TB-Profiler result

Run: SRR15368751
Summary

Run ID: SRR15368751

Sample name:

Date: 03-04-2023 13:47:26

Number of reads: 6973451

Percentage reads mapped: 45.8

Strain: lineage2.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoC 762989 c.-381G>C upstream_gene_variant 0.12
rpoC 763028 c.-342T>C upstream_gene_variant 0.1
rpoC 763031 c.-339T>C upstream_gene_variant 0.98
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.99
mmpL5 776182 p.Asp767Asn missense_variant 0.97
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.2
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.25
rrs 1472128 n.283G>C non_coding_transcript_exon_variant 0.24
rrs 1472129 n.284G>A non_coding_transcript_exon_variant 0.24
rrs 1472135 n.290C>T non_coding_transcript_exon_variant 0.23
rrs 1472138 n.293C>T non_coding_transcript_exon_variant 0.23
rrs 1472147 n.302G>A non_coding_transcript_exon_variant 0.22
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.36
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.28
rrs 1472153 n.308G>A non_coding_transcript_exon_variant 0.26
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.11
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.25
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.25
rrs 1472235 n.390G>C non_coding_transcript_exon_variant 0.2
rrs 1472240 n.395G>C non_coding_transcript_exon_variant 0.2
rrs 1472242 n.397C>T non_coding_transcript_exon_variant 0.16
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.12
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.11
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.12
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.12
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.15
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.14
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.17
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.15
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.14
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.16
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.21
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.13
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.16
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.18
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.11
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.12
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.11
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.12
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.14
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.13
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.11
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.1
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.12
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.1
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.17
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.15
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.18
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.15
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.16
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.2
rrl 1476235 n.2578A>G non_coding_transcript_exon_variant 0.14
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.21
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.22
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.23
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.24
rrl 1476336 n.2679C>G non_coding_transcript_exon_variant 0.26
rrl 1476356 n.2699C>G non_coding_transcript_exon_variant 0.31
rrl 1476357 n.2700T>A non_coding_transcript_exon_variant 0.35
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.37
rrl 1476368 n.2711T>C non_coding_transcript_exon_variant 0.16
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.24
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.45
rrl 1476384 n.2727G>C non_coding_transcript_exon_variant 0.4
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.44
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.43
rrl 1476428 n.2771C>A non_coding_transcript_exon_variant 0.28
rrl 1476443 n.2786G>C non_coding_transcript_exon_variant 0.35
rrl 1476455 n.2798C>G non_coding_transcript_exon_variant 0.35
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.38
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.38
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.36
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.37
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.22
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.14
inhA 1674645 c.444C>T synonymous_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 0.98
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.98
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448915 p.Ser138Gly missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0