TB-Profiler result

Run: ERR702423
Summary

Run ID: ERR702423

Sample name:

Date: 02-04-2023 03:53:58

Number of reads: 2859672

Percentage reads mapped: 66.75

Strain: lineage5.1.4

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage5 West-Africa 1 AFRI_2;AFRI_3 RD711 1.0
lineage5.1.4 West-Africa 1 AFRI_2;AFRI_3 RD711 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5081 c.-159G>C upstream_gene_variant 1.0
gyrB 6446 p.Ala403Ser missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9566 c.2265C>T synonymous_variant 1.0
gyrA 9771 p.Asp824Asn missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775753 c.2727delC frameshift_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 0.98
rrs 1472089 n.244C>T non_coding_transcript_exon_variant 0.17
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.26
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.31
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.37
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.45
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.48
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.51
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.55
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.55
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.62
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.51
rrs 1472210 n.365A>C non_coding_transcript_exon_variant 0.45
rrs 1472213 n.368G>C non_coding_transcript_exon_variant 0.44
rrs 1472215 n.370A>G non_coding_transcript_exon_variant 0.48
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.42
rrs 1472234 n.389T>C non_coding_transcript_exon_variant 0.3
rrs 1472236 n.391C>G non_coding_transcript_exon_variant 0.28
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.27
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.11
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.22
rrs 1472518 n.673G>C non_coding_transcript_exon_variant 0.22
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.4
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.39
rrs 1472544 n.699C>G non_coding_transcript_exon_variant 0.39
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.42
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.53
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.53
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.53
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.56
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.53
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.49
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.32
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.33
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.35
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.37
rrs 1472779 n.934G>A non_coding_transcript_exon_variant 0.36
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.37
rrs 1472786 n.941C>T non_coding_transcript_exon_variant 0.35
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.38
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.36
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.19
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.19
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.19
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.2
rrl 1474790 n.1133C>T non_coding_transcript_exon_variant 0.36
rrl 1474798 n.1141C>T non_coding_transcript_exon_variant 0.43
rrl 1474804 n.1147C>T non_coding_transcript_exon_variant 0.5
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.51
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.48
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.52
rrl 1474844 n.1187G>T non_coding_transcript_exon_variant 0.58
rrl 1474866 n.1209C>A non_coding_transcript_exon_variant 0.51
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.51
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.46
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 0.4
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.39
rrl 1474913 n.1256T>A non_coding_transcript_exon_variant 0.35
rrl 1474920 n.1263G>A non_coding_transcript_exon_variant 0.26
rrl 1474927 n.1271delC non_coding_transcript_exon_variant 0.19
rrl 1474931 n.1274G>A non_coding_transcript_exon_variant 0.18
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.11
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 0.12
rrl 1475707 n.2050T>A non_coding_transcript_exon_variant 0.12
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.27
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.27
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.31
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.31
rrl 1475843 n.2186G>A non_coding_transcript_exon_variant 0.19
rrl 1475849 n.2192G>A non_coding_transcript_exon_variant 0.2
rrl 1475853 n.2196C>T non_coding_transcript_exon_variant 0.2
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.21
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.11
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.48
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.51
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.59
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.62
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.7
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.7
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.7
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.79
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.78
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.78
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.66
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.58
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.3
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.11
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.25
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.24
rrl 1476577 n.2920T>G non_coding_transcript_exon_variant 0.24
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.24
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.21
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.2
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.21
rrl 1476614 n.2957A>G non_coding_transcript_exon_variant 0.21
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.19
rrl 1476624 n.2967T>A non_coding_transcript_exon_variant 0.22
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.22
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.22
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.22
rrl 1476637 n.2980C>G non_coding_transcript_exon_variant 0.22
inhA 1673338 c.-864G>A upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101921 c.1122G>A synonymous_variant 1.0
ndh 2103112 c.-70G>T upstream_gene_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2290062 c.-821G>A upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
thyX 3067976 c.-31T>G upstream_gene_variant 1.0
ald 3087084 c.266delA frameshift_variant 1.0
ald 3087184 c.368_373delCCGACG disruptive_inframe_deletion 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.98
fprA 3475159 p.Asn385Asp missense_variant 1.0
alr 3840932 c.489C>T synonymous_variant 1.0
rpoA 3878641 c.-134C>G upstream_gene_variant 0.17
ddn 3986987 c.144G>T synonymous_variant 1.0
ddn 3987180 p.Asp113Asn missense_variant 1.0
clpC1 4038857 c.1848C>A synonymous_variant 0.15
clpC1 4040824 c.-120C>T upstream_gene_variant 1.0
embC 4239843 c.-20A>C upstream_gene_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244220 c.988C>T synonymous_variant 0.96
embA 4244635 p.Val468Ala missense_variant 1.0
embA 4245147 p.Pro639Ser missense_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
ethR 4326928 c.-621G>A upstream_gene_variant 1.0
ethA 4327103 p.Gly124Asp missense_variant 1.0
whiB6 4338546 c.-25G>A upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0