TB-Profiler result

Run: ERR2229084
Summary

Run ID: ERR2229084

Sample name:

Date: 31-03-2023 16:39:30

Number of reads: 1528554

Percentage reads mapped: 93.11

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6775 c.-527G>C upstream_gene_variant 0.13
gyrA 6787 c.-515G>A upstream_gene_variant 0.14
gyrA 6793 c.-509T>C upstream_gene_variant 0.14
gyrB 6797 p.Gly520Thr missense_variant 0.15
gyrA 6811 c.-491C>T upstream_gene_variant 0.21
gyrA 6841 c.-461T>C upstream_gene_variant 0.17
gyrA 6844 c.-458T>C upstream_gene_variant 0.17
gyrA 6853 c.-449A>G upstream_gene_variant 0.17
gyrA 6856 c.-446T>C upstream_gene_variant 0.17
gyrA 6859 c.-443T>C upstream_gene_variant 0.16
gyrA 6862 c.-440C>G upstream_gene_variant 0.16
gyrA 6868 c.-434G>C upstream_gene_variant 0.14
gyrA 6901 c.-401G>C upstream_gene_variant 0.14
gyrA 6904 c.-398C>G upstream_gene_variant 0.14
gyrA 6916 c.-386G>C upstream_gene_variant 0.14
gyrA 6919 c.-383T>C upstream_gene_variant 0.13
gyrA 6949 c.-353A>G upstream_gene_variant 0.15
gyrA 6952 c.-350C>G upstream_gene_variant 0.15
gyrA 7362 p.Glu21Gln missense_variant 1.0
fgd1 491217 c.435T>C synonymous_variant 0.14
mshA 576089 p.Ala254Gly missense_variant 0.27
rpoB 760181 c.375T>C synonymous_variant 0.16
rpoB 760184 c.378A>G synonymous_variant 0.15
rpoB 760196 c.390C>G synonymous_variant 0.15
rpoB 760283 c.477G>C synonymous_variant 0.14
rpoB 760340 c.534G>T synonymous_variant 0.14
rpoB 760481 c.675G>C synonymous_variant 0.14
rpoB 760484 c.678A>G synonymous_variant 0.14
rpoB 760522 p.Ser239Asn missense_variant 0.18
rpoB 760611 c.805T>C synonymous_variant 0.21
rpoB 760841 c.1035T>C synonymous_variant 0.14
rpoB 760845 p.Thr347Pro missense_variant 0.14
rpoB 760859 c.1053T>C synonymous_variant 0.18
rpoB 760862 c.1056G>C synonymous_variant 0.15
rpoB 760869 p.Val355Ile missense_variant 0.2
rpoB 760925 c.1119T>C synonymous_variant 0.15
rpoB 760928 c.1122G>C synonymous_variant 0.16
rpoB 760931 c.1125C>G synonymous_variant 0.16
rpoB 760934 c.1128C>T synonymous_variant 0.16
rpoB 760946 c.1140A>G synonymous_variant 0.16
rpoB 760985 c.1179G>C synonymous_variant 0.14
rpoB 760991 c.1185G>C synonymous_variant 0.14
rpoB 761165 c.1359G>C synonymous_variant 0.17
rpoB 761180 c.1374A>C synonymous_variant 0.17
rpoB 761189 c.1383T>C synonymous_variant 0.16
rpoB 761195 c.1389G>C synonymous_variant 0.17
rpoB 761207 c.1401C>T synonymous_variant 0.21
rpoB 761213 c.1407G>C synonymous_variant 0.17
rpoB 761219 c.1413G>C synonymous_variant 0.17
rpoB 761249 c.1443A>G synonymous_variant 0.13
rpoB 761261 c.1455G>T synonymous_variant 0.12
rpoB 761570 c.1764T>C synonymous_variant 0.13
rpoB 761579 c.1773G>C synonymous_variant 0.13
rpoB 761588 c.1782C>T synonymous_variant 0.19
rpoB 761606 c.1800C>G synonymous_variant 0.18
rpoB 761615 c.1809A>C synonymous_variant 0.15
rpoB 761636 c.1830G>T synonymous_variant 0.19
rpoB 761645 c.1839C>G synonymous_variant 0.19
rpoB 761648 c.1842T>C synonymous_variant 0.19
rpoB 761657 c.1851C>G synonymous_variant 0.2
rpoB 761675 c.1869G>C synonymous_variant 0.15
rpoB 761948 c.2142G>C synonymous_variant 0.15
rpoB 761954 c.2148C>G synonymous_variant 0.16
rpoB 762008 c.2202C>T synonymous_variant 0.16
rpoB 762014 c.2208C>T synonymous_variant 0.2
rpoB 762017 c.2211A>G synonymous_variant 0.2
rpoB 762062 c.2256T>C synonymous_variant 0.15
rpoB 762065 c.2259T>C synonymous_variant 0.14
rpoB 762083 c.2277T>C synonymous_variant 0.14
rpoB 762086 c.2280G>C synonymous_variant 0.14
rpoB 762101 c.2295C>G synonymous_variant 0.13
rpoB 762114 p.Ile770Val missense_variant 0.13
rpoC 762929 c.-441G>C upstream_gene_variant 0.14
rpoC 762989 c.-381G>C upstream_gene_variant 0.23
rpoC 762995 c.-375G>T upstream_gene_variant 0.22
rpoC 763013 c.-357C>G upstream_gene_variant 0.15
rpoC 763028 c.-342T>C upstream_gene_variant 0.15
rpoC 763031 c.-339T>G upstream_gene_variant 0.15
rpoC 763034 c.-336C>G upstream_gene_variant 0.15
rpoC 763040 c.-330C>G upstream_gene_variant 0.18
rpoC 763402 c.33C>G synonymous_variant 0.13
rpoC 763441 c.72C>T synonymous_variant 0.16
rpoC 763444 c.75T>C synonymous_variant 0.16
rpoC 763456 c.87A>G synonymous_variant 0.17
rpoC 763594 c.225C>T synonymous_variant 0.17
rpoC 763603 c.234C>T synonymous_variant 0.21
rpoC 763636 c.267T>C synonymous_variant 0.22
rpoC 763696 c.327T>C synonymous_variant 0.14
rpoC 763702 c.333C>G synonymous_variant 0.14
rpoC 763717 c.348T>C synonymous_variant 0.14
rpoC 763723 c.354G>C synonymous_variant 0.14
rpoC 763732 c.363C>G synonymous_variant 0.14
rpoC 763741 c.372C>T synonymous_variant 0.16
rpoC 763744 c.375G>C synonymous_variant 0.16
rpoC 763765 c.396T>C synonymous_variant 0.31
rpoC 763774 c.405G>C synonymous_variant 0.34
rpoC 763807 c.438T>C synonymous_variant 0.34
rpoC 763816 c.447C>G synonymous_variant 0.36
rpoC 763835 p.Ala156Met missense_variant 0.37
rpoC 763853 p.Val162Ile missense_variant 0.29
rpoC 763858 c.489A>G synonymous_variant 0.25
rpoC 763872 p.Gly168Ala missense_variant 0.21
rpoC 763876 p.Glu169Asp missense_variant 0.21
rpoC 763879 c.510A>G synonymous_variant 0.2
rpoC 763888 c.519G>C synonymous_variant 0.19
rpoC 763891 c.522G>C synonymous_variant 0.17
rpoC 763894 c.525A>G synonymous_variant 0.2
rpoC 763900 c.531G>C synonymous_variant 0.24
rpoC 763945 c.576T>C synonymous_variant 0.21
rpoC 763951 c.582G>C synonymous_variant 0.18
rpoC 763960 c.591T>C synonymous_variant 0.15
rpoC 763987 c.618C>T synonymous_variant 0.18
rpoC 763991 p.Ile208Leu missense_variant 0.19
rpoC 763996 c.627T>C synonymous_variant 0.19
rpoC 764002 c.633C>G synonymous_variant 0.26
rpoC 764005 c.636G>C synonymous_variant 0.26
rpoC 764024 c.655_657delTTGinsCTC synonymous_variant 0.18
rpoC 764032 p.Asp221Glu missense_variant 0.19
rpoC 764040 p.Ser224Thr missense_variant 0.14
rpoC 764059 c.690G>T synonymous_variant 0.22
rpoC 764083 c.714A>G synonymous_variant 0.17
rpoC 764112 p.Tyr248Phe missense_variant 0.17
rpoC 764116 c.747C>T synonymous_variant 0.17
rpoC 764419 c.1050C>G synonymous_variant 0.13
rpoC 764489 c.1120C>T synonymous_variant 0.15
rpoC 764510 c.1141C>T synonymous_variant 0.17
rpoC 764543 p.Thr392Asp missense_variant 0.12
rpoC 764593 c.1224C>T synonymous_variant 0.13
rpoC 764611 c.1242G>T synonymous_variant 0.16
rpoC 764650 c.1281G>C synonymous_variant 0.12
rpoC 764651 p.Ser428Thr missense_variant 0.13
rpoC 764764 c.1395T>C synonymous_variant 0.14
rpoC 765346 c.1977C>G synonymous_variant 0.14
rpoC 765349 c.1980T>C synonymous_variant 0.15
rpoC 765352 c.1983G>C synonymous_variant 0.15
rpoC 765364 c.1995G>A synonymous_variant 0.12
rpoC 765478 c.2109T>C synonymous_variant 0.2
rpoC 765499 c.2130C>G synonymous_variant 0.15
rpoC 765529 c.2160C>T synonymous_variant 0.16
rpoC 765541 c.2172C>G synonymous_variant 0.21
rpoC 765553 c.2184C>T synonymous_variant 0.21
rpoC 765556 c.2187G>C synonymous_variant 0.21
rpoC 765559 c.2190G>C synonymous_variant 0.21
rpoC 765580 c.2211G>C synonymous_variant 0.29
rpoC 765613 p.His748Gln missense_variant 0.18
rpoC 765700 c.2331T>C synonymous_variant 0.23
rpoC 765734 c.2365T>C synonymous_variant 0.2
rpoC 765739 c.2370G>T synonymous_variant 0.21
rpoC 765850 c.2481G>C synonymous_variant 0.16
rpoC 765883 c.2514C>G synonymous_variant 0.15
rpoC 765886 c.2517C>G synonymous_variant 0.15
rpoC 765892 c.2523T>C synonymous_variant 0.14
rpoC 765937 c.2568T>C synonymous_variant 0.18
rpoC 765947 c.2578T>C synonymous_variant 0.18
rpoC 765967 c.2598C>T synonymous_variant 0.25
rpoC 765982 c.2613C>G synonymous_variant 0.24
rpoC 765994 c.2625A>T synonymous_variant 0.15
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.19
rpoC 766021 c.2652G>C synonymous_variant 0.18
rpoC 766027 c.2658G>C synonymous_variant 0.13
rpoC 766043 p.Gln892Glu missense_variant 0.13
rpoC 766096 c.2727G>C synonymous_variant 0.17
rpoC 766129 c.2760C>G synonymous_variant 0.19
rpoC 766135 c.2766G>A synonymous_variant 0.18
rpoC 766141 c.2772C>T synonymous_variant 0.16
rpoC 766142 c.2773C>T synonymous_variant 0.15
rpoC 766273 c.2904T>C synonymous_variant 0.15
rpoC 766274 p.Ala969Thr missense_variant 0.15
rpoC 766280 p.Ser971Gly missense_variant 0.15
rpoC 766303 c.2934C>T synonymous_variant 0.17
rpoC 766312 c.2943T>G synonymous_variant 0.14
rpoC 766327 c.2958C>A synonymous_variant 0.26
rpoC 766345 c.2976T>C synonymous_variant 0.24
rpoC 766348 c.2979A>G synonymous_variant 0.21
rpoC 766357 c.2988C>T synonymous_variant 0.22
rpoC 766363 c.2994G>C synonymous_variant 0.2
rpoC 766366 c.2997C>G synonymous_variant 0.2
rpoC 766381 c.3012C>T synonymous_variant 0.2
rpoC 766384 c.3015A>G synonymous_variant 0.18
rpoC 766390 c.3021C>T synonymous_variant 0.17
rpoC 766393 c.3024C>G synonymous_variant 0.17
rpoC 766426 c.3057C>T synonymous_variant 0.14
rpoC 766447 c.3078T>C synonymous_variant 0.13
rpoC 766861 c.3492G>C synonymous_variant 0.16
rpoC 766864 c.3495G>C synonymous_variant 0.16
rpoC 766933 c.3564A>G synonymous_variant 0.13
rpoC 766945 c.3576A>G synonymous_variant 0.13
rpoC 766963 c.3594T>C synonymous_variant 0.16
rpoC 766972 c.3603G>C synonymous_variant 0.25
rpoC 766996 c.3627C>T synonymous_variant 0.2
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781715 c.156T>C synonymous_variant 0.13
rpsL 781808 c.249C>T synonymous_variant 0.14
rpsL 781811 c.252C>T synonymous_variant 0.14
rpsL 781832 c.273T>C synonymous_variant 0.15
rpsL 781838 c.279G>C synonymous_variant 0.15
fbiC 1303747 p.Thr273Ala missense_variant 0.94
fbiC 1304715 c.1785G>C synonymous_variant 0.13
fbiC 1304727 c.1797A>G synonymous_variant 0.13
fbiC 1304742 c.1812T>C synonymous_variant 0.17
fbiC 1304748 c.1818T>C synonymous_variant 0.17
fbiC 1304757 c.1827A>G synonymous_variant 0.17
fbiC 1304778 c.1848T>C synonymous_variant 0.17
fbiC 1304784 c.1854T>C synonymous_variant 0.17
fbiC 1304787 c.1857T>G synonymous_variant 0.17
fbiC 1304808 c.1878C>G synonymous_variant 0.18
fbiC 1304811 c.1881C>G synonymous_variant 0.17
fbiC 1304817 c.1887T>C synonymous_variant 0.19
fbiC 1304829 c.1899T>C synonymous_variant 0.18
fbiC 1304832 c.1902C>T synonymous_variant 0.18
fbiC 1304853 c.1923C>T synonymous_variant 0.15
fbiC 1304856 c.1926C>G synonymous_variant 0.14
fbiC 1304907 c.1977C>G synonymous_variant 0.17
fbiC 1304910 c.1980G>C synonymous_variant 0.17
fbiC 1304916 c.1986T>C synonymous_variant 0.16
fbiC 1304928 c.1998T>C synonymous_variant 0.17
fbiC 1304937 c.2007G>C synonymous_variant 0.17
fbiC 1304958 c.2028T>G synonymous_variant 0.29
fbiC 1304983 c.2053C>T synonymous_variant 0.33
fbiC 1304994 c.2064A>G synonymous_variant 0.21
fbiC 1304995 p.Leu689Met missense_variant 0.21
fbiC 1305006 c.2076A>G synonymous_variant 0.21
fbiC 1305012 c.2082G>C synonymous_variant 0.21
fbiC 1305015 c.2085G>C synonymous_variant 0.23
fbiC 1305021 c.2091C>G synonymous_variant 0.18
fbiC 1305030 c.2100G>C synonymous_variant 0.15
fbiC 1305033 c.2103T>G synonymous_variant 0.15
fbiC 1305042 c.2112A>G synonymous_variant 0.14
fbiC 1305045 c.2115A>G synonymous_variant 0.14
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.17
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.15
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.13
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.2
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.33
rrl 1474958 n.1301A>G non_coding_transcript_exon_variant 0.33
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.33
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.5
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.5
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.5
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.67
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.33
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.13
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.17
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.17
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.17
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.17
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.18
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.18
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.18
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.18
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.23
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.23
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.18
fabG1 1673380 c.-60C>G upstream_gene_variant 0.43
inhA 1673607 c.-595T>C upstream_gene_variant 0.13
fabG1 1673615 p.Glu59Val missense_variant 0.13
inhA 1673619 c.-583T>C upstream_gene_variant 0.13
fabG1 1673633 p.Ser65Asn missense_variant 0.18
fabG1 1673637 p.Asp66Glu missense_variant 0.19
fabG1 1673641 p.Val68Ile missense_variant 0.21
inhA 1673646 c.-556T>C upstream_gene_variant 0.21
fabG1 1673657 p.Thr73Lys missense_variant 0.22
inhA 1673660 c.-542C>A upstream_gene_variant 0.22
inhA 1673664 c.-538A>C upstream_gene_variant 0.19
inhA 1673667 c.-535A>G upstream_gene_variant 0.19
inhA 1673679 c.-523T>C upstream_gene_variant 0.18
inhA 1673685 c.-517C>T upstream_gene_variant 0.18
fabG1 1673710 p.Leu91Ile missense_variant 0.23
fabG1 1673716 p.Ala93Lys missense_variant 0.21
fabG1 1673733 p.Met98Ile missense_variant 0.18
inhA 1673961 c.-241A>C upstream_gene_variant 0.14
inhA 1673985 c.-217C>G upstream_gene_variant 0.15
inhA 1674504 c.303C>G synonymous_variant 0.14
inhA 1674561 c.360C>T synonymous_variant 0.17
inhA 1674582 c.381T>C synonymous_variant 0.15
inhA 1674585 c.384T>C synonymous_variant 0.15
inhA 1674589 p.Met130Leu missense_variant 0.19
inhA 1674601 p.Leu134Thr missense_variant 0.16
inhA 1674624 c.423A>C synonymous_variant 0.12
inhA 1674660 c.459G>C synonymous_variant 0.13
inhA 1674672 c.471C>G synonymous_variant 0.15
inhA 1674718 c.517A>C synonymous_variant 0.16
inhA 1674723 c.522C>T synonymous_variant 0.15
inhA 1674738 c.537C>G synonymous_variant 0.18
inhA 1674741 c.540C>T synonymous_variant 0.18
inhA 1674746 p.Tyr182Phe missense_variant 0.16
inhA 1674750 c.549T>C synonymous_variant 0.17
inhA 1674753 c.552G>C synonymous_variant 0.17
inhA 1674756 c.555T>C synonymous_variant 0.17
inhA 1674759 c.558G>C synonymous_variant 0.18
inhA 1674774 c.573A>G synonymous_variant 0.21
inhA 1674780 c.579T>G synonymous_variant 0.15
rpsA 1833856 c.315A>G synonymous_variant 0.22
rpsA 1833874 c.333T>C synonymous_variant 0.33
rpsA 1833928 c.387G>C synonymous_variant 0.14
rpsA 1834021 c.480C>T synonymous_variant 0.17
rpsA 1834030 c.489C>G synonymous_variant 0.15
rpsA 1834099 c.558C>G synonymous_variant 0.17
rpsA 1834102 c.561T>C synonymous_variant 0.18
rpsA 1834105 c.564C>G synonymous_variant 0.18
rpsA 1834108 c.567C>G synonymous_variant 0.18
rpsA 1834123 c.582C>G synonymous_variant 0.13
rpsA 1834222 c.681T>C synonymous_variant 0.17
rpsA 1834231 c.690T>C synonymous_variant 0.17
rpsA 1834234 c.693G>C synonymous_variant 0.17
rpsA 1834249 c.708T>C synonymous_variant 0.14
rpsA 1834261 c.720A>G synonymous_variant 0.25
rpsA 1834264 c.723G>C synonymous_variant 0.25
rpsA 1834303 c.762T>C synonymous_variant 0.25
rpsA 1834306 c.765T>C synonymous_variant 0.25
rpsA 1834348 c.807T>C synonymous_variant 0.26
rpsA 1834366 c.825A>G synonymous_variant 0.15
rpsA 1834501 c.960G>C synonymous_variant 0.2
rpsA 1834510 c.969C>T synonymous_variant 0.16
rpsA 1834513 c.972C>G synonymous_variant 0.15
rpsA 1834528 c.987T>C synonymous_variant 0.22
rpsA 1834540 c.999G>C synonymous_variant 0.26
rpsA 1834546 c.1005T>C synonymous_variant 0.32
rpsA 1834609 c.1068T>C synonymous_variant 0.26
rpsA 1834618 c.1077G>C synonymous_variant 0.26
rpsA 1834633 c.1092A>G synonymous_variant 0.22
rpsA 1834639 c.1098T>C synonymous_variant 0.22
rpsA 1834654 p.Glu371Asp missense_variant 0.39
rpsA 1834684 c.1143C>T synonymous_variant 0.35
rpsA 1834690 c.1149T>C synonymous_variant 0.29
rpsA 1834732 c.1191T>C synonymous_variant 0.2
rpsA 1834733 p.Ala398Ser missense_variant 0.2
rpsA 1834738 c.1197A>G synonymous_variant 0.2
rpsA 1834753 c.1212T>C synonymous_variant 0.16
rpsA 1834942 c.1401C>T synonymous_variant 0.13
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2170048 p.Leu189Val missense_variant 0.35
PPE35 2170053 p.Thr187Ser missense_variant 0.33
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2517950 c.-165C>G upstream_gene_variant 0.17
kasA 2518606 c.492G>C synonymous_variant 0.16
kasA 2518609 p.Met165Ile missense_variant 0.21
kasA 2519153 p.Ile347Val missense_variant 0.19
kasA 2519167 c.1053T>C synonymous_variant 0.15
kasA 2519171 p.Leu353Val missense_variant 0.14
kasA 2519174 p.Glu354Lys missense_variant 0.13
kasA 2519323 c.1209G>C synonymous_variant 0.15
kasA 2519332 c.1218C>A synonymous_variant 0.13
kasA 2519338 c.1224T>C synonymous_variant 0.13
kasA 2519344 c.1230G>C synonymous_variant 0.13
kasA 2519345 p.Leu411Ile missense_variant 0.13
ribD 2987340 p.Asp168His missense_variant 0.12
Rv2752c 3064896 c.1296T>C synonymous_variant 0.17
thyX 3067439 c.507A>G synonymous_variant 0.16
thyX 3067442 c.504C>T synonymous_variant 0.16
thyX 3067445 c.501C>G synonymous_variant 0.16
thyX 3067457 c.489C>G synonymous_variant 0.21
thyX 3067462 c.484C>T synonymous_variant 0.2
thyX 3067465 p.Ile161Val missense_variant 0.2
thyX 3067466 c.480G>C synonymous_variant 0.21
thyX 3067475 c.471A>G synonymous_variant 0.15
thyX 3067490 c.456C>G synonymous_variant 0.2
thyX 3067493 c.453A>G synonymous_variant 0.2
thyX 3067510 c.436C>T synonymous_variant 0.18
thyX 3067515 p.Ser144Thr missense_variant 0.18
thyX 3067661 c.285C>G synonymous_variant 0.17
thyX 3067685 c.261A>C synonymous_variant 0.15
thyX 3067691 p.Ile85Leu missense_variant 0.15
thyX 3067694 c.252G>C synonymous_variant 0.14
thyX 3067736 c.210C>T synonymous_variant 0.21
thyX 3067781 c.165C>G synonymous_variant 0.13
thyX 3067799 c.147G>A synonymous_variant 0.14
thyX 3067802 c.144C>G synonymous_variant 0.14
thyX 3067814 c.132T>C synonymous_variant 0.18
thyX 3067850 c.96A>C synonymous_variant 0.24
thyA 3074127 c.345G>C synonymous_variant 0.12
thyA 3074130 c.342G>C synonymous_variant 0.13
thyA 3074147 p.Ile109Val missense_variant 0.14
thyA 3074172 c.300G>C synonymous_variant 0.13
thyA 3074175 c.297A>G synonymous_variant 0.14
thyA 3074187 c.285T>C synonymous_variant 0.14
thyA 3074205 p.Glu89Asp missense_variant 0.14
thyA 3074214 c.258T>C synonymous_variant 0.14
ald 3087749 c.930C>G synonymous_variant 0.17
ald 3087750 p.Tyr311Val missense_variant 0.15
ald 3087761 c.942C>G synonymous_variant 0.17
ald 3087770 c.951G>C synonymous_variant 0.17
fprA 3474913 p.Ala303Ser missense_variant 0.12
fprA 3474921 p.Lys305Asn missense_variant 0.14
fprA 3474960 c.954C>G synonymous_variant 0.13
fprA 3474975 c.969C>T synonymous_variant 0.14
fprA 3474984 c.978G>C synonymous_variant 0.14
fprA 3474996 c.990C>G synonymous_variant 0.14
fbiB 3642581 c.1047A>C synonymous_variant 0.14
fbiB 3642656 c.1122G>C synonymous_variant 0.14
fbiB 3642659 c.1125C>G synonymous_variant 0.14
fbiB 3642668 c.1134A>G synonymous_variant 0.17
fbiB 3642677 c.1143A>G synonymous_variant 0.22
fbiB 3642680 c.1146A>G synonymous_variant 0.21
fbiB 3642684 c.1150T>C synonymous_variant 0.2
fbiB 3642701 c.1167C>G synonymous_variant 0.22
fbiB 3642719 c.1185T>C synonymous_variant 0.25
fbiB 3642731 c.1197C>G synonymous_variant 0.15
fbiB 3642743 c.1209T>C synonymous_variant 0.15
fbiB 3642781 p.Val416Ala missense_variant 0.12
rpoA 3877743 c.765T>C synonymous_variant 0.18
rpoA 3877962 c.546G>T synonymous_variant 0.14
rpoA 3878028 c.480G>C synonymous_variant 0.13
rpoA 3878094 c.414C>G synonymous_variant 0.14
rpoA 3878331 c.177A>G synonymous_variant 0.15
rpoA 3878334 c.174T>C synonymous_variant 0.13
clpC1 4038460 p.Leu749Met missense_variant 0.15
clpC1 4038486 p.Gly740Asn missense_variant 0.16
clpC1 4038489 p.Ala739Gly missense_variant 0.16
clpC1 4038494 c.2211G>C synonymous_variant 0.15
clpC1 4038497 p.Ser736Gln missense_variant 0.15
clpC1 4038509 c.2196C>T synonymous_variant 0.15
clpC1 4038989 c.1716T>C synonymous_variant 0.18
clpC1 4038997 c.1708T>C synonymous_variant 0.23
clpC1 4039004 c.1701C>G synonymous_variant 0.12
clpC1 4039064 c.1641C>T synonymous_variant 0.25
clpC1 4039097 c.1608G>C synonymous_variant 0.25
clpC1 4039103 c.1602T>C synonymous_variant 0.13
clpC1 4039112 c.1593C>G synonymous_variant 0.15
clpC1 4039121 c.1584T>C synonymous_variant 0.14
clpC1 4039556 c.1149G>C synonymous_variant 0.16
clpC1 4039559 c.1146C>G synonymous_variant 0.16
clpC1 4039562 c.1143C>G synonymous_variant 0.16
clpC1 4039565 c.1140G>C synonymous_variant 0.15
clpC1 4039570 p.Met379Leu missense_variant 0.15
clpC1 4039576 p.Ala377Pro missense_variant 0.16
clpC1 4039577 c.1128T>C synonymous_variant 0.16
clpC1 4039589 c.1116G>C synonymous_variant 0.15
clpC1 4039610 c.1095G>C synonymous_variant 0.19
clpC1 4039616 c.1089G>C synonymous_variant 0.19
clpC1 4039622 c.1083C>T synonymous_variant 0.19
clpC1 4039661 c.1044T>G synonymous_variant 0.13
clpC1 4039664 c.1041G>C synonymous_variant 0.15
clpC1 4039694 c.1011G>C synonymous_variant 0.14
clpC1 4039865 c.840T>C synonymous_variant 0.16
clpC1 4039979 c.726C>G synonymous_variant 0.16
clpC1 4039988 c.717C>G synonymous_variant 0.15
clpC1 4039991 c.714G>C synonymous_variant 0.15
clpC1 4040291 c.414G>C synonymous_variant 0.14
embC 4240726 c.864G>C synonymous_variant 0.17
embC 4241095 c.1233C>T synonymous_variant 0.18
embC 4241107 c.1245G>C synonymous_variant 0.24
embC 4241140 c.1278A>G synonymous_variant 0.21
embC 4241146 c.1284C>G synonymous_variant 0.22
embC 4241158 c.1296T>C synonymous_variant 0.2
embC 4241161 c.1299C>G synonymous_variant 0.2
embC 4241162 c.1300T>C synonymous_variant 0.21
embC 4241170 c.1308G>C synonymous_variant 0.21
embC 4241173 c.1311C>T synonymous_variant 0.2
embC 4241179 c.1317G>A synonymous_variant 0.2
embC 4241203 c.1341T>C synonymous_variant 0.19
embC 4241206 c.1344G>C synonymous_variant 0.19
embC 4241218 c.1356G>C synonymous_variant 0.15
embC 4241230 c.1368A>G synonymous_variant 0.16
embC 4241233 c.1371G>C synonymous_variant 0.16
embC 4241488 c.1626G>C synonymous_variant 0.21
embC 4241496 p.Ala545Gly missense_variant 0.22
embC 4241500 c.1638A>C synonymous_variant 0.22
embC 4241501 p.Ser547Thr missense_variant 0.22
embC 4241506 c.1644G>C synonymous_variant 0.2
embC 4241518 c.1656A>G synonymous_variant 0.25
embC 4241521 c.1659T>C synonymous_variant 0.25
embC 4241530 c.1668C>G synonymous_variant 0.29
embC 4241536 c.1674A>G synonymous_variant 0.31
embC 4241539 c.1677T>C synonymous_variant 0.31
embC 4241545 c.1683T>C synonymous_variant 0.31
embC 4241548 c.1686T>C synonymous_variant 0.31
embC 4241551 c.1689A>G synonymous_variant 0.31
embC 4241567 p.Ile569Val missense_variant 0.33
embC 4241572 c.1710C>G synonymous_variant 0.28
embC 4241578 c.1716G>C synonymous_variant 0.24
embC 4241584 c.1722T>C synonymous_variant 0.24
embC 4241587 c.1725C>G synonymous_variant 0.24
embC 4241591 p.Leu577Val missense_variant 0.27
embC 4241611 c.1749G>C synonymous_variant 0.29
embC 4241614 c.1752A>C synonymous_variant 0.29
embC 4241626 c.1764T>C synonymous_variant 0.23
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244632 p.Thr467Ile missense_variant 0.12
embA 4245458 p.Glu742Asp missense_variant 0.17
embB 4245737 c.-777A>C upstream_gene_variant 0.15
embB 4245740 c.-774T>C upstream_gene_variant 0.15
embB 4246256 c.-258G>T upstream_gene_variant 0.14
embB 4246259 c.-255G>C upstream_gene_variant 0.18
embA 4246264 p.His1011Arg missense_variant 0.12
embB 4246292 c.-222A>G upstream_gene_variant 0.19
embA 4246305 p.Ser1025Glu missense_variant 0.2
embA 4246308 p.Thr1026Ala missense_variant 0.22
embB 4246316 c.-198T>G upstream_gene_variant 0.25
embB 4246319 c.-195G>C upstream_gene_variant 0.25
embA 4246329 p.Thr1033Ala missense_variant 0.14
embA 4246359 p.Ala1043Ser missense_variant 0.17
embB 4246367 c.-147C>T upstream_gene_variant 0.17
embB 4246373 c.-141T>C upstream_gene_variant 0.19
embB 4246376 c.-138G>C upstream_gene_variant 0.19
embB 4246379 c.-135C>T upstream_gene_variant 0.18
embB 4246400 c.-114G>C upstream_gene_variant 0.18
embB 4246548 p.Pro12Gln missense_variant 0.2
embB 4246555 c.42G>C synonymous_variant 0.27
embB 4246556 p.Ala15Pro missense_variant 0.27
embB 4246567 c.54G>T synonymous_variant 0.25
embB 4247512 c.999T>C synonymous_variant 0.14
embB 4247776 c.1263G>T synonymous_variant 0.15
embB 4247797 c.1284C>G synonymous_variant 0.16
embB 4247800 c.1287A>T synonymous_variant 0.15
embB 4247803 c.1290G>C synonymous_variant 0.15
embB 4247815 c.1302C>G synonymous_variant 0.2
embB 4247819 p.Val436Ile missense_variant 0.23
embB 4247830 c.1317A>G synonymous_variant 0.15
embB 4247836 c.1323A>G synonymous_variant 0.19
embB 4247839 c.1326G>C synonymous_variant 0.17
embB 4247866 c.1353G>C synonymous_variant 0.23
embB 4247875 c.1362G>C synonymous_variant 0.2
embB 4247876 c.1363C>T synonymous_variant 0.2
embB 4247881 c.1368G>C synonymous_variant 0.21
embB 4247887 c.1374C>T synonymous_variant 0.21
embB 4247893 c.1380C>T synonymous_variant 0.24
embB 4247899 p.Met462Ile missense_variant 0.22
embB 4247905 c.1392G>C synonymous_variant 0.23
embB 4247909 c.1396T>C synonymous_variant 0.24
embB 4247914 c.1401G>C synonymous_variant 0.29
embB 4247932 c.1419C>G synonymous_variant 0.26
embB 4247940 p.Leu476Trp missense_variant 0.26
embB 4247945 c.1432T>C synonymous_variant 0.26
embB 4247951 p.Ser480Ala missense_variant 0.25
embB 4247956 c.1443G>C synonymous_variant 0.25
embB 4247974 c.1461C>G synonymous_variant 0.16
embB 4248007 c.1494C>G synonymous_variant 0.16
embB 4248011 p.Ser500Arg missense_variant 0.13
embB 4248014 p.Thr501Ala missense_variant 0.14
embB 4248070 c.1557T>C synonymous_variant 0.14
embB 4248097 c.1584C>G synonymous_variant 0.16
embB 4248130 c.1617G>C synonymous_variant 0.15
embB 4248172 c.1659G>C synonymous_variant 0.17
embB 4248199 c.1686A>G synonymous_variant 0.14
embB 4248200 p.Ile563Val missense_variant 0.14
embB 4248205 c.1692C>G synonymous_variant 0.13
embB 4248206 p.Ser565Gly missense_variant 0.13
embB 4249704 p.Leu1064Pro missense_variant 0.22
aftB 4267244 c.1593T>C synonymous_variant 0.15
aftB 4267256 c.1581C>G synonymous_variant 0.15
aftB 4267262 c.1575T>C synonymous_variant 0.15
aftB 4267266 p.Ala524Gly missense_variant 0.14
aftB 4267268 c.1569T>C synonymous_variant 0.15
aftB 4269042 c.-206G>C upstream_gene_variant 0.14
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448497 c.-6_*1408del transcript_ablation 1.0