TB-Profiler result

Run: ERR5863931
Summary

Run ID: ERR5863931

Sample name:

Date: 01-04-2023 23:00:12

Number of reads: 1769603

Percentage reads mapped: 98.19

Strain: lineage2.2.1

Drug-resistance: Pre-XDR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrB 6750 p.Ala504Val missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
gyrA 7582 p.Asp94Gly missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 1.0 streptomycin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.24 streptomycin
inhA 1674048 c.-154G>A upstream_gene_variant 1.0 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289222 p.Val7Ala missense_variant 1.0 pyrazinamide
eis 2715346 c.-14C>T upstream_gene_variant 1.0 kanamycin, amikacin
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
ethA 4326705 c.768delG frameshift_variant 1.0 ethionamide, ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764817 p.Val483Gly missense_variant 1.0
rpoC 766645 p.Glu1092Asp missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpL5 778922 c.-442G>T upstream_gene_variant 0.12
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.15
rrs 1472122 n.277G>A non_coding_transcript_exon_variant 0.19
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.18
rrs 1472128 n.283G>A non_coding_transcript_exon_variant 0.18
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.18
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.24
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.23
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.26
rrs 1472164 n.319G>A non_coding_transcript_exon_variant 0.26
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.25
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.25
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.26
rrs 1472210 n.365A>C non_coding_transcript_exon_variant 0.26
rrs 1472213 n.368G>C non_coding_transcript_exon_variant 0.25
rrs 1472215 n.370A>G non_coding_transcript_exon_variant 0.25
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.26
rrs 1472234 n.389T>C non_coding_transcript_exon_variant 0.34
rrs 1472236 n.391C>G non_coding_transcript_exon_variant 0.28
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.27
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.1
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.28
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.38
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.38
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.47
rrs 1472541 n.696T>G non_coding_transcript_exon_variant 0.47
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.49
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.49
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.49
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.46
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.46
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.46
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.49
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.49
rrs 1472596 n.751G>T non_coding_transcript_exon_variant 0.47
rrs 1472598 n.753A>T non_coding_transcript_exon_variant 0.46
rrs 1472614 n.769G>T non_coding_transcript_exon_variant 0.5
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.5
rrs 1472695 n.850C>T non_coding_transcript_exon_variant 0.23
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.22
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.23
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.24
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.23
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.23
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.17
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.18
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.18
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.19
rrl 1475726 n.2069G>A non_coding_transcript_exon_variant 0.15
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.22
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.25
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.69
rrl 1476234 n.2577G>A non_coding_transcript_exon_variant 0.72
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.73
rrl 1476268 n.2611A>T non_coding_transcript_exon_variant 0.72
rrl 1476275 n.2618T>A non_coding_transcript_exon_variant 0.72
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.72
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.72
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.74
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.74
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.74
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.74
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.73
rrl 1476301 n.2644A>C non_coding_transcript_exon_variant 0.73
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.72
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.7
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.69
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.68
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.78
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.83
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.82
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.82
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.83
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.84
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.84
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.85
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.84
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.84
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.84
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.86
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.83
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.7
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.58
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.55
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.55
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.56
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.56
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.56
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.56
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.57
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.57
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.57
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.57
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.52
rrl 1476572 n.2915G>A non_coding_transcript_exon_variant 0.44
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.43
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.24
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168785 p.Ile610Val missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339504 p.Ile129Met missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
alr 3841392 p.Lys10Met missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338563 c.-42G>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0