0.18
thyA 3073999 p.Arg158Lys missense_variant 0.18
thyA 3074004 c.468T>C synonymous_variant 0.18
thyA 3074436 c.36C>A synonymous_variant 0.25
ald 3087214 p.Pro132Leu missense_variant 0.22
ald 3087281 c.462G>T synonymous_variant 0.18
ald 3087356 c.537C>T synonymous_variant 0.25
ald 3087533 c.714C>A synonymous_variant 0.17
ald 3087672 p.His285Asn missense_variant 0.15
ald 3087886 p.Ala356Asp missense_variant 0.25
Rv3083 3448540 p.Gly13Cys missense_variant 0.2
Rv3083 3448668 c.165G>T synonymous_variant 0.18
Rv3083 3448739 p.Ala79Val missense_variant 0.22
Rv3083 3448863 c.360C>A synonymous_variant 0.2
Rv3083 3449317 p.Glu272* stop_gained 0.18
Rv3083 3449349 p.Asp282Glu missense_variant 0.22
Rv3083 3449668 p.Gly389Cys missense_variant 0.18
Rv3083 3449733 c.1230G>T synonymous_variant 0.13
Rv3083 3449776 p.Asp425Tyr missense_variant 0.15
Rv3083 3449879 p.Pro459Gln missense_variant 0.2
Rv3083 3449933 p.Pro477His missense_variant 0.18
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.21
fprA 3474434 p.Pro143His missense_variant 0.15
fprA 3475202 p.Pro399Gln missense_variant 0.2
fprA 3475261 p.Thr419Ala missense_variant 0.22
whiB7 3568662 c.18C>T synonymous_variant 0.17
whiB7 3568680 c.-1C>G upstream_gene_variant 0.15
whiB7 3568762 c.-83G>A upstream_gene_variant 0.5
Rv3236c 3611988 p.Leu377Met missense_variant 0.25
Rv3236c 3611995 c.1122C>A synonymous_variant 0.33
Rv3236c 3612120 p.Arg333Trp missense_variant 0.27
Rv3236c 3612167 p.Gly317Val missense_variant 0.14
Rv3236c 3612343 c.774G>T synonymous_variant 0.14
Rv3236c 3612351 p.Ala256Ser missense_variant 0.14
Rv3236c 3612750 p.Gly123Trp missense_variant 0.15
Rv3236c 3612813 p.Thr102Ala missense_variant 0.22
Rv3236c 3612898 c.219G>T synonymous_variant 0.15
fbiA 3640775 p.Gly78Val missense_variant 0.15
fbiA 3641017 p.Pro159Thr missense_variant 0.22
fbiA 3641032 p.Arg164Cys missense_variant 0.2
fbiA 3641050 p.Gln170Lys missense_variant 0.2
fbiB 3641853 p.Gly107Cys missense_variant 0.14
fbiB 3641858 c.324G>T synonymous_variant 0.14
fbiB 3641934 p.Ala134Ser missense_variant 0.14
fbiB 3641967 p.Ala145Ser missense_variant 0.14
fbiB 3641991 p.Gly153* stop_gained 0.17
fbiB 3642296 p.Gln254His missense_variant 0.22
alr 3840284 p.Trp379Cys missense_variant 0.17
alr 3840839 p.Met194Ile missense_variant 0.4
alr 3840928 p.Asn165Tyr missense_variant 0.4
alr 3841307 c.114C>A synonymous_variant 0.14
rpoA 3877533 c.975C>A synonymous_variant 0.2
rpoA 3877602 c.906C>T synonymous_variant 0.22
rpoA 3877617 c.891G>C synonymous_variant 0.18
rpoA 3877638 c.870T>G synonymous_variant 0.23
rpoA 3877647 c.861C>T synonymous_variant 0.23
rpoA 3877656 c.852T>C synonymous_variant 0.23
rpoA 3877662 c.846C>T synonymous_variant 0.21
rpoA 3877665 c.843C>G synonymous_variant 0.21
rpoA 3877668 c.840A>G synonymous_variant 0.21
rpoA 3877674 c.834C>T synonymous_variant 0.21
rpoA 3877679 p.Ala277Ser missense_variant 0.21
rpoA 3877686 c.822A>G synonymous_variant 0.2
rpoA 3877692 c.816G>C synonymous_variant 0.21
rpoA 3877704 c.804G>T synonymous_variant 0.25
rpoA 3877728 c.780C>G synonymous_variant 0.15
rpoA 3877732 p.Arg259Leu missense_variant 0.15
rpoA 3877734 c.774G>C synonymous_variant 0.15
rpoA 3877737 c.771G>C synonymous_variant 0.17
rpoA 3877743 c.765T>C synonymous_variant 0.13
rpoA 3877905 c.603A>G synonymous_variant 0.14
rpoA 3877908 c.600T>C synonymous_variant 0.12
rpoA 3877920 c.588G>C synonymous_variant 0.12
rpoA 3877926 c.582G>C synonymous_variant 0.13
rpoA 3877962 c.546G>C synonymous_variant 0.18
rpoA 3877971 p.Asp179Glu missense_variant 0.18
rpoA 3877986 c.522G>C synonymous_variant 0.13
rpoA 3877989 c.519A>G synonymous_variant 0.13
rpoA 3878105 p.Glu135* stop_gained 0.17
rpoA 3878115 p.Lys131Asn missense_variant 0.15
ddn 3987178 p.Arg112Leu missense_variant 0.17
clpC1 4038704 c.2001T>C synonymous_variant 0.17
clpC1 4038707 c.1998C>G synonymous_variant 0.17
clpC1 4038710 c.1995G>C synonymous_variant 0.2
clpC1 4038713 c.1992T>C synonymous_variant 0.2
clpC1 4038878 c.1827A>G synonymous_variant 0.33
clpC1 4038881 c.1824C>G synonymous_variant 0.4
clpC1 4038890 c.1815G>A synonymous_variant 0.5
clpC1 4038905 c.1800A>C synonymous_variant 0.67
clpC1 4038908 c.1797C>G synonymous_variant 0.5
clpC1 4038911 c.1794G>T synonymous_variant 0.4
clpC1 4038914 c.1791G>C synonymous_variant 0.4
clpC1 4038917 c.1788C>T synonymous_variant 0.4
clpC1 4038923 c.1782A>G synonymous_variant 0.33
clpC1 4038953 c.1752A>G synonymous_variant 0.25
clpC1 4038956 c.1749T>C synonymous_variant 0.29
clpC1 4038965 c.1740T>C synonymous_variant 0.3
clpC1 4038971 c.1734T>C synonymous_variant 0.25
clpC1 4038974 c.1731T>C synonymous_variant 0.25
clpC1 4038980 c.1725C>T synonymous_variant 0.21
clpC1 4038989 c.1716T>C synonymous_variant 0.2
clpC1 4038997 c.1708T>C synonymous_variant 0.19
clpC1 4039001 p.Asn568Ala missense_variant 0.19
clpC1 4039022 c.1683A>G synonymous_variant 0.2
clpC1 4039079 c.1626C>G synonymous_variant 0.13
clpC1 4039085 c.1620A>G synonymous_variant 0.13
clpC1 4039091 c.1614G>C synonymous_variant 0.13
clpC1 4039097 c.1608G>C synonymous_variant 0.13
clpC1 4039121 c.1584T>C synonymous_variant 0.15
clpC1 4039142 c.1563A>G synonymous_variant 0.15
clpC1 4039145 p.Gly520Cys missense_variant 0.15
clpC1 4039302 p.Trp468Leu missense_variant 0.25
clpC1 4039334 c.1371G>T synonymous_variant 0.2
clpC1 4039395 p.Ser437* stop_gained 0.22
clpC1 4039898 c.807C>G synonymous_variant 0.22
clpC1 4039931 c.774T>C synonymous_variant 0.2
clpC1 4039934 c.771G>C synonymous_variant 0.2
clpC1 4039937 c.768G>C synonymous_variant 0.18
clpC1 4039946 c.759A>C synonymous_variant 0.15
clpC1 4039949 c.756G>C synonymous_variant 0.15
clpC1 4039952 c.753T>C synonymous_variant 0.17
clpC1 4039979 c.726C>G synonymous_variant 0.15
clpC1 4039991 c.714G>C synonymous_variant 0.12
clpC1 4040015 c.690G>C synonymous_variant 0.12
panD 4043879 c.403C>A synonymous_variant 0.22
panD 4044128 p.Gly52Arg missense_variant 0.12
embC 4239974 p.Leu38Met missense_variant 0.22
embC 4240878 p.Thr339Lys missense_variant 0.29
embC 4240993 c.1131G>C synonymous_variant 0.25
embC 4241459 p.Arg533Ser missense_variant 0.22
embC 4241627 p.His589Asn missense_variant 0.15
embC 4241638 c.1776G>A synonymous_variant 0.15
embA 4243294 p.Gly21Val missense_variant 0.15
embA 4243329 p.Leu33Met missense_variant 0.18
embA 4243748 c.516C>A synonymous_variant 0.67
embA 4244360 p.Asn376Lys missense_variant 0.25
embA 4245433 p.Ala734Val missense_variant 0.22
embB 4245839 c.-675G>A upstream_gene_variant 0.29
embA 4245997 p.Trp922Leu missense_variant 0.17
embB 4246254 c.-260C>T upstream_gene_variant 0.15
embA 4246390 p.Asp1053Val missense_variant 0.17
embA 4246479 p.Gly1083Cys missense_variant 0.22
embB 4247108 p.Gly199Arg missense_variant 0.2
embB 4247119 c.606C>A synonymous_variant 0.18
embB 4247150 c.637C>A synonymous_variant 0.15
embB 4247161 c.648G>T synonymous_variant 0.15
embB 4249551 p.Arg1013Pro missense_variant 0.2
embB 4249736 p.Pro1075Ser missense_variant 0.13
embB 4249779 p.Trp1089Leu missense_variant 0.14
aftB 4267633 p.Val402Phe missense_variant 0.17
aftB 4267635 p.Arg401Leu missense_variant 0.17
aftB 4267647 p.Asp397Gly missense_variant 0.18
aftB 4267657 p.Gly394Cys missense_variant 0.22
aftB 4268442 p.Arg132Leu missense_variant 0.25
aftB 4268709 p.Ala43Asp missense_variant 0.14
aftB 4269324 c.-488C>A upstream_gene_variant 0.17
aftB 4269375 c.-539G>A upstream_gene_variant 0.17
ubiA 4269506 p.Gly110* stop_gained 0.15
ethA 4326099 p.Gln459Lys missense_variant 0.14
ethA 4326333 p.Ala381Ser missense_variant 0.13
ethA 4326412 c.1062G>A synonymous_variant 0.14
ethR 4327444 c.-105C>A upstream_gene_variant 0.15
ethR 4327708 p.Ala54Ser missense_variant 0.14
ethR 4327780 p.Arg78Gly missense_variant 0.17
ethA 4327950 c.-477G>A upstream_gene_variant 0.18
whiB6 4338177 c.345G>T synonymous_variant 0.18
whiB6 4338595 c.-75delG upstream_gene_variant 0.17
whiB6 4338663 c.-142G>A upstream_gene_variant 0.15
gid 4407588 c.615A>G synonymous_variant 0.21