TB-Profiler result

Run: ERR4822101
Summary

Run ID: ERR4822101

Sample name:

Date: 2025-09-15T15:34:50.636676

Number of reads: 2202581

Percentage reads mapped: 78.9

Median coverage: 49.0

Strain: lineage1.1.2;lineage4.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1 Indo-Oceanic RD239 48.47
lineage1.1 Indo-Oceanic RD239 49.11
lineage1.1.2 Indo-Oceanic RD239 50.0
lineage4.1 Euro-American None 51.83
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6112 p.Met291Ile missense_variant 0.25 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6124 c.885C>T synonymous_variant 0.25 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
gyrA 7427 c.126G>C synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8435 c.1134C>G synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8452 p.Ala384Val missense_variant 0.57 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9143 c.1842T>C synonymous_variant 0.49 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9191 c.1890G>C synonymous_variant 0.13 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9200 c.1899A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 0.42 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 0.36 isoniazid Not assoc w R
fgd1 490812 c.30A>G synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 490815 c.33G>C synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 490827 c.45C>T synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 490851 c.69A>T synonymous_variant 0.13 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 490868 p.Ala29Gly missense_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 0.47 clofazimine Not assoc w R
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
mshA 575376 p.Ser10Leu missense_variant 0.65 ethionamide Uncertain significance
isoniazid Uncertain significance
Rv0565c 657269 p.Ser68Pro missense_variant 0.47 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.35 ethionamide Uncertain significance
nusG 734116 c.-138T>C upstream_gene_variant 0.42 rifampicin Not assoc w R
nusG 734424 c.171G>A synonymous_variant 0.12 rifampicin Uncertain significance
nusG 734442 c.189G>A synonymous_variant 0.17 rifampicin Uncertain significance
nusG 734457 c.204C>G synonymous_variant 0.13 rifampicin Uncertain significance
nusG 734472 c.219T>C synonymous_variant 0.14 rifampicin Uncertain significance
nusG 734475 c.222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760674 c.868T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 761312 c.1506G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoB 761327 c.1521A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 761354 c.1548C>T synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 761360 c.1554T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 763031 c.3225T>C synonymous_variant 0.46 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763884 p.Ala172Val missense_variant 0.57 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.6 rifampicin Not assoc w R
rpoC 764278 c.909A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.13 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.13 rifampicin Uncertain significance
rpoC 764948 c.1579T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.53 rifampicin Not assoc w R
rpoC 765171 p.Pro601Leu missense_variant 0.42 rifampicin Not assoc w R
rpoC 765421 c.2052C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.25 rifampicin Uncertain significance
rpoC 765541 c.2172C>G synonymous_variant 0.28 rifampicin Uncertain significance
rpoC 765553 c.2184C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.24 rifampicin Uncertain significance
rpoC 765559 c.2190G>C synonymous_variant 0.25 rifampicin Uncertain significance
rpoC 765580 c.2211G>C synonymous_variant 0.23 rifampicin Uncertain significance
rpoC 765613 p.His748Gln missense_variant 0.2 rifampicin Uncertain significance
rpoC 765625 c.2256C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.16 rifampicin Uncertain significance
rpoC 765700 c.2331T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 765937 c.2568T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 765994 c.2625A>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 0.36 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781421 c.-139C>A upstream_gene_variant 0.5 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 0.52 linezolid Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.49 isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
fbiC 1304161 p.Arg411Ser missense_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304169 c.1239T>C synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304174 p.Val415Ala missense_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304184 c.1254G>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304187 c.1257T>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304208 c.1278C>T synonymous_variant 0.12 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304610 c.1680C>T synonymous_variant 0.44 clofazimine Not assoc w R - Interim
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
fbiC 1304784 c.1854T>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304808 c.1878C>G synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304811 c.1881C>G synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304817 c.1887T>C synonymous_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304829 c.1899T>C synonymous_variant 0.25 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304907 c.1977C>G synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304910 c.1980G>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304916 c.1986T>C synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
embR 1417019 p.Cys110Tyr missense_variant 0.33 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 0.44 ethambutol Uncertain significance
embR 1417793 c.-446C>T upstream_gene_variant 0.5 ethambutol Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.28 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.23 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.23 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.25 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1473660 n.3G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833595 c.54T>C synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833787 c.246C>G synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833841 c.300C>G synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833847 c.306C>G synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833856 c.315A>G synonymous_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834609 c.1068T>C synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1834633 c.1092A>G synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834639 c.1098T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834690 c.1149T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834732 c.1191T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834738 c.1197A>G synonymous_variant 0.13 pyrazinamide Uncertain significance
rpsA 1834753 c.1212T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834765 p.Glu408Asp missense_variant 0.14 pyrazinamide Uncertain significance
tsnR 1853974 c.369C>T synonymous_variant 0.71 linezolid Not assoc w R
tsnR 1854045 p.Tyr147Cys missense_variant 0.68 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 0.96 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 0.46 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
streptomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 0.29 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.41 pyrazinamide Not assoc w R
PPE35 2167983 p.Gly877Asp missense_variant 0.31 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 0.51 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518132 c.18C>T synonymous_variant 0.5 isoniazid Uncertain significance
ahpC 2726051 c.-142G>A upstream_gene_variant 0.5 isoniazid Uncertain significance
Rv2477c 2783015 p.Ser343Thr missense_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783035 c.1008G>C synonymous_variant 0.12 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783761 c.282G>C synonymous_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783766 p.Met93Leu missense_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783971 c.72G>C synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783980 c.63C>G synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783992 c.51T>C synonymous_variant 0.14 amikacin Uncertain significance
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
Rv2681 2996912 c.174C>T synonymous_variant 0.58 capreomycin Not assoc w R
Rv2752c 3064632 c.1560C>T synonymous_variant 0.42 ethambutol Not assoc w R
isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
thyX 3067439 c.507A>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067445 c.501C>G synonymous_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067457 c.489C>G synonymous_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067465 p.Ile161Val missense_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067475 c.471A>G synonymous_variant 0.19 para-aminosalicylic_acid Uncertain significance
thyX 3067490 c.456C>G synonymous_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyX 3067493 c.453A>G synonymous_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyX 3067515 p.Ser144Thr missense_variant 0.13 para-aminosalicylic_acid Uncertain significance
thyA 3073860 c.612C>G synonymous_variant 0.14 para-aminosalicylic_acid Uncertain significance
thyA 3073872 p.Ile200Met missense_variant 0.13 para-aminosalicylic_acid Uncertain significance
thyA 3073920 c.552C>G synonymous_variant 0.15 para-aminosalicylic_acid Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 0.98 cycloserine Uncertain significance
Rv3083 3448714 p.Asp71His missense_variant 0.42 ethionamide Uncertain significance
lpqB 3624236 c.675C>A synonymous_variant 0.47 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 0.55 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624660 p.Ala84Gly missense_variant 0.26 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 0.96 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625837 c.777C>G synonymous_variant 0.16 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.15 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625852 c.762A>G synonymous_variant 0.13 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.16 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625876 c.738G>C synonymous_variant 0.15 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3626987 c.-374C>G upstream_gene_variant 0.13 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627008 c.-395G>C upstream_gene_variant 0.16 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627011 c.-398T>G upstream_gene_variant 0.16 bedaquiline Uncertain significance
rifampicin Uncertain significance
rpoA 3877656 c.852T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877679 p.Ala277Ser missense_variant 0.17 rifampicin Uncertain significance
rpoA 3877686 c.822A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoA 3877743 c.765T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoA 3877875 c.633T>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3877878 c.630G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3877905 c.603A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3879121 c.-614T>G upstream_gene_variant 0.14 rifampicin Uncertain significance
clpC1 4038812 c.1893T>C synonymous_variant 0.21 pyrazinamide Uncertain significance
clpC1 4039178 c.1527G>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039183 c.1522T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039517 c.1188C>G synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4039616 c.1089G>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4039952 c.753T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4040517 p.Val63Ala missense_variant 0.43 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 0.56 ethambutol Not assoc w R
isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R
glpK 4139165 c.591A>G synonymous_variant 0.15 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4139168 c.588T>C synonymous_variant 0.16 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4139177 c.579T>C synonymous_variant 0.16 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4139183 c.573T>C synonymous_variant 0.15 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4139186 c.570G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
isoniazid Not assoc w R - Interim
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
glpK 4139195 c.561G>T synonymous_variant 0.13 ethambutol Not assoc w R - Interim
isoniazid Not assoc w R - Interim
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
streptomycin Uncertain significance
glpK 4139611 p.Ile49Val missense_variant 0.14 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
glpK 4139615 c.141G>A synonymous_variant 0.14 ethambutol Uncertain significance
isoniazid Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
streptomycin Uncertain significance
glpK 4139651 p.His35Glu missense_variant 0.14 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 0.46 ethambutol Not assoc w R
embC 4241042 p.Asn394Asp missense_variant 0.51 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.5 ethambutol Not assoc w R
embA 4243848 p.Val206Met missense_variant 0.68 ethambutol Not assoc w R
embA 4245083 c.1851A>C synonymous_variant 0.15 ethambutol Uncertain significance
embA 4245089 c.1857G>C synonymous_variant 0.19 ethambutol Uncertain significance
embA 4245092 c.1860C>G synonymous_variant 0.18 ethambutol Uncertain significance
embA 4245101 c.1869G>C synonymous_variant 0.2 ethambutol Uncertain significance
embA 4245137 c.1905T>C synonymous_variant 0.23 ethambutol Uncertain significance
embA 4245146 c.1914G>A synonymous_variant 0.23 ethambutol Uncertain significance
embA 4245149 c.1917C>G synonymous_variant 0.24 ethambutol Uncertain significance
embA 4245153 p.Ile641Val missense_variant 0.21 ethambutol Uncertain significance
embA 4245182 c.1950T>C synonymous_variant 0.13 ethambutol Uncertain significance
embA 4245969 p.Pro913Ser missense_variant 0.61 ethambutol Not assoc w R
embB 4247356 c.843C>T synonymous_variant 0.53 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 0.56 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 0.48 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 0.51 ethambutol Not assoc w R
whiB6 4338441 p.Tyr27* stop_gained 0.36 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338449 p.Ala25Pro missense_variant 0.39 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 0.33 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.99 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 0.36 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 0.36 streptomycin Not assoc w R